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Items: 1 to 50 of 132

1.

Self-Priming Enzymatic Fabrication of Multiply Modified DNA.

Whitfield CJ, Little RC, Khan K, Ijiro K, Connolly BA, Tuite EM, Pike AR.

Chemistry. 2018 Oct 12;24(57):15267-15274. doi: 10.1002/chem.201801976. Epub 2018 Sep 14.

PMID:
29931815
2.

An interspecific barberry hybrid enables genetic dissection of non-host resistance to the stem rust pathogen Puccinia graminis.

Bartaula R, Melo ATO, Connolly BA, Jin Y, Hale I.

J Exp Bot. 2018 Apr 27;69(10):2483-2493. doi: 10.1093/jxb/ery066.

3.

Low Levels of Physical Activity During Critical Illness and Weaning: The Evidence-Reality Gap.

Connolly BA, Mortimore JL, Douiri A, Rose JW, Hart N, Berney SC.

J Intensive Care Med. 2017 Jan 1:885066617716377. doi: 10.1177/0885066617716377. [Epub ahead of print]

PMID:
28675113
5.

Archaeoglobus Fulgidus DNA Polymerase D: A Zinc-Binding Protein Inhibited by Hypoxanthine and Uracil.

Abellón-Ruiz J, Waldron KJ, Connolly BA.

J Mol Biol. 2016 Jul 17;428(14):2805-13. doi: 10.1016/j.jmb.2016.06.008. Epub 2016 Jun 16.

6.

The Telomere Binding Protein Cdc13 and the Single-Stranded DNA Binding Protein RPA Protect Telomeric DNA from Resection by Exonucleases.

Greetham M, Skordalakes E, Lydall D, Connolly BA.

J Mol Biol. 2015 Sep 25;427(19):3023-30. doi: 10.1016/j.jmb.2015.08.002. Epub 2015 Aug 8.

7.

Enzymatic Method for the Synthesis of Long DNA Sequences with Multiple Repeat Units.

Whitfield CJ, Turley AT, Tuite EM, Connolly BA, Pike AR.

Angew Chem Int Ed Engl. 2015 Jul 27;54(31):8971-4. doi: 10.1002/anie.201502971. Epub 2015 Jun 10.

PMID:
26095610
8.

Microsatellite marker development for the coastal dune shrub Prunus maritima (Rosaceae).

Badgley EM, Grubisha LC, Roland AK, Connolly BA, Klooster MR.

Appl Plant Sci. 2015 Jan 30;3(2). pii: apps.1400119. doi: 10.3732/apps.1400119. eCollection 2015 Feb.

9.

An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family.

Jozwiakowski SK, Keith BJ, Gilroy L, Doherty AJ, Connolly BA.

Nucleic Acids Res. 2014 Sep;42(15):9949-63. doi: 10.1093/nar/gku683. Epub 2014 Jul 24.

10.

DNA polymerase hybrids derived from the family-B enzymes of Pyrococcus furiosus and Thermococcus kodakarensis: improving performance in the polymerase chain reaction.

Elshawadfy AM, Keith BJ, Ee Ooi H, Kinsman T, Heslop P, Connolly BA.

Front Microbiol. 2014 May 27;5:224. doi: 10.3389/fmicb.2014.00224. eCollection 2014.

11.

Human immunodeficiency virus reverse transcriptase displays dramatically higher fidelity under physiological magnesium conditions in vitro.

Achuthan V, Keith BJ, Connolly BA, DeStefano JJ.

J Virol. 2014 Aug;88(15):8514-27. doi: 10.1128/JVI.00752-14. Epub 2014 May 21. Erratum in: J Virol. 2015 Feb;89(3):1944.

12.

Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions.

Malgor R, Bhatt PM, Connolly BA, Jacoby DL, Feldmann KJ, Silver MJ, Nakazawa M, McCall KD, Goetz DJ.

Inflamm Res. 2014 Apr;63(4):277-85. doi: 10.1007/s00011-013-0697-x. Epub 2013 Dec 18.

13.

Clinical predictive value of manual muscle strength testing during critical illness: an observational cohort study.

Connolly BA, Jones GD, Curtis AA, Murphy PB, Douiri A, Hopkinson NS, Polkey MI, Moxham J, Hart N.

Crit Care. 2013 Oct 10;17(5):R229. doi: 10.1186/cc13052.

14.

The high-fat high-fructose hamster as an animal model for niacin's biological activities in humans.

Connolly BA, O'Connell DP, Lamon-Fava S, LeBlanc DF, Kuang YL, Schaefer EJ, Coppage AL, Benedict CR, Kiritsy CP, Bachovchin WW.

Metabolism. 2013 Dec;62(12):1840-9. doi: 10.1016/j.metabol.2013.08.001. Epub 2013 Sep 13.

PMID:
24035454
15.

Underutilized chokeberry (Aronia melanocarpa, Aronia arbutifolia, Aronia prunifolia) accessions are rich sources of anthocyanins, flavonoids, hydroxycinnamic acids, and proanthocyanidins.

Taheri R, Connolly BA, Brand MH, Bolling BW.

J Agric Food Chem. 2013 Sep 11;61(36):8581-8. doi: 10.1021/jf402449q. Epub 2013 Aug 26.

PMID:
23941506
16.

Archaeal DNA polymerase D but not DNA polymerase B is required for genome replication in Thermococcus kodakarensis.

Cubonová L, Richardson T, Burkhart BW, Kelman Z, Connolly BA, Reeve JN, Santangelo TJ.

J Bacteriol. 2013 May;195(10):2322-8. doi: 10.1128/JB.02037-12. Epub 2013 Mar 15.

17.

Novel inhibition of archaeal family-D DNA polymerase by uracil.

Richardson TT, Gilroy L, Ishino Y, Connolly BA, Henneke G.

Nucleic Acids Res. 2013 Apr;41(7):4207-18. doi: 10.1093/nar/gkt083. Epub 2013 Feb 13.

18.

Unwinding of primer-templates by archaeal family-B DNA polymerases in response to template-strand uracil.

Richardson TT, Wu X, Keith BJ, Heslop P, Jones AC, Connolly BA.

Nucleic Acids Res. 2013 Feb 1;41(4):2466-78. doi: 10.1093/nar/gks1364. Epub 2013 Jan 8.

19.

Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions.

Wilkinson OJ, Latypov V, Tubbs JL, Millington CL, Morita R, Blackburn H, Marriott A, McGown G, Thorncroft M, Watson AJ, Connolly BA, Grasby JA, Masui R, Hunter CA, Tainer JA, Margison GP, Williams DM.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18755-60. doi: 10.1073/pnas.1209451109. Epub 2012 Oct 29.

20.

A plasmid-based lacZα gene assay for DNA polymerase fidelity measurement.

Keith BJ, Jozwiakowski SK, Connolly BA.

Anal Biochem. 2013 Feb 15;433(2):153-61. doi: 10.1016/j.ab.2012.10.019. Epub 2012 Oct 22.

21.

Synthesis, characterisation and electrical properties of supramolecular DNA-templated polymer nanowires of 2,5-(bis-2-thienyl)-pyrrole.

Watson SM, Hedley JH, Galindo MA, Al-Said SA, Wright NG, Connolly BA, Horrocks BR, Houlton A.

Chemistry. 2012 Sep 17;18(38):12008-19. doi: 10.1002/chem.201201495. Epub 2012 Aug 9.

PMID:
22887143
22.

4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities.

Wu W, Liu Y, Milo LJ Jr, Shu Y, Zhao P, Li Y, Woznica I, Yu G, Sanford DG, Zhou Y, Poplawski SE, Connolly BA, Sudmeier JL, Bachovchin WW, Lai JH.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5536-40. doi: 10.1016/j.bmcl.2012.07.033. Epub 2012 Jul 14.

PMID:
22853995
23.

Quadriceps wasting and physical inactivity in patients with COPD.

Shrikrishna D, Patel M, Tanner RJ, Seymour JM, Connolly BA, Puthucheary ZA, Walsh SL, Bloch SA, Sidhu PS, Hart N, Kemp PR, Moxham J, Polkey MI, Hopkinson NS.

Eur Respir J. 2012 Nov;40(5):1115-22. doi: 10.1183/09031936.00170111. Epub 2012 Feb 23.

24.

DNA-modified single crystal and nanoporous silicon.

Houlton A, Connolly BA, Pike AR, Horrocks BR.

Methods Mol Biol. 2011;749:199-207. doi: 10.1007/978-1-61779-142-0_14.

PMID:
21674374
25.

Role of disulfide bridges in archaeal family-B DNA polymerases.

Killelea T, Connolly BA.

Chembiochem. 2011 Jun 14;12(9):1330-6. doi: 10.1002/cbic.201100145. Epub 2011 May 20.

PMID:
21598372
26.

Determinants of precatalytic conformational transitions in the DNA cytosine methyltransferase M.HhaI.

Matje DM, Coughlin DF, Connolly BA, Dahlquist FW, Reich NO.

Biochemistry. 2011 Mar 8;50(9):1465-73. doi: 10.1021/bi101446g. Epub 2011 Feb 10.

PMID:
21229971
27.

A modified family-B archaeal DNA polymerase with reverse transcriptase activity.

Jozwiakowski SK, Connolly BA.

Chembiochem. 2011 Jan 3;12(1):35-7. doi: 10.1002/cbic.201000640. No abstract available.

PMID:
21117129
28.

Modification of DNA-templated conductive polymer nanowires via click chemistry.

Hannant J, Hedley JH, Pate J, Walli A, Farha Al-Said SA, Galindo MA, Connolly BA, Horrocks BR, Houlton A, Pike AR.

Chem Commun (Camb). 2010 Aug 28;46(32):5870-2. doi: 10.1039/c0cc00693a. Epub 2010 Jul 13.

PMID:
20625612
29.

Probing the interaction of archaeal DNA polymerases with deaminated bases using X-ray crystallography and non-hydrogen bonding isosteric base analogues.

Killelea T, Ghosh S, Tan SS, Heslop P, Firbank SJ, Kool ET, Connolly BA.

Biochemistry. 2010 Jul 13;49(27):5772-81. doi: 10.1021/bi100421r.

30.

The 3'-5' proofreading exonuclease of archaeal family-B DNA polymerase hinders the copying of template strand deaminated bases.

Russell HJ, Richardson TT, Emptage K, Connolly BA.

Nucleic Acids Res. 2009 Dec;37(22):7603-11. doi: 10.1093/nar/gkp800.

31.

Plasmid-based lacZalpha assay for DNA polymerase fidelity: application to archaeal family-B DNA polymerase.

Jozwiakowski SK, Connolly BA.

Nucleic Acids Res. 2009 Aug;37(15):e102. doi: 10.1093/nar/gkp494. Epub 2009 Jun 10.

32.

Physical and functional interactions between Escherichia coli MutL and the Vsr repair endonuclease.

Heinze RJ, Giron-Monzon L, Solovyova A, Elliot SL, Geisler S, Cupples CG, Connolly BA, Friedhoff P.

Nucleic Acids Res. 2009 Jul;37(13):4453-63. doi: 10.1093/nar/gkp380. Epub 2009 May 27.

33.

Immobilisation of proteins at silicon surfaces using undecenylaldehyde: demonstration of the retention of protein functionality and detection strategies.

Hong Q, Rogero C, Lakey JH, Connolly BA, Houlton A, Horrocks BR.

Analyst. 2009 Mar;134(3):593-601. doi: 10.1039/b813328j. Epub 2008 Dec 17.

PMID:
19238299
34.

Recognition of deaminated bases by archaeal family-B DNA polymerases.

Connolly BA.

Biochem Soc Trans. 2009 Feb;37(Pt 1):65-8. doi: 10.1042/BST0370065. Review.

PMID:
19143603
35.

Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety.

Connolly BA, Sanford DG, Chiluwal AK, Healey SE, Peters DE, Dimare MT, Wu W, Liu Y, Maw H, Zhou Y, Li Y, Jin Z, Sudmeier JL, Lai JH, Bachovchin WW.

J Med Chem. 2008 Oct 9;51(19):6005-13. doi: 10.1021/jm800390n. Epub 2008 Sep 11.

PMID:
18783201
36.

Interplay between DNA polymerase and proliferating cell nuclear antigen switches off base excision repair of uracil and hypoxanthine during replication in archaea.

Emptage K, O'Neill R, Solovyova A, Connolly BA.

J Mol Biol. 2008 Nov 21;383(4):762-71. doi: 10.1016/j.jmb.2008.08.018. Epub 2008 Aug 14.

PMID:
18761016
37.

Uracil recognition in archaeal DNA polymerases captured by X-ray crystallography.

Firbank SJ, Wardle J, Heslop P, Lewis RJ, Connolly BA.

J Mol Biol. 2008 Sep 5;381(3):529-39. doi: 10.1016/j.jmb.2008.06.004. Epub 2008 Jun 7.

PMID:
18614176
38.

Template-directed addition of nucleosides to DNA by the BfiI restriction enzyme.

Sasnauskas G, Connolly BA, Halford SE, Siksnys V.

Nucleic Acids Res. 2008 Jul;36(12):3969-77. doi: 10.1093/nar/gkn343. Epub 2008 May 30.

39.

Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya.

Wardle J, Burgers PM, Cann IK, Darley K, Heslop P, Johansson E, Lin LJ, McGlynn P, Sanvoisin J, Stith CM, Connolly BA.

Nucleic Acids Res. 2008 Feb;36(3):705-11. Epub 2007 Nov 21.

40.

Interaction of the family-B DNA polymerase from the archaeon Pyrococcus furiosus with deaminated bases.

Gill S, O'Neill R, Lewis RJ, Connolly BA.

J Mol Biol. 2007 Sep 28;372(4):855-63. Epub 2007 Jul 21.

PMID:
17692870
41.

Site-specific DNA transesterification catalyzed by a restriction enzyme.

Sasnauskas G, Connolly BA, Halford SE, Siksnys V.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2115-20. Epub 2007 Jan 31.

42.

Synthesis, manipulation and conductivity of supramolecular polymer nanowires.

Dong L, Hollis T, Fishwick S, Connolly BA, Wright NG, Horrocks BR, Houlton A.

Chemistry. 2007;13(3):822-8.

PMID:
17154323
43.

A proteomic analysis of Streptomyces coelicolor programmed cell death.

Manteca A, Mäder U, Connolly BA, Sanchez J.

Proteomics. 2006 Nov;6(22):6008-22.

PMID:
17051639
44.

Predicting metals sensed by ArsR-SmtB repressors: allosteric interference by a non-effector metal.

Harvie DR, Andreini C, Cavallaro G, Meng W, Connolly BA, Yoshida K, Fujita Y, Harwood CR, Radford DS, Tottey S, Cavet JS, Robinson NJ.

Mol Microbiol. 2006 Feb;59(4):1341-56.

45.

Mechanism of the Escherichia coli DNA T:G-mismatch endonuclease (Vsr protein) probed with thiophosphate-containing oligodeoxynucleotides.

Elliott SL, Brazier J, Cosstick R, Connolly BA.

J Mol Biol. 2005 Oct 28;353(3):692-703. Epub 2005 Sep 8.

PMID:
16188275
46.

Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation.

Connolly BA, Rice J, Feig LA, Buchsbaum RJ.

Mol Cell Biol. 2005 Jun;25(11):4602-14. Erratum in: Mol Cell Biol. 2005 Sep;25(17):7928.

47.

Low-fidelity Pyrococcus furiosus DNA polymerase mutants useful in error-prone PCR.

Biles BD, Connolly BA.

Nucleic Acids Res. 2004 Dec 15;32(22):e176.

48.

Ferrocenyl-modified DNA: synthesis, characterization and integration with semiconductor electrodes.

Pike AR, Ryder LC, Horrocks BR, Clegg W, Connolly BA, Houlton A.

Chemistry. 2004 Dec 17;11(1):344-53.

PMID:
15551318
49.

Unusual 2-aminopurine fluorescence from a complex of DNA and the EcoKI methyltransferase.

Su TJ, Connolly BA, Darlington C, Mallin R, Dryden DT.

Nucleic Acids Res. 2004 Apr 23;32(7):2223-30. Print 2004.

50.

Recognition of the pro-mutagenic base uracil by family B DNA polymerases from archaea.

Shuttleworth G, Fogg MJ, Kurpiewski MR, Jen-Jacobson L, Connolly BA.

J Mol Biol. 2004 Mar 26;337(3):621-34.

PMID:
15019782

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