Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 32

1.

High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL/6J mice.

Nolan SO, Hodges SL, Condon SM, Muhammed IDA, Tomac LA, Binder MS, Reynolds CD, Lugo JN.

Epilepsy Behav. 2019 Jun;95:26-33. doi: 10.1016/j.yebeh.2019.03.037. Epub 2019 Apr 22.

PMID:
31022661
2.

Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-κB signaling by degrading TRAF2-associated cIAP1 in cancer cells.

Mitsuuchi Y, Benetatos CA, Deng Y, Haimowitz T, Beck SC, Arnone MR, Kapoor GS, Seipel ME, Chunduru SK, McKinlay MA, Begley CG, Condon SM.

Cell Death Discov. 2017 Jan 16;3:16046. doi: 10.1038/cddiscovery.2016.46. eCollection 2017.

3.

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

Tanzer MC, Khan N, Rickard JA, Etemadi N, Lalaoui N, Spall SK, Hildebrand JM, Segal D, Miasari M, Chau D, Wong WL, McKinlay M, Chunduru SK, Benetatos CA, Condon SM, Vince JE, Herold MJ, Silke J.

Cell Death Differ. 2017 Mar;24(3):481-491. doi: 10.1038/cdd.2016.147. Epub 2017 Jan 20.

4.

Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling.

Condon SM.

Cell Death Dis. 2016 Sep 29;7(9):e2385. doi: 10.1038/cddis.2016.283. No abstract available.

5.

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NN, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M, Johnstone RW, Munoz L, Wei A, Ekert PG, Vaux DL, Wong WW, Silke J.

Cancer Cell. 2016 Sep 12;30(3):499-500. doi: 10.1016/j.ccell.2016.08.009. Epub 2016 Sep 12. No abstract available.

6.

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.

Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J.

Sci Transl Med. 2016 May 18;8(339):339ra69. doi: 10.1126/scitranslmed.aad3099. Erratum in: Sci Transl Med. 2017 May 31;9(392):.

PMID:
27194727
7.

Electrophilic Oxidation and [1,2]-Rearrangement of the Biindole Core of Birinapant.

Deng Y, Haimowitz T, LaPorte MG, Rippin SR, Alexander MD, Kumar PT, Hendi MS, Lee YH, Condon SM.

ACS Med Chem Lett. 2016 Jan 9;7(3):318-23. doi: 10.1021/acsmedchemlett.5b00461. eCollection 2016 Mar 10.

8.

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NY, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M, Johnstone RW, Munoz L, Wei A, Ekert PG, Vaux DL, Wong WW, Silke J.

Cancer Cell. 2016 Feb 8;29(2):145-58. doi: 10.1016/j.ccell.2016.01.006. Erratum in: Cancer Cell. 2016 Sep 12;30(3):499-500.

9.

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.

Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE.

Nat Commun. 2015 Feb 18;6:6282. doi: 10.1038/ncomms7282.

10.

Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies.

Condon SM, Mitsuuchi Y, Deng Y, LaPorte MG, Rippin SR, Haimowitz T, Alexander MD, Kumar PT, Hendi MS, Lee YH, Benetatos CA, Yu G, Kapoor GS, Neiman E, Seipel ME, Burns JM, Graham MA, McKinlay MA, Li X, Wang J, Shi Y, Feltham R, Bettjeman B, Cumming MH, Vince JE, Khan N, Silke J, Day CL, Chunduru SK.

J Med Chem. 2014 May 8;57(9):3666-77. doi: 10.1021/jm500176w. Epub 2014 Apr 15.

PMID:
24684347
11.

Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models.

Benetatos CA, Mitsuuchi Y, Burns JM, Neiman EM, Condon SM, Yu G, Seipel ME, Kapoor GS, Laporte MG, Rippin SR, Deng Y, Hendi MS, Tirunahari PK, Lee YH, Haimowitz T, Alexander MD, Graham MA, Weng D, Shi Y, McKinlay MA, Chunduru SK.

Mol Cancer Ther. 2014 Apr;13(4):867-79. doi: 10.1158/1535-7163.MCT-13-0798. Epub 2014 Feb 21. Erratum in: Mol Cancer Ther. 2014 Sep;13(9):2246-7. Dosage error in article text.

12.

Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase.

Nakatani Y, Kleffmann T, Linke K, Condon SM, Hinds MG, Day CL.

Biochem J. 2013 Mar 15;450(3):629-38. doi: 10.1042/BJ20121702.

PMID:
23259674
13.

The discovery and structure-activity relationships of pyrano[3,4-b]indole-based inhibitors of hepatitis C virus NS5B polymerase.

Jackson RW, LaPorte MG, Herbertz T, Draper TL, Gaboury JA, Rippin SR, Patel R, Chunduru SK, Benetatos CA, Young DC, Burns CJ, Condon SM.

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3227-31. doi: 10.1016/j.bmcl.2011.04.052. Epub 2011 Apr 21.

PMID:
21550237
14.

Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization.

Feltham R, Bettjeman B, Budhidarmo R, Mace PD, Shirley S, Condon SM, Chunduru SK, McKinlay MA, Vaux DL, Silke J, Day CL.

J Biol Chem. 2011 May 13;286(19):17015-28. doi: 10.1074/jbc.M111.222919. Epub 2011 Mar 10.

15.

The discovery and structure-activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase.

LaPorte MG, Draper TL, Miller LE, Blackledge CW, Leister LK, Amparo E, Hussey AR, Young DC, Chunduru SK, Benetatos CA, Rhodes G, Gopalsamy A, Herbertz T, Burns CJ, Condon SM.

Bioorg Med Chem Lett. 2010 May 1;20(9):2968-73. doi: 10.1016/j.bmcl.2010.03.002. Epub 2010 Mar 6.

PMID:
20347591
16.

The discovery of pyrano[3,4-b]indole-based allosteric inhibitors of HCV NS5B polymerase with in vivo activity.

Laporte MG, Jackson RW, Draper TL, Gaboury JA, Galie K, Herbertz T, Hussey AR, Rippin SR, Benetatos CA, Chunduru SK, Christensen JS, Coburn GA, Rizzo CJ, Rhodes G, O'Connell J, Howe AY, Mansour TS, Collett MS, Pevear DC, Young DC, Gao T, Tyrrell DL, Kneteman NM, Burns CJ, Condon SM.

ChemMedChem. 2008 Oct;3(10):1508-15. doi: 10.1002/cmdc.200800168. No abstract available.

PMID:
18729128
17.

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

Vince JE, Chau D, Callus B, Wong WW, Hawkins CJ, Schneider P, McKinlay M, Benetatos CA, Condon SM, Chunduru SK, Yeoh G, Brink R, Vaux DL, Silke J.

J Cell Biol. 2008 Jul 14;182(1):171-84. doi: 10.1083/jcb.200801010. Epub 2008 Jul 7.

18.

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.

Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, Brink R, Leverkus M, Tergaonkar V, Schneider P, Callus BA, Koentgen F, Vaux DL, Silke J.

Cell. 2007 Nov 16;131(4):682-93.

19.

Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4.

Blackburn C, Guan B, Brown J, Cullis C, Condon SM, Jenkins TJ, Peluso S, Ye Y, Gimeno RE, Punreddy S, Sun Y, Wu H, Hubbard B, Kaushik V, Tummino P, Sanchetti P, Yu Sun D, Daniels T, Tozzo E, Balani SK, Raman P.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3504-9. Epub 2006 Apr 27.

PMID:
16644217
20.

Analogues of human parathyroid hormone (1-31)NH(2): further evaluation of the effect of conformational constraint on biological activity.

Condon SM, Darnbrough S, Burns CJ, Bobko MA, Morize I, Uhl J, Jariwala NU, Burke K, Labaudiniere RF.

Bioorg Med Chem. 2002 Mar;10(3):731-6.

PMID:
11814862
21.

Dual inhibition of phosphodiesterase 4 and matrix metalloproteinases by an (arylsulfonyl)hydroxamic acid template.

Groneberg RD, Burns CJ, Morrissette MM, Ullrich JW, Morris RL, Darnbrough S, Djuric SW, Condon SM, McGeehan GM, Labaudiniere R, Neuenschwander K, Scotese AC, Kline JA.

J Med Chem. 1999 Feb 25;42(4):541-4. No abstract available.

PMID:
10052961
22.

Nanomolar Inhibitors for Two Distinct Biological Target Families from a Single Synthetic Sequence: A Next Step in Combinatorial Library Design?

Burns CJ, Groneberg RD, Salvino JM, McGeehan G, Condon SM, Morris R, Morrissette M, Mathew R, Darnbrough S, Neuenschwander K, Scotese A, Djuric SW, Ullrich J, Labaudiniere R.

Angew Chem Int Ed Engl. 1998 Nov 2;37(20):2848-2850. doi: 10.1002/(SICI)1521-3773(19981102)37:20<2848::AID-ANIE2848>3.0.CO;2-C.

PMID:
29711099
23.

Gait abnormalities in hemiplegia: their correction by ankle-foot orthoses.

Lehmann JF, Condon SM, Price R, deLateur BJ.

Arch Phys Med Rehabil. 1987 Nov;68(11):763-71.

PMID:
3675173
24.

The role of the biomechanics laboratory in the analysis of the gait of individuals with arthritis.

Lehmann JF, Price R, Condon SM, de Lateur BJ.

J Rheumatol Suppl. 1987 Aug;14 Suppl 15:46-52.

PMID:
3656306
25.
26.

Gait abnormalities in peroneal nerve paralysis and their corrections by orthoses: a biomechanical study.

Lehmann JF, Condon SM, de Lateur BJ, Price R.

Arch Phys Med Rehabil. 1986 Jun;67(6):380-6.

PMID:
3718197
27.

Cognitive spatial processing and the regulation of posture.

Kerr B, Condon SM, McDonald LA.

J Exp Psychol Hum Percept Perform. 1985 Oct;11(5):617-22.

PMID:
2932533
28.

Ankle-foot orthoses: effect on gait abnormalities in tibial nerve paralysis.

Lehmann JF, Condon SM, de Lateur BJ, Smith JC.

Arch Phys Med Rehabil. 1985 Apr;66(4):212-8.

PMID:
3985771
29.

Gait abnormalities in tibial nerve paralysis: a biomechanical study.

Lehmann JF, Condon SM, de Lateur BJ, Smith JC.

Arch Phys Med Rehabil. 1985 Feb;66(2):80-5.

PMID:
3970662
30.

Can Ib axons be selectively activated by electrical stimuli in human subjects?

Heckman CJ, Condon SM, Hutton RS, Enoka RM.

Exp Neurol. 1984 Dec;86(3):576-82.

PMID:
6499994
31.

Purification and properties of retinol- and retinoic acid-binding proteins from a transplantable mouse colon tumor.

Sani BP, Condon SM, Banerjee CK.

Biochim Biophys Acta. 1980 Jul 24;624(1):226-36.

PMID:
6250631
32.

Retinoic acid-binding protein in experimental and human colon tumors.

Sani BP, Condon SM, Brockman RW, Weiland LH, Schutt AJ.

Cancer. 1980 Mar 15;45(5 Suppl):1199-206.

PMID:
7188879

Supplemental Content

Loading ...
Support Center