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Items: 1 to 50 of 571

1.

Peptidomic analysis in the discovery of therapeutically valuable peptides in amphibian skin secretions.

Conlon JM, Mechkarska M, Leprince J.

Expert Rev Proteomics. 2019 Nov 15. doi: 10.1080/14789450.2019.1693894. [Epub ahead of print]

PMID:
31729236
2.

Structural and positional studies of the antimicrobial peptide brevinin-1BYa in membrane-mimetic environments.

Timmons PB, O'Flynn D, Conlon JM, Hewage CM.

J Pept Sci. 2019 Nov;25(11):e3208. doi: 10.1002/psc.3208.

PMID:
31721374
3.

Conformational analysis and in vitro immunomodulatory and insulinotropic properties of the frog skin host-defense peptide rhinophrynin-27 and selected analogs.

Scorciapino MA, Carta P, Pantic J, Lukic ML, Lukic A, Musale V, Abdel-Wahab YHA, Conlon JM.

Biochimie. 2019 Oct 19;167:198-206. doi: 10.1016/j.biochi.2019.10.007. [Epub ahead of print]

PMID:
31639404
4.

A long-acting, dual-agonist analogue of lamprey GLP-1 shows potent insulinotropic, β-cell protective, and anorexic activities and improves glucose homeostasis in high fat-fed mice.

Graham GV, McCloskey A, Abdel-Wahab YH, Conlon JM, Flatt PR.

Mol Cell Endocrinol. 2020 Jan 1;499:110584. doi: 10.1016/j.mce.2019.110584. Epub 2019 Sep 17.

PMID:
31539596
5.

Insights into conformation and membrane interactions of the acyclic and dicarba-bridged brevinin-1BYa antimicrobial peptides.

Timmons PB, O'Flynn D, Conlon JM, Hewage CM.

Eur Biophys J. 2019 Dec;48(8):701-710. doi: 10.1007/s00249-019-01395-y. Epub 2019 Sep 12.

PMID:
31515575
6.

Selection of antimicrobial frog peptides and temporin-1DRa analogs for treatment of bacterial infections based on their cytotoxicity and differential activity against pathogens.

Gaiser RA, Ayerra Mangado J, Mechkarska M, Kaman WE, van Baarlen P, Conlon JM, Wells JM.

Chem Biol Drug Des. 2019 May 18. doi: 10.1111/cbdd.13569. [Epub ahead of print]

PMID:
31102497
7.

Immunomodulatory, insulinotropic, and cytotoxic activities of phylloseptins and plasticin-TR from the Trinidanian leaf frog Phyllomedusa trinitatis.

Pantic J, Guilhaudis L, Musale V, Attoub S, Lukic ML, Mechkarska M, Conlon JM.

J Pept Sci. 2019 Apr;25(4):e3153. doi: 10.1002/psc.3153. Epub 2019 Feb 7.

PMID:
30734396
8.

Peptidomic analysis of the host-defense peptides in skin secretions of Rana graeca provides insight into phylogenetic relationships among Eurasian Rana species.

Mechkarska M, Kolodziejek J, Musale V, Coquet L, Leprince J, Jouenne T, Nowotny N, Conlon JM.

Comp Biochem Physiol Part D Genomics Proteomics. 2019 Mar;29:228-234. doi: 10.1016/j.cbd.2018.12.006. Epub 2018 Dec 27.

PMID:
30599276
9.

Towards establishing a higher acceptance rate for PEPTIDES - The peer review process and criteria for acceptance or rejection.

Conlon JM, Herzig KH.

Peptides. 2019 Feb;112:32-33. doi: 10.1016/j.peptides.2018.11.004. Epub 2018 Nov 24. No abstract available.

PMID:
30481536
10.

Glucagon-related peptides from phylogenetically ancient fish reveal new approaches to the development of dual GCGR and GLP1R agonists for type 2 diabetes therapy.

Graham GV, Conlon JM, Abdel-Wahab YH, Flatt PR.

Peptides. 2018 Dec;110:19-29. doi: 10.1016/j.peptides.2018.10.013. Epub 2018 Nov 1.

PMID:
30391422
11.

Glucagon-like peptides-1 from phylogenetically ancient fish show potent anti-diabetic activities by acting as dual GLP1R and GCGR agonists.

Graham GV, Conlon JM, Abdel-Wahab YH, Flatt PR.

Mol Cell Endocrinol. 2019 Jan 15;480:54-64. doi: 10.1016/j.mce.2018.10.011. Epub 2018 Oct 9.

PMID:
30312651
12.

Insulinotropic activity of the host-defense peptide frenatin 2D: Conformational, structure-function and mechanistic studies.

Musale V, Guilhaudis L, Abdel-Wahab YHA, Flatt PR, Conlon JM.

Biochimie. 2019 Jan;156:12-21. doi: 10.1016/j.biochi.2018.09.008. Epub 2018 Sep 19.

PMID:
30244134
13.

Peptidomic analysis of the host-defense peptides in skin secretions of the Trinidadian leaf frog Phyllomedusa trinitatis (Phyllomedusidae).

Mechkarska M, Coquet L, Leprince J, Auguste RJ, Jouenne T, Mangoni ML, Conlon JM.

Comp Biochem Physiol Part D Genomics Proteomics. 2018 Dec;28:72-79. doi: 10.1016/j.cbd.2018.06.006. Epub 2018 Jun 30.

PMID:
29980138
14.

Insulinotropic, glucose-lowering, and beta-cell anti-apoptotic actions of peptides related to esculentin-1a(1-21).NH2.

Musale V, Abdel-Wahab YHA, Flatt PR, Conlon JM, Mangoni ML.

Amino Acids. 2018 Jun;50(6):723-734. doi: 10.1007/s00726-018-2551-5. Epub 2018 Mar 17.

PMID:
29549522
15.

Identification of Components in Frog Skin Secretions with Therapeutic Potential as Antidiabetic Agents.

Conlon JM, Moffett RC, Leprince J, Flatt PR.

Methods Mol Biol. 2018;1719:319-333. doi: 10.1007/978-1-4939-7537-2_21.

PMID:
29476521
16.

Editorial: Newer peptide-based agents for treatment of patients with Type 2 diabetes.

Flatt PR, Conlon JM.

Peptides. 2018 Feb;100:1-2. doi: 10.1016/j.peptides.2018.01.004. No abstract available.

PMID:
29412809
17.

Assessment of the potential of temporin peptides from the frog Rana temporaria (Ranidae) as anti-diabetic agents.

Musale V, Casciaro B, Mangoni ML, Abdel-Wahab YHA, Flatt PR, Conlon JM.

J Pept Sci. 2018 Feb;24(2). doi: 10.1002/psc.3065. Epub 2018 Jan 19.

PMID:
29349894
18.

The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents.

Pantic JM, Jovanovic IP, Radosavljevic GD, Arsenijevic NN, Conlon JM, Lukic ML.

Molecules. 2017 Dec 13;22(12). pii: E2071. doi: 10.3390/molecules22122071. Review.

19.

Evaluation of the insulinotropic and glucose-lowering actions of zebrafish GIP in mammalian systems: Evidence for involvement of the GLP-1 receptor.

Graham GV, Conlon JM, Abdel-Wahab YH, Gault VA, Flatt PR.

Peptides. 2018 Feb;100:182-189. doi: 10.1016/j.peptides.2017.11.007. Epub 2017 Nov 20.

PMID:
29157578
20.

Peptidomic analysis of skin secretions of the Mexican burrowing toad Rhinophrynus dorsalis (Rhinophrynidae): Insight into the origin of host-defense peptides within the Pipidae and characterization of a proline-arginine-rich peptide.

Conlon JM, Guilhaudis L, Leprince J, Coquet L, Mangoni ML, Attoub S, Jouenne T, King JD.

Peptides. 2017 Nov;97:22-28. doi: 10.1016/j.peptides.2017.09.012. Epub 2017 Sep 23.

PMID:
28951157
21.

Peptides from frog skin with potential for development into agents for Type 2 diabetes therapy.

Conlon JM, Mechkarska M, Abdel-Wahab YH, Flatt PR.

Peptides. 2018 Feb;100:275-281. doi: 10.1016/j.peptides.2017.09.001. Epub 2017 Sep 5. Review.

PMID:
28887047
22.

Anti-diabetic actions of esculentin-2CHa(1-30) and its stable analogues in a diet-induced model of obesity-diabetes.

Vasu S, Ojo OO, Moffett RC, Conlon JM, Flatt PR, Abdel-Wahab YHA.

Amino Acids. 2017 Oct;49(10):1705-1717. doi: 10.1007/s00726-017-2469-3. Epub 2017 Aug 23.

PMID:
28836148
23.

Cytotoxic peptides with insulin-releasing activities from skin secretions of the Italian stream frog Rana italica (Ranidae).

Conlon JM, Musale V, Attoub S, Mangoni ML, Leprince J, Coquet L, Jouenne T, Abdel-Wahab YHA, Flatt PR, Rinaldi AC.

J Pept Sci. 2017 Oct;23(10):769-776. doi: 10.1002/psc.3025. Epub 2017 Jul 11.

PMID:
28699258
24.

The frog skin host-defense peptide frenatin 2.1S enhances recruitment, activation and tumoricidal capacity of NK cells.

Pantic JM, Jovanovic IP, Radosavljevic GD, Gajovic NM, Arsenijevic NN, Conlon JM, Lukic ML.

Peptides. 2017 Jul;93:44-50. doi: 10.1016/j.peptides.2017.05.006. Epub 2017 May 16.

PMID:
28526557
25.

The activity of the rectal gland of the North Pacific spiny dogfish Squalus suckleyi is glucose dependent and stimulated by glucagon-like peptide-1.

Deck CA, Anderson WG, Conlon JM, Walsh PJ.

J Comp Physiol B. 2017 Dec;187(8):1155-1161. doi: 10.1007/s00360-017-1102-9. Epub 2017 Apr 25.

PMID:
28444441
26.

Actions of PGLa-AM1 and its [A14K] and [A20K] analogues and their therapeutic potential as anti-diabetic agents.

Owolabi BO, Musale V, Ojo OO, Moffett RC, McGahon MK, Curtis TM, Conlon JM, Flatt PR, Abdel-Wahab YHA.

Biochimie. 2017 Jul;138:1-12. doi: 10.1016/j.biochi.2017.04.004. Epub 2017 Apr 7.

PMID:
28392407
27.

2016 AMCA Memorial Lecture Honoree: Thomas Oscar Fultz, Jr.: A Modern Mosquito Pioneer.

Conlon JM.

J Am Mosq Control Assoc. 2017 Mar;33(1):75-80. doi: 10.2987/16-6632.1. No abstract available.

PMID:
28388326
28.

Esculentin-2CHa(1-30) and its analogues: stability and mechanisms of insulinotropic action.

Vasu S, McGahon MK, Moffett RC, Curtis TM, Conlon JM, Abdel-Wahab YH, Flatt PR.

J Endocrinol. 2017 Mar;232(3):423-435. doi: 10.1530/JOE-16-0453.

PMID:
28115493
29.

Purification, Conformational Analysis, and Properties of a Family of Tigerinin Peptides from Skin Secretions of the Crowned Bullfrog Hoplobatrachus occipitalis.

McLaughlin CM, Lampis S, Mechkarska M, Coquet L, Jouenne T, King JD, Mangoni ML, Lukic ML, Scorciapino MA, Conlon JM.

J Nat Prod. 2016 Sep 23;79(9):2350-6. doi: 10.1021/acs.jnatprod.6b00494. Epub 2016 Aug 25.

PMID:
27560386
30.

Dogfish glucagon analogues counter hyperglycaemia and enhance both insulin secretion and action in diet-induced obese diabetic mice.

O'Harte FP, Ng MT, Lynch AM, Conlon JM, Flatt PR.

Diabetes Obes Metab. 2016 Oct;18(10):1013-24. doi: 10.1111/dom.12713. Epub 2016 Aug 15.

PMID:
27357054
31.

Peptidomic analysis of the extensive array of host-defense peptides in skin secretions of the dodecaploid frog Xenopus ruwenzoriensis (Pipidae).

Coquet L, Kolodziejek J, Jouenne T, Nowotny N, King JD, Conlon JM.

Comp Biochem Physiol Part D Genomics Proteomics. 2016 Sep;19:18-24. doi: 10.1016/j.cbd.2016.04.006. Epub 2016 Jun 3.

PMID:
27290612
32.

Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice.

O'Harte FP, Ng MT, Lynch AM, Conlon JM, Flatt PR.

Mol Cell Endocrinol. 2016 Aug 15;431:133-44. doi: 10.1016/j.mce.2016.05.012. Epub 2016 May 11.

PMID:
27179756
33.

Putative histidine kinase inhibitors with antibacterial effect against multi-drug resistant clinical isolates identified by in vitro and in silico screens.

Velikova N, Fulle S, Manso AS, Mechkarska M, Finn P, Conlon JM, Oggioni MR, Wells JM, Marina A.

Sci Rep. 2016 May 13;6:26085. doi: 10.1038/srep26085.

34.

Glucoregulatory, endocrine and morphological effects of [P5K]hymenochirin-1B in mice with diet-induced glucose intolerance and insulin resistance.

Owolabi BO, Ojo OO, Srinivasan DK, Conlon JM, Flatt PR, Abdel-Wahab YH.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Jul;389(7):769-81. doi: 10.1007/s00210-016-1243-5. Epub 2016 Apr 12.

PMID:
27068334
35.

Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance.

Ojo OO, Srinivasan DK, Owolabi BO, McGahon MK, Moffett RC, Curtis TM, Conlon JM, Flatt PR, Abdel-Wahab YH.

Biol Chem. 2016 Aug 1;397(8):753-64. doi: 10.1515/hsz-2016-0120.

PMID:
26966929
36.

Conformational Analysis of the Host-Defense Peptides Pseudhymenochirin-1Pb and -2Pa and Design of Analogues with Insulin-Releasing Activities and Reduced Toxicities.

Manzo G, Scorciapino MA, Srinivasan D, Attoub S, Mangoni ML, Rinaldi AC, Casu M, Flatt PR, Conlon JM.

J Nat Prod. 2015 Dec 24;78(12):3041-8. doi: 10.1021/acs.jnatprod.5b00843. Epub 2015 Nov 25.

PMID:
26606380
37.

Esculentin-2CHa-Related Peptides Modulate Islet Cell Function and Improve Glucose Tolerance in Mice with Diet-Induced Obesity and Insulin Resistance.

Ojo OO, Srinivasan DK, Owolabi BO, Vasu S, Conlon JM, Flatt PR, Abdel-Wahab YH.

PLoS One. 2015 Oct 29;10(10):e0141549. doi: 10.1371/journal.pone.0141549. eCollection 2015.

38.

In vitro and in vivo insulinotropic properties of the multifunctional frog skin peptide hymenochirin-1B: a structure-activity study.

Owolabi BO, Ojo OO, Srinivasan DK, Conlon JM, Flatt PR, Abdel-Wahab YH.

Amino Acids. 2016 Feb;48(2):535-47. doi: 10.1007/s00726-015-2107-x. Epub 2015 Oct 6.

PMID:
26439377
39.

[I10W]tigerinin-1R enhances both insulin sensitivity and pancreatic beta cell function and decreases adiposity and plasma triglycerides in high-fat mice.

Srinivasan DK, Ojo OO, Owolabi BO, Conlon JM, Flatt PR, Abdel-Wahab YH.

Acta Diabetol. 2016 Apr;53(2):303-15. doi: 10.1007/s00592-015-0783-3. Epub 2015 Jul 3.

PMID:
26138324
40.

The frog skin host-defense peptide CPF-SE1 improves glucose tolerance, insulin sensitivity and islet function and decreases plasma lipids in high-fat fed mice.

Srinivasan D, Ojo OO, Owolabi BO, Conlon JM, Flatt PR, Abdel-Wahab YH.

Eur J Pharmacol. 2015 Oct 5;764:38-47. doi: 10.1016/j.ejphar.2015.06.042. Epub 2015 Jun 27.

PMID:
26123844
41.

In vivo administration of the frog skin peptide frenatin 2.1S induces immunostimulatory phenotypes of mouse mononuclear cells.

Pantic JM, Radosavljevic GD, Jovanovic IP, Arsenijevic NN, Conlon JM, Lukic ML.

Peptides. 2015 Sep;71:269-75. doi: 10.1016/j.peptides.2015.03.028. Epub 2015 Apr 8.

PMID:
25861850
42.

Host-defense and trefoil factor family peptides in skin secretions of the Mawa clawed frog Xenopus boumbaensis (Pipidae).

Conlon JM, Mechkarska M, Kolodziejek J, Leprince J, Coquet L, Jouenne T, Vaudry H, Nowotny N, King JD.

Peptides. 2015 Oct;72:44-9. doi: 10.1016/j.peptides.2015.03.025. Epub 2015 Apr 4.

PMID:
25849343
43.

Host-defense peptides of the skin with therapeutic potential: From hagfish to human.

Conlon JM.

Peptides. 2015 May;67:29-38. doi: 10.1016/j.peptides.2015.03.005. Epub 2015 Mar 18. Review.

PMID:
25794853
44.

Host-defense peptides from skin secretions of Fraser's clawed frog Xenopus fraseri (Pipidae): Further insight into the evolutionary history of the Xenopodinae.

Conlon JM, Mechkarska M, Kolodziejek J, Nowotny N, Coquet L, Leprince J, Jouenne T, Vaudry H.

Comp Biochem Physiol Part D Genomics Proteomics. 2014 Dec;12:45-52. doi: 10.1016/j.cbd.2014.10.001. Epub 2014 Oct 13.

PMID:
25463057
45.

Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice.

Ojo OO, Srinivasan DK, Owolabi BO, Conlon JM, Flatt PR, Abdel-Wahab YH.

Biochim Biophys Acta. 2015 Jan;1850(1):80-7. doi: 10.1016/j.bbagen.2014.10.011. Epub 2014 Oct 20.

PMID:
25459513
46.

Anti-cancer, immunoregulatory, and antimicrobial activities of the frog skin host-defense peptides pseudhymenochirin-1Pb and pseudhymenochirin-2Pa.

Mechkarska M, Attoub S, Sulaiman S, Pantic J, Lukic ML, Conlon JM.

Regul Pept. 2014 Nov;194-195:69-76. doi: 10.1016/j.regpep.2014.11.001. Epub 2014 Nov 13.

PMID:
25447194
47.

Antimicrobial and immunomodulatory properties of PGLa-AM1, CPF-AM1, and magainin-AM1: potent activity against oral pathogens.

McLean DT, McCrudden MT, Linden GJ, Irwin CR, Conlon JM, Lundy FT.

Regul Pept. 2014 Nov;194-195:63-8. doi: 10.1016/j.regpep.2014.11.002. Epub 2014 Nov 13.

PMID:
25447193
48.

Evidence from peptidomic analysis of skin secretions that allopatric populations of Xenopus gilli (Anura:Pipidae) constitute distinct lineages.

Conlon JM, Mechkarska M, Coquet L, Leprince J, Jouenne T, Vaudry H, Measey GJ.

Peptides. 2015 Jan;63:118-25. doi: 10.1016/j.peptides.2014.11.005. Epub 2014 Nov 26.

PMID:
25433327
49.

Conformational analysis and cytotoxic activities of the frog skin host-defense peptide, hymenochirin-1Pa.

Serra I, Scorciapino MA, Manzo G, Casu M, Rinaldi AC, Attoub S, Mechkarska M, Conlon JM.

Peptides. 2014 Nov;61:114-21. doi: 10.1016/j.peptides.2014.08.017. Epub 2014 Sep 19.

PMID:
25241629
50.

Host-defense peptides from skin secretions of the octoploid frogs Xenopus vestitus and Xenopus wittei (Pipidae): insights into evolutionary relationships.

Mechkarska M, Coquet L, Leprince J, Jouenne T, Vaudry H, Michalak K, Michalak P, Conlon JM.

Comp Biochem Physiol Part D Genomics Proteomics. 2014 Sep;11:20-8. doi: 10.1016/j.cbd.2014.07.002. Epub 2014 Jul 18.

PMID:
25086320

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