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Items: 24

1.

Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters.

Kim W, Steele AD, Zhu W, Csatary EE, Fricke N, Dekarske MM, Jayamani E, Pan W, Kwon B, Sinitsa IF, Rosen JL, Conery AL, Fuchs BB, Vlahovska PM, Ausubel FM, Gao H, Wuest WM, Mylonakis E.

ACS Infect Dis. 2018 Nov 9;4(11):1540-1545. doi: 10.1021/acsinfecdis.8b00161. Epub 2018 Aug 28.

PMID:
30132650
2.

A new class of synthetic retinoid antibiotics effective against bacterial persisters.

Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM, Gilmore MS, Gao H, Ausubel FM, Mylonakis E.

Nature. 2018 Apr 5;556(7699):103-107. doi: 10.1038/nature26157. Epub 2018 Mar 28.

3.

Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway.

McEwan DL, Feinbaum RL, Stroustrup N, Haas W, Conery AL, Anselmo A, Sadreyev R, Ausubel FM.

BMC Biol. 2016 Dec 7;14(1):105.

4.

A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport.

Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G.

Genes Dev. 2016 Jul 1;30(13):1515-28. doi: 10.1101/gad.283895.116.

5.

NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption.

Kim W, Fricke N, Conery AL, Fuchs BB, Rajamuthiah R, Jayamani E, Vlahovska PM, Ausubel FM, Mylonakis E.

Future Med Chem. 2016;8(3):257-69. doi: 10.4155/fmc.15.189. Epub 2016 Feb 24.

6.

Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans.

Cheesman HK, Feinbaum RL, Thekkiniath J, Dowen RH, Conery AL, Pukkila-Worley R.

G3 (Bethesda). 2016 Jan 27;6(3):541-9. doi: 10.1534/g3.115.025650.

7.

On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials.

Dolla NK, Chen C, Larkins-Ford J, Rajamuthiah R, Jagadeesan S, Conery AL, Ausubel FM, Mylonakis E, Bremner JB, Lewis K, Kelso MJ.

Aust J Chem. 2015;67:1471-1480.

8.

Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile.

Rajamuthiah R, Jayamani E, Majed H, Conery AL, Kim W, Kwon B, Fuchs BB, Kelso MJ, Ausubel FM, Mylonakis E.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5203-7. doi: 10.1016/j.bmcl.2015.09.066. Epub 2015 Sep 30.

9.

A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus.

Rajamuthiah R, Jayamani E, Conery AL, Fuchs BB, Kim W, Johnston T, Vilcinskas A, Ausubel FM, Mylonakis E.

PLoS One. 2015 Jun 10;10(6):e0128576. doi: 10.1371/journal.pone.0128576. eCollection 2015.

10.

Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy.

Kim W, Conery AL, Rajamuthiah R, Fuchs BB, Ausubel FM, Mylonakis E.

PLoS One. 2015 Jun 3;10(6):e0127640. doi: 10.1371/journal.pone.0127640. eCollection 2015.

11.

Repurposing salicylanilide anthelmintic drugs to combat drug resistant Staphylococcus aureus.

Rajamuthiah R, Fuchs BB, Conery AL, Kim W, Jayamani E, Kwon B, Ausubel FM, Mylonakis E.

PLoS One. 2015 Apr 21;10(4):e0124595. doi: 10.1371/journal.pone.0124595. eCollection 2015.

12.

A new antibiotic with potent activity targets MscL.

Iscla I, Wray R, Blount P, Larkins-Ford J, Conery AL, Ausubel FM, Ramu S, Kavanagh A, Huang JX, Blaskovich MA, Cooper MA, Obregon-Henao A, Orme I, Tjandra ES, Stroeher UH, Brown MH, Macardle C, van Holst N, Ling Tong C, Slattery AD, Gibson CT, Raston CL, Boulos RA.

J Antibiot (Tokyo). 2015 Jul;68(7):453-62. doi: 10.1038/ja.2015.4. Epub 2015 Feb 4.

13.

Insect-derived cecropins display activity against Acinetobacter baumannii in a whole-animal high-throughput Caenorhabditis elegans model.

Jayamani E, Rajamuthiah R, Larkins-Ford J, Fuchs BB, Conery AL, Vilcinskas A, Ausubel FM, Mylonakis E.

Antimicrob Agents Chemother. 2015 Mar;59(3):1728-37. doi: 10.1128/AAC.04198-14. Epub 2015 Jan 12.

14.

The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxification.

Pukkila-Worley R, Feinbaum RL, McEwan DL, Conery AL, Ausubel FM.

PLoS Pathog. 2014 May 29;10(5):e1004143. doi: 10.1371/journal.ppat.1004143. eCollection 2014 May.

15.

High- and low-throughput scoring of fat mass and body fat distribution in C. elegans.

Wählby C, Conery AL, Bray MA, Kamentsky L, Larkins-Ford J, Sokolnicki KL, Veneskey M, Michaels K, Carpenter AE, O'Rourke EJ.

Methods. 2014 Aug 1;68(3):492-9. doi: 10.1016/j.ymeth.2014.04.017. Epub 2014 Apr 28.

16.

High-throughput screening for novel anti-infectives using a C. elegans pathogenesis model.

Conery AL, Larkins-Ford J, Ausubel FM, Kirienko NV.

Curr Protoc Chem Biol. 2014 Mar 14;6(1):25-37. doi: 10.1002/9780470559277.ch130160.

17.

Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection.

Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel FM.

PLoS Genet. 2012;8(6):e1002733. doi: 10.1371/journal.pgen.1002733. Epub 2012 Jun 14.

18.

An image analysis toolbox for high-throughput C. elegans assays.

Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE.

Nat Methods. 2012 Apr 22;9(7):714-6. doi: 10.1038/nmeth.1984.

19.

RESOLVING CLUSTERED WORMS VIA PROBABILISTIC SHAPE MODELS.

Wählby C, Riklin-Raviv T, Ljosa V, Conery AL, Golland P, Ausubel FM, Carpenter AE.

Proc IEEE Int Symp Biomed Imaging. 2010 Jun 21;2010(14-17 April 2010):552-555.

20.

Morphology-guided graph search for untangling objects: C. elegans analysis.

Raviv TR, Ljosa V, Conery AL, Ausubel FM, Carpenter AE, Golland P, Wählby C.

Med Image Comput Comput Assist Interv. 2010;13(Pt 3):634-41.

21.

Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.

Okoli I, Coleman JJ, Tampakakis E, An WF, Holson E, Wagner F, Conery AL, Larkins-Ford J, Wu G, Stern A, Ausubel FM, Mylonakis E.

PLoS One. 2009 Sep 14;4(9):e7025. doi: 10.1371/journal.pone.0007025. Erratum in: PLoS One. 2010;5(4) doi:10.1371/annotation/76699885-a47e-426c-accd-35576696c4f2.. Tempakakis, Emmanouil [corrected to Tampakakis, Emmanouil].

22.

High-throughput screen for novel antimicrobials using a whole animal infection model.

Moy TI, Conery AL, Larkins-Ford J, Wu G, Mazitschek R, Casadei G, Lewis K, Carpenter AE, Ausubel FM.

ACS Chem Biol. 2009 Jul 17;4(7):527-33. doi: 10.1021/cb900084v.

23.

Whole-animal high-throughput screens: the C. elegans model.

O'Rourke EJ, Conery AL, Moy TI.

Methods Mol Biol. 2009;486:57-75. doi: 10.1007/978-1-60327-545-3_5.

PMID:
19347616
24.

The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.

Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK.

Cell. 2008 May 30;133(5):903-15. doi: 10.1016/j.cell.2008.04.035.

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