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Items: 44


Epigenetic dynamics in infancy and the impact of maternal engagement.

Krol KM, Moulder RG, Lillard TS, Grossmann T, Connelly JJ.

Sci Adv. 2019 Oct 16;5(10):eaay0680. doi: 10.1126/sciadv.aay0680. eCollection 2019 Oct.


Epigenetic modification of the oxytocin receptor gene is associated with emotion processing in the infant brain.

Krol KM, Puglia MH, Morris JP, Connelly JJ, Grossmann T.

Dev Cogn Neurosci. 2019 Jun;37:100648. doi: 10.1016/j.dcn.2019.100648. Epub 2019 Apr 26.


Behavioral and epigenetic consequences of oxytocin treatment at birth.

Kenkel WM, Perkeybile AM, Yee JR, Pournajafi-Nazarloo H, Lillard TS, Ferguson EF, Wroblewski KL, Ferris CF, Carter CS, Connelly JJ.

Sci Adv. 2019 May 1;5(5):eaav2244. doi: 10.1126/sciadv.aav2244. eCollection 2019 May.


DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology.

Lancaster K, Goldbeck L, Puglia MH, Morris JP, Connelly JJ.

Soc Cogn Affect Neurosci. 2018 Nov 8;13(11):1155-1162. doi: 10.1093/scan/nsy086.


Early nurture epigenetically tunes the oxytocin receptor.

Perkeybile AM, Carter CS, Wroblewski KL, Puglia MH, Kenkel WM, Lillard TS, Karaoli T, Gregory SG, Mohammadi N, Epstein L, Bales KL, Connelly JJ.

Psychoneuroendocrinology. 2019 Jan;99:128-136. doi: 10.1016/j.psyneuen.2018.08.037. Epub 2018 Aug 31.


The Role of Endogenous Oxytocin in Anxiolysis: Structural and Functional Correlates.

Lancaster K, Goldbeck L, Pournajafi-Nazarloo H, Connelly JJ, Carter CS, Morris JP.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Jul;3(7):618-625. doi: 10.1016/j.bpsc.2017.10.003. Epub 2017 Oct 24.


Epigenetic regulation of the oxytocin receptor is associated with neural response during selective social attention.

Puglia MH, Connelly JJ, Morris JP.

Transl Psychiatry. 2018 Jun 15;8(1):116. doi: 10.1038/s41398-018-0159-x.


Empowering genomic medicine by establishing critical sequencing result data flows: the eMERGE example.

Aronson S, Babb L, Ames D, Gibbs RA, Venner E, Connelly JJ, Marsolo K, Weng C, Williams MS, Hartzler AL, Liang WH, Ralston JD, Devine EB, Murphy S, Chute CG, Caraballo PJ, Kullo IJ, Freimuth RR, Rasmussen LV, Wehbe FH, Peterson JF, Robinson JR, Wiley K, Overby Taylor C; eMERGE Network EHRI Working Group.

J Am Med Inform Assoc. 2018 Oct 1;25(10):1375-1381. doi: 10.1093/jamia/ocy051.


Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood.

Ebner NC, Lin T, Muradoglu M, Weir DH, Plasencia GM, Lillard TS, Pournajafi-Nazarloo H, Cohen RA, Sue Carter C, Connelly JJ.

Int J Psychophysiol. 2019 Feb;136:22-32. doi: 10.1016/j.ijpsycho.2018.01.008. Epub 2018 Feb 2.


Oxytocin receptor genotype and low economic privilege reverses ventral striatum-social anxiety association.

Gonzalez MZ, Puglia MH, Morris JP, Connelly JJ.

Soc Neurosci. 2019 Feb;14(1):67-79. doi: 10.1080/17470919.2017.1403954. Epub 2017 Nov 17.


Neuroimaging Epigenetics: Challenges and Recommendations for Best Practices.

Lancaster K, Morris JP, Connelly JJ.

Neuroscience. 2018 Feb 1;370:88-100. doi: 10.1016/j.neuroscience.2017.08.004. Epub 2017 Aug 8. Review.


Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.

Durgin BG, Cherepanova OA, Gomez D, Karaoli T, Alencar GF, Butcher JT, Zhou YQ, Bendeck MP, Isakson BE, Owens GK, Connelly JJ.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H943-H958. doi: 10.1152/ajpheart.00029.2017. Epub 2017 Mar 10.


Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective.

Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, Alencar GF, Hess DL, Bevard MH, Greene ES, Murgai M, Turner SD, Geng YJ, Bekiranov S, Connelly JJ, Tomilin A, Owens GK.

Nat Med. 2016 Jun;22(6):657-65. doi: 10.1038/nm.4109. Epub 2016 May 16.


Sex and diagnosis specific associations between DNA methylation of the oxytocin receptor gene with emotion processing and temporal-limbic and prefrontal brain volumes in psychotic disorders.

Rubin LH, Connelly JJ, Reilly JL, Carter CS, Drogos LL, Pournajafi-Nazarloo H, Ruocco AC, Keedy SK, Matthew I, Tandon N, Pearlson GD, Clementz BA, Tamminga CA, Gershon ES, Keshavan MS, Bishop JR, Sweeney JA.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Mar 1;1(2):141-151. Epub 2015 Nov 9.


Interaction between oxytocin receptor DNA methylation and genotype is associated with risk of postpartum depression in women without depression in pregnancy.

Bell AF, Carter CS, Steer CD, Golding J, Davis JM, Steffen AD, Rubin LH, Lillard TS, Gregory SP, Harris JC, Connelly JJ.

Front Genet. 2015 Jul 21;6:243. doi: 10.3389/fgene.2015.00243. eCollection 2015.


Childbirth and symptoms of postpartum depression and anxiety: a prospective birth cohort study.

Bell AF, Carter CS, Davis JM, Golding J, Adejumo O, Pyra M, Connelly JJ, Rubin LH.

Arch Womens Ment Health. 2016 Apr;19(2):219-27. doi: 10.1007/s00737-015-0555-7. Epub 2015 Jul 23.


Plasma oxytocin explains individual differences in neural substrates of social perception.

Lancaster K, Carter CS, Pournajafi-Nazarloo H, Karaoli T, Lillard TS, Jack A, Davis JM, Morris JP, Connelly JJ.

Front Hum Neurosci. 2015 Mar 17;9:132. doi: 10.3389/fnhum.2015.00132. eCollection 2015.


Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain.

Puglia MH, Lillard TS, Morris JP, Connelly JJ.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3308-13. doi: 10.1073/pnas.1422096112. Epub 2015 Feb 9.


Personality, behavior and environmental features associated with OXTR genetic variants in British mothers.

Connelly JJ, Golding J, Gregory SP, Ring SM, Davis JM, Davey Smith G, Harris JC, Carter CS, Pembrey M.

PLoS One. 2014 Mar 12;9(3):e90465. doi: 10.1371/journal.pone.0090465. eCollection 2014.


A functionally significant polymorphism in ID3 is associated with human coronary pathology.

Manichaikul A, Rich SS, Perry H, Yeboah J, Law M, Davis M, Parker M, Ragosta M, Connelly JJ, McNamara CA, Taylor AM.

PLoS One. 2014 Mar 6;9(3):e90222. doi: 10.1371/journal.pone.0090222. eCollection 2014. Erratum in: PLoS One. 2014;9(9):e109222.


Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring.

Laker RC, Lillard TS, Okutsu M, Zhang M, Hoehn KL, Connelly JJ, Yan Z.

Diabetes. 2014 May;63(5):1605-11. doi: 10.2337/db13-1614. Epub 2014 Jan 15.


Oxytocin receptor gene variation predicts empathic concern and autonomic arousal while perceiving harm to others.

Smith KE, Porges EC, Norman GJ, Connelly JJ, Decety J.

Soc Neurosci. 2014 Feb;9(1):1-9. doi: 10.1080/17470919.2013.863223. Epub 2013 Dec 3.


Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis.

Connelly JJ, Cherepanova OA, Doss JF, Karaoli T, Lillard TS, Markunas CA, Nelson S, Wang T, Ellis PD, Langford CF, Haynes C, Seo DM, Goldschmidt-Clermont PJ, Shah SH, Kraus WE, Hauser ER, Gregory SG.

Hum Mol Genet. 2013 Dec 20;22(25):5107-20. doi: 10.1093/hmg/ddt365. Epub 2013 Aug 2.


DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli.

Jack A, Connelly JJ, Morris JP.

Front Hum Neurosci. 2012 Oct 10;6:280. doi: 10.3389/fnhum.2012.00280. eCollection 2012.


Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression.

Wolstenholme JT, Edwards M, Shetty SR, Gatewood JD, Taylor JA, Rissman EF, Connelly JJ.

Endocrinology. 2012 Aug;153(8):3828-38. doi: 10.1210/en.2012-1195. Epub 2012 Jun 15.


A longitudinal study of the course of asymptomatic antibody-mediated rejection in heart transplantation.

Kfoury AG, Snow GL, Budge D, Alharethi RA, Stehlik J, Everitt MD, Miller DV, Drakos SG, Reid BB, Revelo MP, Gilbert EM, Selzman CH, Bader FM, Connelly JJ, Hammond ME.

J Heart Lung Transplant. 2012 Jan;31(1):46-51. doi: 10.1016/j.healun.2011.10.009.


Gestational exposure to low dose bisphenol A alters social behavior in juvenile mice.

Wolstenholme JT, Taylor JA, Shetty SR, Edwards M, Connelly JJ, Rissman EF.

PLoS One. 2011;6(9):e25448. doi: 10.1371/journal.pone.0025448. Epub 2011 Sep 28.


Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease.

Minear MA, Crosslin DR, Sutton BS, Connelly JJ, Nelson SC, Gadson-Watson S, Wang T, Seo D, Vance JM, Sketch MH Jr, Haynes C, Goldschmidt-Clermont PJ, Shah SH, Kraus WE, Hauser ER, Gregory SG.

Hum Genet. 2011 Jun;129(6):641-54. doi: 10.1007/s00439-011-0959-z. Epub 2011 Feb 5.


The role of Bisphenol A in shaping the brain, epigenome and behavior.

Wolstenholme JT, Rissman EF, Connelly JJ.

Horm Behav. 2011 Mar;59(3):296-305. doi: 10.1016/j.yhbeh.2010.10.001. Epub 2010 Oct 26. Review.


Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies.

Zhang L, Connelly JJ, Peppel K, Brian L, Shah SH, Nelson S, Crosslin DR, Wang T, Allen A, Kraus WE, Gregory SG, Hauser ER, Freedman NJ.

Hum Mol Genet. 2010 Jul 15;19(14):2754-66. doi: 10.1093/hmg/ddq172. Epub 2010 Apr 26.


Genomic and epigenetic evidence for oxytocin receptor deficiency in autism.

Gregory SG, Connelly JJ, Towers AJ, Johnson J, Biscocho D, Markunas CA, Lintas C, Abramson RK, Wright HH, Ellis P, Langford CF, Worley G, Delong GR, Murphy SK, Cuccaro ML, Persico A, Pericak-Vance MA.

BMC Med. 2009 Oct 22;7:62. doi: 10.1186/1741-7015-7-62.


A general integrative genomic feature transcription factor binding site prediction method applied to analysis of USF1 binding in cardiovascular disease.

Wang T, Furey TS, Connelly JJ, Ji S, Nelson S, Heber S, Gregory SG, Hauser ER.

Hum Genomics. 2009 Apr;3(3):221-35.


Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.

Crosslin DR, Shah SH, Nelson SC, Haynes CS, Connelly JJ, Gadson S, Goldschmidt-Clermont PJ, Vance JM, Rose J, Granger CB, Seo D, Gregory SG, Kraus WE, Hauser ER.

Hum Genet. 2009 Mar;125(2):217-29. doi: 10.1007/s00439-008-0619-0. Epub 2009 Jan 8.


Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.

Shah SH, Freedman NJ, Zhang L, Crosslin DR, Stone DH, Haynes C, Johnson J, Nelson S, Wang L, Connelly JJ, Muehlbauer M, Ginsburg GS, Crossman DC, Jones CJ, Vance J, Sketch MH, Granger CB, Newgard CB, Gregory SG, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER.

PLoS Genet. 2009 Jan;5(1):e1000318. doi: 10.1371/journal.pgen.1000318. Epub 2009 Jan 2.


Refinement of 2q and 7p loci in a large multiplex NTD family.

Stamm DS, Siegel DG, Mehltretter L, Connelly JJ, Trott A, Ellis N, Zismann V, Stephan DA, George TM, Vekemans M, Ashley-Koch A, Gilbert JR, Gregory SG, Speer MC; NTD Collaborative Group.

Birth Defects Res A Clin Mol Teratol. 2008 Jun;82(6):441-52. doi: 10.1002/bdra.20462.


Genetic and functional association of FAM5C with myocardial infarction.

Connelly JJ, Shah SH, Doss JF, Gadson S, Nelson S, Crosslin DR, Hale AB, Lou X, Wang T, Haynes C, Seo D, Crossman DC, Mooser V, Granger CB, Jones CJ, Kraus WE, Hauser ER, Gregory SG.

BMC Med Genet. 2008 Apr 22;9:33. doi: 10.1186/1471-2350-9-33.


Rtt107/Esc4 binds silent chromatin and DNA repair proteins using different BRCT motifs.

Zappulla DC, Maharaj AS, Connelly JJ, Jockusch RA, Sternglanz R.

BMC Mol Biol. 2006 Nov 9;7:40.


GATA2 is associated with familial early-onset coronary artery disease.

Connelly JJ, Wang T, Cox JE, Haynes C, Wang L, Shah SH, Crosslin DR, Hale AB, Nelson S, Crossman DC, Granger CB, Haines JL, Jones CJ, Vance JM, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER, Gregory SG.

PLoS Genet. 2006 Aug 25;2(8):e139. Epub 2006 Jul 20.


The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor.

Xiang S, Kim EY, Connelly JJ, Nassar N, Kirsch J, Winking J, Schwarz G, Schindelin H.

J Mol Biol. 2006 May 26;359(1):35-46. Epub 2006 Mar 29.


Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain.

Connelly JJ, Yuan P, Hsu HC, Li Z, Xu RM, Sternglanz R.

Mol Cell Biol. 2006 Apr;26(8):3256-65.


Importance of the Sir3 N terminus and its acetylation for yeast transcriptional silencing.

Wang X, Connelly JJ, Wang CL, Sternglanz R.

Genetics. 2004 Sep;168(1):547-51.


Children are not expendable.


N Engl J Med. 1953 Jan 1;248(1):1-5. No abstract available.


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