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A point-of-care diagnostic for differentiating Ebola from endemic febrile diseases.

Sebba D, Lastovich AG, Kuroda M, Fallows E, Johnson J, Ahouidi A, Honko AN, Fu H, Nielson R, Carruthers E, Diédhiou C, Ahmadou D, Soropogui B, Ruedas J, Peters K, Bartkowiak M, Magassouba N, Mboup S, Ben Amor Y, Connor JH, Weidemaier K.

Sci Transl Med. 2018 Dec 12;10(471). pii: eaat0944. doi: 10.1126/scitranslmed.aat0944.


Comparative Transcriptomics in Ebola Makona-Infected Ferrets, Nonhuman Primates, and Humans.

Cross RW, Speranza E, Borisevich V, Widen SG, Wood TG, Shim RS, Adams RD, Gerhardt DM, Bennett RS, Honko AN, Johnson JC, Hensley LE, Geisbert TW, Connor JH.

J Infect Dis. 2018 Nov 22;218(suppl_5):S486-S495. doi: 10.1093/infdis/jiy455.


Differential Mechanisms for the Involvement of Polyamines and Hypusinated eIF5A in Ebola Virus Gene Expression.

Olsen ME, Cressey TN, Mühlberger E, Connor JH.

J Virol. 2018 Sep 26;92(20). pii: e01260-18. doi: 10.1128/JVI.01260-18. Print 2018 Oct 15.


Growth-Adaptive Mutations in the Ebola Virus Makona Glycoprotein Alter Different Steps in the Virus Entry Pathway.

Ruedas JB, Arnold CE, Palacios G, Connor JH.

J Virol. 2018 Sep 12;92(19). pii: e00820-18. doi: 10.1128/JVI.00820-18. Print 2018 Oct 1.


T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans.

Speranza E, Ruibal P, Port JR, Feng F, Burkhardt L, Grundhoff A, Günther S, Oestereich L, Hiscox JA, Connor JH, Muñoz-Fontela C.

J Infect Dis. 2018 Nov 22;218(suppl_5):S508-S518. doi: 10.1093/infdis/jiy352.


Correction for Olsen et al., "Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication".

Olsen ME, Filone CM, Rozelle D, Mire CE, Agans KN, Hensley L, Connor JH.

MBio. 2018 Jun 5;9(3). pii: e01065-18. doi: 10.1128/mBio.01065-18. No abstract available.


Wolbachia wStri Blocks Zika Virus Growth at Two Independent Stages of Viral Replication.

Schultz MJ, Tan AL, Gray CN, Isern S, Michael SF, Frydman HM, Connor JH.

MBio. 2018 May 22;9(3). pii: e00738-18. doi: 10.1128/mBio.00738-18.


Dual Insect specific virus infection limits Arbovirus replication in Aedes mosquito cells.

Schultz MJ, Frydman HM, Connor JH.

Virology. 2018 May;518:406-413. doi: 10.1016/j.virol.2018.03.022. Epub 2018 Apr 3.


A conserved transcriptional response to intranasal Ebola virus exposure in nonhuman primates prior to onset of fever.

Speranza E, Bixler SL, Altamura LA, Arnold CE, Pratt WD, Taylor-Howell C, Burrows C, Aguilar W, Rossi F, Shamblin JD, Wollen SE, Zelko JM, Minogue T, Nagle E, Palacios G, Goff AJ, Connor JH.

Sci Transl Med. 2018 Mar 28;10(434). pii: eaaq1016. doi: 10.1126/scitranslmed.aaq1016.


Group B Wolbachia Strain-Dependent Inhibition of Arboviruses.

Schultz MJ, Connor JH, Frydman HM.

DNA Cell Biol. 2018 Jan;37(1):2-6. doi: 10.1089/dna.2017.4025. Epub 2018 Jan 3.


Comparison of Transcriptomic Platforms for Analysis of Whole Blood from Ebola-Infected Cynomolgus Macaques.

Speranza E, Altamura LA, Kulcsar K, Bixler SL, Rossi CA, Schoepp RJ, Nagle E, Aguilar W, Douglas CE, Delp KL, Minogue TD, Palacios G, Goff AJ, Connor JH.

Sci Rep. 2017 Nov 7;7(1):14756. doi: 10.1038/s41598-017-15145-7.


HoTResDB: Host Transcriptional Response Database for Viral Hemorrhagic Fevers.

Lo J, Zhang D, Speranza E, Negron JA, Connor JH.

Bioinformatics. 2017 Sep 22. doi: 10.1093/bioinformatics/btx599. [Epub ahead of print]


Robust Visualization and Discrimination of Nanoparticles by Interferometric Imaging.

Trueb J, Avci O, Sevenler D, Connor JH, Ünlü MS.

IEEE J Sel Top Quantum Electron. 2017 Mar-Apr;23(2). pii: 6900610. doi: 10.1109/JSTQE.2016.2639824. Epub 2016 Dec 14.


Host Transcriptional Response to Ebola Virus Infection.

Speranza E, Connor JH.

Vaccines (Basel). 2017 Sep 20;5(3). pii: E30. doi: 10.3390/vaccines5030030. Review.


Polyamines and Their Role in Virus Infection.

Mounce BC, Olsen ME, Vignuzzi M, Connor JH.

Microbiol Mol Biol Rev. 2017 Sep 13;81(4). pii: e00029-17. doi: 10.1128/MMBR.00029-17. Print 2017 Dec. Review.


An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening.

Nelson EV, Pacheco JR, Hume AJ, Cressey TN, Deflubé LR, Ruedas JB, Connor JH, Ebihara H, Mühlberger E.

Antiviral Res. 2017 Oct;146:21-27. doi: 10.1016/j.antiviral.2017.08.005. Epub 2017 Aug 12.


Enhanced light microscopy visualization of virus particles from Zika virus to filamentous ebolaviruses.

Daaboul GG, Freedman DS, Scherr SM, Carter E, Rosca A, Bernstein D, Mire CE, Agans KN, Hoenen T, Geisbert TW, Ünlü MS, Connor JH.

PLoS One. 2017 Jun 26;12(6):e0179728. doi: 10.1371/journal.pone.0179728. eCollection 2017.


Visualizing Ebolavirus Particles Using Single-Particle Interferometric Reflectance Imaging Sensor (SP-IRIS).

Carter EP, Seymour EÇ, Scherr SM, Daaboul GG, Freedman DS, Selim Ünlü M, Connor JH.

Methods Mol Biol. 2017;1628:259-270. doi: 10.1007/978-1-4939-7116-9_21.


Spontaneous Mutation at Amino Acid 544 of the Ebola Virus Glycoprotein Potentiates Virus Entry and Selection in Tissue Culture.

Ruedas JB, Ladner JT, Ettinger CR, Gummuluru S, Palacios G, Connor JH.

J Virol. 2017 Jul 12;91(15). pii: e00392-17. doi: 10.1128/JVI.00392-17. Print 2017 Aug 1.


Variable Inhibition of Zika Virus Replication by Different Wolbachia Strains in Mosquito Cell Cultures.

Schultz MJ, Isern S, Michael SF, Corley RB, Connor JH, Frydman HM.

J Virol. 2017 Jun 26;91(14). pii: e00339-17. doi: 10.1128/JVI.00339-17. Print 2017 Jul 15.


Generating Recombinant Vesicular Stomatitis Viruses for Use as Vaccine Platforms.

Ruedas JB, Connor JH.

Methods Mol Biol. 2017;1581:203-222. doi: 10.1007/978-1-4939-6869-5_12.


Zika virus induced cellular remodelling.

Rossignol ED, Peters KN, Connor JH, Bullitt E.

Cell Microbiol. 2017 Aug;19(8). doi: 10.1111/cmi.12740. Epub 2017 Apr 18.


DNA-Directed Antibody Immobilization for Robust Protein Microarrays: Application to Single Particle Detection 'DNA-Directed Antibody Immobilization.

Ünlü NL, Kanik FE, Seymour E, Connor JH, Ünlü MS.

Methods Mol Biol. 2017;1571:187-206. doi: 10.1007/978-1-4939-6848-0_12.


Disposable cartridge platform for rapid detection of viral hemorrhagic fever viruses.

Scherr SM, Freedman DS, Agans KN, Rosca A, Carter E, Kuroda M, Fawcett HE, Mire CE, Geisbert TW, Ünlü MS, Connor JH.

Lab Chip. 2017 Feb 28;17(5):917-925. doi: 10.1039/c6lc01528j.


Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus.

Liu X, Speranza E, Muñoz-Fontela C, Haldenby S, Rickett NY, Garcia-Dorival I, Fang Y, Hall Y, Zekeng EG, Lüdtke A, Xia D, Kerber R, Krumkamp R, Duraffour S, Sissoko D, Kenny J, Rockliffe N, Williamson ED, Laws TR, N'Faly M, Matthews DA, Günther S, Cossins AR, Sprecher A, Connor JH, Carroll MW, Hiscox JA.

Genome Biol. 2017 Jan 19;18(1):4. doi: 10.1186/s13059-016-1137-3.


Hypusination of eIF5A as a Target for Antiviral Therapy.

Olsen ME, Connor JH.

DNA Cell Biol. 2017 Mar;36(3):198-201. doi: 10.1089/dna.2016.3611. Epub 2017 Jan 12. No abstract available.


Multiplexed Metagenomic Deep Sequencing To Analyze the Composition of High-Priority Pathogen Reagents.

Wilson MR, Fedewa G, Stenglein MD, Olejnik J, Rennick LJ, Nambulli S, Feldmann F, Duprex WP, Connor JH, Mühlberger E, DeRisi JL.

mSystems. 2016 Jul 19;1(4). pii: e00058-16. eCollection 2016 Jul-Aug.


New Approaches for Virus Detection through Multidisciplinary Partnerships.

Fawcett H, Ünlü MS, Connor JH.

ACS Infect Dis. 2016 Jun 10;2(6):378-81. doi: 10.1021/acsinfecdis.6b00063. Epub 2016 May 11.


In vivo Ebola virus infection leads to a strong innate response in circulating immune cells.

Caballero IS, Honko AN, Gire SK, Winnicki SM, Melé M, Gerhardinger C, Lin AE, Rinn JL, Sabeti PC, Hensley LE, Connor JH.

BMC Genomics. 2016 Sep 5;17:707. doi: 10.1186/s12864-016-3060-0.


Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication.

Olsen ME, Filone CM, Rozelle D, Mire CE, Agans KN, Hensley L, Connor JH.

MBio. 2016 Jul 26;7(4). pii: e00882-16. doi: 10.1128/mBio.00882-16. Erratum in: MBio. 2018 Jun 5;9(3):.


Real-Time Capture and Visualization of Individual Viruses in Complex Media.

Scherr SM, Daaboul GG, Trueb J, Sevenler D, Fawcett H, Goldberg B, Connor JH, Ünlü MS.

ACS Nano. 2016 Feb 23;10(2):2827-33. doi: 10.1021/acsnano.5b07948. Epub 2016 Jan 22.


DNA-Directed Antibody Immobilization for Enhanced Detection of Single Viral Pathogens.

Seymour E, Daaboul GG, Zhang X, Scherr SM, Ünlü NL, Connor JH, Ünlü MS.

Anal Chem. 2015 Oct 20;87(20):10505-12. doi: 10.1021/acs.analchem.5b02702. Epub 2015 Oct 7.


Transcriptional Profiling of the Immune Response to Marburg Virus Infection.

Connor JH, Yen J, Caballero IS, Garamszegi S, Malhotra S, Lin K, Hensley L, Goff AJ.

J Virol. 2015 Oct;89(19):9865-74. doi: 10.1128/JVI.01142-15. Epub 2015 Jul 22.


Temporal Characterization of Marburg Virus Angola Infection following Aerosol Challenge in Rhesus Macaques.

Lin KL, Twenhafel NA, Connor JH, Cashman KA, Shamblin JD, Donnelly GC, Esham HL, Wlazlowski CB, Johnson JC, Honko AN, Botto MA, Yen J, Hensley LE, Goff AJ.

J Virol. 2015 Oct;89(19):9875-85. doi: 10.1128/JVI.01147-15. Epub 2015 Jul 22.


A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs.

Mire CE, Geisbert JB, Versteeg KM, Mamaeva N, Agans KN, Geisbert TW, Connor JH.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S384-8. doi: 10.1093/infdis/jiv126. Epub 2015 May 9.


Probing the virus host interaction in high containment: an approach using pooled short hairpin RNA.

Filone CM, Dower K, Cowley GS, Hensley LE, Connor JH.

Assay Drug Dev Technol. 2015 Jan-Feb;13(1):34-43. doi: 10.1089/adt.2014.613. Epub 2015 Feb 3.


Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection.

Caballero IS, Yen JY, Hensley LE, Honko AN, Goff AJ, Connor JH.

BMC Genomics. 2014 Nov 6;15:960. doi: 10.1186/1471-2164-15-960.


Transcriptional correlates of disease outcome in anticoagulant-treated non-human primates infected with ebolavirus.

Garamszegi S, Yen JY, Honko AN, Geisbert JB, Rubins KH, Geisbert TW, Xia Y, Hensley LE, Connor JH.

PLoS Negl Trop Dis. 2014 Jul 31;8(7):e3061. doi: 10.1371/journal.pntd.0003061. eCollection 2014.


Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2.

Chung DH, Jonsson CB, Tower NA, Chu YK, Sahin E, Golden JE, Noah JW, Schroeder CE, Sotsky JB, Sosa MI, Cramer DE, McKellip SN, Rasmussen L, White EL, Schmaljohn CS, Julander JG, Smith JM, Filone CM, Connor JH, Sakurai Y, Davey RA.

PLoS Pathog. 2014 Jun 26;10(6):e1004213. doi: 10.1371/journal.ppat.1004213. eCollection 2014 Jun.


A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection.

Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JH, Conte D Jr, Gundersen-Rindal DE, Marshall WL, Yates JR, Silverman N, Mello CC.

Elife. 2014 Jun 25;3. doi: 10.7554/eLife.02910.


Vaccinia reporter viruses for quantifying viral function at all stages of gene expression.

Rozelle DK, Filone CM, Dower K, Connor JH.

J Vis Exp. 2014 May 15;(87). doi: 10.3791/51522.


Digital sensing and sizing of vesicular stomatitis virus pseudotypes in complex media: a model for Ebola and Marburg detection.

Daaboul GG, Lopez CA, Chinnala J, Goldberg BB, Connor JH, Ünlü MS.

ACS Nano. 2014 Jun 24;8(6):6047-6055. doi: 10.1021/nn501312q. Epub 2014 Jun 4.


Activation of stress response pathways promotes formation of antiviral granules and restricts virus replication.

Rozelle DK, Filone CM, Kedersha N, Connor JH.

Mol Cell Biol. 2014 Jun;34(11):2003-16. doi: 10.1128/MCB.01630-13. Epub 2014 Mar 24.


An interferometric reflectance imaging sensor for point of care viral diagnostics.

Reddington AP, Trueb JT, Freedman DS, Tuysuzoglu A, Daaboul GG, Lopez CA, Karl WC, Connor JH, Fawcett H, Ünlu MS.

IEEE Trans Biomed Eng. 2013 Dec;60(12):3276-83. doi: 10.1109/TBME.2013.2272666.


Transcriptional profiling of the circulating immune response to lassa virus in an aerosol model of exposure.

Malhotra S, Yen JY, Honko AN, Garamszegi S, Caballero IS, Johnson JC, Mucker EM, Trefry JC, Hensley LE, Connor JH.

PLoS Negl Trop Dis. 2013 Apr 25;7(4):e2171. doi: 10.1371/journal.pntd.0002171. Print 2013.


Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach.

Filone CM, Hodges EN, Honeyman B, Bushkin GG, Boyd K, Platt A, Ni F, Strom K, Hensley L, Snyder JK, Connor JH.

Chem Biol. 2013 Mar 21;20(3):424-33. doi: 10.1016/j.chembiol.2013.02.011.


Myxoma and vaccinia viruses bind differentially to human leukocytes.

Chan WM, Bartee EC, Moreb JS, Dower K, Connor JH, McFadden G.

J Virol. 2013 Apr;87(8):4445-60. doi: 10.1128/JVI.03488-12. Epub 2013 Feb 6.


Translational control by negative-strand RNA viruses: methods for the study of a crucial virus/host interaction.

Hodges EN, Connor JH.

Methods. 2013 Feb;59(2):180-7. doi: 10.1016/j.ymeth.2012.09.003. Epub 2012 Sep 23. Review.


A vesiculovirus showing a steepened transcription gradient and dominant trans-repression of virus transcription.

Hodges EN, Heinrich BS, Connor JH.

J Virol. 2012 Aug;86(16):8884-9. doi: 10.1128/JVI.00358-12. Epub 2012 Jun 6.


HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis.

Dunn EF, Connor JH.

Prog Mol Biol Transl Sci. 2012;106:223-50. doi: 10.1016/B978-0-12-396456-4.00002-X. Review.


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