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High doses of CRISPR/Cas9 ribonucleoprotein efficiently induce gene knockout with low mosaicism in the hydrozoan Clytia hemisphaerica through microhomology-mediated deletion.

Momose T, De Cian A, Shiba K, Inaba K, Giovannangeli C, Concordet JP.

Sci Rep. 2018 Aug 6;8(1):11734. doi: 10.1038/s41598-018-30188-0.


Cooperation, cis-interactions, versatility and evolutionary plasticity of multiple cis-acting elements underlie krox20 hindbrain regulation.

Torbey P, Thierion E, Collombet S, de Cian A, Desmarquet-Trin-Dinh C, Dura M, Concordet JP, Charnay P, Gilardi-Hebenstreit P.

PLoS Genet. 2018 Aug 6;14(8):e1007581. doi: 10.1371/journal.pgen.1007581. eCollection 2018 Aug.


Modeling of Aniridia-Related Keratopathy by CRISPR/Cas9 Genome Editing of Human Limbal Epithelial Cells and Rescue by Recombinant PAX6 Protein.

Roux LN, Petit I, Domart R, Concordet JP, Qu J, Zhou H, Joliot A, Ferrigno O, Aberdam D.

Stem Cells. 2018 Sep;36(9):1421-1429. doi: 10.1002/stem.2858. Epub 2018 Jul 18.


CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens.

Concordet JP, Haeussler M.

Nucleic Acids Res. 2018 Jul 2;46(W1):W242-W245. doi: 10.1093/nar/gky354.


Generation of Immunodeficient Rats With Rag1 and Il2rg Gene Deletions and Human Tissue Grafting Models.

Ménoret S, Ouisse LH, Tesson L, Delbos F, Garnier D, Remy S, Usal C, Concordet JP, Giovannangeli C, Chenouard V, Brusselle L, Merieau E, Nerrière-Daguin V, Duteille F, Bellier-Waast F, Fraichard A, Nguyen TH, Anegon I.

Transplantation. 2018 Aug;102(8):1271-1278. doi: 10.1097/TP.0000000000002251.


Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments.

Canver MC, Haeussler M, Bauer DE, Orkin SH, Sanjana NE, Shalem O, Yuan GC, Zhang F, Concordet JP, Pinello L.

Nat Protoc. 2018 May;13(5):946-986. doi: 10.1038/nprot.2018.005. Epub 2018 Apr 12.


CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair.

Charpentier M, Khedher AHY, Menoret S, Brion A, Lamribet K, Dardillac E, Boix C, Perrouault L, Tesson L, Geny S, De Cian A, Itier JM, Anegon I, Lopez B, Giovannangeli C, Concordet JP.

Nat Commun. 2018 Mar 19;9(1):1133. doi: 10.1038/s41467-018-03475-7.


An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System.

Di Donato V, De Santis F, Albadri S, Auer TO, Duroure K, Charpentier M, Concordet JP, Gebhardt C, Del Bene F.

Neuron. 2018 Mar 7;97(5):1049-1062.e6. doi: 10.1016/j.neuron.2018.01.030. Epub 2018 Feb 8.


Generation of gene-edited rats by delivery of CRISPR/Cas9 protein and donor DNA into intact zygotes using electroporation.

Remy S, Chenouard V, Tesson L, Usal C, Ménoret S, Brusselle L, Heslan JM, Nguyen TH, Bellien J, Merot J, De Cian A, Giovannangeli C, Concordet JP, Anegon I.

Sci Rep. 2017 Nov 29;7(1):16554. doi: 10.1038/s41598-017-16328-y.


CRISPR-Cas systems for genome engineering and investigation.

Concordet JP, Giovannangeli C.

Methods. 2017 May 15;121-122:1-2. doi: 10.1016/j.ymeth.2017.06.006. No abstract available.


Neu5Gc and α1-3 GAL Xenoantigen Knockout Does Not Affect Glycemia Homeostasis and Insulin Secretion in Pigs.

Salama A, Mosser M, Lévêque X, Perota A, Judor JP, Danna C, Pogu S, Mouré A, Jégou D, Gaide N, Abadie J, Gauthier O, Concordet JP, Le Bas-Bernardet S, Riochet D, Le Berre L, Hervouet J, Minault D, Weiss P, Guicheux J, Brouard S, Bosch S, Lagutina I, Duchi R, Lazzari G, Cozzi E, Blancho G, Conchon S, Galli C, Soulillou JP, Bach JM.

Diabetes. 2017 Apr;66(4):987-993. doi: 10.2337/db16-1060. Epub 2017 Jan 12.


Argonaute proteins regulate HIV-1 multiply spliced RNA and viral production in a Dicer independent manner.

Eckenfelder A, Ségéral E, Pinzón N, Ulveling D, Amadori C, Charpentier M, Nidelet S, Concordet JP, Zagury JF, Paillart JC, Berlioz-Torrent C, Seitz H, Emiliani S, Gallois-Montbrun S.

Nucleic Acids Res. 2017 Apr 20;45(7):4158-4173. doi: 10.1093/nar/gkw1289.


Diving into marine genomics with CRISPR/Cas9 systems.

Momose T, Concordet JP.

Mar Genomics. 2016 Dec;30:55-65. doi: 10.1016/j.margen.2016.10.003. Epub 2016 Oct 12. Review.


Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.

Gammage PA, Gaude E, Van Haute L, Rebelo-Guiomar P, Jackson CB, Rorbach J, Pekalski ML, Robinson AJ, Charpentier M, Concordet JP, Frezza C, Minczuk M.

Nucleic Acids Res. 2016 Sep 19;44(16):7804-16. doi: 10.1093/nar/gkw676. Epub 2016 Jul 27.


Heritable genome editing with CRISPR/Cas9 induces anosmia in a crop pest moth.

Koutroumpa FA, Monsempes C, François MC, de Cian A, Royer C, Concordet JP, Jacquin-Joly E.

Sci Rep. 2016 Jul 12;6:29620. doi: 10.1038/srep29620.


Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR.

Haeussler M, Schönig K, Eckert H, Eschstruth A, Mianné J, Renaud JB, Schneider-Maunoury S, Shkumatava A, Teboul L, Kent J, Joly JS, Concordet JP.

Genome Biol. 2016 Jul 5;17(1):148. doi: 10.1186/s13059-016-1012-2.


MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis.

Santolini M, Sakakibara I, Gauthier M, Ribas-Aulinas F, Takahashi H, Sawasaki T, Mouly V, Concordet JP, Defossez PA, Hakim V, Maire P.

Nucleic Acids Res. 2016 Oct 14;44(18):8621-8640. Epub 2016 Jun 14.


klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis.

Steed E, Faggianelli N, Roth S, Ramspacher C, Concordet JP, Vermot J.

Nat Commun. 2016 May 25;7:11646. doi: 10.1038/ncomms11646.


Genome Editing with CRISPR-Cas9: Can It Get Any Better?

Haeussler M, Concordet JP.

J Genet Genomics. 2016 May 20;43(5):239-50. doi: 10.1016/j.jgg.2016.04.008. Epub 2016 Apr 24. Review.


2C-Cas9: a versatile tool for clonal analysis of gene function.

Di Donato V, De Santis F, Auer TO, Testa N, Sánchez-Iranzo H, Mercader N, Concordet JP, Del Bene F.

Genome Res. 2016 May;26(5):681-92. doi: 10.1101/gr.196170.115. Epub 2016 Mar 8.


CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits.

Böhm UL, Prendergast A, Djenoune L, Nunes Figueiredo S, Gomez J, Stokes C, Kaiser S, Suster M, Kawakami K, Charpentier M, Concordet JP, Rio JP, Del Bene F, Wyart C.

Nat Commun. 2016 Mar 7;7:10866. doi: 10.1038/ncomms10866.


Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases.

Renaud JB, Boix C, Charpentier M, De Cian A, Cochennec J, Duvernois-Berthet E, Perrouault L, Tesson L, Edouard J, Thinard R, Cherifi Y, Menoret S, Fontanière S, de Crozé N, Fraichard A, Sohm F, Anegon I, Concordet JP, Giovannangeli C.

Cell Rep. 2016 Mar 8;14(9):2263-2272. doi: 10.1016/j.celrep.2016.02.018. Epub 2016 Feb 25.


Genome Editing and Dialogic Responsibility: "What's in a Name?".

Blasimme A, Anegon I, Concordet JP, De Vos J, Dubart-Kupperschmitt A, Fellous M, Fouchet P, Frydman N, Giovannangeli C, Jouannet P, Serre JL, Steffann J, Rial-Sebbag E, Thomsen M, Cambon-Thomsen A.

Am J Bioeth. 2015;15(12):54-7. doi: 10.1080/15265161.2015.1103811. No abstract available.


Genome Editing in Rats Using TALE Nucleases.

Tesson L, Remy S, Ménoret S, Usal C, Thinard R, Savignard C, De Cian A, Giovannangeli C, Concordet JP, Anegon I.

Methods Mol Biol. 2016;1338:245-59. doi: 10.1007/978-1-4939-2932-0_18.


Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins.

Ménoret S, De Cian A, Tesson L, Remy S, Usal C, Boulé JB, Boix C, Fontanière S, Crénéguy A, Nguyen TH, Brusselle L, Thinard R, Gauguier D, Concordet JP, Cherifi Y, Fraichard A, Giovannangeli C, Anegon I.

Sci Rep. 2015 Oct 7;5:14410. doi: 10.1038/srep14410.


Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3.

Auer TO, Xiao T, Bercier V, Gebhardt C, Duroure K, Concordet JP, Wyart C, Suster M, Kawakami K, Wittbrodt J, Baier H, Del Bene F.

Elife. 2015 Jun 15;4. doi: 10.7554/eLife.05061.


Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo.

Reinhardt R, Centanin L, Tavhelidse T, Inoue D, Wittbrodt B, Concordet JP, Martinez-Morales JR, Wittbrodt J.

EMBO J. 2015 Jun 3;34(11):1572-88. doi: 10.15252/embj.201490706. Epub 2015 Apr 23.


CRISPR/Cas9-mediated conversion of eGFP- into Gal4-transgenic lines in zebrafish.

Auer TO, Duroure K, Concordet JP, Del Bene F.

Nat Protoc. 2014 Dec;9(12):2823-40. doi: 10.1038/nprot.2014.187. Epub 2014 Nov 13.


Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy.

Larcher T, Lafoux A, Tesson L, Remy S, Thepenier V, François V, Le Guiner C, Goubin H, Dutilleul M, Guigand L, Toumaniantz G, De Cian A, Boix C, Renaud JB, Cherel Y, Giovannangeli C, Concordet JP, Anegon I, Huchet C.

PLoS One. 2014 Oct 13;9(10):e110371. doi: 10.1371/journal.pone.0110371. eCollection 2014.


Editing and investigating genomes with TALE and CRISPR/Cas systems: applications of artificial TALE and CRISPR-Cas systems.

Giovannangeli C, Concordet JP.

Methods. 2014 Sep;69(2):119-20. doi: 10.1016/j.ymeth.2014.08.013. No abstract available.


Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases.

Remy S, Tesson L, Menoret S, Usal C, De Cian A, Thepenier V, Thinard R, Baron D, Charpentier M, Renaud JB, Buelow R, Cost GJ, Giovannangeli C, Fraichard A, Concordet JP, Anegon I.

Genome Res. 2014 Aug;24(8):1371-83. doi: 10.1101/gr.171538.113. Epub 2014 Jul 2.


Gene targeting in rats using transcription activator-like effector nucleases.

Ménoret S, Tesson L, Rémy S, Usal C, Thépenier V, Thinard R, Ouisse LH, De Cian A, Giovannangeli C, Concordet JP, Anegon I.

Methods. 2014 Aug 15;69(1):102-7. doi: 10.1016/j.ymeth.2014.02.027. Epub 2014 Feb 28.


Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair.

Auer TO, Duroure K, De Cian A, Concordet JP, Del Bene F.

Genome Res. 2014 Jan;24(1):142-53. doi: 10.1101/gr.161638.113. Epub 2013 Oct 31.


Cancer translocations in human cells induced by zinc finger and TALE nucleases.

Piganeau M, Ghezraoui H, De Cian A, Guittat L, Tomishima M, Perrouault L, René O, Katibah GE, Zhang L, Holmes MC, Doyon Y, Concordet JP, Giovannangeli C, Jasin M, Brunet E.

Genome Res. 2013 Jul;23(7):1182-93. doi: 10.1101/gr.147314.112. Epub 2013 Apr 8.


PAX3/FOXO1 fusion gene status is the key prognostic molecular marker in rhabdomyosarcoma and significantly improves current risk stratification.

Missiaglia E, Williamson D, Chisholm J, Wirapati P, Pierron G, Petel F, Concordet JP, Thway K, Oberlin O, Pritchard-Jones K, Delattre O, Delorenzi M, Shipley J.

J Clin Oncol. 2012 May 10;30(14):1670-7. doi: 10.1200/JCO.2011.38.5591. Epub 2012 Mar 26.


Genetic and epigenetic mechanisms collaborate to control SERPINA3 expression and its association with placental diseases.

Chelbi ST, Wilson ML, Veillard AC, Ingles SA, Zhang J, Mondon F, Gascoin-Lachambre G, Doridot L, Mignot TM, Rebourcet R, Carbonne B, Concordet JP, Barbaux S, Vaiman D.

Hum Mol Genet. 2012 May 1;21(9):1968-78. doi: 10.1093/hmg/dds006. Epub 2012 Jan 13.


Transfection and mutagenesis of target genes in mosquito cells by locked nucleic acid-modified oligonucleotides.

Pakpour N, Cheung KW, Souvannaseng L, Concordet JP, Luckhart S.

J Vis Exp. 2010 Dec 26;(46). pii: 2355. doi: 10.3791/2355.


Retraction for Cannata et al., Triplex-forming oligonucleotide-orthophenanthroline conjugates for efficient targeted genome modification.

Brunet E, Perrouault L, Roig V, Ait-Si-Ali S, Asseline U, Concordet JP, Giovannangeli C.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5261. doi: 10.1073/pnas.1000844107. Epub 2010 Feb 16. No abstract available.


Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control.

Molla-Herman A, Boularan C, Ghossoub R, Scott MG, Burtey A, Zarka M, Saunier S, Concordet JP, Marullo S, Benmerah A.

PLoS One. 2008;3(11):e3728. doi: 10.1371/journal.pone.0003728. Epub 2008 Nov 14.


Triplex-forming oligonucleotide-orthophenanthroline conjugates for efficient targeted genome modification.

Cannata F, Brunet E, Perrouault L, Roig V, Ait-Si-Ali S, Asseline U, Concordet JP, Giovannangeli C.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9576-81. doi: 10.1073/pnas.0710433105. Epub 2008 Jul 3. Retraction in: Brunet E, Perrouault L, Roig V, Ait-Si-Ali S, Asseline U, Concordet JP, Giovannangeli C. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5261.


Targeting DNA with triplex-forming oligonucleotides to modify gene sequence.

Simon P, Cannata F, Concordet JP, Giovannangeli C.

Biochimie. 2008 Aug;90(8):1109-16. doi: 10.1016/j.biochi.2008.04.004. Epub 2008 Apr 18. Review.


Sequence-specific DNA cleavage mediated by bipyridine polyamide conjugates.

Simon P, Cannata F, Perrouault L, Halby L, Concordet JP, Boutorine A, Ryabinin V, Sinyakov A, Giovannangeli C.

Nucleic Acids Res. 2008 Jun;36(11):3531-8. doi: 10.1093/nar/gkn231. Epub 2008 May 1.


Targeted gene correction with 5' acridine-oligonucleotide conjugates.

de Piédoue G, Andrieu-Soler C, Concordet JP, Maurisse R, Sun JS, Lopez B, Kuzniak I, Leboulch P, Feugeas JP.

Oligonucleotides. 2007 Summer;17(2):258-63.


Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.

Tempé D, Casas M, Karaz S, Blanchet-Tournier MF, Concordet JP.

Mol Cell Biol. 2006 Jun;26(11):4316-26.


Stable transmission of targeted gene modification using single-stranded oligonucleotides with flanking LNAs.

Andrieu-Soler C, Casas M, Faussat AM, Gandolphe C, Doat M, Tempé D, Giovannangeli C, Behar-Cohen F, Concordet JP.

Nucleic Acids Res. 2005 Jul 7;33(12):3733-42. Print 2005.


Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype.

Grifone R, Laclef C, Spitz F, Lopez S, Demignon J, Guidotti JE, Kawakami K, Xu PX, Kelly R, Petrof BJ, Daegelen D, Concordet JP, Maire P.

Mol Cell Biol. 2004 Jul;24(14):6253-67.


Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality.

Parlakian A, Tuil D, Hamard G, Tavernier G, Hentzen D, Concordet JP, Paulin D, Li Z, Daegelen D.

Mol Cell Biol. 2004 Jun;24(12):5281-9.


Muscle electrotransfer as a tool for studying muscle fiber-specific and nerve-dependent activity of promoters.

Bertrand A, Ngô-Muller V, Hentzen D, Concordet JP, Daegelen D, Tuil D.

Am J Physiol Cell Physiol. 2003 Nov;285(5):C1071-81. Epub 2003 Jul 2.


Regulation of left-right asymmetries in the zebrafish by Shh and BMP4.

Schilling TF, Concordet JP, Ingham PW.

Dev Biol. 1999 Jun 15;210(2):277-87.

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