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Items: 1 to 50 of 82

1.

Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2.

Confalonieri S, Colaluca IN, Basile A, Pece S, Di Fiore PP.

G3 (Bethesda). 2019 Oct 7;9(10):3359-3367. doi: 10.1534/g3.119.400494.

2.

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.

Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S.

Cell Rep. 2019 Jun 4;27(10):3049-3061.e6. doi: 10.1016/j.celrep.2019.05.017.

3.

Identification and clinical validation of a multigene assay that interrogates the biology of cancer stem cells and predicts metastasis in breast cancer: A retrospective consecutive study.

Pece S, Disalvatore D, Tosoni D, Vecchi M, Confalonieri S, Bertalot G, Viale G, Colleoni M, Veronesi P, Galimberti V, Di Fiore PP.

EBioMedicine. 2019 Apr;42:352-362. doi: 10.1016/j.ebiom.2019.02.036. Epub 2019 Mar 5.

4.

Redundant and nonredundant organismal functions of EPS15 and EPS15L1.

Milesi C, Alberici P, Pozzi B, Oldani A, Beznoussenko GV, Raimondi A, Soppo BE, Amodio S, Caldieri G, Malabarba MG, Bertalot G, Confalonieri S, Parazzoli D, Mironov AA, Tacchetti C, Di Fiore PP, Sigismund S, Offenhäuser N.

Life Sci Alliance. 2019 Jan 28;2(1). pii: e201800273. doi: 10.26508/lsa.201800273. Print 2019 Feb.

5.

A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility.

Zobel M, Disanza A, Senic-Matuglia F, Franco M, Colaluca IN, Confalonieri S, Bisi S, Barbieri E, Caldieri G, Sigismund S, Pece S, Chavrier P, Di Fiore PP, Scita G.

J Cell Biol. 2018 Sep 3;217(9):3161-3182. doi: 10.1083/jcb.201802023. Epub 2018 Jul 30.

6.

Author Correction: The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries.

Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, di Cantogno LV, Dallaglio K, Castellano I, Amici A, Centonze G, Sharma N, Lunardi S, Cabodi S, Cavallo F, Lamolinara A, Stramucci L, Moiso E, Provero P, Albini A, Sapino A, Staaf J, Di Fiore PP, Bertalot G, Pece S, Tosoni D, Confalonieri S, Iezzi M, Di Stefano P, Turco E, Defilippi P.

Nat Commun. 2018 Mar 30;9:16203. doi: 10.1038/ncomms16203.

7.

CD73 Regulates Stemness and Epithelial-Mesenchymal Transition in Ovarian Cancer-Initiating Cells.

Lupia M, Angiolini F, Bertalot G, Freddi S, Sachsenmeier KF, Chisci E, Kutryb-Zajac B, Confalonieri S, Smolenski RT, Giovannoni R, Colombo N, Bianchi F, Cavallaro U.

Stem Cell Reports. 2018 Apr 10;10(4):1412-1425. doi: 10.1016/j.stemcr.2018.02.009. Epub 2018 Mar 15.

8.

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H.

EMBO J. 2018 Mar 15;37(6). pii: e99170. doi: 10.15252/embj.201899170. No abstract available.

9.

A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.

Colaluca IN, Basile A, Freiburger L, D'Uva V, Disalvatore D, Vecchi M, Confalonieri S, Tosoni D, Cecatiello V, Malabarba MG, Yang CJ, Kainosho M, Sattler M, Mapelli M, Pece S, Di Fiore PP.

J Cell Biol. 2018 Feb 5;217(2):745-762. doi: 10.1083/jcb.201709092. Epub 2017 Dec 21.

10.

Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.

Caldieri G, Barbieri E, Nappo G, Raimondi A, Bonora M, Conte A, Verhoef LGGC, Confalonieri S, Malabarba MG, Bianchi F, Cuomo A, Bonaldi T, Martini E, Mazza D, Pinton P, Tacchetti C, Polo S, Di Fiore PP, Sigismund S.

Science. 2017 May 12;356(6338):617-624. doi: 10.1126/science.aah6152.

11.

Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer.

Francavilla C, Lupia M, Tsafou K, Villa A, Kowalczyk K, Rakownikow Jersie-Christensen R, Bertalot G, Confalonieri S, Brunak S, Jensen LJ, Cavallaro U, Olsen JV.

Cell Rep. 2017 Mar 28;18(13):3242-3256. doi: 10.1016/j.celrep.2017.03.015.

12.

The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries.

Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, Verdun di Cantogno L, Dallaglio K, Castellano I, Amici A, Centonze G, Sharma N, Lunardi S, Cabodi S, Cavallo F, Lamolinara A, Stramucci L, Moiso E, Provero P, Albini A, Sapino A, Staaf J, Di Fiore PP, Bertalot G, Pece S, Tosoni D, Confalonieri S, Iezzi M, Di Stefano P, Turco E, Defilippi P.

Nat Commun. 2017 Mar 16;8:14797. doi: 10.1038/ncomms14797. Erratum in: Nat Commun. 2018 Mar 30;9:16203.

13.

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H.

EMBO J. 2017 Feb 1;36(3):260-273. doi: 10.15252/embj.201694795. Epub 2016 Dec 22. Erratum in: EMBO J. 2018 Mar 15;37(6):.

14.

Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling.

Calcagnì A, Kors L, Verschuren E, De Cegli R, Zampelli N, Nusco E, Confalonieri S, Bertalot G, Pece S, Settembre C, Malouf GG, Leemans JC, de Heer E, Salvatore M, Peters DJ, Di Fiore PP, Ballabio A.

Elife. 2016 Sep 26;5. pii: e17047. doi: 10.7554/eLife.17047.

15.

RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.

Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, Di Fiore PP, Oldani A, Garre M, Beznoussenko GV, Palamidessi A, Vecchi M, Chavrier P, Perez F, Scita G.

EMBO Rep. 2016 Jul;17(7):1061-80. doi: 10.15252/embr.201642032. Epub 2016 Jun 2.

16.

Increasing both the public health potential of basic research and the scientist satisfaction. An international survey of bio-scientists.

Sorrentino C, Boggio A, Confalonieri S, Hemenway D, Scita G, Ballabeni A.

Version 2. F1000Res. 2016 Jan 12 [revised 2016 Jan 1];5:56. doi: 10.12688/f1000research.7683.2. eCollection 2016.

17.

The alternative splicing factor Nova2 regulates vascular development and lumen formation.

Giampietro C, Deflorian G, Gallo S, Di Matteo A, Pradella D, Bonomi S, Belloni E, Nyqvist D, Quaranta V, Confalonieri S, Bertalot G, Orsenigo F, Pisati F, Ferrero E, Biamonti G, Fredrickx E, Taveggia C, Wyatt CD, Irimia M, Di Fiore PP, Blencowe BJ, Dejana E, Ghigna C.

Nat Commun. 2015 Oct 8;6:8479. doi: 10.1038/ncomms9479.

18.

Mining cancer gene expression databases for latent information on intronic microRNAs.

Monterisi S, D'Ario G, Dama E, Rotmensz N, Confalonieri S, Tordonato C, Troglio F, Bertalot G, Maisonneuve P, Viale G, Nicassio F, Vecchi M, Di Fiore PP, Bianchi F.

Mol Oncol. 2015 Feb;9(2):473-87. doi: 10.1016/j.molonc.2014.10.001. Epub 2014 Oct 15.

19.

Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis.

Baschieri F, Confalonieri S, Bertalot G, Di Fiore PP, Dietmaier W, Leist M, Crespo P, Macara IG, Farhan H.

Nat Commun. 2014 Sep 11;5:4839. doi: 10.1038/ncomms5839.

20.

The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.

Rolland Y, Marighetti P, Malinverno C, Confalonieri S, Luise C, Ducano N, Palamidessi A, Bisi S, Kajiho H, Troglio F, Shcherbakova OG, Dunn AR, Oldani A, Lanzetti L, Di Fiore PP, Disanza A, Scita G.

Dev Cell. 2014 Sep 8;30(5):553-68. doi: 10.1016/j.devcel.2014.08.006.

21.

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization.

Magrini E, Villa A, Angiolini F, Doni A, Mazzarol G, Rudini N, Maddaluno L, Komuta M, Topal B, Prenen H, Schachner M, Confalonieri S, Dejana E, Bianchi F, Mazzone M, Cavallaro U.

J Clin Invest. 2014 Oct;124(10):4335-50. doi: 10.1172/JCI70683. Epub 2014 Aug 26.

22.

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.

Frittoli E, Palamidessi A, Marighetti P, Confalonieri S, Bianchi F, Malinverno C, Mazzarol G, Viale G, Martin-Padura I, Garré M, Parazzoli D, Mattei V, Cortellino S, Bertalot G, Di Fiore PP, Scita G.

J Cell Biol. 2014 Jul 21;206(2):307-28. doi: 10.1083/jcb.201403127.

23.

Efficacy of spermatic vein ligation in patients affected by high grade left varicocele.

Grasso M, Lania C, Blanco S, Confalonieri S, Grasso AA.

Int Braz J Urol. 2014 Jan-Feb;40(1):62-6. doi: 10.1590/S1677-5538.IBJU.2014.01.09.

24.

Maspin expression and melanoma progression: a matter of sub-cellular localization.

Martinoli C, Gandini S, Luise C, Mazzarol G, Confalonieri S, Giuseppe Pelicci P, Testori A, Ferrucci PF.

Mod Pathol. 2014 Mar;27(3):412-9. doi: 10.1038/modpathol.2013.157. Epub 2013 Sep 13.

25.

A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode.

Tsushima H, Malabarba MG, Confalonieri S, Senic-Matuglia F, Verhoef LG, Bartocci C, D'Ario G, Cocito A, Di Fiore PP, Salcini AE.

PLoS One. 2013;8(2):e56383. doi: 10.1371/journal.pone.0056383. Epub 2013 Feb 12.

26.

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop.

Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz PJ, Pachkov M, Elledge SJ, van Nimwegen E, Stadler MB, Bentires-Alj M.

Nat Med. 2012 Mar 4;18(4):529-37. doi: 10.1038/nm.2645.

PMID:
22388088
27.

Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.

Sigismund S, Confalonieri S, Ciliberto A, Polo S, Scita G, Di Fiore PP.

Physiol Rev. 2012 Jan;92(1):273-366. doi: 10.1152/physrev.00005.2011. Review.

28.

Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression.

Murakami M, Giampietro C, Giannotta M, Corada M, Torselli I, Orsenigo F, Cocito A, d'Ario G, Mazzarol G, Confalonieri S, Di Fiore PP, Dejana E.

PLoS One. 2011;6(6):e21242. doi: 10.1371/journal.pone.0021242. Epub 2011 Jun 17.

29.

[Transrectal ultrasound assessment of anastomosis after videolaparoscopic radical prostatectomy: our experience].

Franzoso F, Confalonieri S, Scuzzarella S, Piacentini I, Fortuna F, Bianchi A, Colapaoli L.

Urologia. 2011 Jan-Mar;78(1):27-30. Italian.

PMID:
21452157
30.

An atlas of altered expression of deubiquitinating enzymes in human cancer.

Luise C, Capra M, Donzelli M, Mazzarol G, Jodice MG, Nuciforo P, Viale G, Di Fiore PP, Confalonieri S.

PLoS One. 2011 Jan 25;6(1):e15891. doi: 10.1371/journal.pone.0015891.

31.

Zebrafish numb and numblike are involved in primitive erythrocyte differentiation.

Bresciani E, Confalonieri S, Cermenati S, Cimbro S, Foglia E, Beltrame M, Di Fiore PP, Cotelli F.

PLoS One. 2010 Dec 13;5(12):e14296. doi: 10.1371/journal.pone.0014296.

32.

UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway.

Pinato S, Gatti M, Scandiuzzi C, Confalonieri S, Penengo L.

Mol Cell Biol. 2011 Jan;31(1):118-26. doi: 10.1128/MCB.00818-10. Epub 2010 Nov 1.

33.

NUMB-ing down cancer by more than just a NOTCH.

Pece S, Confalonieri S, R Romano P, Di Fiore PP.

Biochim Biophys Acta. 2011 Jan;1815(1):26-43. doi: 10.1016/j.bbcan.2010.10.001. Epub 2010 Oct 16. Review.

PMID:
20940030
34.

Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping.

Hertzog M, Milanesi F, Hazelwood L, Disanza A, Liu H, Perlade E, Malabarba MG, Pasqualato S, Maiolica A, Confalonieri S, Le Clainche C, Offenhauser N, Block J, Rottner K, Di Fiore PP, Carlier MF, Volkmann N, Hanein D, Scita G.

PLoS Biol. 2010 Jun 1;8(6):e1000387. doi: 10.1371/journal.pbio.1000387.

35.

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content.

Pece S, Tosoni D, Confalonieri S, Mazzarol G, Vecchi M, Ronzoni S, Bernard L, Viale G, Pelicci PG, Di Fiore PP.

Cell. 2010 Jan 8;140(1):62-73. doi: 10.1016/j.cell.2009.12.007.

36.

Chromosomal rearrangements in acute myeloid leukemia (AML).

Belloni E, Trubia M, Gasparini P, Micucci C, Tapinassi C, Confalonieri S, Nuciforo P, Martino B, Lo-Coco F, Di Fiore P, Pelicci P.

Ecancermedicalscience. 2010;4:183. doi: 10.3332/ecancer.2010.183. Epub 2010 Sep 30. No abstract available.

37.

Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.

Giuliani C, Troglio F, Bai Z, Patel FB, Zucconi A, Malabarba MG, Disanza A, Stradal TB, Cassata G, Confalonieri S, Hardin JD, Soto MC, Grant BD, Scita G.

PLoS Genet. 2009 Oct;5(10):e1000675. doi: 10.1371/journal.pgen.1000675. Epub 2009 Oct 2.

38.

Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor.

Confalonieri S, Quarto M, Goisis G, Nuciforo P, Donzelli M, Jodice G, Pelosi G, Viale G, Pece S, Di Fiore PP.

Oncogene. 2009 Aug 20;28(33):2959-68. doi: 10.1038/onc.2009.156. Epub 2009 Jun 22.

PMID:
19543318
39.
40.

IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions.

Scita G, Confalonieri S, Lappalainen P, Suetsugu S.

Trends Cell Biol. 2008 Feb;18(2):52-60. doi: 10.1016/j.tcb.2007.12.002. Epub 2008 Jan 22. Review.

PMID:
18215522
41.

The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway.

Frittoli E, Palamidessi A, Pizzigoni A, Lanzetti L, Garrè M, Troglio F, Troilo A, Fukuda M, Di Fiore PP, Scita G, Confalonieri S.

Mol Biol Cell. 2008 Apr;19(4):1304-16. doi: 10.1091/mbc.E07-06-0594. Epub 2008 Jan 16.

42.

Breast cancer metastases are molecularly distinct from their primary tumors.

Vecchi M, Confalonieri S, Nuciforo P, Viganò MA, Capra M, Bianchi M, Nicosia D, Bianchi F, Galimberti V, Viale G, Palermo G, Riccardi A, Campanini R, Daidone MG, Pierotti MA, Pece S, Di Fiore PP.

Oncogene. 2008 Apr 3;27(15):2148-58. Epub 2007 Oct 22.

PMID:
17952122
43.

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.

Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, Martinato F, Sardella D, Verrecchia A, Bennett S, Confalonieri S, Cesaroni M, Marchesi F, Gasco M, Scanziani E, Capra M, Mai S, Nuciforo P, Crook T, Lough J, Amati B.

Nature. 2007 Aug 30;448(7157):1063-7.

PMID:
17728759
44.

Gene expression analysis of early and advanced gastric cancers.

Vecchi M, Nuciforo P, Romagnoli S, Confalonieri S, Pellegrini C, Serio G, Quarto M, Capra M, Roviaro GC, Contessini Avesani E, Corsi C, Coggi G, Di Fiore PP, Bosari S.

Oncogene. 2007 Jun 21;26(29):4284-94. Epub 2007 Feb 5.

PMID:
17297478
45.

Molecular mechanisms of coupled monoubiquitination.

Woelk T, Oldrini B, Maspero E, Confalonieri S, Cavallaro E, Di Fiore PP, Polo S.

Nat Cell Biol. 2006 Nov;8(11):1246-54. Epub 2006 Oct 1.

PMID:
17013377
46.

Frequent alterations in the expression of serine/threonine kinases in human cancers.

Capra M, Nuciforo PG, Confalonieri S, Quarto M, Bianchi M, Nebuloni M, Boldorini R, Pallotti F, Viale G, Gishizky ML, Draetta GF, Di Fiore PP.

Cancer Res. 2006 Aug 15;66(16):8147-54.

47.

Determinants of conformational dimerization of Mad2 and its inhibition by p31comet.

Mapelli M, Filipp FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S, Piatti S, Sattler M, Musacchio A.

EMBO J. 2006 Mar 22;25(6):1273-84. Epub 2006 Mar 9.

48.

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.

Penengo L, Mapelli M, Murachelli AG, Confalonieri S, Magri L, Musacchio A, Di Fiore PP, Polo S, Schneider TR.

Cell. 2006 Mar 24;124(6):1183-95. Epub 2006 Feb 23.

49.

Percutaneous therapy of low stage and grade urothelial neoplasia: long-term follow up.

Montanari E, Del Nero A, Bernardini P, Mangiarotti B, Confalonieri S, Grisotto M, Cordima G.

Arch Ital Urol Androl. 2005 Dec;77(4):211-4.

PMID:
16444935
50.

TTP specifically regulates the internalization of the transferrin receptor.

Tosoni D, Puri C, Confalonieri S, Salcini AE, De Camilli P, Tacchetti C, Di Fiore PP.

Cell. 2005 Dec 2;123(5):875-88.

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