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Items: 1 to 50 of 104


Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion.

Centeno PP, Herberger A, Mun HC, Tu C, Nemeth EF, Chang W, Conigrave AD, Ward DT.

Nat Commun. 2019 Oct 16;10(1):4693. doi: 10.1038/s41467-019-12399-9.


Homer1 mediates CaSR-dependent activation of mTOR complex 2 and initiates a novel pathway for AKT-dependent β-catenin stabilization in osteoblasts.

Rybchyn MS, Islam KS, Brennan-Speranza TC, Cheng Z, Brennan SC, Chang W, Mason RS, Conigrave AD.

J Biol Chem. 2019 Nov 1;294(44):16337-16350. doi: 10.1074/jbc.RA118.006587. Epub 2019 Sep 16.


Identification of Serine-875 as an Inhibitory Phosphorylation Site in the Calcium-Sensing Receptor.

Binmahfouz LS, Centeno PP, Conigrave AD, Ward DT.

Mol Pharmacol. 2019 Aug;96(2):204-211. doi: 10.1124/mol.119.116178. Epub 2019 Jun 12. Erratum in: Mol Pharmacol. 2019 Sep;96(3):307.


L-Amino Acids Promote Calcitonin Release via a Calcium-Sensing Receptor: Gq/11-Mediated Pathway in Human C-Cells.

Mun HC, Leach KM, Conigrave AD.

Endocrinology. 2019 Jul 1;160(7):1590-1599. doi: 10.1210/en.2018-00860.


Determinants of vitamin D status of healthy office workers in Sydney, Australia.

Fayet-Moore F, Brock KE, Wright J, Ridges L, Small P, Seibel MJ, Conigrave AD, Mason RS.

J Steroid Biochem Mol Biol. 2019 May;189:127-134. doi: 10.1016/j.jsbmb.2019.02.017. Epub 2019 Mar 1.


Identification of Global and Ligand-Specific Calcium Sensing Receptor Activation Mechanisms.

Keller AN, Kufareva I, Josephs TM, Diao J, Mai VT, Conigrave AD, Christopoulos A, Gregory KJ, Leach K.

Mol Pharmacol. 2018 Jun;93(6):619-630. doi: 10.1124/mol.118.112086. Epub 2018 Apr 10.


The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor.

Ward BK, Rea SL, Magno AL, Pedersen B, Brown SJ, Mullin S, Arulpragasam A, Ingley E, Conigrave AD, Ratajczak T.

J Cell Physiol. 2018 Jan;233(1):38-56. doi: 10.1002/jcp.25957. Epub 2017 Jun 5.


The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future.

Conigrave AD.

Front Physiol. 2016 Dec 15;7:563. doi: 10.3389/fphys.2016.00563. eCollection 2016. Review.


Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework.

Solon-Biet SM, Cogger VC, Pulpitel T, Heblinski M, Wahl D, McMahon AC, Warren A, Durrant-Whyte J, Walters KA, Krycer JR, Ponton F, Gokarn R, Wali JA, Ruohonen K, Conigrave AD, James DE, Raubenheimer D, Morrison CD, Le Couteur DG, Simpson SJ.

Cell Metab. 2016 Oct 11;24(4):555-565. doi: 10.1016/j.cmet.2016.09.001. Epub 2016 Sep 29.


Raised FGF-21 and Triglycerides Accompany Increased Energy Intake Driven by Protein Leverage in Lean, Healthy Individuals: A Randomised Trial.

Gosby AK, Lau NS, Tam CS, Iglesias MA, Morrison CD, Caterson ID, Brand-Miller J, Conigrave AD, Raubenheimer D, Simpson SJ.

PLoS One. 2016 Aug 18;11(8):e0161003. doi: 10.1371/journal.pone.0161003. eCollection 2016.


Structural mechanism of ligand activation in human calcium-sensing receptor.

Geng Y, Mosyak L, Kurinov I, Zuo H, Sturchler E, Cheng TC, Subramanyam P, Brown AP, Brennan SC, Mun HC, Bush M, Chen Y, Nguyen TX, Cao B, Chang DD, Quick M, Conigrave AD, Colecraft HM, McDonald P, Fan QR.

Elife. 2016 Jul 19;5. pii: e13662. doi: 10.7554/eLife.13662.


Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.

Leach K, Gregory KJ, Kufareva I, Khajehali E, Cook AE, Abagyan R, Conigrave AD, Sexton PM, Christopoulos A.

Cell Res. 2016 May;26(5):574-92. doi: 10.1038/cr.2016.36. Epub 2016 Mar 22.


Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias.

Leach K, Conigrave AD, Sexton PM, Christopoulos A.

Trends Pharmacol Sci. 2015 Apr;36(4):215-25. doi: 10.1016/ Epub 2015 Mar 9. Review.


Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization.

Brennan SC, Mun HC, Leach K, Kuchel PW, Christopoulos A, Conigrave AD.

Endocrinology. 2015 Apr;156(4):1330-42. doi: 10.1210/en.2014-1771. Epub 2015 Jan 21.


Pathophysiologic Changes in Extracellular pH Modulate Parathyroid Calcium-Sensing Receptor Activity and Secretion via a Histidine-Independent Mechanism.

Campion KL, McCormick WD, Warwicker J, Khayat ME, Atkinson-Dell R, Steward MC, Delbridge LW, Mun HC, Conigrave AD, Ward DT.

J Am Soc Nephrol. 2015 Sep;26(9):2163-71. doi: 10.1681/ASN.2014070653. Epub 2015 Jan 2.


Osteocalcin: an osteoblast-derived polypeptide hormone that modulates whole body energy metabolism.

Brennan-Speranza TC, Conigrave AD.

Calcif Tissue Int. 2015 Jan;96(1):1-10. doi: 10.1007/s00223-014-9931-y. Epub 2014 Nov 22. Review.


Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics.

Cook AE, Mistry SN, Gregory KJ, Furness SG, Sexton PM, Scammells PJ, Conigrave AD, Christopoulos A, Leach K.

Br J Pharmacol. 2015 Jan;172(1):185-200. doi: 10.1111/bph.12937. Epub 2014 Dec 1.


Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor.

Goolam MA, Ward JH, Avlani VA, Leach K, Christopoulos A, Conigrave AD.

FEBS Lett. 2014 Sep 17;588(18):3340-6. doi: 10.1016/j.febslet.2014.07.022. Epub 2014 Jul 28.


Membrane flickering of the human erythrocyte: physical and chemical effectors.

Puckeridge M, Chapman BE, Conigrave AD, Kuchel PW.

Eur Biophys J. 2014 May;43(4-5):169-77. doi: 10.1007/s00249-014-0952-2. Epub 2014 Mar 26.


Protein leverage and energy intake.

Gosby AK, Conigrave AD, Raubenheimer D, Simpson SJ.

Obes Rev. 2014 Mar;15(3):183-91. doi: 10.1111/obr.12131. Epub 2013 Oct 28.


Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders.

Leach K, Sexton PM, Christopoulos A, Conigrave AD.

Br J Pharmacol. 2014 Mar;171(5):1142-55. doi: 10.1111/bph.12420. Review.


Proceedings of conference on Mechanism-Based Development of Natural Products for Human Health.

Roufogalis BD, Conigrave AD, Strehler EE.

J Pharm Pharm Sci. 2013;16(2):125-76.


Calcium-sensing receptor (CaSR): pharmacological properties and signaling pathways.

Conigrave AD, Ward DT.

Best Pract Res Clin Endocrinol Metab. 2013 Jun;27(3):315-31. doi: 10.1016/j.beem.2013.05.010. Epub 2013 Jun 17. Review.



Brown EM, Conigrave AD.

Best Pract Res Clin Endocrinol Metab. 2013 Jun;27(3):283-4. doi: 10.1016/j.beem.2013.05.009. Epub 2013 Jun 14. No abstract available.


Stoichiometric relationship between Na(+) ions transported and glucose consumed in human erythrocytes: Bayesian analysis of (23)Na and (13)C NMR time course data.

Puckeridge M, Chapman BE, Conigrave AD, Grieve SM, Figtree GA, Kuchel PW.

Biophys J. 2013 Apr 16;104(8):1676-84. doi: 10.1016/j.bpj.2013.03.019.


Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells.

Avlani VA, Ma W, Mun HC, Leach K, Delbridge L, Christopoulos A, Conigrave AD.

Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1097-104. doi: 10.1152/ajpendo.00054.2013. Epub 2013 Mar 26.


Effects of dietary protein to carbohydrate balance on energy intake, fat storage, and heat production in mice.

Huang X, Hancock DP, Gosby AK, McMahon AC, Solon SM, Le Couteur DG, Conigrave AD, Raubenheimer D, Simpson SJ.

Obesity (Silver Spring). 2013 Jan;21(1):85-92. doi: 10.1002/oby.20007.


Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators.

Leach K, Wen A, Cook AE, Sexton PM, Conigrave AD, Christopoulos A.

Endocrinology. 2013 Mar;154(3):1105-16. doi: 10.1210/en.2012-1887. Epub 2013 Jan 31.


Isolation breeds naivety: island living robs Australian varanid lizards of toad-toxin immunity via four-base-pair mutation.

Ujvari B, Mun HC, Conigrave AD, Bray A, Osterkamp J, Halling P, Madsen T.

Evolution. 2013 Jan;67(1):289-94. doi: 10.1111/j.1558-5646.2012.01751.x. Epub 2012 Aug 22.


Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor.

Leach K, Wen A, Davey AE, Sexton PM, Conigrave AD, Christopoulos A.

Endocrinology. 2012 Sep;153(9):4304-16. doi: 10.1210/en.2012-1449. Epub 2012 Jul 13.


Quantitative model of NMR chemical shifts of 23Na+ induced by TmDOTP: applications in studies of Na+ transport in human erythrocytes.

Puckeridge M, Chapman BE, Conigrave AD, Kuchel PW.

J Inorg Biochem. 2012 Oct;115:211-9. doi: 10.1016/j.jinorgbio.2012.03.009. Epub 2012 Apr 21. Erratum in: J Inorg Biochem. 2013 Apr;121:196.


Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.

Davey AE, Leach K, Valant C, Conigrave AD, Sexton PM, Christopoulos A.

Endocrinology. 2012 Mar;153(3):1232-41. doi: 10.1210/en.2011-1426. Epub 2011 Dec 30.


Testing protein leverage in lean humans: a randomised controlled experimental study.

Gosby AK, Conigrave AD, Lau NS, Iglesias MA, Hall RM, Jebb SA, Brand-Miller J, Caterson ID, Raubenheimer D, Simpson SJ.

PLoS One. 2011;6(10):e25929. doi: 10.1371/journal.pone.0025929. Epub 2011 Oct 12.


The adaptor protein 14-3-3 binds to the calcium-sensing receptor and attenuates receptor-mediated Rho kinase signalling.

Arulpragasam A, Magno AL, Ingley E, Brown SJ, Conigrave AD, Ratajczak T, Ward BK.

Biochem J. 2012 Feb 1;441(3):995-1006. doi: 10.1042/BJ20111277.


Calcium-sensing receptor modulates cell adhesion and migration via integrins.

Tharmalingam S, Daulat AM, Antflick JE, Ahmed SM, Nemeth EF, Angers S, Conigrave AD, Hampson DR.

J Biol Chem. 2011 Nov 25;286(47):40922-33. doi: 10.1074/jbc.M111.265454. Epub 2011 Oct 3.


Testin, a novel binding partner of the calcium-sensing receptor, enhances receptor-mediated Rho-kinase signalling.

Magno AL, Ingley E, Brown SJ, Conigrave AD, Ratajczak T, Ward BK.

Biochem Biophys Res Commun. 2011 Sep 9;412(4):584-9. doi: 10.1016/j.bbrc.2011.07.132. Epub 2011 Aug 6.


An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts.

Rybchyn MS, Slater M, Conigrave AD, Mason RS.

J Biol Chem. 2011 Jul 8;286(27):23771-9. doi: 10.1074/jbc.M111.251116. Epub 2011 May 12.


Allosteric modulation of the calcium-sensing receptor by gamma-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids.

Broadhead GK, Mun HC, Avlani VA, Jourdon O, Church WB, Christopoulos A, Delbridge L, Conigrave AD.

J Biol Chem. 2011 Mar 18;286(11):8786-97. doi: 10.1074/jbc.M110.149724. Epub 2010 Dec 27.


A novel mutation of the primary protein kinase C phosphorylation site in the calcium-sensing receptor causes autosomal dominant hypocalcemia.

Lazarus S, Pretorius CJ, Khafagi F, Campion KL, Brennan SC, Conigrave AD, Brown EM, Ward DT.

Eur J Endocrinol. 2011 Mar;164(3):429-35. doi: 10.1530/EJE-10-0907. Epub 2010 Dec 6.


Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis.

Ooi LL, Zheng Y, Zhou H, Trivedi T, Conigrave AD, Seibel MJ, Dunstan CR.

Bone. 2010 Oct;47(4):795-803. doi: 10.1016/j.bone.2010.07.012. Epub 2010 Jul 16.


Design and testing of foods differing in protein to energy ratios.

Gosby AK, Soares-Wynter S, Campbell C, Badaloo A, Antonelli M, Hall RM, Martinez-Cordero C, Jebb SA, Brand-Miller J, Caterson ID, Conigrave AD, Forrester TG, Raubenheimer D, Simpson SJ.

Appetite. 2010 Oct;55(2):367-70. doi: 10.1016/j.appet.2010.06.009. Epub 2010 Jun 19.


Broad-spectrum amino acid-sensing class C G-protein coupled receptors: molecular mechanisms, physiological significance and options for drug development.

Conigrave AD, Hampson DR.

Pharmacol Ther. 2010 Sep;127(3):252-60. doi: 10.1016/j.pharmthera.2010.04.007. Epub 2010 May 6. Review.


Increased receptor stimulation elicits differential calcium-sensing receptor(T888) dephosphorylation.

McCormick WD, Atkinson-Dell R, Campion KL, Mun HC, Conigrave AD, Ward DT.

J Biol Chem. 2010 May 7;285(19):14170-7. doi: 10.1074/jbc.M109.071084. Epub 2010 Mar 16.


Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis.

Ooi LL, Zhou H, Kalak R, Zheng Y, Conigrave AD, Seibel MJ, Dunstan CR.

Cancer Res. 2010 Mar 1;70(5):1835-44. doi: 10.1158/0008-5472.CAN-09-3194. Epub 2010 Feb 16.


Mechanisms of multimodal sensing by extracellular Ca(2+)-sensing receptors: a domain-based survey of requirements for binding and signalling.

Khan MA, Conigrave AD.

Br J Pharmacol. 2010 Mar;159(5):1039-50. doi: 10.1111/j.1476-5381.2009.00603.x. Epub 2010 Feb 5. Review.


The gastrointestinal tract as a nutrient-balancing organ.

Clissold FJ, Tedder BJ, Conigrave AD, Simpson SJ.

Proc Biol Sci. 2010 Jun 7;277(1688):1751-9. doi: 10.1098/rspb.2009.2045. Epub 2010 Feb 3.


Comparison of human chromosome 19q13 and syntenic region on mouse chromosome 7 reveals absence, in man, of 11.6 Mb containing four mouse calcium-sensing receptor-related sequences: relevance to familial benign hypocalciuric hypercalcaemia type 3.

Hannan FM, Nesbit MA, Turner JJ, Stacey JM, Cianferotti L, Christie PT, Conigrave AD, Whyte MP, Thakker RV.

Eur J Hum Genet. 2010 Apr;18(4):442-7. doi: 10.1038/ejhg.2009.161. Epub 2009 Oct 7.


Adenomatous human parathyroid cells exhibit impaired sensitivity to L-amino acids.

Mun HC, Brennan SC, Delbridge L, Wilkinson M, Brown EM, Conigrave AD.

J Clin Endocrinol Metab. 2009 Sep;94(9):3567-74. doi: 10.1210/jc.2008-2714. Epub 2009 Jun 30.


Osteoblasts play key roles in the mechanisms of action of strontium ranelate.

Brennan TC, Rybchyn MS, Green W, Atwa S, Conigrave AD, Mason RS.

Br J Pharmacol. 2009 Aug;157(7):1291-300. doi: 10.1111/j.1476-5381.2009.00305.x. Epub 2009 Jun 25.


Effectors of the frequency of calcium oscillations in HEK-293 cells: wavelet analysis and a computer model.

Szekely D, Brennan SC, Mun HC, Conigrave AD, Kuchel PW.

Eur Biophys J. 2009 Dec;39(1):149-65. doi: 10.1007/s00249-009-0469-2. Epub 2009 Jun 3.


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