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Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.

Rodriguez A, Trigatti BL, Mineo C, Knaack D, Wilkins JT, Sahoo D, Asztalos BF, Mora S, Cuchel M, Pownall HJ, Rosales C, Bernatchez P, Ribeiro Martins da Silva A, Getz GS, Barber JL, Shearer GC, Zivkovic AM, Tietge UJF, Sacks FM, Connelly MA, Oda MN, Davidson WS, Sorci-Thomas MG, Vaisar T, Ruotolo G, Vickers KC, Martel C.

Arterioscler Thromb Vasc Biol. 2019 Oct 10:ATVBAHA119313340. doi: 10.1161/ATVBAHA.119.313340. [Epub ahead of print]


Concentration of Branched-Chain Amino Acids Is a Strong Risk Marker for Incident Hypertension.

Flores-Guerrero JL, Groothof D, Connelly MA, Otvos JD, Bakker SJL, Dullaart RPF.

Hypertension. 2019 Oct 7:HYPERTENSIONAHA11913735. doi: 10.1161/HYPERTENSIONAHA.119.13735. [Epub ahead of print]


A multiple lines of evidence approach for identifying geologic heterogeneities in conceptual site models for performance assessments.

Freedman V, Connelly M, Rockhold M, Hasan N, Mehta S, McMahon WJ, Kozak M, Hou ZJ, Bergeron M.

Sci Total Environ. 2019 Nov 20;692:450-464. doi: 10.1016/j.scitotenv.2019.07.213. Epub 2019 Jul 15.


Demographic, clinical, and treatment characteristics of the juvenile primary fibromyalgia syndrome cohort enrolled in the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.

Weiss JE, Schikler KN, Boneparth AD, Connelly M; CARRA Registry Investigators.

Pediatr Rheumatol Online J. 2019 Jul 26;17(1):51. doi: 10.1186/s12969-019-0356-z.


Plasma MicroRNAs in Established Rheumatoid Arthritis Relate to Adiposity and Altered Plasma and Skeletal Muscle Cytokine and Metabolic Profiles.

Andonian BJ, Chou CH, Ilkayeva OR, Koves TR, Connelly MA, Kraus WE, Kraus VB, Huffman KM.

Front Immunol. 2019 Jun 27;10:1475. doi: 10.3389/fimmu.2019.01475. eCollection 2019.


GlycA, a novel pro-inflammatory glycoprotein biomarker is associated with mortality: results from the PREVEND study and meta-analysis.

Gruppen EG, Kunutsor SK, Kieneker LM, van der Vegt B, Connelly MA, de Bock GH, Gansevoort RT, Bakker SJL, Dullaart RPF.

J Intern Med. 2019 Nov;286(5):596-609. doi: 10.1111/joim.12953. Epub 2019 Jul 24.


Blood Mg2+ is more closely associated with hyperglycaemia than with hypertriacylglycerolaemia: the PREVEND study.

van Dijk PR, Schutten JC, Jeyarajah EJ, Kootstra-Ros JE, Connelly MA, Bakker SJL, Dullaart RPF.

Diabetologia. 2019 Sep;62(9):1732-1734. doi: 10.1007/s00125-019-4929-7. Epub 2019 Jun 27. No abstract available.


Rates and Predictors of Using Opioids in the Emergency Department to Treat Migraine in Adolescents and Young Adults.

Connelly M, Glynn EF, Hoffman MA, Bickel J.

Pediatr Emerg Care. 2019 Jun 22. doi: 10.1097/PEC.0000000000001851. [Epub ahead of print]


Predicting history.

Risi J, Sharma A, Shah R, Connelly M, Watts DJ.

Nat Hum Behav. 2019 Sep;3(9):906-912. doi: 10.1038/s41562-019-0620-8. Epub 2019 Jun 3.


A Message to Medical School Promotion Committees: Proper Credit for Peer-Reviewed Online Educational Materials.

Rifai N, Smith BR, Connelly MT.

Clin Chem. 2019 Jun;65(6):715-717. doi: 10.1373/clinchem.2019.305862. Epub 2019 Apr 19. No abstract available.


The effects of incomplete milking and increased milking frequency on milk production rate and milk composition1.

Kuehnl JM, Connelly MK, Dzidic A, Lauber M, Fricker HP, Klister M, Olstad E, Balbach M, Timlin E, Pszczolkowski V, Crump PM, Reinemann DJ, Hernandez LL.

J Anim Sci. 2019 May 30;97(6):2424-2432. doi: 10.1093/jas/skz113.


Analysis of Sublethal Toxicity in Developing Zebrafish Embryos Exposed to a Range of Petroleum Substances.

Hedgpeth BM, Redman AD, Alyea RA, Letinski DJ, Connelly MJ, Butler JD, Zhou H, Lampi MA.

Environ Toxicol Chem. 2019 Jun;38(6):1302-1312. doi: 10.1002/etc.4428. Epub 2019 May 6.


Non-Alcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: Role of Circulating Branched-Chain Amino Acids.

van den Berg EH, Flores-Guerrero JL, Gruppen EG, de Borst MH, Wolak-Dinsmore J, Connelly MA, Bakker SJL, Dullaart RPF.

Nutrients. 2019 Mar 26;11(3). pii: E705. doi: 10.3390/nu11030705.


Erratum: Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity.

Douglass JD, Zhou YX, Wu A, Zadroga JA, Gajda AM, Lackey AI, Lang W, Chevalier KM, Sutton SW, Zhang SP, Flores CM, Connelly MA, Storch J.

J Lipid Res. 2019 Mar;60(3):717. doi: 10.1194/jlr.M058586ERR. No abstract available.


Compositional Features of HDL Particles Interact with Albuminuria to Modulate Cardiovascular Disease Risk.

Corsetti JP, Bakker SJL, Gansevoort RT, Gruppen EG, Connelly MA, Sparks CE, Dullaart RPF.

Int J Mol Sci. 2019 Feb 23;20(4). pii: E977. doi: 10.3390/ijms20040977.


Lower Plasma Magnesium, Measured by Nuclear Magnetic Resonance Spectroscopy, is Associated with Increased Risk of Developing Type 2 Diabetes Mellitus in Women: Results from a Dutch Prospective Cohort Study.

Schutten JC, Gomes-Neto AW, Navis G, Gansevoort RT, Dullaart RPF, Kootstra-Ros JE, Danel RM, Goorman F, Gans ROB, de Borst MH, Jeyarajah EJ, Shalaurova I, Otvos JD, Connelly MA, Bakker SJL.

J Clin Med. 2019 Feb 1;8(2). pii: E169. doi: 10.3390/jcm8020169.


Current perspectives on the development and treatment of chronic daily headache in children and adolescents.

Connelly M, Sekhon S.

Pain Manag. 2019 Mar 1;9(2):175-189. doi: 10.2217/pmt-2018-0057. Epub 2019 Jan 25. Review.


The depth of anaesthesia associated with the administration of isoflurane 2.5% during cardiopulmonary bypass.

Alston RP, Connelly M, MacKenzie C, Just G, Homer N.

Perfusion. 2019 Jul;34(5):392-398. doi: 10.1177/0267659118822946. Epub 2019 Jan 12.


Lipoprotein insulin resistance index, a high-throughput measure of insulin resistance, is associated with incident type II diabetes mellitus in the Prevention of Renal and Vascular End-Stage Disease study.

Flores-Guerrero JL, Connelly MA, Shalaurova I, Gruppen EG, Kieneker LM, Dullaart RPF, Bakker SJL.

J Clin Lipidol. 2019 Jan - Feb;13(1):129-137.e1. doi: 10.1016/j.jacl.2018.11.009. Epub 2018 Dec 1.


Substance Use and Psychosocial Functioning in a Sample of Liver Transplant Recipients with Alcohol-Related Liver Disease.

Sacco P, Sultan S, Tuten M, Powell JM, Connelly M, Barth RN, Hodorowicz M, LaMattina JC.

Transplant Proc. 2018 Dec;50(10):3689-3693. doi: 10.1016/j.transproceed.2018.07.003. Epub 2018 Jul 9.


A Pathophysiologic Approach Combining Genetics and Insulin Resistance to Predict the Severity of Nonalcoholic Fatty Liver Disease.

Danford CJ, Connelly MA, Shalaurova I, Kim M, Herman MA, Nasser I, Otvos JD, Afdhal NH, Jiang ZG, Lai M.

Hepatol Commun. 2018 Nov 1;2(12):1467-1478. doi: 10.1002/hep4.1267. eCollection 2018 Dec.


Rosuvastatin improves the FGF19 analogue NGM282-associated lipid changes in patients with non-alcoholic steatohepatitis.

Rinella ME, Trotter JF, Abdelmalek MF, Paredes AH, Connelly MA, Jaros MJ, Ling L, Rossi SJ, DePaoli AM, Harrison SA.

J Hepatol. 2019 Apr;70(4):735-744. doi: 10.1016/j.jhep.2018.11.032. Epub 2018 Dec 8.


Plasma Branched-Chain Amino Acids and Risk of Incident Type 2 Diabetes: Results from the PREVEND Prospective Cohort Study.

Flores-Guerrero JL, Osté MCJ, Kieneker LM, Gruppen EG, Wolak-Dinsmore J, Otvos JD, Connelly MA, Bakker SJL, Dullaart RPF.

J Clin Med. 2018 Dec 4;7(12). pii: E513. doi: 10.3390/jcm7120513.


Academic promotion policies and equity in global health collaborations.

Hedt-Gauthier B, Airhihenbuwa CO, Bawah AA, Burke KS, Cherian T, Connelly MT, Hibberd PL, Ivers LC, Jerome JG, Kateera F, Manabe YC, Maru D, Murray M, Shankar AH, Shuchman M, Volmink J.

Lancet. 2018 Nov 3;392(10158):1607-1609. doi: 10.1016/S0140-6736(18)32345-6. No abstract available.


Primary aldosteronism is associated with decreased low-density and high-density lipoprotein particle concentrations and increased GlycA, a pro-inflammatory glycoprotein biomarker.

Berends AMA, Buitenwerf E, Gruppen EG, Sluiter WJ, Bakker SJL, Connelly MA, Kerstens MN, Dullaart RPF.

Clin Endocrinol (Oxf). 2019 Jan;90(1):79-87. doi: 10.1111/cen.13891. Epub 2018 Nov 20.


Higher plasma GlycA, a novel pro-inflammatory glycoprotein biomarker, is associated with reduced life expectancy: The PREVEND study.

Gruppen EG, Connelly MA, Sluiter WJ, Bakker SJL, Dullaart RPF.

Clin Chim Acta. 2019 Jan;488:7-12. doi: 10.1016/j.cca.2018.10.029. Epub 2018 Oct 23.


Decreased GlycA after lifestyle intervention among obese, prediabetic adolescent Latinos.

Olson ML, Rentería-Mexía A, Connelly MA, Vega-López S, Soltero EG, Konopken YP, Williams AN, Castro FG, Keller CS, Yang HP, Todd MW, Shaibi GQ.

J Clin Lipidol. 2019 Jan - Feb;13(1):186-193. doi: 10.1016/j.jacl.2018.09.011. Epub 2018 Sep 22.


Multisite Randomized Clinical Trial Evaluating an Online Self-Management Program for Adolescents With Juvenile Idiopathic Arthritis.

Connelly M, Schanberg LE, Ardoin S, Blakley M, Carrasco R, Chira P, Hayward K, Ibarra M, Kimura Y, Kingsbury DJ, Klein-Gitelman MS, Lawson E, Stinson J.

J Pediatr Psychol. 2019 Apr 1;44(3):363-374. doi: 10.1093/jpepsy/jsy066.


Multi-Snapshot Imaging for Chromatographic Peak Analysis.

Hopgood JR, Connelly M, McHoull B, Troy D.

IEEE Trans Biomed Eng. 2019 Jan;66(1):119-129. doi: 10.1109/TBME.2018.2826144. Epub 2018 Apr 12.


Pediatric Headache Clinic Model: Implementation of Integrative Therapies in Practice.

Esparham A, Herbert A, Pierzchalski E, Tran C, Dilts J, Boorigie M, Wingert T, Connelly M, Bickel J.

Children (Basel). 2018 Jun 12;5(6). pii: E74. doi: 10.3390/children5060074. Review.


GlycA and hsCRP are independent and additive predictors of future cardiovascular events among patients undergoing angiography: The intermountain heart collaborative study.

Muhlestein JB, May HT, Galenko O, Knowlton KU, Otvos JD, Connelly MA, Lappe DL, Anderson JL.

Am Heart J. 2018 Aug;202:27-32. doi: 10.1016/j.ahj.2018.04.003. Epub 2018 Apr 6.


A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships.

Mathew B, Snowden TS, Connelly MC, Guy RK, Reynolds RC.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2136-2142. doi: 10.1016/j.bmcl.2018.05.023. Epub 2018 May 10.


Oxazole and thiazole analogs of sulindac for cancer prevention.

Mathew B, Hobrath JV, Connelly MC, Guy RK, Reynolds RC.

Future Med Chem. 2018 Apr 1;10(7):743-753. doi: 10.4155/fmc-2017-0182. Epub 2018 Apr 19.


Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

Hammill JT, Scott DC, Min J, Connelly MC, Holbrook G, Zhu F, Matheny A, Yang L, Singh B, Schulman BA, Guy RK.

J Med Chem. 2018 Apr 12;61(7):2680-2693. doi: 10.1021/acs.jmedchem.7b01277. Epub 2018 Mar 26.


Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

Hammill JT, Bhasin D, Scott DC, Min J, Chen Y, Lu Y, Yang L, Kim HS, Connelly MC, Hammill C, Holbrook G, Jeffries C, Singh B, Schulman BA, Guy RK.

J Med Chem. 2018 Apr 12;61(7):2694-2706. doi: 10.1021/acs.jmedchem.7b01282. Epub 2018 Mar 26.


Amine Containing Analogs of Sulindac for Cancer Prevention.

Mathew B, Hobrath JV, Connelly MC, Guy RK, Reynolds RC.

Open Med Chem J. 2018 Jan 31;12:1-12. doi: 10.2174/1874104501812010001. eCollection 2018.


Lipid profile and effect of statin treatment in pooled phase II and phase III baricitinib studies.

Taylor PC, Kremer JM, Emery P, Zuckerman SH, Ruotolo G, Zhong J, Chen L, Witt S, Saifan C, Kurzawa M, Otvos JD, Connelly MA, Macias WL, Schlichting DE, Rooney TP, de Bono S, McInnes IB.

Ann Rheum Dis. 2018 Jul;77(7):988-995. doi: 10.1136/annrheumdis-2017-212461. Epub 2018 Feb 20. Review.


A novel NMR-based assay to measure circulating concentrations of branched-chain amino acids: Elevation in subjects with type 2 diabetes mellitus and association with carotid intima media thickness.

Wolak-Dinsmore J, Gruppen EG, Shalaurova I, Matyus SP, Grant RP, Gegen R, Bakker SJL, Otvos JD, Connelly MA, Dullaart RPF.

Clin Biochem. 2018 Apr;54:92-99. doi: 10.1016/j.clinbiochem.2018.02.001. Epub 2018 Feb 9.


Relations of GlycA and lipoprotein particle subspecies with cardiovascular events and mortality: A post hoc analysis of the AIM-HIGH trial.

Otvos JD, Guyton JR, Connelly MA, Akapame S, Bittner V, Kopecky SL, Lacy M, Marcovina SM, Muhlestein JB, Boden WE.

J Clin Lipidol. 2018 Mar - Apr;12(2):348-355.e2. doi: 10.1016/j.jacl.2018.01.002. Epub 2018 Jan 12.


Advancing Professional Development Through a Community of Practice: the New England Network for Faculty Affairs.

Power CM, Thorndyke LE, Milner RJ, Lowney K, Irvin CG, Fonseca-Kelly Z, Benjamin EJ, Bhasin RM, Connelly MT.

J Contin Educ Health Prof. 2018 Winter;38(1):73-78. doi: 10.1097/CEH.0000000000000186.


Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases.

Rogalski E, Gefen T, Mao Q, Connelly M, Weintraub S, Geula C, Bigio EH, Mesulam MM.

Hippocampus. 2019 May;29(5):458-467. doi: 10.1002/hipo.22828. Epub 2018 Feb 5.


Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.

Ortiz D, Guiguemde WA, Hammill JT, Carrillo AK, Chen Y, Connelly M, Stalheim K, Elya C, Johnson A, Min J, Shelat A, Smithson DC, Yang L, Zhu F, Guy RK, Landfear SM.

PLoS Negl Trop Dis. 2017 Dec 29;11(12):e0006157. doi: 10.1371/journal.pntd.0006157. eCollection 2017 Dec.


Circulating tumor cells as a predictive biomarker in patients with small cell lung cancer undergoing chemotherapy.

Aggarwal C, Wang X, Ranganathan A, Torigian D, Troxel A, Evans T, Cohen RB, Vaidya B, Rao C, Connelly M, Vachani A, Langer C, Albelda S.

Lung Cancer. 2017 Oct;112:118-125. doi: 10.1016/j.lungcan.2017.08.008. Epub 2017 Aug 12.


Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

Shadrick WR, Slavish PJ, Chai SC, Waddell B, Connelly M, Low JA, Tallant C, Young BM, Bharatham N, Knapp S, Boyd VA, Morfouace M, Roussel MF, Chen T, Lee RE, Kiplin Guy R, Shelat AA, Potter PM.

Bioorg Med Chem. 2018 Jan 1;26(1):25-36. doi: 10.1016/j.bmc.2017.10.042. Epub 2017 Nov 4.


Effects of hepato-preferential basal insulin peglispro on nuclear magnetic resonance biomarkers lipoprotein insulin resistance index and GlycA in patients with diabetes.

Connelly MA, Otvos JD, Zhang Q, Zhang S, Antalis CJ, Chang AM, Hoogwerf BJ.

Biomark Med. 2017 Nov;11(11):991-1001. doi: 10.2217/bmm-2017-0112.


Enumeration and characterization of circulating multiple myeloma cells in patients with plasma cell disorders.

Foulk B, Schaffer M, Gross S, Rao C, Smirnov D, Connelly MC, Chaturvedi S, Reddy M, Brittingham G, Mata M, Repollet M, Rojas C, Auclair D, DeRome M; MMRF CoMMpass Network, Weiss B, Sasser AK.

Br J Haematol. 2018 Jan;180(1):71-81. doi: 10.1111/bjh.15003. Epub 2017 Nov 5.


GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk.

Connelly MA, Otvos JD, Shalaurova I, Playford MP, Mehta NN.

J Transl Med. 2017 Oct 27;15(1):219. doi: 10.1186/s12967-017-1321-6. Review.


TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function.

Gruppen EG, Garcia E, Connelly MA, Jeyarajah EJ, Otvos JD, Bakker SJL, Dullaart RPF.

Sci Rep. 2017 Oct 23;7(1):13781. doi: 10.1038/s41598-017-13739-9.

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