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Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries.

Ghosh TS, Rampelli S, Jeffery IB, Santoro A, Neto M, Capri M, Giampieri E, Jennings A, Candela M, Turroni S, Zoetendal EG, Hermes GDA, Elodie C, Meunier N, Brugere CM, Pujos-Guillot E, Berendsen AM, De Groot LCPGM, Feskins EJM, Kaluza J, Pietruszka B, Bielak MJ, Comte B, Maijo-Ferre M, Nicoletti C, De Vos WM, Fairweather-Tait S, Cassidy A, Brigidi P, Franceschi C, O'Toole PW.

Gut. 2020 Feb 17. pii: gutjnl-2019-319654. doi: 10.1136/gutjnl-2019-319654. [Epub ahead of print]


Metabolomic and Lipidomic Signatures of Metabolic Syndrome and its Physiological Components in Adults: A Systematic Review.

Monnerie S, Comte B, Ziegler D, Morais JA, Pujos-Guillot E, Gaudreau P.

Sci Rep. 2020 Jan 20;10(1):669. doi: 10.1038/s41598-019-56909-7.


Analytic Correlation Filtration: A New Tool to Reduce Analytical Complexity of Metabolomic Datasets.

Monnerie S, Petera M, Lyan B, Gaudreau P, Comte B, Pujos-Guillot E.

Metabolites. 2019 Oct 24;9(11). pii: E250. doi: 10.3390/metabo9110250.


Multi-block PLS discriminant analysis for the joint analysis of metabolomic and epidemiological data.

Brandolini-Bunlon M, Pétéra M, Gaudreau P, Comte B, Bougeard S, Pujos-Guillot E.

Metabolomics. 2019 Oct 3;15(10):134. doi: 10.1007/s11306-019-1598-y.


Referral pathway of patients aged 75 years and older after a telephone triage by the French emergency medical communication center (SAMU).

Vincent A, Jomard N, Haesebaert J, Comte B, Gilbert T, Schott AM.

Arch Gerontol Geriatr. 2019 Sep - Oct;84:103893. doi: 10.1016/j.archger.2019.05.018. Epub 2019 May 29. Review.


Identification of Pre-frailty Sub-Phenotypes in Elderly Using Metabolomics.

Pujos-Guillot E, Pétéra M, Jacquemin J, Centeno D, Lyan B, Montoliu I, Madej D, Pietruszka B, Fabbri C, Santoro A, Brzozowska A, Franceschi C, Comte B.

Front Physiol. 2019 Jan 24;9:1903. doi: 10.3389/fphys.2018.01903. eCollection 2018.


An onco-geriatric approach to select older patients for optimal treatments of pancreatic adenocarcinoma.

Castel-Kremer E, De Talhouet S, Charlois AL, Graillot E, Chopin-Laly X, Adham M, Comte B, Lombard-Bohas C, Walter T, Boschetti G.

J Geriatr Oncol. 2018 Jul;9(4):373-381. doi: 10.1016/j.jgo.2018.03.007. Epub 2018 Jun 9.


Systems Metabolomics for Prediction of Metabolic Syndrome.

Pujos-Guillot E, Brandolini M, Pétéra M, Grissa D, Joly C, Lyan B, Herquelot É, Czernichow S, Zins M, Goldberg M, Comte B.

J Proteome Res. 2017 Jun 2;16(6):2262-2272. doi: 10.1021/acs.jproteome.7b00116. Epub 2017 May 4.


Factors associated with Clostridium difficile infection: A nested case-control study in a three year prospective cohort.

Khanafer N, Vanhems P, Barbut F, Luxemburger C; CDI01 Study group, Demont C, Hulin M, Dauwalder O, Vandenesch F; Teams of:, Argaud L, Badet L, Barth X, Bertrand M Dr., Burillon C, Chapurlat R, Chuzeville M, Comte B, Disant F, Fessy MH, Gouillat C, Juillard L, Lermusiaux P, Monneuse O, Morelon E, Ninet J, Ponchon T, Poulet E, Rimmele T, Tazarourte K.

Anaerobe. 2017 Apr;44:117-123. doi: 10.1016/j.anaerobe.2017.03.003. Epub 2017 Mar 6.


Weight for gestational age and metabolically healthy obesity in adults from the Haguenau cohort.

Matta J, Carette C, Levy Marchal C, Bertrand J, Pétéra M, Zins M, Pujos-Guillot E, Comte B, Czernichow S.

BMJ Open. 2016 Aug 31;6(8):e011367. doi: 10.1136/bmjopen-2016-011367.


Metabolic adaptations to HFHS overfeeding: how whole body and tissues postprandial metabolic flexibility adapt in Yucatan mini-pigs.

Polakof S, Rémond D, Bernalier-Donadille A, Rambeau M, Pujos-Guillot E, Comte B, Dardevet D, Savary-Auzeloux I.

Eur J Nutr. 2018 Feb;57(1):119-135. doi: 10.1007/s00394-016-1302-1. Epub 2016 Aug 27.


Dietary intake in young adults born small or appropriate for gestational age: data from the Haguenau cohort.

Matta J, Carette C, Levy Marchal C, Bertrand J, Pétéra M, Zins M, Pujos-Guillot E, Comte B, Czernichow S.

BMJ Open. 2016 Jul 29;6(7):e012309. doi: 10.1136/bmjopen-2016-012309.


Feature Selection Methods for Early Predictive Biomarker Discovery Using Untargeted Metabolomic Data.

Grissa D, Pétéra M, Brandolini M, Napoli A, Comte B, Pujos-Guillot E.

Front Mol Biosci. 2016 Jul 8;3:30. doi: 10.3389/fmolb.2016.00030. eCollection 2016.


Quantification of 4-hydroxy-2-nonenal-protein adducts in the in vivo gastric digesta of mini-pigs using a GC-MS/MS method with accuracy profile validation.

Delosière M, Santé-Lhoutellier V, Chantelauze C, Durand D, Thomas A, Joly C, Pujos-Guillot E, Rémond D, Comte B, Gladine C, Guy A, Durand T, Laurentie M, Dufour C.

Food Funct. 2016 Aug 10;7(8):3497-504. doi: 10.1039/c6fo00413j. Epub 2016 Jul 15.


Time Course of Molecular and Metabolic Events in the Development of Insulin Resistance in Fructose-Fed Rats.

Polakof S, Dardevet D, Lyan B, Mosoni L, Gatineau E, Martin JF, Pujos-Guillot E, Mazur A, Comte B.

J Proteome Res. 2016 Jun 3;15(6):1862-74. doi: 10.1021/acs.jproteome.6b00043. Epub 2016 May 4.


Contacts between health care workers and patients in a short-stay geriatric unit during the peak of a seasonal influenza epidemic compared with a nonepidemic period.

Oussaid N, Voirin N, Régis C, Khanafer N, Martin-Gaujard G, Vincent A, Comte B, Bénet T, Vanhems P.

Am J Infect Control. 2016 Aug 1;44(8):905-9. doi: 10.1016/j.ajic.2016.02.002. Epub 2016 Mar 31.


Impact of a transition nurse program on the prevention of thirty-day hospital readmissions of elderly patients discharged from short-stay units: study protocol of the PROUST stepped-wedge cluster randomised trial.

Occelli P, Touzet S, Rabilloud M, Ganne C, Poupon Bourdy S, Galamand B, Debray M, Dartiguepeyrou A, Chuzeville M, Comte B, Turkie B, Tardy M, Luiggi JS, Jacquet-Francillon T, Gilbert T, Bonnefoy M.

BMC Geriatr. 2016 Mar 3;16:57. doi: 10.1186/s12877-016-0233-2.


[Diagnosis of a pancreatic neuroendocrine tumor in an 84 year old patient].

Rossignol-Dalat H, Ricanet-Delannoy A, Comte B.

Soins Gerontol. 2015 May-Jun;(113):43-4. French. No abstract available.


DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation.

Capel F, Acquaviva C, Pitois E, Laillet B, Rigaudière JP, Jouve C, Pouyet C, Gladine C, Comte B, Vianey Saban C, Morio B.

J Nutr Biochem. 2015 Sep;26(9):949-59. doi: 10.1016/j.jnutbio.2015.04.003. Epub 2015 May 11.


Combining high-resolution contact data with virological data to investigate influenza transmission in a tertiary care hospital.

Voirin N, Payet C, Barrat A, Cattuto C, Khanafer N, Régis C, Kim BA, Comte B, Casalegno JS, Lina B, Vanhems P.

Infect Control Hosp Epidemiol. 2015 Mar;36(3):254-60. doi: 10.1017/ice.2014.53.


Methyl donor deficiency in H9c2 cardiomyoblasts induces ER stress as an important part of the proteome response.

Martinez E, Deval C, Jousse C, Mazur A, Brachet P, Comte B.

Int J Biochem Cell Biol. 2015 Feb;59:62-72. doi: 10.1016/j.biocel.2014.11.013. Epub 2014 Dec 6.


Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and α-linolenic acids; bioactivities and potential use as biomarkers.

Galano JM, Lee JC, Gladine C, Comte B, Le Guennec JY, Oger C, Durand T.

Biochim Biophys Acta. 2015 Apr;1851(4):446-55. doi: 10.1016/j.bbalip.2014.11.004. Epub 2014 Nov 14. Review.


Detection of hospital outbreaks of influenza-like illness based on excess of incidence rates compared to the community.

Vanhems P, Voirin N, Bénet T, Roche S, Escuret V, Régis C, Giard M, Lina B, Comte B, Coppéré B, Ecochard R.

Am J Infect Control. 2014 Dec;42(12):1325-7. doi: 10.1016/j.ajic.2014.08.011. Epub 2014 Oct 16.


The omega-3 fatty acid docosahexaenoic acid favorably modulates the inflammatory pathways and macrophage polarization within aorta of LDLR(-/-) mice.

Gladine C, Zmojdzian M, Joumard-Cubizolles L, Verny MA, Comte B, Mazur A.

Genes Nutr. 2014 Sep;9(5):424. doi: 10.1007/s12263-014-0424-4. Epub 2014 Aug 19.


Remodeling of aorta extracellular matrix as a result of transient high oxygen exposure in newborn rats: implication for arterial rigidity and hypertension risk.

Huyard F, Yzydorczyk C, Castro MM, Cloutier A, Bertagnolli M, Sartelet H, Germain N, Comte B, Schulz R, DeBlois D, Nuyt AM.

PLoS One. 2014 Apr 17;9(4):e92287. doi: 10.1371/journal.pone.0092287. eCollection 2014.


New biomarkers of coffee consumption identified by the non-targeted metabolomic profiling of cohort study subjects.

Rothwell JA, Fillâtre Y, Martin JF, Lyan B, Pujos-Guillot E, Fezeu L, Hercberg S, Comte B, Galan P, Touvier M, Manach C.

PLoS One. 2014 Apr 8;9(4):e93474. doi: 10.1371/journal.pone.0093474. eCollection 2014.


Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention.

Gladine C, Newman JW, Durand T, Pedersen TL, Galano JM, Demougeot C, Berdeaux O, Pujos-Guillot E, Mazur A, Comte B.

PLoS One. 2014 Feb 18;9(2):e89393. doi: 10.1371/journal.pone.0089393. eCollection 2014.


Five years of hospital based surveillance of influenza-like illness and influenza in a short-stay geriatric unit.

Régis C, Voirin N, Escuret V, Kim BA, Robert O, Lina B, Comte B, Vanhems P.

BMC Res Notes. 2014 Feb 21;7:99. doi: 10.1186/1756-0500-7-99.


Routes of transmission during a nosocomial influenza A(H3N2) outbreak among geriatric patients and healthcare workers.

Eibach D, Casalegno JS, Bouscambert M, Bénet T, Regis C, Comte B, Kim BA, Vanhems P, Lina B.

J Hosp Infect. 2014 Mar;86(3):188-93. doi: 10.1016/j.jhin.2013.11.009. Epub 2014 Jan 8.


Health care workers travelling abroad: investigation of carbapenemase-producing enterobacteriaceae infection possibly acquired overseas.

Munier E, Bénet T, Nicolle MC, Oltra L, Ricanet-Delannoy A, Comte B, Vanhems P.

Am J Infect Control. 2014 Jan;42(1):85-6. doi: 10.1016/j.ajic.2013.08.004. No abstract available.


Estimating potential infection transmission routes in hospital wards using wearable proximity sensors.

Vanhems P, Barrat A, Cattuto C, Pinton JF, Khanafer N, Régis C, Kim BA, Comte B, Voirin N.

PLoS One. 2013 Sep 11;8(9):e73970. doi: 10.1371/journal.pone.0073970. eCollection 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/b20d3cec-62b7-44ec-9150-8a06a9b30a9b.


Resistant starch intake partly restores metabolic and inflammatory alterations in the liver of high-fat-diet-fed rats.

Polakof S, Díaz-Rubio ME, Dardevet D, Martin JF, Pujos-Guillot E, Scalbert A, Sebedio JL, Mazur A, Comte B.

J Nutr Biochem. 2013 Nov;24(11):1920-30. doi: 10.1016/j.jnutbio.2013.05.008. Epub 2013 Sep 3.


Time-resolved fluorescence spectroscopy investigation of the effect of 4-hydroxynonenal on endogenous NAD(P)H in living cardiac myocytes.

Chorvatova A, Aneba S, Mateasik A, Chorvat D Jr, Comte B.

J Biomed Opt. 2013 Jun;18(6):067009. doi: 10.1117/1.JBO.18.6.067009.


Mass spectrometry-based metabolomics for the discovery of biomarkers of fruit and vegetable intake: citrus fruit as a case study.

Pujos-Guillot E, Hubert J, Martin JF, Lyan B, Quintana M, Claude S, Chabanas B, Rothwell JA, Bennetau-Pelissero C, Scalbert A, Comte B, Hercberg S, Morand C, Galan P, Manach C.

J Proteome Res. 2013 Apr 5;12(4):1645-59. doi: 10.1021/pr300997c. Epub 2013 Mar 5.


Glucose-induced insulin secretion: nutritional prevention and novel avenues for therapy.

Polakof S, Comte B.

Adv Exp Med Biol. 2012;771:319-39. Review.


Myocardium proteome remodelling after nutritional deprivation of methyl donors.

Martinez E, Gérard N, Garcia MM, Mazur A, Guéant-Rodriguez RM, Comte B, Guéant JL, Brachet P.

J Nutr Biochem. 2013 Jul;24(7):1241-50. doi: 10.1016/j.jnutbio.2012.09.008. Epub 2013 Jan 11.


Developmental programming of eNOS uncoupling and enhanced vascular oxidative stress in adult rats after transient neonatal oxygen exposure.

Yzydorczyk C, Comte B, Huyard F, Cloutier A, Germain N, Bertagnolli M, Nuyt AM.

J Cardiovasc Pharmacol. 2013 Jan;61(1):8-16. doi: 10.1097/FJC.0b013e318274d1c4.


Hexapeptides from human milk prevent the induction of oxidative stress from parenteral nutrition in the newborn guinea pig.

Miloudi K, Tsopmo A, Friel JK, Rouleau T, Comte B, Lavoie JC.

Pediatr Res. 2012 Jun;71(6):675-81. doi: 10.1038/pr.2012.29. Epub 2012 Feb 15.


Influenza vaccination of healthcare workers in acute-care hospitals: a case-control study of its effect on hospital-acquired influenza among patients.

Bénet T, Régis C, Voirin N, Robert O, Lina B, Cronenberger S, Comte B, Coppéré B, Vanhems P.

BMC Infect Dis. 2012 Feb 1;12:30. doi: 10.1186/1471-2334-12-30.


The mode of administration of total parenteral nutrition and nature of lipid content influence the generation of peroxides and aldehydes.

Miloudi K, Comte B, Rouleau T, Montoudis A, Levy E, Lavoie JC.

Clin Nutr. 2012 Aug;31(4):526-34. doi: 10.1016/j.clnu.2011.12.012. Epub 2012 Jan 9.


Influenza vaccine effectiveness among adult patients in a University of Lyon hospital (2004-2009).

Amour S, Voirin N, Regis C, Bouscambert-Duchamp M, Comte B, Coppéré B, Pires-Cronenberger S, Lina B, Vanhems P.

Vaccine. 2012 Jan 20;30(5):821-4. doi: 10.1016/j.vaccine.2011.11.033. Epub 2011 Dec 2.


Increasing intake of long-chain n-3 PUFA enhances lipoperoxidation and modulates hepatic gene expression in a dose-dependent manner.

Gladine C, Roy NC, Rigaudière JP, Laillet B, Da Silva G, Joly C, Pujos-Guillot E, Morio B, Feillet-Coudray C, McNabb WC, Chardigny JM, Comte B.

Br J Nutr. 2012 May;107(9):1254-73. doi: 10.1017/S0007114511004259. Epub 2011 Sep 14.


Metabolic remodelling of cardiac myocytes during pregnancy: the role of mineralocorticoids.

Bassien-Capsa V, Elzwiei FM, Aneba S, Fouron JC, Comte B, Chorvatova A.

Can J Cardiol. 2011 Nov-Dec;27(6):834-42. doi: 10.1016/j.cjca.2011.05.009. Epub 2011 Sep 9.


Impact of a multifaceted program to prevent postoperative delirium in the elderly: the CONFUCIUS stepped wedge protocol.

Mouchoux C, Rippert P, Duclos A, Fassier T, Bonnefoy M, Comte B, Heitz D, Colin C, Krolak-Salmon P.

BMC Geriatr. 2011 May 18;11:25. doi: 10.1186/1471-2318-11-25.


The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established.

Hollman PC, Cassidy A, Comte B, Heinonen M, Richelle M, Richling E, Serafini M, Scalbert A, Sies H, Vidry S.

J Nutr. 2011 May;141(5):989S-1009S. doi: 10.3945/jn.110.131490. Epub 2011 Mar 30. Review.


Risk of influenza-like illness in an acute health care setting during community influenza epidemics in 2004-2005, 2005-2006, and 2006-2007: a prospective study.

Vanhems P, Voirin N, Roche S, Escuret V, Regis C, Gorain C, Pires-Cronenberger S, Giard M, Lina B, Najioullah F, Barret B, Pollissard L, David S, Crozet MN, Comte B, Hirschel B, Ecochard R.

Arch Intern Med. 2011 Jan 24;171(2):151-7. doi: 10.1001/archinternmed.2010.500.


Decision to forgo life-sustaining therapies for elderly critically ill patients is a multidisciplinary challenge.

Fassier T, Duclos A, Comte B, Tardy B.

Intensive Care Med. 2011 Jan;37(1):175-6. doi: 10.1007/s00134-010-2059-2. Epub 2010 Oct 20. No abstract available.


Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress.

Ntimbane T, Comte B, Mailhot G, Berthiaume Y, Poitout V, Prentki M, Rabasa-Lhoret R, Levy E.

Clin Biochem Rev. 2009 Nov;30(4):153-77.


Differential distribution of 4-hydroxynonenal adducts to sulfur and nitrogen residues in blood proteins as revealed using Raney nickel and gas chromatography-mass spectrometry.

Lesgards JF, Frayne IR, Comte B, Busseuil D, Rhéaume E, Tardif JC, Rosiers CD.

Free Radic Biol Med. 2009 Nov 15;47(10):1375-85. doi: 10.1016/j.freeradbiomed.2009.08.002. Epub 2009 Aug 12.


Neonatal oxygen exposure in rats leads to cardiovascular and renal alterations in adulthood.

Yzydorczyk C, Comte B, Cambonie G, Lavoie JC, Germain N, Ting Shun Y, Wolff J, Deschepper C, Touyz RM, Lelièvre-Pegorier M, Nuyt AM.

Hypertension. 2008 Nov;52(5):889-95. doi: 10.1161/HYPERTENSIONAHA.108.116251. Epub 2008 Oct 13.


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