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Items: 45


Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry.

Kafader JO, Durbin KR, Melani RD, Des Soye BJ, Schachner LF, Senko MW, Compton PD, Kelleher NL.

J Proteome Res. 2020 Feb 11. doi: 10.1021/acs.jproteome.9b00797. [Epub ahead of print]


Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions.

Kafader JO, Melani RD, Schachner LF, Ives AN, Patrie SM, Kelleher NL, Compton PD.

J Am Soc Mass Spectrom. 2020 Feb 4. doi: 10.1021/jasms.9b00040. [Epub ahead of print]


Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics.

Fornelli L, Srzentić K, Toby TK, Doubleday PF, Huguet R, Mullen C, Melani RD, Dos Santos Seckler H, DeHart CJ, Weisbrod CR, Durbin KR, Greer JB, Early BP, Fellers RT, Zabrouskov V, Thomas PM, Compton PD, Kelleher NL.

Mol Cell Proteomics. 2020 Feb;19(2):405-420. doi: 10.1074/mcp.TIR119.001638. Epub 2019 Dec 30.


Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry.

Park HM, Winton VJ, Drader JJ, Manalili Wheeler S, Lazar GA, Kelleher NL, Liu Y, Tran JC, Compton PD.

Anal Chem. 2020 Jan 21;92(2):2186-2193. doi: 10.1021/acs.analchem.9b04826. Epub 2020 Jan 10.


STORI Plots Enable Accurate Tracking of Individual Ion Signals.

Kafader JO, Beu SC, Early BP, Melani RD, Durbin KR, Zabrouskov V, Makarov AA, Maze JT, Shinholt DL, Yip PF, Kelleher NL, Compton PD, Senko MW.

J Am Soc Mass Spectrom. 2019 Nov;30(11):2200-2203. doi: 10.1007/s13361-019-02309-0. Epub 2019 Sep 11.


Standard Proteoforms and Their Complexes for Native Mass Spectrometry.

Schachner LF, Ives AN, McGee JP, Melani RD, Kafader JO, Compton PD, Patrie SM, Kelleher NL.

J Am Soc Mass Spectrom. 2019 Jul;30(7):1190-1198. doi: 10.1007/s13361-019-02191-w. Epub 2019 Apr 8.


Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins.

Kafader JO, Melani RD, Senko MW, Makarov AA, Kelleher NL, Compton PD.

Anal Chem. 2019 Feb 19;91(4):2776-2783. doi: 10.1021/acs.analchem.8b04519. Epub 2019 Jan 29.


A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies.

Cline EN, Das A, Bicca MA, Mohammad SN, Schachner LF, Kamel JM, DiNunno N, Weng A, Paschall JD, Bu RL, Khan FM, Rollins MG, Ives AN, Shekhawat G, Nunes-Tavares N, de Mello FG, Compton PD, Kelleher NL, Klein WL.

J Neurochem. 2019 Mar;148(6):822-836. doi: 10.1111/jnc.14647. Epub 2019 Jan 29.


Estimating the Distribution of Protein Post-Translational Modification States by Mass Spectrometry.

Compton PD, Kelleher NL, Gunawardena J.

J Proteome Res. 2018 Aug 3;17(8):2727-2734. doi: 10.1021/acs.jproteome.8b00150. Epub 2018 Jul 10.


Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques.

Fornelli L, Srzentić K, Huguet R, Mullen C, Sharma S, Zabrouskov V, Fellers RT, Durbin KR, Compton PD, Kelleher NL.

Anal Chem. 2018 Jul 17;90(14):8421-8429. doi: 10.1021/acs.analchem.8b00984. Epub 2018 Jun 28.


A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity.

Seckler HDS, Fornelli L, Mutharasan RK, Thaxton CS, Fellers R, Daviglus M, Sniderman A, Rader D, Kelleher NL, Lloyd-Jones DM, Compton PD, Wilkins JT.

J Proteome Res. 2018 Jun 1;17(6):2156-2164. doi: 10.1021/acs.jproteome.8b00100. Epub 2018 Apr 27.


Top-down characterization of endogenous protein complexes with native proteomics.

Skinner OS, Haverland NA, Fornelli L, Melani RD, Do Vale LHF, Seckler HS, Doubleday PF, Schachner LF, Srzentić K, Kelleher NL, Compton PD.

Nat Chem Biol. 2018 Jan;14(1):36-41. doi: 10.1038/nchembio.2515. Epub 2017 Nov 13.


The Ups and Downs of Repeated Cleavage and Internal Fragment Production in Top-Down Proteomics.

Lyon YA, Riggs D, Fornelli L, Compton PD, Julian RR.

J Am Soc Mass Spectrom. 2018 Jan;29(1):150-157. doi: 10.1007/s13361-017-1823-8. Epub 2017 Oct 16.


Native Electron Capture Dissociation Maps to Iron-Binding Channels in Horse Spleen Ferritin.

Skinner OS, McAnally MO, Van Duyne RP, Schatz GC, Breuker K, Compton PD, Kelleher NL.

Anal Chem. 2017 Oct 17;89(20):10711-10716. doi: 10.1021/acs.analchem.7b01581. Epub 2017 Oct 4.


Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry.

Haverland NA, Skinner OS, Fellers RT, Tariq AA, Early BP, LeDuc RD, Fornelli L, Compton PD, Kelleher NL.

J Am Soc Mass Spectrom. 2017 Jun;28(6):1203-1215. doi: 10.1007/s13361-017-1635-x. Epub 2017 Apr 3.


Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer.

Fornelli L, Durbin KR, Fellers RT, Early BP, Greer JB, LeDuc RD, Compton PD, Kelleher NL.

J Proteome Res. 2017 Feb 3;16(2):609-618. doi: 10.1021/acs.jproteome.6b00698. Epub 2016 Dec 2.


Chromatographic efficiency and selectivity in top-down proteomics of histones.

Zhou Y, Zhang X, Fornelli L, Compton PD, Kelleher N, Wirth MJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Feb 15;1044-1045:47-53. doi: 10.1016/j.jchromb.2016.12.027. Epub 2016 Dec 23.


Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics.

Melani RD, Skinner OS, Fornelli L, Domont GB, Compton PD, Kelleher NL.

Mol Cell Proteomics. 2016 Jul;15(7):2423-34. doi: 10.1074/mcp.M115.056523. Epub 2016 May 13.


CN-GELFrEE - Clear Native Gel-eluted Liquid Fraction Entrapment Electrophoresis.

Melani RD, Seckler HS, Skinner OS, Do Vale LH, Catherman AD, Havugimana PC, Valle de Sousa M, Domont GB, Kelleher NL, Compton PD.

J Vis Exp. 2016 Feb 29;(108):53597. doi: 10.3791/53597.


An informatic framework for decoding protein complexes by top-down mass spectrometry.

Skinner OS, Havugimana PC, Haverland NA, Fornelli L, Early BP, Greer JB, Fellers RT, Durbin KR, Do Vale LH, Melani RD, Seckler HS, Nelp MT, Belov ME, Horning SR, Makarov AA, LeDuc RD, Bandarian V, Compton PD, Kelleher NL.

Nat Methods. 2016 Mar;13(3):237-40. doi: 10.1038/nmeth.3731. Epub 2016 Jan 18.


Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics.

Kim K, Compton PD, Toby TK, Thomas PM, Wilkins JT, Mutharasan RK, Kelleher NL.

EuPA Open Proteom. 2015 Sep;8:40-47. Epub 2015 Jun 5.


Probing Asymmetric Charge Partitioning of Protein Oligomers during Tandem Mass Spectrometry.

Compton PD, Fornelli L, Kelleher NL, Skinner OS.

Int J Mass Spectrom. 2015 Nov 15;390:132-136.


Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts.

Ntai I, LeDuc RD, Fellers RT, Erdmann-Gilmore P, Davies SR, Rumsey J, Early BP, Thomas PM, Li S, Compton PD, Ellis MJ, Ruggles KV, Fenyö D, Boja ES, Rodriguez H, Townsend RR, Kelleher NL.

Mol Cell Proteomics. 2016 Jan;15(1):45-56. doi: 10.1074/mcp.M114.047480. Epub 2015 Oct 26.


Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression.

Zheng Y, Fornelli L, Compton PD, Sharma S, Canterbury J, Mullen C, Zabrouskov V, Fellers RT, Thomas PM, Licht JD, Senko MW, Kelleher NL.

Mol Cell Proteomics. 2016 Mar;15(3):776-90. doi: 10.1074/mcp.M115.053819. Epub 2015 Aug 13.


Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid.

Lee H, Le HV, Wu R, Doud E, Sanishvili R, Kellie JF, Compton PD, Pachaiyappan B, Liu D, Kelleher NL, Silverman RB.

ACS Chem Biol. 2015 Sep 18;10(9):2087-98. doi: 10.1021/acschembio.5b00212. Epub 2015 Jul 6.


Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry.

Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL.

J Proteomics. 2016 Feb 16;134:76-84. doi: 10.1016/j.jprot.2015.04.025. Epub 2015 May 4.


Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry.

Kim KH, Compton PD, Tran JC, Kelleher NL.

J Proteome Res. 2015 May 1;14(5):2199-206. doi: 10.1021/pr501331q. Epub 2015 Apr 15.


Native GELFrEE: a new separation technique for biomolecular assemblies.

Skinner OS, Do Vale LH, Catherman AD, Havugimana PC, de Sousa MV, Compton PD, Kelleher NL.

Anal Chem. 2015 Mar 3;87(5):3032-8. doi: 10.1021/ac504678d. Epub 2015 Feb 20.


Deep and quantitative top-down proteomics in clinical and translational research.

Kelleher NL, Thomas PM, Ntai I, Compton PD, LeDuc RD.

Expert Rev Proteomics. 2014 Dec;11(6):649-51. doi: 10.1586/14789450.2014.976559. Epub 2014 Oct 28.


Fragmentation of integral membrane proteins in the gas phase.

Skinner OS, Catherman AD, Early BP, Thomas PM, Compton PD, Kelleher NL.

Anal Chem. 2014 May 6;86(9):4627-34. doi: 10.1021/ac500864w. Epub 2014 Apr 17.


Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins.

Li Y, Compton PD, Tran JC, Ntai I, Kelleher NL.

Proteomics. 2014 May;14(10):1158-64. doi: 10.1002/pmic.201300381. Epub 2014 Apr 10.


Autopilot: an online data acquisition control system for the enhanced high-throughput characterization of intact proteins.

Durbin KR, Fellers RT, Ntai I, Kelleher NL, Compton PD.

Anal Chem. 2014 Feb 4;86(3):1485-92. doi: 10.1021/ac402904h. Epub 2014 Jan 23.


From protein complexes to subunit backbone fragments: a multi-stage approach to native mass spectrometry.

Belov ME, Damoc E, Denisov E, Compton PD, Horning S, Makarov AA, Kelleher NL.

Anal Chem. 2013 Dec 3;85(23):11163-73. doi: 10.1021/ac4029328. Epub 2013 Nov 20.


Front-end electron transfer dissociation: a new ionization source.

Earley L, Anderson LC, Bai DL, Mullen C, Syka JE, English AM, Dunyach JJ, Stafford GC Jr, Shabanowitz J, Hunt DF, Compton PD.

Anal Chem. 2013 Sep 3;85(17):8385-90. doi: 10.1021/ac401783f. Epub 2013 Aug 19.


Top down proteomics of human membrane proteins from enriched mitochondrial fractions.

Catherman AD, Li M, Tran JC, Durbin KR, Compton PD, Early BP, Thomas PM, Kelleher NL.

Anal Chem. 2013 Feb 5;85(3):1880-8. doi: 10.1021/ac3031527. Epub 2013 Jan 23.


Spinning up mass spectrometry for whole protein complexes.

Compton PD, Kelleher NL.

Nat Methods. 2012 Nov;9(11):1065-6. doi: 10.1038/nmeth.2216. No abstract available.


Evaluation of the compact high-field orbitrap for top-down proteomics of human cells.

Ahlf DR, Compton PD, Tran JC, Early BP, Thomas PM, Kelleher NL.

J Proteome Res. 2012 Aug 3;11(8):4308-14. doi: 10.1021/pr3004216. Epub 2012 Jul 13.


Optimization of electron transfer dissociation via informed selection of reagents and operating parameters.

Compton PD, Strukl JV, Bai DL, Shabanowitz J, Hunt DF.

Anal Chem. 2012 Feb 7;84(3):1781-5. doi: 10.1021/ac202807h. Epub 2012 Jan 6.


Mapping intact protein isoforms in discovery mode using top-down proteomics.

Tran JC, Zamdborg L, Ahlf DR, Lee JE, Catherman AD, Durbin KR, Tipton JD, Vellaichamy A, Kellie JF, Li M, Wu C, Sweet SM, Early BP, Siuti N, LeDuc RD, Compton PD, Thomas PM, Kelleher NL.

Nature. 2011 Oct 30;480(7376):254-8. doi: 10.1038/nature10575.


On the scalability and requirements of whole protein mass spectrometry.

Compton PD, Zamdborg L, Thomas PM, Kelleher NL.

Anal Chem. 2011 Sep 1;83(17):6868-74. doi: 10.1021/ac2010795. Epub 2011 Jul 29.


Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis.

Wang Z, Udeshi ND, Slawson C, Compton PD, Sakabe K, Cheung WD, Shabanowitz J, Hunt DF, Hart GW.

Sci Signal. 2010 Jan 12;3(104):ra2. doi: 10.1126/scisignal.2000526.


Methods for analyzing peptides and proteins on a chromatographic timescale by electron-transfer dissociation mass spectrometry.

Udeshi ND, Compton PD, Shabanowitz J, Hunt DF, Rose KL.

Nat Protoc. 2008;3(11):1709-17. doi: 10.1038/nprot.2008.159.


Effects of methanol cryosolvents on the structural and catalytic properties of bovine trypsin.

Compton PD, Coll RJ, Fink AL.

J Biol Chem. 1986 Jan 25;261(3):1248-52.


Preparation and properties of covalent compounds and intermediates of serine proteases.

Coll RJ, Compton PD, Fink AL.

Methods Enzymol. 1982;87:66-76. No abstract available.


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