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TLR7 Protein Expression in Mild and Severe Lupus-Prone Models Is Regulated in a Leukocyte, Genetic, and IRAK4 Dependent Manner.

Celhar T, Lu HK, Benso L, Rakhilina L, Lee HY, Tripathi S, Zharkova O, Ong WY, Yasuga H, Au B, Marlier D, Lim LHK, Thamboo TP, Mudgett JS, Mackey MF, Zaller DM, Connolly JE, Fairhurst AM.

Front Immunol. 2019 Jul 10;10:1546. doi: 10.3389/fimmu.2019.01546. eCollection 2019.


Enhancing Antigen Cross-Presentation in Human Monocyte-Derived Dendritic Cells by Recruiting the Intracellular Fc Receptor TRIM21.

Ng PML, Kaliaperumal N, Lee CY, Chin WJ, Tan HC, Au VB, Goh AX, Tan QW, Yeo DSG, Connolly JE, Wang CI.

J Immunol. 2019 Apr 15;202(8):2307-2319. doi: 10.4049/jimmunol.1800462. Epub 2019 Feb 22.


Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine.

Skibinski DAG, Jones LA, Zhu YO, Xue LW, Au B, Lee B, Naim ANM, Lee A, Kaliaperumal N, Low JGH, Lee LS, Poidinger M, Saudan P, Bachmann M, Ooi EE, Hanson BJ, Novotny-Diermayr V, Matter A, Fairhurst AM, Hibberd ML, Connolly JE.

Sci Rep. 2018 Dec 20;8(1):18007. doi: 10.1038/s41598-018-36703-7.


A Flow Cytometry-Based Assay for High-Throughput Detection and Quantification of Neutrophil Extracellular Traps in Mixed Cell Populations.

Zharkova O, Tay SH, Lee HY, Shubhita T, Ong WY, Lateef A, MacAry PA, Lim LHK, Connolly JE, Fairhurst AM.

Cytometry A. 2019 Mar;95(3):268-278. doi: 10.1002/cyto.a.23672. Epub 2018 Dec 14.


Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding.

Zhong FL, Robinson K, Teo DET, Tan KY, Lim C, Harapas CR, Yu CH, Xie WH, Sobota RM, Au VB, Hopkins R, D'Osualdo A, Reed JC, Connolly JE, Masters SL, Reversade B.

J Biol Chem. 2018 Dec 7;293(49):18864-18878. doi: 10.1074/jbc.RA118.004350. Epub 2018 Oct 5.


Distinct "Immunoallertypes" of Disease and High Frequencies of Sensitization in Non-Cystic Fibrosis Bronchiectasis.

Mac Aogáin M, Tiew PY, Lim AYH, Low TB, Tan GL, Hassan T, Ong TH, Pang SL, Lee ZY, Gwee XW, Martinus C, Sio YY, Matta SA, Ong TC, Tiong YS, Wong KN, Narayanan S, Au VB, Marlier D, Keir HR, Tee A, Abisheganaden JA, Koh MS, Wang Y, Connolly JE, Chew FT, Chalmers JD, Chotirmall SH.

Am J Respir Crit Care Med. 2019 Apr 1;199(7):842-853. doi: 10.1164/rccm.201807-1355OC.


Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects.

He Q, Au B, Kulkarni M, Shen Y, Lim KJ, Maimaiti J, Wong CK, Luijten MNH, Chong HC, Lim EH, Rancati G, Sinha I, Fu Z, Wang X, Connolly JE, Crasta KC.

Oncogenesis. 2018 Aug 15;7(8):62. doi: 10.1038/s41389-018-0072-4.


Autophagy Governs Protumorigenic Effects of Mitotic Slippage-induced Senescence.

Jakhar R, Luijten MNH, Wong AXF, Cheng B, Guo K, Neo SP, Au B, Kulkarni M, Lim KJ, Maimaiti J, Chong HC, Lim EH, Tan TBK, Ong KW, Sim Y, Wong JSL, Khoo JBK, Ho JTS, Chua BT, Sinha I, Wang X, Connolly JE, Gunaratne J, Crasta KC.

Mol Cancer Res. 2018 Nov;16(11):1625-1640. doi: 10.1158/1541-7786.MCR-18-0024. Epub 2018 Jul 23.


Immunological corollary of the pulmonary mycobiome in bronchiectasis: the CAMEB study.

Mac Aogáin M, Chandrasekaran R, Lim AYH, Low TB, Tan GL, Hassan T, Ong TH, Hui Qi Ng A, Bertrand D, Koh JY, Pang SL, Lee ZY, Gwee XW, Martinus C, Sio YY, Matta SA, Chew FT, Keir HR, Connolly JE, Abisheganaden JA, Koh MS, Nagarajan N, Chalmers JD, Chotirmall SH.

Eur Respir J. 2018 Jul 27;52(1). pii: 1800766. doi: 10.1183/13993003.00766-2018. Print 2018 Jul.


Toll-Like Receptor 9 Deficiency Breaks Tolerance to RNA-Associated Antigens and Up-Regulates Toll-Like Receptor 7 Protein in Sle1 Mice.

Celhar T, Yasuga H, Lee HY, Zharkova O, Tripathi S, Thornhill SI, Lu HK, Au B, Lim LHK, Thamboo TP, Akira S, Wakeland EK, Connolly JE, Fairhurst AM.

Arthritis Rheumatol. 2018 Oct;70(10):1597-1609. doi: 10.1002/art.40535.


The walking dead: sequential nuclear and organelle destruction during hair development.

Jones LA, Harland DP, Jarrold BB, Connolly JE, Davis MG.

Br J Dermatol. 2018 Jun;178(6):1341-1352. doi: 10.1111/bjd.16148. Epub 2018 Mar 26.


Brief report: Decreased expression of CD244 (SLAMF4) on monocytes and platelets in patients with systemic lupus erythematosus.

Mak A, Thornhill SI, Lee HY, Lee B, Poidinger M, Connolly JE, Fairhurst AM.

Clin Rheumatol. 2018 Mar;37(3):811-816. doi: 10.1007/s10067-017-3698-2. Epub 2017 Jun 8.


Monocyte Siglec-14 expression is upregulated in patients with systemic lupus erythematosus and correlates with lupus disease activity.

Thornhill SI, Mak A, Lee B, Lee HY, Poidinger M, Connolly JE, Fairhurst AM.

Rheumatology (Oxford). 2017 Jun 1;56(6):1025-1030. doi: 10.1093/rheumatology/kew498.


Intraperitoneal immunotherapy with T cells stably and transiently expressing anti-EpCAM CAR in xenograft models of peritoneal carcinomatosis.

Ang WX, Li Z, Chi Z, Du SH, Chen C, Tay JC, Toh HC, Connolly JE, Xu XH, Wang S.

Oncotarget. 2017 Feb 21;8(8):13545-13559. doi: 10.18632/oncotarget.14592.


Multiplex Serum Protein Analysis Identifies Novel Biomarkers of Advanced Fibrosis in Patients with Chronic Liver Disease with the Potential to Improve Diagnostic Accuracy of Established Biomarkers.

Irvine KM, Wockner LF, Hoffmann I, Horsfall LU, Fagan KJ, Bijin V, Lee B, Clouston AD, Lampe G, Connolly JE, Powell EE.

PLoS One. 2016 Nov 18;11(11):e0167001. doi: 10.1371/journal.pone.0167001. eCollection 2016.


Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation.

Zhong FL, Mamaï O, Sborgi L, Boussofara L, Hopkins R, Robinson K, Szeverényi I, Takeichi T, Balaji R, Lau A, Tye H, Roy K, Bonnard C, Ahl PJ, Jones LA, Baker PJ, Lacina L, Otsuka A, Fournie PR, Malecaze F, Lane EB, Akiyama M, Kabashima K, Connolly JE, Masters SL, Soler VJ, Omar SS, McGrath JA, Nedelcu R, Gribaa M, Denguezli M, Saad A, Hiller S, Reversade B.

Cell. 2016 Sep 22;167(1):187-202.e17. doi: 10.1016/j.cell.2016.09.001.


Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare.

Chng KR, Tay AS, Li C, Ng AH, Wang J, Suri BK, Matta SA, McGovern N, Janela B, Wong XF, Sio YY, Au BV, Wilm A, De Sessions PF, Lim TC, Tang MB, Ginhoux F, Connolly JE, Lane EB, Chew FT, Common JE, Nagarajan N.

Nat Microbiol. 2016 Jul 11;1(9):16106. doi: 10.1038/nmicrobiol.2016.106.


Extended Evaluation of Virological, Immunological and Pharmacokinetic Endpoints of CELADEN: A Randomized, Placebo-Controlled Trial of Celgosivir in Dengue Fever Patients.

Sung C, Wei Y, Watanabe S, Lee HS, Khoo YM, Fan L, Rathore AP, Chan KW, Choy MM, Kamaraj US, Sessions OM, Aw P, de Sessions PF, Lee B, Connolly JE, Hibberd ML, Vijaykrishna D, Wijaya L, Ooi EE, Low JG, Vasudevan SG.

PLoS Negl Trop Dis. 2016 Aug 10;10(8):e0004851. doi: 10.1371/journal.pntd.0004851. eCollection 2016 Aug.


Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes.

Sim WJ, Malinarich F, Fairhurst AM, Connolly JE.

J Vis Exp. 2016 Jun 22;(112). doi: 10.3791/54128.


Metabolism Is Central to Tolerogenic Dendritic Cell Function.

Sim WJ, Ahl PJ, Connolly JE.

Mediators Inflamm. 2016;2016:2636701. doi: 10.1155/2016/2636701. Epub 2016 Feb 11. Review.


TLR7 and TLR9 ligands regulate antigen presentation by macrophages.

Celhar T, Pereira-Lopes S, Thornhill SI, Lee HY, Dhillon MK, Poidinger M, Connolly JE, Lim LH, Biswas SK, Fairhurst AM.

Int Immunol. 2016 May;28(5):223-32. doi: 10.1093/intimm/dxv066. Epub 2015 Nov 13.


RNA sensing by conventional dendritic cells is central to the development of lupus nephritis.

Celhar T, Hopkins R, Thornhill SI, De Magalhaes R, Hwang SH, Lee HY, Yasuga H, Jones LA, Casco J, Lee B, Thamboo TP, Zhou XJ, Poidinger M, Connolly JE, Wakeland EK, Fairhurst AM.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6195-204. doi: 10.1073/pnas.1507052112. Epub 2015 Oct 28.


Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients.

Benham H, Nel HJ, Law SC, Mehdi AM, Street S, Ramnoruth N, Pahau H, Lee BT, Ng J, Brunck ME, Hyde C, Trouw LA, Dudek NL, Purcell AW, O'Sullivan BJ, Connolly JE, Paul SK, Lê Cao KA, Thomas R.

Sci Transl Med. 2015 Jun 3;7(290):290ra87. doi: 10.1126/scitranslmed.aaa9301.


High mitochondrial respiration and glycolytic capacity represent a metabolic phenotype of human tolerogenic dendritic cells.

Malinarich F, Duan K, Hamid RA, Bijin A, Lin WX, Poidinger M, Fairhurst AM, Connolly JE.

J Immunol. 2015 Jun 1;194(11):5174-86. doi: 10.4049/jimmunol.1303316. Epub 2015 Apr 27.


Characterization of fetal keratinocytes, showing enhanced stem cell-like properties: a potential source of cells for skin reconstruction.

Tan KK, Salgado G, Connolly JE, Chan JK, Lane EB.

Stem Cell Reports. 2014 Aug 12;3(2):324-38. doi: 10.1016/j.stemcr.2014.06.005. Epub 2014 Jul 10.


Human plasmacytoid dendritic cells regulate IFN-α production through activation-induced splicing of IL-18Rα.

Chao Y, Kaliaperumal N, Chretien AS, Tang S, Lee B, Poidinger M, Fairhurst AM, Connolly JE.

J Leukoc Biol. 2014 Dec;96(6):1037-46. doi: 10.1189/jlb.2A0813-465RR. Epub 2014 Aug 28.


Genetic variants of inducible costimulator are associated with allergic asthma susceptibility.

Andiappan AK, Narayanan S, Myers RA, Lee B, Nieuwenhuis MA, Nardin A, Park CS, Shin HD, Kim JH, Westra HJ, Franke L, Esko T, Metspalu A, Teo YY, Saw SM, Khor CC, Liu J, Koppelman GH, Postma DS, Poidinger M, Connolly JE, Wang de Y, Rotzschke O, Curotto de Lafaille MA, Chew FT.

J Allergy Clin Immunol. 2015 Feb;135(2):556-8. doi: 10.1016/j.jaci.2014.06.028. Epub 2014 Aug 7. No abstract available.


Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers.

Low JG, Lee LS, Ooi EE, Ethirajulu K, Yeo P, Matter A, Connolly JE, Skibinski DA, Saudan P, Bachmann M, Hanson BJ, Lu Q, Maurer-Stroh S, Lim S, Novotny-Diermayr V.

Vaccine. 2014 Sep 3;32(39):5041-8. doi: 10.1016/j.vaccine.2014.07.011. Epub 2014 Jul 18.


Development of a multiplex bead-based assay to monitor dengue virus seroconversion.

Ng K, Connolly JE.

Methods Mol Biol. 2014;1138:53-74. doi: 10.1007/978-1-4939-0348-1_5.


Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue.

Chan KR, Ong EZ, Tan HC, Zhang SL, Zhang Q, Tang KF, Kaliaperumal N, Lim AP, Hibberd ML, Chan SH, Connolly JE, Krishnan MN, Lok SM, Hanson BJ, Lin CN, Ooi EE.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2722-7. doi: 10.1073/pnas.1317454111. Epub 2014 Jan 13.


Recognizing the prevalence of changing adult foot size: an opportunity to prevent diabetic foot ulcers?

Connolly JE, Wrobel JS.

J Am Podiatr Med Assoc. 2014 Jan-Feb;104(1):118-22.


Adoptive T-cell transfer and chemotherapy in the first-line treatment of metastatic and/or locally recurrent nasopharyngeal carcinoma.

Chia WK, Teo M, Wang WW, Lee B, Ang SF, Tai WM, Chee CL, Ng J, Kan R, Lim WT, Tan SH, Ong WS, Cheung YB, Tan EH, Connolly JE, Gottschalk S, Toh HC.

Mol Ther. 2014 Jan;22(1):132-9. doi: 10.1038/mt.2013.242. Epub 2013 Oct 17.


Enhanced neutralizing antibody titers and Th1 polarization from a novel Escherichia coli derived pandemic influenza vaccine.

Skibinski DA, Hanson BJ, Lin Y, von Messling V, Jegerlehner A, Tee JB, Chye de H, Wong SK, Ng AA, Lee HY, Au B, Lee BT, Santoso L, Poidinger M, Fairhurst AM, Matter A, Bachmann MF, Saudan P, Connolly JE.

PLoS One. 2013 Oct 18;8(10):e76571. doi: 10.1371/journal.pone.0076571. eCollection 2013.


Personal reflections on the first 50 years of cardiovascular surgery.

Connolly JE.

J Am Coll Surg. 2013 Aug;217(2):358-73. doi: 10.1016/j.jamcollsurg.2013.02.026. Epub 2013 May 8. No abstract available.


B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice.

Hwang SH, Lee H, Yamamoto M, Jones LA, Dayalan J, Hopkins R, Zhou XJ, Yarovinsky F, Connolly JE, Curotto de Lafaille MA, Wakeland EK, Fairhurst AM.

J Immunol. 2012 Dec 15;189(12):5786-96. doi: 10.4049/jimmunol.1202195. Epub 2012 Nov 12.


Optimal cellular preservation for high dimensional flow cytometric analysis of multicentre trials.

Ng AA, Lee BT, Teo TS, Poidinger M, Connolly JE.

J Immunol Methods. 2012 Nov 30;385(1-2):79-89. doi: 10.1016/j.jim.2012.08.010. Epub 2012 Aug 24.


The specialized roles of immature and mature dendritic cells in antigen cross-presentation.

Hopkins RA, Connolly JE.

Immunol Res. 2012 Sep;53(1-3):91-107. doi: 10.1007/s12026-012-8300-z. Review.


Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model.

Rathore AP, Paradkar PN, Watanabe S, Tan KH, Sung C, Connolly JE, Low J, Ooi EE, Vasudevan SG.

Antiviral Res. 2011 Dec;92(3):453-60. doi: 10.1016/j.antiviral.2011.10.002. Epub 2011 Oct 12.


Unique Cytokine/Chemokine Signatures for HIV-1 and HCV Mono-infection versus Co-infection as Determined by the Luminex® Analyses.

Rahman S, Connolly JE, Manuel SL, Chehimi J, Montaner LJ, Jain P.

J Clin Cell Immunol. 2011 Jan 7;2(1). pii: 1000104.


Historical perspectives of The American Association for Thoracic Surgery: Paul C. Samson (1905-1982).

Fann JI, Connolly JE.

J Thorac Cardiovasc Surg. 2011 Nov;142(5):967-9. doi: 10.1016/j.jtcvs.2011.05.014. Epub 2011 Aug 5. No abstract available.


The history of the in situ saphenous vein bypass.

Connolly JE.

J Vasc Surg. 2011 Jan;53(1):241-4. doi: 10.1016/j.jvs.2010.05.018. Epub 2010 Jul 17. No abstract available.


Intraosseous epidermoid inclusion cyst presenting as a paronychia of the hallux.

Connolly JE, Ratcliffe NR.

J Am Podiatr Med Assoc. 2010 Mar-Apr;100(2):133-7.


Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis.

Fairhurst AM, Xie C, Fu Y, Wang A, Boudreaux C, Zhou XJ, Cibotti R, Coyle A, Connolly JE, Wakeland EK, Mohan C.

J Immunol. 2009 Nov 15;183(10):6831-8. doi: 10.4049/jimmunol.0900742. Epub 2009 Oct 28.


CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions.

Matsui T, Connolly JE, Michnevitz M, Chaussabel D, Yu CI, Glaser C, Tindle S, Pypaert M, Freitas H, Piqueras B, Banchereau J, Palucka AK.

J Immunol. 2009 Jun 1;182(11):6815-23. doi: 10.4049/jimmunol.0802008.


Clinical factors associated with a conservative gait pattern in older male veterans with diabetes.

Wrobel JS, Crews RT, Connolly JE.

J Foot Ankle Res. 2009 Apr 23;2:11. doi: 10.1186/1757-1146-2-11.


Evidence for Induced Expression of HLA Class II on Human Islets: Possible Mechanism for HLA Sensitization in Transplant Recipients.

Jackson AM, Connolly JE, Matsumoto S, Noguchi H, Onaca N, Levy MF, Naziruddin B.

Transplantation. 2009 Feb 27;87(4):500-6. doi: 10.1097/TP.0b013e318195fc33.


"Spot and hop": internal referencing for surface plasmon resonance imaging using a three-dimensional microfluidic flow cell array.

Eddings MA, Eckman JW, Arana CA, Papalia GA, Connolly JE, Gale BK, Myszka DG.

Anal Biochem. 2009 Feb 15;385(2):309-13. doi: 10.1016/j.ab.2008.11.014. Epub 2008 Nov 20.


Yaa autoimmune phenotypes are conferred by overexpression of TLR7.

Fairhurst AM, Hwang SH, Wang A, Tian XH, Boudreaux C, Zhou XJ, Casco J, Li QZ, Connolly JE, Wakeland EK.

Eur J Immunol. 2008 Jul;38(7):1971-8. doi: 10.1002/eji.200838138.


Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice.

Fairhurst AM, Mathian A, Connolly JE, Wang A, Gray HF, George TA, Boudreaux CD, Zhou XJ, Li QZ, Koutouzov S, Banchereau J, Wakeland EK.

Eur J Immunol. 2008 Jul;38(7):1948-60. doi: 10.1002/eji.200837925.


Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I.

Di Pucchio T, Chatterjee B, Smed-Sörensen A, Clayton S, Palazzo A, Montes M, Xue Y, Mellman I, Banchereau J, Connolly JE.

Nat Immunol. 2008 May;9(5):551-7. doi: 10.1038/ni.1602. Epub 2008 Mar 30.

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