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α-Globin pre-mRNA splicing, revisited.

Conboy JG.

Blood. 2019 May 23;133(21):2250-2251. doi: 10.1182/blood-2019-03-901108. No abstract available.


An important class of intron retention events in human erythroblasts is regulated by cryptic exons proposed to function as splicing decoys.

Parra M, Booth BW, Weiszmann R, Yee B, Yeo GW, Brown JB, Celniker SE, Conboy JG.

RNA. 2018 Sep;24(9):1255-1265. doi: 10.1261/rna.066951.118. Epub 2018 Jun 29.


Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating.

Huang YS, Delgadillo LF, Cyr KH, Kingsley PD, An X, McGrath KE, Mohandas N, Conboy JG, Waugh RE, Wan J, Palis J.

Sci Rep. 2017 Jul 12;7(1):5164. doi: 10.1038/s41598-017-05498-4.


RNA splicing during terminal erythropoiesis.

Conboy JG.

Curr Opin Hematol. 2017 May;24(3):215-221. doi: 10.1097/MOH.0000000000000329. Review.


Developmental regulation of RNA processing by Rbfox proteins.

Conboy JG.

Wiley Interdiscip Rev RNA. 2017 Mar;8(2). doi: 10.1002/wrna.1398. Epub 2016 Oct 17. Review.


A dynamic intron retention program enriched in RNA processing genes regulates gene expression during terminal erythropoiesis.

Pimentel H, Parra M, Gee SL, Mohandas N, Pachter L, Conboy JG.

Nucleic Acids Res. 2016 Jan 29;44(2):838-51. doi: 10.1093/nar/gkv1168. Epub 2015 Nov 3.


A dynamic alternative splicing program regulates gene expression during terminal erythropoiesis.

Pimentel H, Parra M, Gee S, Ghanem D, An X, Li J, Mohandas N, Pachter L, Conboy JG.

Nucleic Acids Res. 2014 Apr;42(6):4031-42. doi: 10.1093/nar/gkt1388. Epub 2014 Jan 17.


Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges.

Lovci MT, Ghanem D, Marr H, Arnold J, Gee S, Parra M, Liang TY, Stark TJ, Gehman LT, Hoon S, Massirer KB, Pratt GA, Black DL, Gray JW, Conboy JG, Yeo GW.

Nat Struct Mol Biol. 2013 Dec;20(12):1434-42. doi: 10.1038/nsmb.2699. Epub 2013 Nov 10.


Deep intron elements mediate nested splicing events at consecutive AG dinucleotides to regulate alternative 3' splice site choice in vertebrate 4.1 genes.

Parra MK, Gallagher TL, Amacher SL, Mohandas N, Conboy JG.

Mol Cell Biol. 2012 Jun;32(11):2044-53. doi: 10.1128/MCB.05716-11. Epub 2012 Apr 2.


Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions.

Gallagher TL, Arribere JA, Geurts PA, Exner CR, McDonald KL, Dill KK, Marr HL, Adkar SS, Garnett AT, Amacher SL, Conboy JG.

Dev Biol. 2011 Nov 15;359(2):251-61. doi: 10.1016/j.ydbio.2011.08.025. Epub 2011 Sep 7.


Efficient in vivo manipulation of alternative pre-mRNA splicing events using antisense morpholinos in mice.

Parra MK, Gee S, Mohandas N, Conboy JG.

J Biol Chem. 2011 Feb 25;286(8):6033-9. doi: 10.1074/jbc.M110.158154. Epub 2010 Dec 14.


Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland: implications for functions.

Wang H, Liu C, Debnath G, Baines AJ, Conboy JG, Mohandas N, An X.

Histochem Cell Biol. 2010 Oct;134(4):411-20. doi: 10.1007/s00418-010-0749-z. Epub 2010 Oct 2.


Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis.

Yamamoto ML, Clark TA, Gee SL, Kang JA, Schweitzer AC, Wickrema A, Conboy JG.

Blood. 2009 Apr 2;113(14):3363-70. doi: 10.1182/blood-2008-05-160325. Epub 2009 Feb 4.


FIRMA: a method for detection of alternative splicing from exon array data.

Purdom E, Simpson KM, Robinson MD, Conboy JG, Lapuk AV, Speed TP.

Bioinformatics. 2008 Aug 1;24(15):1707-14. doi: 10.1093/bioinformatics/btn284. Epub 2008 Jun 23.


Intrasplicing coordinates alternative first exons with alternative splicing in the protein 4.1R gene.

Parra MK, Tan JS, Mohandas N, Conboy JG.

EMBO J. 2008 Jan 9;27(1):122-31. Epub 2007 Dec 13.


A correlation with exon expression approach to identify cis-regulatory elements for tissue-specific alternative splicing.

Das D, Clark TA, Schweitzer A, Yamamoto M, Marr H, Arribere J, Minovitsky S, Poliakov A, Dubchak I, Blume JE, Conboy JG.

Nucleic Acids Res. 2007;35(14):4845-57. Epub 2007 Jul 10.


Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16.

Ponthier JL, Schluepen C, Chen W, Lersch RA, Gee SL, Hou VC, Lo AJ, Short SA, Chasis JA, Winkelmann JC, Conboy JG.

J Biol Chem. 2006 May 5;281(18):12468-74. Epub 2006 Mar 14.


High frequency of alternative first exons in erythroid genes suggests a critical role in regulating gene function.

Tan JS, Mohandas N, Conboy JG.

Blood. 2006 Mar 15;107(6):2557-61. Epub 2005 Nov 17.


The splicing regulatory element, UGCAUG, is phylogenetically and spatially conserved in introns that flank tissue-specific alternative exons.

Minovitsky S, Gee SL, Schokrpur S, Dubchak I, Conboy JG.

Nucleic Acids Res. 2005 Feb 3;33(2):714-24. Print 2005.


Putative tumor suppressor protein 4.1B is differentially expressed in kidney and brain via alternative promoters and 5' alternative splicing.

Gascard P, Parra MK, Zhao Z, Calinisan VR, Nunomura W, Rivkees SA, Mohandas N, Conboy JG.

Biochim Biophys Acta. 2004 Oct 21;1680(2):71-82.


Differential domain evolution and complex RNA processing in a family of paralogous EPB41 (protein 4.1) genes facilitate expression of diverse tissue-specific isoforms.

Parra M, Gee S, Chan N, Ryaboy D, Dubchak I, Mohandas N, Gascard PD, Conboy JG.

Genomics. 2004 Oct;84(4):637-46.


Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron.

Ramez M, Blot-Chabaud M, Cluzeaud F, Chanan S, Patterson M, Walensky LD, Marfatia S, Baines AJ, Chasis JA, Conboy JG, Mohandas N, Gascard P.

Kidney Int. 2003 Apr;63(4):1321-37.


Alternative 5' exons and differential splicing regulate expression of protein 4.1R isoforms with distinct N-termini.

Parra MK, Gee SL, Koury MJ, Mohandas N, Conboy JG.

Blood. 2003 May 15;101(10):4164-71. Epub 2003 Jan 9.


Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch.

Hou VC, Lersch R, Gee SL, Ponthier JL, Lo AJ, Wu M, Turck CW, Koury M, Krainer AR, Mayeda A, Conboy JG.

EMBO J. 2002 Nov 15;21(22):6195-204.


Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing.

Brudno M, Gelfand MS, Spengler S, Zorn M, Dubchak I, Conboy JG.

Nucleic Acids Res. 2001 Jun 1;29(11):2338-48.


Regulation of alternative pre-mRNA splicing during erythroid differentiation.

Hou VC, Conboy JG.

Curr Opin Hematol. 2001 Mar;8(2):74-9. Review.


Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain.

Parra M, Gascard P, Walensky LD, Gimm JA, Blackshaw S, Chan N, Takakuwa Y, Berger T, Lee G, Chasis JA, Snyder SH, Mohandas N, Conboy JG.

J Biol Chem. 2000 Feb 4;275(5):3247-55.


Alternative splicing of protein 4.1R exon 16: ordered excision of flanking introns ensures proper splice site choice.

Gee SL, Aoyagi K, Lersch R, Hou V, Wu M, Conboy JG.

Blood. 2000 Jan 15;95(2):692-9.


A novel neuron-enriched homolog of the erythrocyte membrane cytoskeletal protein 4.1.

Walensky LD, Blackshaw S, Liao D, Watkins CC, Weier HU, Parra M, Huganir RL, Conboy JG, Mohandas N, Snyder SH.

J Neurosci. 1999 Aug 1;19(15):6457-67.


Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R.

Gascard P, Nunomura W, Lee G, Walensky LD, Krauss SW, Takakuwa Y, Chasis JA, Mohandas N, Conboy JG.

Mol Biol Cell. 1999 Jun;10(6):1783-98.


Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities.

Shi ZT, Afzal V, Coller B, Patel D, Chasis JA, Parra M, Lee G, Paszty C, Stevens M, Walensky L, Peters LL, Mohandas N, Rubin E, Conboy JG.

J Clin Invest. 1999 Feb;103(3):331-40.


Characterization of multiple isoforms of protein 4.1R expressed during erythroid terminal differentiation.

Gascard P, Lee G, Coulombel L, Auffray I, Lum M, Parra M, Conboy JG, Mohandas N, Chasis JA.

Blood. 1998 Dec 1;92(11):4404-14.


Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.

Peters LL, Weier HU, Walensky LD, Snyder SH, Parra M, Mohandas N, Conboy JG.

Genomics. 1998 Dec 1;54(2):348-50.


Neurobehavioral deficits in mice lacking the erythrocyte membrane cytoskeletal protein 4.1.

Walensky LD, Shi ZT, Blackshaw S, DeVries AC, Demas GE, Gascard P, Nelson RJ, Conboy JG, Rubin EM, Snyder SH, Mohandas N.

Curr Biol. 1998 Nov 19;8(23):1269-72.


The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane.

Chishti AH, Kim AC, Marfatia SM, Lutchman M, Hanspal M, Jindal H, Liu SC, Low PS, Rouleau GA, Mohandas N, Chasis JA, Conboy JG, Gascard P, Takakuwa Y, Huang SC, Benz EJ Jr, Bretscher A, Fehon RG, Gusella JF, Ramesh V, Solomon F, Marchesi VT, Tsukita S, Tsukita S, Hoover KB, et al.

Trends Biochem Sci. 1998 Aug;23(8):281-2. Review. No abstract available.


Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family.

Parra M, Gascard P, Walensky LD, Snyder SH, Mohandas N, Conboy JG.

Genomics. 1998 Apr 15;49(2):298-306.


The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1.

Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH.

J Cell Biol. 1998 Apr 6;141(1):143-53.


Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43.

Gee S, Krauss SW, Miller E, Aoyagi K, Arenas J, Conboy JG.

Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11803-7.


Cell shape-dependent regulation of protein 4.1 alternative pre-mRNA splicing in mammary epithelial cells.

Schischmanoff PO, Yaswen P, Parra MK, Lee G, Chasis JA, Mohandas N, Conboy JG.

J Biol Chem. 1997 Apr 11;272(15):10254-9.


Evolutionarily conserved alternative pre-mRNA splicing regulates structure and function of the spectrin-actin binding domain of erythroid protein 4.1.

Winardi R, Discher D, Kelley C, Zon L, Mays K, Mohandas N, Conboy JG.

Blood. 1995 Dec 1;86(11):4315-22.


Defining of the minimal domain of protein 4.1 involved in spectrin-actin binding.

Schischmanoff PO, Winardi R, Discher DE, Parra MK, Bicknese SE, Witkowska HE, Conboy JG, Mohandas N.

J Biol Chem. 1995 Sep 8;270(36):21243-50.


Mechanochemistry of the alternatively spliced spectrin-actin binding domain in membrane skeletal protein 4.1.

Discher D, Parra M, Conboy JG, Mohandas N.

J Biol Chem. 1993 Apr 5;268(10):7186-95.


Human erythroid 5-aminolevulinate synthase. Gene structure and species-specific differences in alternative RNA splicing.

Conboy JG, Cox TC, Bottomley SS, Bawden MJ, May BK.

J Biol Chem. 1992 Sep 15;267(26):18753-8.


Hereditary elliptocytosis due to both qualitative and quantitative defects in membrane skeletal protein 4.1.

Conboy JG, Shitamoto R, Parra M, Winardi R, Kabra A, Smith J, Mohandas N.

Blood. 1991 Nov 1;78(9):2438-43.


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