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Items: 36


To help aging populations, classify organismal senescence.

Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, Fleming GA, Conboy M, Antebi A, Small GW, Gil J, Lakatta EG, Richardson A, Rosen C, Nikolich K, Wyss-Coray T, Steinman L, Montine T, de Magalhães JP, Campisi J, Church G.

Science. 2019 Nov 1;366(6465):576-578. doi: 10.1126/science.aay7319. No abstract available.


Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age.

Mehdipour M, Etienne J, Chen CC, Gathwala R, Rehman M, Kato C, Liu C, Liu Y, Zuo Y, Conboy MJ, Conboy IM.

Aging (Albany NY). 2019 Aug 15;11(15):5628-5645. doi: 10.18632/aging.102148. Epub 2019 Aug 15.


Graphene-based biosensor for on-chip detection of bio-orthogonally labeled proteins to identify the circulating biomarkers of aging during heterochronic parabiosis.

Sadlowski C, Balderston S, Sandhu M, Hajian R, Liu C, Tran TP, Conboy MJ, Paredes J, Murthy N, Conboy IM, Aran K.

Lab Chip. 2018 Oct 23;18(21):3230-3238. doi: 10.1039/c8lc00446c.


Addendum: Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis.

Liu Y, Conboy MJ, Mehdipour M, Liu Y, Tran TP, Blotnick A, Rajan P, Santos TC, Conboy IM.

Nat Commun. 2018 Mar 13;9(1):1052. doi: 10.1038/s41467-017-02779-4. No abstract available.


Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis.

Liu Y, Conboy MJ, Mehdipour M, Liu Y, Tran TP, Blotnick A, Rajan P, Santos TC, Conboy IM.

Nat Commun. 2017 Sep 21;8(1):643. doi: 10.1038/s41467-017-00698-y. Erratum in: Nat Commun. 2018 Mar 13;9(1):1052.


Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair.

Lee K, Conboy M, Park HM, Jiang F, Kim HJ, Dewitt MA, Mackley VA, Chang K, Rao A, Skinner C, Shobha T, Mehdipour M, Liu H, Huang WC, Lan F, Bray NL, Li S, Corn JE, Kataoka K, Doudna JA, Conboy I, Murthy N.

Nat Biomed Eng. 2017;1:889-901. doi: 10.1038/s41551-017-0137-2. Epub 2017 Oct 2.


A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood.

Rebo J, Mehdipour M, Gathwala R, Causey K, Liu Y, Conboy MJ, Conboy IM.

Nat Commun. 2016 Nov 22;7:13363. doi: 10.1038/ncomms13363.


Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein.

Dunning CJ, Black HL, Andrews KL, Davenport EC, Conboy M, Chawla S, Dowle AA, Ashford D, Thomas JR, Evans GJ.

J Neurochem. 2016 May;137(4):518-27. doi: 10.1111/jnc.13571. Epub 2016 Mar 1.


Systemic Problems: A perspective on stem cell aging and rejuvenation.

Conboy IM, Conboy MJ, Rebo J.

Aging (Albany NY). 2015 Oct;7(10):754-65. Review.


Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal.

Yousef H, Conboy MJ, Morgenthaler A, Schlesinger C, Bugaj L, Paliwal P, Greer C, Conboy IM, Schaffer D.

Oncotarget. 2015 May 20;6(14):11959-78.


Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis.

Yousef H, Conboy MJ, Mamiya H, Zeiderman M, Schlesinger C, Schaffer DV, Conboy IM.

Aging (Albany NY). 2014 Aug;6(8):602-20.


DNA methyltransferase-3-dependent nonrandom template segregation in differentiating embryonic stem cells.

Elabd C, Cousin W, Chen RY, Chooljian MS, Pham JT, Conboy IM, Conboy MJ.

J Cell Biol. 2013 Oct 14;203(1):73-85. doi: 10.1083/jcb.201307110.


hESC-secreted proteins can be enriched for multiple regenerative therapies by heparin-binding.

Yousef H, Conboy MJ, Li J, Zeiderman M, Vazin T, Schlesinger C, Schaffer DV, Conboy IM.

Aging (Albany NY). 2013 May;5(5):357-72.


Pharmacological inhibition of myostatin/TGF-β receptor/pSmad3 signaling rescues muscle regenerative responses in mouse model of type 1 diabetes.

Jeong J, Conboy MJ, Conboy IM.

Acta Pharmacol Sin. 2013 Aug;34(8):1052-60. doi: 10.1038/aps.2013.67. Epub 2013 Jun 17.


Alterations in the endocannabinoid system in the rat valproic acid model of autism.

Kerr DM, Downey L, Conboy M, Finn DP, Roche M.

Behav Brain Res. 2013 Jul 15;249:124-32. doi: 10.1016/j.bbr.2013.04.043. Epub 2013 May 1.


Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity.

Conboy MJ, Conboy IM, Rando TA.

Aging Cell. 2013 Jun;12(3):525-30. doi: 10.1111/acel.12065. Epub 2013 Apr 10. Review.


Sorting single satellite cells from individual myofibers reveals heterogeneity in cell-surface markers and myogenic capacity.

Chapman MR, Balakrishnan KR, Li J, Conboy MJ, Huang H, Mohanty SK, Jabart E, Hack J, Conboy IM, Sohn LL.

Integr Biol (Camb). 2013 Apr;5(4):692-702. doi: 10.1039/c3ib20290a. Epub 2013 Feb 13.


SnoN activates p53 directly to regulate aging and tumorigenesis.

Pan D, Zhu Q, Conboy MJ, Conboy IM, Luo K.

Aging Cell. 2012 Oct;11(5):902-911. doi: 10.1111/j.1474-9726.2012.00857.x. Epub 2012 Aug 27.


Embryonic anti-aging niche.

Conboy IM, Yousef H, Conboy MJ.

Aging (Albany NY). 2011 May;3(5):555-63.


Understanding stewardship behaviour: factors facilitating and constraining private water well stewardship.

Kreutzwiser R, de Loë R, Imgrund K, Conboy MJ, Simpson H, Plummer R.

J Environ Manage. 2011 Apr;92(4):1104-14. doi: 10.1016/j.jenvman.2010.11.017. Epub 2010 Dec 24.


Immuno-analysis and FACS sorting of adult muscle fiber-associated stem/precursor cells.

Conboy MJ, Cerletti M, Wagers AJ, Conboy IM.

Methods Mol Biol. 2010;621:165-73. doi: 10.1007/978-1-60761-063-2_11.


Preparation of adult muscle fiber-associated stem/precursor cells.

Conboy MJ, Conboy IM.

Methods Mol Biol. 2010;621:149-63. doi: 10.1007/978-1-60761-063-2_10.


Molecular aging and rejuvenation of human muscle stem cells.

Carlson ME, Suetta C, Conboy MJ, Aagaard P, Mackey A, Kjaer M, Conboy I.

EMBO Mol Med. 2009 Nov;1(8-9):381-91. doi: 10.1002/emmm.200900045.


Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses.

Carlson ME, Conboy MJ, Hsu M, Barchas L, Jeong J, Agrawal A, Mikels AJ, Agrawal S, Schaffer DV, Conboy IM.

Aging Cell. 2009 Dec;8(6):676-89. doi: 10.1111/j.1474-9726.2009.00517.x. Epub 2009 Sep 2.


A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.

Brack AS, Conboy IM, Conboy MJ, Shen J, Rando TA.

Cell Stem Cell. 2008 Jan 10;2(1):50-9. doi: 10.1016/j.stem.2007.10.006.


Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis.

Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C, Rando TA.

Science. 2007 Aug 10;317(5839):807-10.


High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny.

Conboy MJ, Karasov AO, Rando TA.

PLoS Biol. 2007 May;5(5):e102. Erratum in: PLoS Biol. 2007 Jul;5(7):e182.


Rejuvenation of aged progenitor cells by exposure to a young systemic environment.

Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA.

Nature. 2005 Feb 17;433(7027):760-4.


Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle.

Sherwood RI, Christensen JL, Conboy IM, Conboy MJ, Rando TA, Weissman IL, Wagers AJ.

Cell. 2004 Nov 12;119(4):543-54.


Notch-mediated restoration of regenerative potential to aged muscle.

Conboy IM, Conboy MJ, Smythe GM, Rando TA.

Science. 2003 Nov 28;302(5650):1575-7.


Analysis of regulatory elements of the developmentally controlled chorion s15 promoter in transgenic Drosophila.

Mariani BD, Shea MJ, Conboy MJ, Conboy I, King DL, Kafatos FC.

Dev Biol. 1996 Feb 25;174(1):115-24.


Tumor suppression by RNA from the 3' untranslated region of alpha-tropomyosin.

Rastinejad F, Conboy MJ, Rando TA, Blau HM.

Cell. 1993 Dec 17;75(6):1107-17.


A reasonable probability of substantial harm? Health care workers, AIDS, and the duty to disclose.

Ottley BL, Conboy MN.

J Health Hosp Law. 1992 Mar;25(3):65-79. No abstract available.


Inhibition of monocyte oxidative responses by Bordetella pertussis adenylate cyclase toxin.

Pearson RD, Symes P, Conboy M, Weiss AA, Hewlett EL.

J Immunol. 1987 Oct 15;139(8):2749-54.


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