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Items: 1 to 50 of 126

1.

Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease.

Lu T, Connolly PJ, Philippar U, Sun W, Cummings MD, Barbay K, Gys L, Van Nuffel L, Austin N, Bekkers M, Shen F, Cai A, Attar R, Meerpoel L, Edwards J.

Bioorg Med Chem Lett. 2019 Dec 1;29(23):126743. doi: 10.1016/j.bmcl.2019.126743. Epub 2019 Oct 17.

PMID:
31678006
2.

Venous Thromboembolism Prophylaxis for Patients Having Elective Spine Surgery: When, Why, and How Much.

Rockson HB, DiPaola CP, Connolly PJ, Stauff MP.

J Bone Joint Surg Am. 2019 Jul 3;101(13):1220-1229. doi: 10.2106/JBJS.18.00849. No abstract available.

PMID:
31274725
3.

Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.

Lu T, Schubert C, Cummings MD, Bignan G, Connolly PJ, Smans K, Ludovici D, Parker MH, Meyer C, Rocaboy C, Alexander R, Grasberger B, De Breucker S, Esser N, Fraiponts E, Gilissen R, Janssens B, Peeters D, Van Nuffel L, Vermeulen P, Bischoff J, Meerpoel L.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2159-2164. doi: 10.1016/j.bmcl.2018.05.014. Epub 2018 May 8.

PMID:
29779975
4.

Controversies in the Management of Central Cord Syndrome: The State of the Art.

Wagner PJ, DiPaola CP, Connolly PJ, Stauff MP.

J Bone Joint Surg Am. 2018 Apr 4;100(7):618-626. doi: 10.2106/JBJS.17.00811. Review. No abstract available.

PMID:
29613932
5.

Landscape context and the biophysical response of rivers to dam removal in the United States.

Foley MM, Magilligan FJ, Torgersen CE, Major JJ, Anderson CW, Connolly PJ, Wieferich D, Shafroth PB, Evans JE, Infante D, Craig LS.

PLoS One. 2017 Jul 10;12(7):e0180107. doi: 10.1371/journal.pone.0180107. eCollection 2017.

6.

Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists.

Matthews JM, McNally JJ, Connolly PJ, Xia M, Zhu B, Black S, Chen C, Hou C, Liang Y, Tang Y, Macielag MJ.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5346-5349. doi: 10.1016/j.bmcl.2016.09.025. Epub 2016 Sep 10.

PMID:
27671496
7.

From Nanodiscs to Isotropic Bicelles: A Procedure for Solution Nuclear Magnetic Resonance Studies of Detergent-Sensitive Integral Membrane Proteins.

Laguerre A, Löhr F, Henrich E, Hoffmann B, Abdul-Manan N, Connolly PJ, Perozo E, Moore JM, Bernhard F, Dötsch V.

Structure. 2016 Oct 4;24(10):1830-1841. doi: 10.1016/j.str.2016.07.017. Epub 2016 Sep 15.

8.

A potential hidden layer of meteorites below the ice surface of Antarctica.

Evatt GW, Coughlan MJ, Joy KH, Smedley AR, Connolly PJ, Abrahams ID.

Nat Commun. 2016 Feb 16;7:10679. doi: 10.1038/ncomms10679.

9.

Spatial complexity reduces interaction strengths in the meta-food web of a river floodplain mosaic.

Bellmore JR, Baxter CV, Connolly PJ.

Ecology. 2015 Jan;96(1):274-83.

PMID:
26236912
10.

Lockean superaddition and Lockean humility.

Connolly PJ.

Stud Hist Philos Sci. 2015 Jun;51:53-61. doi: 10.1016/j.shpsa.2015.03.001. Epub 2015 Mar 31.

PMID:
26227231
11.

A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety.

Ross TM, Battista K, Bignan GC, Brenneman DE, Connolly PJ, Liu J, Middleton SA, Orsini M, Reitz AB, Rosenthal DI, Scott MK, Vaidya AH.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):602-6. doi: 10.1016/j.bmcl.2014.12.015. Epub 2014 Dec 17.

PMID:
25556095
12.

Time-shared experiments for efficient assignment of triple-selectively labeled proteins.

Löhr F, Laguerre A, Bock C, Reckel S, Connolly PJ, Abdul-Manan N, Tumulka F, Abele R, Moore JM, Dötsch V.

J Magn Reson. 2014 Nov;248:81-95. doi: 10.1016/j.jmr.2014.09.014. Epub 2014 Sep 30.

13.

Factors determining the most efficient spray distribution for marine cloud brightening.

Connolly PJ, McFiggans GB, Wood R, Tsiamis A.

Philos Trans A Math Phys Eng Sci. 2014 Dec 28;372(2031). pii: 20140056. doi: 10.1098/rsta.2014.0056.

14.

Commentary on perioperative variables and minimally invasive surgical techniques: are we asking the right questions?

Stauff MP, Connolly PJ, Hurwitz EL.

Spine J. 2014 Aug 1;14(8):1709-11. doi: 10.1016/j.spinee.2014.03.004. No abstract available.

PMID:
25085724
15.

Bioabsorbable pins for bone fixation in the less invasive innominate osteotomy.

Dawson PH, O'Briain DE, Connolly PJ, McCormack D.

J Pediatr Orthop B. 2014 Sep;23(5):426-9. doi: 10.1097/BPB.0000000000000069.

PMID:
24911940
16.

Use of a cyanoacrylate skin adhesive to reduce external ventricular drain infection rates.

Bookland MJ, Sukul V, Connolly PJ.

J Neurosurg. 2014 Jul;121(1):189-94. doi: 10.3171/2013.12.JNS13700. Epub 2014 Feb 7.

PMID:
24506244
17.

Deep brain stimulation of the globus pallidus suppresses post-traumatic dystonic tremor.

Carvalho KS, Sukul VV, Bookland MJ, Koch SA, Connolly PJ.

J Clin Neurosci. 2014 Jan;21(1):153-5. doi: 10.1016/j.jocn.2013.02.009. Epub 2013 Jul 27.

PMID:
23896546
18.

The floodplain food web mosaic: a study of its importance to salmon and steelhead with implications for their recovery.

Bellmore JR, Baxter CV, Martens K, Connolly PJ.

Ecol Appl. 2013 Jan;23(1):189-207.

PMID:
23495646
19.

Estimating the effective radiation dose imparted to patients by intraoperative cone-beam computed tomography in thoracolumbar spinal surgery.

Lange J, Karellas A, Street J, Eck JC, Lapinsky A, Connolly PJ, Dipaola CP.

Spine (Phila Pa 1976). 2013 Mar 1;38(5):E306-12. doi: 10.1097/BRS.0b013e318281d70b.

PMID:
23238490
20.

An international survey of deep brain stimulation procedural steps.

Abosch A, Timmermann L, Bartley S, Rietkerk HG, Whiting D, Connolly PJ, Lanctin D, Hariz MI.

Stereotact Funct Neurosurg. 2013;91(1):1-11. doi: 10.1159/000343207. Epub 2012 Nov 13.

21.

The association between preoperative spinal cord rotation and postoperative C5 nerve palsy.

Eskander MS, Balsis SM, Balinger C, Howard CM, Lewing NW, Eskander JP, Aubin ME, Lange J, Eck J, Connolly PJ, Jenis LG.

J Bone Joint Surg Am. 2012 Sep 5;94(17):1605-9.

PMID:
22992851
22.

Does intraoperative neurophysiological monitoring have predictive value for functional recovery following spinal cord injury? A case report.

Eck JC, Martin CJ, Lapinsky A, Connolly PJ, Dipaola C.

J Clin Monit Comput. 2013 Feb;27(1):93-6. doi: 10.1007/s10877-012-9395-4. Epub 2012 Sep 2.

PMID:
22941585
23.

Error reduction with routine checklist use during deep brain stimulation surgery.

Kramer DR, Halpern CH, Connolly PJ, Jaggi JL, Baltuch GH.

Stereotact Funct Neurosurg. 2012;90(4):255-9. doi: 10.1159/000338091. Epub 2012 Jun 14.

PMID:
22699928
24.

Implications for programming strategy of the location of the active contact in subthalamic nucleus deep brain stimulation.

Connolly PJ, Halpern CH, Baltuch GH, Danish SF, Jaggi JL.

J Clin Neurosci. 2012 Jul;19(7):1029-31. doi: 10.1016/j.jocn.2011.12.002. Epub 2012 May 1.

PMID:
22551587
25.

A multicenter, single-blind, prospective randomized trial to evaluate the safety of a polyethylene glycol hydrogel (Duraseal Dural Sealant System) as a dural sealant in cranial surgery.

Osbun JW, Ellenbogen RG, Chesnut RM, Chin LS, Connolly PJ, Cosgrove GR, Delashaw JB Jr, Golfinos JG, Greenlee JD, Haines SJ, Jallo J, Muizelaar JP, Nanda A, Shaffrey M, Shah MV, Tew JM Jr, van Loveren HR, Weinand ME, White JA, Wilberger JE.

World Neurosurg. 2012 Nov;78(5):498-504. doi: 10.1016/j.wneu.2011.12.011. Epub 2011 Dec 10.

PMID:
22381303
26.

Combinatorial triple-selective labeling as a tool to assist membrane protein backbone resonance assignment.

Löhr F, Reckel S, Karbyshev M, Connolly PJ, Abdul-Manan N, Bernhard F, Moore JM, Dötsch V.

J Biomol NMR. 2012 Mar;52(3):197-210. doi: 10.1007/s10858-012-9601-1. Epub 2012 Jan 18.

27.

54-year follow-up of lumbar posterior fusion with tibial graft.

Liu MX, Cai DM, Connolly PJ, Eskander MS.

Orthopedics. 2011 Nov;34(11):838-9. doi: 10.3928/01477447-20110922-03. No abstract available.

PMID:
22050248
28.

The characteristics of patients with type 1: intraforaminal vertebral artery anomalies?

Eskander MS, Aubin ME, Major JW, Huning BA, Drew J, Marvin J, Connolly PJ.

Orthopedics. 2011 Jun 14;34(6):184. doi: 10.3928/01477447-20110427-09.

PMID:
21667905
29.

4-aminopyrimidine-5-carbaldehyde oximes as potent VEGFR-2 inhibitors. Part II.

Huang S, Li R, LaMontagne KR, Greenberger LM, Connolly PJ.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1815-8. doi: 10.1016/j.bmcl.2011.01.053. Epub 2011 Jan 21.

PMID:
21316232
30.

Is there a difference between simultaneous or staged decompressions for combined cervical and lumbar stenosis?

Eskander MS, Aubin ME, Drew JM, Eskander JP, Balsis SM, Eck J, Lapinsky AS, Connolly PJ.

J Spinal Disord Tech. 2011 Aug;24(6):409-13. doi: 10.1097/BSD.0b013e318201bf94.

PMID:
21150658
31.

Identification of type 1: interforaminal vertebral artery anomalies in cervical spine MRIs.

Aubin ME, Eskander MS, Drew JM, Marvin J, Eskander JP, Eck J, Connolly PJ.

Spine (Phila Pa 1976). 2010 Dec 15;35(26):E1610-1. doi: 10.1097/BRS.0b013e3181eea537.

PMID:
21116215
32.

Revision strategy for posterior extrusion of the CHARITÉ polyethylene core.

Eskander MS, Onyedika II, Eskander JP, Connolly PJ, Eck JC, Lapinsky A.

Spine (Phila Pa 1976). 2010 Nov 15;35(24):E1430-4. doi: 10.1097/BRS.0b013e3181e9bf30. Review.

PMID:
21030890
33.

Vertebral artery anatomy: a review of two hundred fifty magnetic resonance imaging scans.

Eskander MS, Drew JM, Aubin ME, Marvin J, Franklin PD, Eck JC, Patel N, Boyle K, Connolly PJ.

Spine (Phila Pa 1976). 2010 Nov 1;35(23):2035-40. doi: 10.1097/BRS.0b013e3181c9f3d4.

PMID:
20938397
34.

A modified technique for dowel fibular strut graft placement and circumferential fusion in the setting of L5-S1 spondylolisthesis and multilevel degenerative disc disease.

Eskander MS, Eskander JP, Drew JM, Pelow-Aidlen JL, Eslami MH, Connolly PJ.

Neurosurgery. 2010 Sep;67(3 Suppl Operative):ons91-5; discussion ons95. doi: 10.1227/01.NEU.0000382968.90735.7F.

PMID:
20679943
35.

Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor.

Koth CM, Abdul-Manan N, Lepre CA, Connolly PJ, Yoo S, Mohanty AK, Lippke JA, Zwahlen J, Coll JT, Doran JD, Garcia-Guzman M, Moore JM.

Biochemistry. 2010 Mar 9;49(9):1862-72. doi: 10.1021/bi901848m.

PMID:
20099900
36.

Enhanced SAR maps: expanding the data rendering capabilities of a popular medicinal chemistry tool.

Kolpak J, Connolly PJ, Lobanov VS, Agrafiotis DK.

J Chem Inf Model. 2009 Oct;49(10):2221-30. doi: 10.1021/ci900264n.

PMID:
19791782
37.

A highly selective, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor has potent activity in vitro and in vivo.

LaMontagne KR, Butler J, Borowski VB, Fuentes-Pesquera AR, Blevitt JM, Huang S, Li R, Connolly PJ, Greenberger LM.

Angiogenesis. 2009;12(3):287-96. doi: 10.1007/s10456-009-9151-7. Epub 2009 Jun 21.

PMID:
19544081
38.

Injury of an aberrant vertebral artery during a routine corpectomy: a case report and literature review.

Eskander MS, Connolly PJ, Eskander JP, Brooks DD.

Spinal Cord. 2009 Oct;47(10):773-5. doi: 10.1038/sc.2009.29. Epub 2009 Mar 24. Review.

PMID:
19308072
39.

Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors.

Lin R, Johnson SG, Connolly PJ, Wetter SK, Binnun E, Hughes TV, Murray WV, Pandey NB, Moreno-Mazza SJ, Adams M, Fuentes-Pesquera AR, Middleton SA.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2333-7. doi: 10.1016/j.bmcl.2009.02.067. Epub 2009 Feb 21.

PMID:
19286381
40.

Feasibility of an operational standardized checklist for movement disorder surgery. A pilot study.

Connolly PJ, Kilpatrick M, Jaggi JL, Church E, Baltuch GH.

Stereotact Funct Neurosurg. 2009;87(2):94-100. doi: 10.1159/000202975. Epub 2009 Feb 18.

PMID:
19223695
41.

Synthesis, in vitro activities of (2-cyclopropoxyphenyl)piperidine derivatives for alpha 1a and alpha 1d adrenergic receptor inhibitors.

Li S, Chiu G, Pulito VL, Liu J, Connolly PJ, Middleton SA.

Med Chem. 2009 Jan;5(1):15-22.

PMID:
19149646
42.

7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: design, synthesis, and biological activity.

Hughes TV, Emanuel SL, O'Grady HR, Connolly PJ, Rugg C, Fuentes-Pesquera AR, Karnachi P, Alexander R, Middleton SA.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5130-3. doi: 10.1016/j.bmcl.2008.07.090. Epub 2008 Jul 26.

PMID:
18718756
43.

A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: design, synthesis, and biological activity.

Hughes TV, Xu G, Wetter SK, Connolly PJ, Emanuel SL, Karnachi P, Pollack SR, Pandey N, Adams M, Moreno-Mazza S, Middleton SA, Greenberger LM.

Bioorg Med Chem Lett. 2008 Sep 1;18(17):4896-9. doi: 10.1016/j.bmcl.2008.07.057. Epub 2008 Jul 17.

PMID:
18678484
44.

4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors.

Xu G, Abad MC, Connolly PJ, Neeper MP, Struble GT, Springer BA, Emanuel SL, Pandey N, Gruninger RH, Adams M, Moreno-Mazza S, Fuentes-Pesquera AR, Middleton SA.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4615-9. doi: 10.1016/j.bmcl.2008.07.020. Epub 2008 Jul 10.

PMID:
18653333
45.

Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases.

Xu G, Searle LL, Hughes TV, Beck AK, Connolly PJ, Abad MC, Neeper MP, Struble GT, Springer BA, Emanuel SL, Gruninger RH, Pandey N, Adams M, Moreno-Mazza S, Fuentes-Pesquera AR, Middleton SA, Greenberger LM.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3495-9. doi: 10.1016/j.bmcl.2008.05.024. Epub 2008 May 10.

PMID:
18508264
46.

Scalable synthesis of the VEGF-R2 kinase inhibitor JNJ-17029259 using ultrasound-mediated addition of MeLi-CeCl3 to a nitrile.

Reuman M, Beish S, Davis J, Batchelor MJ, Hutchings MC, Moffat DF, Connolly PJ, Russell RK.

J Org Chem. 2008 Feb 1;73(3):1121-3. doi: 10.1021/jo7021372. Epub 2008 Jan 3.

PMID:
18171079
47.
48.

Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors.

Emanuel SL, Hughes TV, Adams M, Rugg CA, Fuentes-Pesquera A, Connolly PJ, Pandey N, Moreno-Mazza S, Butler J, Borowski V, Middleton SA, Gruninger RH, Story JR, Napier C, Hollister B, Greenberger LM.

Mol Pharmacol. 2008 Feb;73(2):338-48. Epub 2007 Nov 1.

PMID:
17975007
49.

SAR maps: a new SAR visualization technique for medicinal chemists.

Agrafiotis DK, Shemanarev M, Connolly PJ, Farnum M, Lobanov VS.

J Med Chem. 2007 Nov 29;50(24):5926-37. Epub 2007 Oct 25.

PMID:
17958407
50.

Aminocyclohexylsulfonamides: discovery of metabolically stable alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS).

Chiu G, Li S, Cai H, Connolly PJ, Peng S, Stauber K, Pulito V, Liu J, Middleton SA.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6123-8. Epub 2007 Sep 18.

PMID:
17904840

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