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Items: 1 to 50 of 94

1.

Quantitative methods to measure aneuploidy and chromosomal instability.

Godek KM, Compton DA.

Methods Cell Biol. 2018;144:15-32. doi: 10.1016/bs.mcb.2018.03.002. Epub 2018 Apr 24.

PMID:
29804667
2.

Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.

Dumitru AMG, Rusin SF, Clark AEM, Kettenbach AN, Compton DA.

Elife. 2017 Nov 20;6. pii: e29303. doi: 10.7554/eLife.29303.

3.

Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities.

Bakhoum SF, Kabeche L, Compton DA, Powell SN, Bastians H.

Trends Cancer. 2017 Mar;3(3):225-234. doi: 10.1016/j.trecan.2017.02.001. Epub 2017 Feb 28. Review.

4.

Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells.

Orr B, Talje L, Liu Z, Kwok BH, Compton DA.

Cell Rep. 2016 Nov 8;17(7):1755-1763. doi: 10.1016/j.celrep.2016.10.030.

5.

Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2.

Danilov AV, Hu S, Orr B, Godek K, Mustachio LM, Sekula D, Liu X, Kawakami M, Johnson FM, Compton DA, Freemantle SJ, Dmitrovsky E.

Mol Cancer Ther. 2016 Nov;15(11):2758-2766. Epub 2016 Aug 22.

6.

Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells.

Godek KM, Venere M, Wu Q, Mills KD, Hickey WF, Rich JN, Compton DA.

Cancer Discov. 2016 May;6(5):532-45. doi: 10.1158/2159-8290.CD-15-1154. Epub 2016 Mar 21.

7.

Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2.

Kim JS, He X, Orr B, Wutz G, Hill V, Peters JM, Compton DA, Waldman T.

PLoS Genet. 2016 Feb 12;12(2):e1005865. doi: 10.1371/journal.pgen.1005865. eCollection 2016 Feb.

8.

Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.

Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E.

Mol Cancer Ther. 2015 Nov;14(11):2576-85. doi: 10.1158/1535-7163.MCT-15-0443. Epub 2015 Aug 24.

9.

Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation.

Meppelink A, Kabeche L, Vromans MJ, Compton DA, Lens SM.

Cell Rep. 2015 Apr 28;11(4):508-15. doi: 10.1016/j.celrep.2015.03.052. Epub 2015 Apr 16.

10.

CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.

Hu S, Danilov AV, Godek K, Orr B, Tafe LJ, Rodriguez-Canales J, Behrens C, Mino B, Moran CA, Memoli VA, Mustachio LM, Galimberti F, Ravi S, DeCastro A, Lu Y, Sekula D, Andrew AS, Wistuba II, Freemantle S, Compton DA, Dmitrovsky E.

Cancer Res. 2015 May 15;75(10):2029-38. doi: 10.1158/0008-5472.CAN-14-1494. Epub 2015 Mar 25.

11.

Numerical chromosomal instability mediates susceptibility to radiation treatment.

Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA.

Nat Commun. 2015 Jan 21;6:5990. doi: 10.1038/ncomms6990.

12.

Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis.

Godek KM, Kabeche L, Compton DA.

Nat Rev Mol Cell Biol. 2015 Jan;16(1):57-64. doi: 10.1038/nrm3916. Epub 2014 Dec 3. Review.

13.

DNA-damage response during mitosis induces whole-chromosome missegregation.

Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA.

Cancer Discov. 2014 Nov;4(11):1281-9. doi: 10.1158/2159-8290.CD-14-0403. Epub 2014 Aug 8.

14.

STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments.

Kleyman M, Kabeche L, Compton DA.

J Cell Sci. 2014 Oct 1;127(Pt 19):4225-33. doi: 10.1242/jcs.151613. Epub 2014 Jul 29.

15.

The mitotic origin of chromosomal instability.

Bakhoum SF, Silkworth WT, Nardi IK, Nicholson JM, Compton DA, Cimini D.

Curr Biol. 2014 Feb 17;24(4):R148-9. doi: 10.1016/j.cub.2014.01.019. No abstract available.

16.

Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.

Kabeche L, Compton DA.

Nature. 2013 Oct 3;502(7469):110-3. doi: 10.1038/nature12507. Epub 2013 Sep 8.

17.

A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability.

Orr B, Compton DA.

Front Oncol. 2013 Jun 27;3:164. doi: 10.3389/fonc.2013.00164. Print 2013.

18.

Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments.

Maia AR, Garcia Z, Kabeche L, Barisic M, Maffini S, Macedo-Ribeiro S, Cheeseman IM, Compton DA, Kaverina I, Maiato H.

J Cell Biol. 2012 Oct 15;199(2):285-301. doi: 10.1083/jcb.201203091. Epub 2012 Oct 8.

19.

Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.

Hood EA, Kettenbach AN, Gerber SA, Compton DA.

Mol Biol Cell. 2012 Jun;23(12):2264-74. doi: 10.1091/mbc.E11-12-1013. Epub 2012 Apr 25.

20.

Chromosomal instability and cancer: a complex relationship with therapeutic potential.

Bakhoum SF, Compton DA.

J Clin Invest. 2012 Apr;122(4):1138-43. doi: 10.1172/JCI59954. Epub 2012 Apr 2. Review.

21.

Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells.

Kabeche L, Compton DA.

Curr Biol. 2012 Apr 10;22(7):638-44. doi: 10.1016/j.cub.2012.02.030. Epub 2012 Mar 8.

22.

Kinetochores and disease: keeping microtubule dynamics in check!

Bakhoum SF, Compton DA.

Curr Opin Cell Biol. 2012 Feb;24(1):64-70. doi: 10.1016/j.ceb.2011.11.012. Epub 2011 Dec 21. Review.

23.

Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma.

Bakhoum SF, Danilova OV, Kaur P, Levy NB, Compton DA.

Clin Cancer Res. 2011 Dec 15;17(24):7704-11. doi: 10.1158/1078-0432.CCR-11-2049.

24.

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors.

Thompson SL, Compton DA.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17974-8. doi: 10.1073/pnas.1109720108. Epub 2011 Oct 13.

25.

Spindle pole mechanics studied in mitotic asters: dynamic distribution of spindle forces through compliant linkages.

Charlebois BD, Kollu S, Schek HT, Compton DA, Hunt AJ.

Biophys J. 2011 Apr 6;100(7):1756-64. doi: 10.1016/j.bpj.2011.02.017.

26.

Anaphase catastrophe is a target for cancer therapy.

Galimberti F, Thompson SL, Ravi S, Compton DA, Dmitrovsky E.

Clin Cancer Res. 2011 Mar 15;17(6):1218-22. doi: 10.1158/1078-0432.CCR-10-1178. Epub 2011 Feb 2.

27.

Chromosomes and cancer cells.

Thompson SL, Compton DA.

Chromosome Res. 2011 Apr;19(3):433-44. doi: 10.1007/s10577-010-9179-y. Review.

28.

CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity.

Manning AL, Bakhoum SF, Maffini S, Correia-Melo C, Maiato H, Compton DA.

EMBO J. 2010 Oct 20;29(20):3531-43. doi: 10.1038/emboj.2010.230. Epub 2010 Sep 17.

29.

Mechanisms of aneuploidy.

Compton DA.

Curr Opin Cell Biol. 2011 Feb;23(1):109-13. doi: 10.1016/j.ceb.2010.08.007.

30.

Mechanisms of chromosomal instability.

Thompson SL, Bakhoum SF, Compton DA.

Curr Biol. 2010 Mar 23;20(6):R285-95. doi: 10.1016/j.cub.2010.01.034. Review.

31.

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.

Thompson SL, Compton DA.

J Cell Biol. 2010 Feb 8;188(3):369-81. doi: 10.1083/jcb.200905057. Epub 2010 Feb 1.

32.

Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe.

Galimberti F, Thompson SL, Liu X, Li H, Memoli V, Green SR, DiRenzo J, Greninger P, Sharma SV, Settleman J, Compton DA, Dmitrovsky E.

Clin Cancer Res. 2010 Jan 1;16(1):109-20. doi: 10.1158/1078-0432.CCR-09-2151. Epub 2009 Dec 22.

33.

Interplay of microtubule dynamics and sliding during bipolar spindle formation in mammalian cells.

Kollu S, Bakhoum SF, Compton DA.

Curr Biol. 2009 Dec 29;19(24):2108-13. doi: 10.1016/j.cub.2009.10.056.

34.

Deviant kinetochore microtubule dynamics underlie chromosomal instability.

Bakhoum SF, Genovese G, Compton DA.

Curr Biol. 2009 Dec 1;19(22):1937-42. doi: 10.1016/j.cub.2009.09.055. Epub 2009 Oct 29.

35.

Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.

Maffini S, Maia AR, Manning AL, Maliga Z, Pereira AL, Junqueira M, Shevchenko A, Hyman A, Yates JR 3rd, Galjart N, Compton DA, Maiato H.

Curr Biol. 2009 Sep 29;19(18):1566-72. doi: 10.1016/j.cub.2009.07.059. Epub 2009 Sep 3.

36.

Cancer: CINful centrosomes.

Bakhoum SF, Compton DA.

Curr Biol. 2009 Aug 11;19(15):R642-5. doi: 10.1016/j.cub.2009.06.039. Review.

37.

Genome stability is ensured by temporal control of kinetochore-microtubule dynamics.

Bakhoum SF, Thompson SL, Manning AL, Compton DA.

Nat Cell Biol. 2009 Jan;11(1):27-35. doi: 10.1038/ncb1809. Epub 2008 Dec 7.

38.

SnapShot: Nonmotor proteins in spindle assembly.

Manning AL, Compton DA.

Cell. 2008 Aug 22;134(4):694. doi: 10.1016/j.cell.2008.08.001. No abstract available.

39.

Examining the link between chromosomal instability and aneuploidy in human cells.

Thompson SL, Compton DA.

J Cell Biol. 2008 Feb 25;180(4):665-72. doi: 10.1083/jcb.200712029. Epub 2008 Feb 18.

40.

Structural and regulatory roles of nonmotor spindle proteins.

Manning AL, Compton DA.

Curr Opin Cell Biol. 2008 Feb;20(1):101-6. doi: 10.1016/j.ceb.2007.11.004. Epub 2008 Jan 4. Review.

41.

Chromosome orientation.

Compton DA.

J Cell Biol. 2007 Oct 22;179(2):179-81.

42.

Mitosis: springtime for chromatin.

Myers LC, Compton DA.

Curr Biol. 2007 Jun 19;17(12):R460-2.

43.

The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.

Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA.

Mol Biol Cell. 2007 Aug;18(8):2970-9. Epub 2007 May 30.

44.
45.

Mitosis: disorderly conduct at the kinetochore.

Compton DA.

Curr Biol. 2006 Jul 11;16(13):R494-6.

46.

Chromosomes walk the line.

Compton DA.

Nat Cell Biol. 2006 Apr;8(4):308-10. No abstract available.

PMID:
16607267
47.

Functional roles of poleward microtubule flux during mitosis.

Ganem NJ, Compton DA.

Cell Cycle. 2006 Mar;5(5):481-5. Epub 2006 Mar 1. Review.

PMID:
16552178
48.

Efficient mitosis in human cells lacking poleward microtubule flux.

Ganem NJ, Upton K, Compton DA.

Curr Biol. 2005 Oct 25;15(20):1827-32.

49.

Regulation of mitosis by poly(ADP-ribosyl)ation.

Compton DA.

Biochem J. 2005 Oct 15;391(Pt 2):e5-6.

50.

Mitosis: PARty time in the spindle.

Compton DA.

Curr Biol. 2005 Mar 8;15(5):R178-9. Review.

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