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Items: 47

1.

ER stress signaling has an activating transcription factor 6α (ATF6)-dependent "off-switch".

Walter F, O'Brien A, Concannon CG, Düssmann H, Prehn JHM.

J Biol Chem. 2018 Nov 23;293(47):18270-18284. doi: 10.1074/jbc.RA118.002121. Epub 2018 Oct 4.

PMID:
30287689
2.

Erratum to: Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer.

Ryan D, Carberry S, Murphy ÁC, Lindner AU, Fay J, Hector S, McCawley N, Bacon O, Concannon CG, Kay EW, McNamara DA, Prehn JH.

J Transl Med. 2016 Jul 26;14(1):222. No abstract available.

3.

Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer.

Ryan D, Carberry S, Murphy ÁC, Lindner AU, Fay J, Hector S, McCawley N, Bacon O, Concannon CG, Kay EW, McNamara DA, Prehn JH.

J Transl Med. 2016 Jul 1;14(1):196. doi: 10.1186/s12967-016-0948-z. Erratum in: J Transl Med. 2016;14(1):222.

4.

Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.

Boland K, Flanagan L, McCawley N, Pabari R, Kay EW, McNamara DA, Murray F, Byrne AT, Ramtoola Z, Concannon CG, Prehn JH.

Eur J Pharmacol. 2016 Jun 5;780:53-64. doi: 10.1016/j.ejphar.2016.03.031. Epub 2016 Mar 17.

PMID:
26997367
5.

Endoplasmic reticulum stress-mediated upregulation of miR-29a enhances sensitivity to neuronal apoptosis.

Nolan K, Walter F, Tuffy LP, Poeschel S, Gallagher R, Haunsberger S, Bray I, Stallings RL, Concannon CG, Prehn JH.

Eur J Neurosci. 2016 Mar;43(5):640-52. doi: 10.1111/ejn.13160. Epub 2016 Feb 9.

PMID:
26750440
6.

Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival.

Walter F, Schmid J, Düssmann H, Concannon CG, Prehn JH.

Cell Death Differ. 2015 Sep;22(9):1502-16. doi: 10.1038/cdd.2014.241. Epub 2015 Jan 30.

7.

Increased expression of microRNA-29a in ALS mice: functional analysis of its inhibition.

Nolan K, Mitchem MR, Jimenez-Mateos EM, Henshall DC, Concannon CG, Prehn JH.

J Mol Neurosci. 2014 Jun;53(2):231-41. doi: 10.1007/s12031-014-0290-y. Epub 2014 Apr 4.

PMID:
24696165
8.

Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis.

Ramapathiran L, Bernas T, Walter F, Williams L, Düssmann H, Concannon CG, Prehn JH.

J Cell Sci. 2014 Feb 1;127(Pt 3):609-19. doi: 10.1242/jcs.137158. Epub 2013 Nov 27.

9.

Identification of circulating microRNAs in HNF1A-MODY carriers.

Bonner C, Nyhan KC, Bacon S, Kyithar MP, Schmid J, Concannon CG, Bray IM, Stallings RL, Prehn JH, Byrne MM.

Diabetologia. 2013 Aug;56(8):1743-51. doi: 10.1007/s00125-013-2939-4. Epub 2013 May 15.

PMID:
23674172
10.

CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures.

Engel T, Sanz-Rodgriguez A, Jimenez-Mateos EM, Concannon CG, Jimenez-Pacheco A, Moran C, Mesuret G, Petit E, Delanty N, Farrell MA, O'Brien DF, Prehn JH, Lucas JJ, Henshall DC.

Brain. 2013 Feb;136(Pt 2):577-92. doi: 10.1093/brain/aws337. Epub 2013 Jan 29.

PMID:
23361066
11.

Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy.

Lindner AU, Concannon CG, Boukes GJ, Cannon MD, Llambi F, Ryan D, Boland K, Kehoe J, McNamara DA, Murray F, Kay EW, Hector S, Green DR, Huber HJ, Prehn JH.

Cancer Res. 2013 Jan 15;73(2):519-28. doi: 10.1158/0008-5472.CAN-12-2269.

12.

AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1.

Anilkumar U, Weisová P, Düssmann H, Concannon CG, König HG, Prehn JH.

J Neurochem. 2013 Mar;124(5):721-34. doi: 10.1111/jnc.12108. Epub 2012 Dec 26.

13.

Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate.

Davila D, Connolly NM, Bonner H, Weisová P, Dussmann H, Concannon CG, Huber HJ, Prehn JH.

Cell Death Differ. 2012 Oct;19(10):1677-88. doi: 10.1038/cdd.2012.49. Epub 2012 Apr 27.

14.

Motoneurons secrete angiogenin to induce RNA cleavage in astroglia.

Skorupa A, King MA, Aparicio IM, Dussmann H, Coughlan K, Breen B, Kieran D, Concannon CG, Marin P, Prehn JH.

J Neurosci. 2012 Apr 11;32(15):5024-38. doi: 10.1523/JNEUROSCI.6366-11.2012.

15.

Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer.

Hector S, Conlon S, Schmid J, Dicker P, Cummins RJ, Concannon CG, Johnston PG, Kay EW, Prehn JH.

Br J Cancer. 2012 Apr 24;106(9):1499-1505. doi: 10.1038/bjc.2012.133.

16.

'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity.

Weisová P, Anilkumar U, Ryan C, Concannon CG, Prehn JH, Ward MW.

Biochim Biophys Acta. 2012 May;1817(5):744-53. doi: 10.1016/j.bbabio.2012.01.016. Epub 2012 Feb 7.

17.

Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy.

Hector S, Rehm M, Schmid J, Kehoe J, McCawley N, Dicker P, Murray F, McNamara D, Kay EW, Concannon CG, Huber HJ, Prehn JH.

Gut. 2012 May;61(5):725-33. doi: 10.1136/gutjnl-2011-300433. Epub 2011 Nov 14.

PMID:
22082587
18.

Analyzing proteasomal subunit expression reveals Rpt4 as a prognostic marker in stage II colorectal cancer.

McCawley N, Conlon S, Hector S, Cummins RJ, Dicker P, Johnston PG, Kay EW, McNamara DA, Prehn JH, Concannon CG.

Int J Cancer. 2012 Aug 15;131(4):E494-500. doi: 10.1002/ijc.26468. Epub 2011 Nov 8.

19.

The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis.

Kögel D, Concannon CG, Müller T, König H, Bonner C, Poeschel S, Chang S, Egensperger R, Prehn JH.

Neurobiol Aging. 2012 Sep;33(9):2200-9. doi: 10.1016/j.neurobiolaging.2011.06.012. Epub 2011 Jul 30.

PMID:
21803450
20.

Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.

Bonner C, Farrelly AM, Concannon CG, Dussmann H, Baquié M, Virard I, Wobser H, Kögel D, Wollheim CB, Rupnik M, Byrne MM, König HG, Prehn JH.

J Biol Chem. 2011 Jul 22;286(29):25719-28. doi: 10.1074/jbc.M110.215525. Epub 2011 May 31.

21.

Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.

Tsuchiya T, Bonner HP, Engel T, Woods I, Matsushima S, Ward MW, Taki W, Henshall DC, Concannon CG, Prehn JH.

Eur J Neurosci. 2011 Feb;33(3):401-8. doi: 10.1111/j.1460-9568.2010.07538.x. Epub 2010 Dec 31.

PMID:
21198986
22.

Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition.

Tuffy LP, Concannon CG, D'Orsi B, King MA, Woods I, Huber HJ, Ward MW, Prehn JH.

Mol Cell Biol. 2010 Dec;30(23):5484-501. doi: 10.1128/MCB.00575-10. Epub 2010 Oct 4.

23.

AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.

Kilbride SM, Farrelly AM, Bonner C, Ward MW, Nyhan KC, Concannon CG, Wollheim CB, Byrne MM, Prehn JH.

J Biol Chem. 2010 Nov 12;285(46):36199-206. doi: 10.1074/jbc.M110.138107. Epub 2010 Sep 14.

24.

Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.

Weisová P, Dávila D, Tuffy LP, Ward MW, Concannon CG, Prehn JH.

Antioxid Redox Signal. 2011 May 15;14(10):1863-76. doi: 10.1089/ars.2010.3544. Epub 2011 Feb 18. Review.

PMID:
20712420
25.

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells.

Bonner C, Bacon S, Concannon CG, Rizvi SR, Baquié M, Farrelly AM, Kilbride SM, Dussmann H, Ward MW, Boulanger CM, Wollheim CB, Graf R, Byrne MM, Prehn JH.

Diabetes. 2010 Nov;59(11):2799-808. doi: 10.2337/db09-1478. Epub 2010 Aug 3.

26.

Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability.

Bonner HP, Concannon CG, Bonner C, Woods I, Ward MW, Prehn JH.

J Neurochem. 2010 Jul;114(2):606-16. doi: 10.1111/j.1471-4159.2010.06790.x. Epub 2010 Apr 30.

27.

The amyloid precursor protein intracellular domain(AICD) disrupts actin dynamics and mitochondrial bioenergetics.

Ward MW, Concannon CG, Whyte J, Walsh CM, Corley B, Prehn JH.

J Neurochem. 2010 Apr;113(1):275-84.

28.

Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation.

Hellwig CT, Ludwig-Galezowska AH, Concannon CG, Litchfield DW, Prehn JH, Rehm M.

J Cell Sci. 2010 May 1;123(Pt 9):1401-6. doi: 10.1242/jcs.061143. Epub 2010 Mar 31.

29.

AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis.

Concannon CG, Tuffy LP, Weisová P, Bonner HP, Dávila D, Bonner C, Devocelle MC, Strasser A, Ward MW, Prehn JH.

J Cell Biol. 2010 Apr 5;189(1):83-94. doi: 10.1083/jcb.200909166. Epub 2010 Mar 29.

30.

Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma.

Engel T, Murphy BM, Hatazaki S, Jimenez-Mateos EM, Concannon CG, Woods I, Prehn JH, Henshall DC.

FASEB J. 2010 Mar;24(3):853-61. doi: 10.1096/fj.09-145870. Epub 2009 Nov 4.

31.

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

Düssmann H, Rehm M, Concannon CG, Anguissola S, Würstle M, Kacmar S, Völler P, Huber HJ, Prehn JH.

Cell Death Differ. 2010 Feb;17(2):278-90. doi: 10.1038/cdd.2009.123. Epub 2009 Sep 11.

32.

Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells.

Anguissola S, Köhler B, O'Byrne R, Düssmann H, Cannon MD, Murray FE, Concannon CG, Rehm M, Kögel D, Prehn JH.

Mol Pharmacol. 2009 Nov;76(5):998-1010. doi: 10.1124/mol.109.058156. Epub 2009 Aug 27.

PMID:
19713356
33.

Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons.

Weisová P, Concannon CG, Devocelle M, Prehn JH, Ward MW.

J Neurosci. 2009 Mar 4;29(9):2997-3008. doi: 10.1523/JNEUROSCI.0354-09.2009.

34.

Effects of transient focal cerebral ischemia in mice deficient in puma.

Kuroki K, Virard I, Concannon CG, Engel T, Woods I, Taki W, Plesnila N, Henshall DC, Prehn JH.

Neurosci Lett. 2009 Feb 27;451(3):237-40. doi: 10.1016/j.neulet.2009.01.019. Epub 2009 Jan 13.

PMID:
19159665
35.

Control of motoneuron survival by angiogenin.

Kieran D, Sebastia J, Greenway MJ, King MA, Connaughton D, Concannon CG, Fenner B, Hardiman O, Prehn JH.

J Neurosci. 2008 Dec 24;28(52):14056-61. doi: 10.1523/JNEUROSCI.3399-08.2008.

36.

Early loss of mammalian target of rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-alpha (HNF1A) function in INS-1 insulinoma cells.

Farrelly AM, Wobser H, Bonner C, Anguissola S, Rehm M, Concannon CG, Prehn JH, Byrne MM.

Diabetologia. 2009 Jan;52(1):136-44. doi: 10.1007/s00125-008-1168-8. Epub 2008 Oct 24.

PMID:
18949455
37.

Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects.

Köhler B, Anguissola S, Concannon CG, Rehm M, Kögel D, Prehn JH.

PLoS One. 2008 Jul 30;3(7):e2844. doi: 10.1371/journal.pone.0002844.

38.

NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner.

Concannon CG, Ward MW, Bonner HP, Kuroki K, Tuffy LP, Bonner CT, Woods I, Engel T, Henshall DC, Prehn JH.

J Neurochem. 2008 May;105(3):891-903. Epub 2007 Dec 13.

39.

6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA.

Gomez-Lazaro M, Galindo MF, Concannon CG, Segura MF, Fernandez-Gomez FJ, Llecha N, Comella JX, Prehn JH, Jordan J.

J Neurochem. 2008 Mar;104(6):1599-612. Epub 2007 Nov 6.

40.

Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.

Gomez-Lazaro M, Galindo MF, Melero-Fernandez de Mera RM, Fernandez-Gómez FJ, Concannon CG, Segura MF, Comella JX, Prehn JH, Jordan J.

Mol Pharmacol. 2007 Mar;71(3):736-43. Epub 2006 Dec 15.

PMID:
17172466
41.

Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD).

Müller T, Concannon CG, Ward MW, Walsh CM, Tirniceriu AL, Tribl F, Kögel D, Prehn JH, Egensperger R.

Mol Biol Cell. 2007 Jan;18(1):201-10. Epub 2006 Nov 8.

42.

Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway.

Concannon CG, Koehler BF, Reimertz C, Murphy BM, Bonner C, Thurow N, Ward MW, Villunger A, Strasser A, Kögel D, Prehn JH.

Oncogene. 2007 Mar 15;26(12):1681-92. Epub 2006 Sep 18.

PMID:
16983338
43.

Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL.

Ní Chonghaile T, Concannon CG, Szegezdi E, Gorman AM, Samali A.

Apoptosis. 2006 Jul;11(7):1247-55.

PMID:
16699951
44.

Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis.

Ward MW, Rehm M, Duessmann H, Kacmar S, Concannon CG, Prehn JH.

J Biol Chem. 2006 Mar 3;281(9):5837-44. Epub 2005 Dec 28.

45.

CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization.

Concannon CG, FitzGerald U, Holmberg CI, Szegezdi E, Sistonen L, Samali A.

Cell Stress Chaperones. 2005 Spring;10(1):59-65.

46.

On the role of Hsp27 in regulating apoptosis.

Concannon CG, Gorman AM, Samali A.

Apoptosis. 2003 Jan;8(1):61-70. Review.

PMID:
12510153
47.

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