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Items: 25

1.

Autotaxin Inhibitor Protects from Chronic Allograft Injury in Rat Kidney Allotransplantation.

Cortinovis M, Aiello S, Mister M, Conde-Knape K, Noris M, Novelli R, Solini S, Rodriguez Ordonez PY, Benigni A, Remuzzi G.

Nephron. 2020;144(1):38-48. doi: 10.1159/000502908. Epub 2019 Sep 24.

PMID:
31550726
2.

BMP7-induced-Pten inhibits Akt and prevents renal fibrosis.

Higgins DF, Ewart LM, Masterson E, Tennant S, Grebnev G, Prunotto M, Pomposiello S, Conde-Knape K, Martin FM, Godson C.

Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3095-3104. doi: 10.1016/j.bbadis.2017.09.011. Epub 2017 Sep 18.

3.

Incretin-like effects of small molecule trace amine-associated receptor 1 agonists.

Raab S, Wang H, Uhles S, Cole N, Alvarez-Sanchez R, Künnecke B, Ullmer C, Matile H, Bedoucha M, Norcross RD, Ottaway-Parker N, Perez-Tilve D, Conde Knape K, Tschöp MH, Hoener MC, Sewing S.

Mol Metab. 2015 Nov 1;5(1):47-56. doi: 10.1016/j.molmet.2015.09.015. eCollection 2016 Jan.

4.

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.

Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH.

Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8.

PMID:
25485909
5.

Discovery of camphor-derived pyrazolones as 11β-hydroxysteroid dehydrogenase type 1 inhibitors.

Gillespie P, Pietranico-Cole S, Myers M, Bilotta JA, Conde-Knape K, Fotouhi N, Goodnow RA Jr, Guertin KR, Hamilton MM, Haynes NE, Liu B, Qi L, Ren Y, Scott NR, So SS, Spence C, Taub R, Thakkar K, Tilley JW, Zwingelstein C.

Bioorg Med Chem Lett. 2014 Jun 15;24(12):2707-11. doi: 10.1016/j.bmcl.2014.04.049. Epub 2014 Apr 21.

PMID:
24815509
6.

Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia.

Kelly MJ, Pietranico-Cole S, Larigan JD, Haynes NE, Reynolds CH, Scott N, Vermeulen J, Dvorozniak M, Conde-Knape K, Huang KS, So SS, Thakkar K, Qian Y, Banner B, Mennona F, Danzi S, Klein I, Taub R, Tilley J.

J Med Chem. 2014 May 22;57(10):3912-23. doi: 10.1021/jm4019299. Epub 2014 Apr 8.

PMID:
24712661
7.

Discovery of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists.

Gillespie P, Goodnow RA Jr, Saha G, Bose G, Moulik K, Zwingelstein C, Myers M, Conde-Knape K, Pietranico-Cole S, So SS.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):949-53. doi: 10.1016/j.bmcl.2013.12.063. Epub 2013 Dec 24.

PMID:
24412066
8.

Preparation and characterization of albumin conjugates of a truncated peptide YY analogue for half-life extension.

Ehrlich GK, Michel H, Truitt T, Riboulet W, Pop-Damkov P, Goelzer P, Hainzl D, Qureshi F, Lueckel B, Danho W, Conde-Knape K, Konkar A.

Bioconjug Chem. 2013 Dec 18;24(12):2015-24. doi: 10.1021/bc400340z. Epub 2013 Nov 27.

PMID:
24251972
9.

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH.

Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218.

10.

Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.

Dehmlow H, Alvarez Sánchez R, Bachmann S, Bissantz C, Bliss F, Conde-Knape K, Graf M, Martin RE, Obst Sander U, Raab S, Richter HG, Sewing S, Sprecher U, Ullmer C, Mattei P.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4627-32. doi: 10.1016/j.bmcl.2013.06.017. Epub 2013 Jun 19.

PMID:
23831134
11.

PK modulation of haptenylated peptides via non-covalent antibody complexation.

Hoffmann E, Konkar A, Dziadek S, Josel HP, Conde-Knape K, Kropp H, Kling L, Stubenrauch K, Thorey I, Dengl S, Brinkmann U.

J Control Release. 2013 Oct 10;171(1):48-56. doi: 10.1016/j.jconrel.2013.06.021. Epub 2013 Jun 22.

12.

Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs.

Qian Y, Conde-Knape K, Erickson SD, Falcioni F, Gillespie P, Hakimi I, Mennona F, Ren Y, Salari H, So SS, Tilley JW.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4216-20. doi: 10.1016/j.bmcl.2013.05.017. Epub 2013 May 15.

PMID:
23743277
13.

Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators.

Qian Y, Bolin D, Conde-Knape K, Gillespie P, Hayden S, Huang KS, Olivier AR, Sato T, Xiang Q, Yun W, Zhang X.

Bioorg Med Chem Lett. 2013 May 15;23(10):2936-40. doi: 10.1016/j.bmcl.2013.03.049. Epub 2013 Mar 22.

PMID:
23582275
14.

Systemic bile acid sensing by G protein-coupled bile acid receptor 1 (GPBAR1) promotes PYY and GLP-1 release.

Ullmer C, Alvarez Sanchez R, Sprecher U, Raab S, Mattei P, Dehmlow H, Sewing S, Iglesias A, Beauchamp J, Conde-Knape K.

Br J Pharmacol. 2013 Jun;169(3):671-84. doi: 10.1111/bph.12158.

15.

Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors.

Yun W, Ahmad M, Chen Y, Gillespie P, Conde-Knape K, Kazmer S, Li S, Qian Y, Taub R, Wertheimer SJ, Whittard T, Bolin D.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7205-9. doi: 10.1016/j.bmcl.2011.09.039. Epub 2011 Sep 22.

PMID:
22001092
16.

Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors.

Qian Y, Ahmad M, Chen S, Gillespie P, Le N, Mennona F, Mischke S, So SS, Wang H, Burghardt C, Tannu S, Conde-Knape K, Kochan J, Bolin D.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6264-9. doi: 10.1016/j.bmcl.2011.09.009. Epub 2011 Sep 10.

PMID:
21958546
17.

Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.

Qian Y, Wertheimer SJ, Ahmad M, Cheung AW, Firooznia F, Hamilton MM, Hayden S, Li S, Marcopulos N, McDermott L, Tan J, Yun W, Guo L, Pamidimukkala A, Chen Y, Huang KS, Ramsey GB, Whittard T, Conde-Knape K, Taub R, Rondinone CM, Tilley J, Bolin D.

J Med Chem. 2011 Apr 14;54(7):2433-46. doi: 10.1021/jm101580m. Epub 2011 Mar 17.

PMID:
21413799
18.

Potent, selective MCH-1 receptor antagonists.

Erickson SD, Banner B, Berthel S, Conde-Knape K, Falcioni F, Hakimi I, Hennessy B, Kester RF, Kim K, Ma C, McComas W, Mennona F, Mischke S, Orzechowski L, Qian Y, Salari H, Tengi J, Thakkar K, Taub R, Tilley JW, Wang H.

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1402-6. doi: 10.1016/j.bmcl.2008.01.010. Epub 2008 Jan 8.

PMID:
18243691
19.

The common insertional polymorphism in the APOC1 promoter is associated with serum apolipoprotein C-I levels in Hispanic children.

Shachter NS, Rabinowitz D, Stohl S, Conde-Knape K, Cohn JS, Deckelbaum RJ, Berglund L, Shea S.

Atherosclerosis. 2005 Apr;179(2):387-93. Epub 2004 Dec 13.

PMID:
15777558
20.

Beneficial effects of weight loss on plasma apolipoproteins in postmenopausal women.

Fernandez ML, Metghalchi S, Vega-López S, Conde-Knape K, Lohman TG, Cordero-Macintyre ZR.

J Nutr Biochem. 2004 Dec;15(12):717-21.

PMID:
15607644
21.

Fatty acids increase presenilin-1 levels and [gamma]-secretase activity in PSwt-1 cells.

Liu Y, Yang L, Conde-Knape K, Beher D, Shearman MS, Shachter NS.

J Lipid Res. 2004 Dec;45(12):2368-76. Epub 2004 Sep 16.

22.

Overexpression of apoC-III produces lesser hypertriglyceridemia in apoB-48-only gene-targeted mice than in apoB-100-only mice.

Conde-Knape K, Okada K, Ramakrishnan R, Shachter NS.

J Lipid Res. 2004 Dec;45(12):2235-44. Epub 2004 Sep 1.

23.

Overexpression of apoC-I in apoE-null mice: severe hypertriglyceridemia due to inhibition of hepatic lipase.

Conde-Knape K, Bensadoun A, Sobel JH, Cohn JS, Shachter NS.

J Lipid Res. 2002 Dec;43(12):2136-45.

24.

Sex and hormonal status influence the effects of psyllium on lipoprotein remodeling and composition.

Vega-López S, Conde-Knape K, Vidal-Quintanar RL, Shachter NS, Fernandez ML.

Metabolism. 2002 Apr;51(4):500-7.

PMID:
11912561
25.

Heparan sulfate proteoglycans in experimental models of diabetes: a role for perlecan in diabetes complications.

Conde-Knape K.

Diabetes Metab Res Rev. 2001 Nov-Dec;17(6):412-21. Review.

PMID:
11757076

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