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Items: 1 to 50 of 96

1.

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.

Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV.

Am J Respir Crit Care Med. 2019 May 1;199(9):1076-1085. doi: 10.1164/rccm.201810-1869OC.

PMID:
30888839
2.

Endothelial Phenotype Evoked by Low Dose Carvedilol in Pulmonary Hypertension.

Cheong HI, Farha S, Park MM, Thomas JD, Saygin D, Comhair SAA, Sharp J, Highland KB, Tang WHW, Erzurum SC.

Front Cardiovasc Med. 2018 Dec 12;5:180. doi: 10.3389/fcvm.2018.00180. eCollection 2018.

3.

The utility of biomarkers in diagnosis of aspirin exacerbated respiratory disease.

Comhair SAA, Bochenek G, Baicker-McKee S, Wang Z, Stachura T, Sanak M, Hammel JP, Hazen SL, Erzurum SC, Nizankowska-Mogilnicka E.

Respir Res. 2018 Oct 30;19(1):210. doi: 10.1186/s12931-018-0909-6.

4.

ALX receptor ligands define a biochemical endotype for severe asthma.

Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD; National Heart Lung and Blood Institute’s Severe Asthma Research Program- Investigators.

JCI Insight. 2018 Mar 22;3(6). pii: 120932. doi: 10.1172/jci.insight.120932. No abstract available.

5.

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.

Peters MC, Kerr S, Dunican EM, Woodruff PG, Fajt ML, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Wenzel SE, Fahy JV; National Heart, Lung and Blood Institute Severe Asthma Research Program 3.

J Allergy Clin Immunol. 2019 Jan;143(1):104-113.e14. doi: 10.1016/j.jaci.2017.12.1009. Epub 2018 Mar 7.

PMID:
29524537
6.

Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38-Mitogen-activated Protein Kinase-Dependent Apoptosis.

Allawzi AM, Vang A, Clements RT, Jhun BS, Kue NR, Mancini TJ, Landi AK, Terentyev D, O-Uchi J, Comhair SA, Erzurum SC, Choudhary G.

Am J Respir Cell Mol Biol. 2018 May;58(5):658-667. doi: 10.1165/rcmb.2016-0344OC.

7.

PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics.

Hemnes AR, Beck GJ, Newman JH, Abidov A, Aldred MA, Barnard J, Berman Rosenzweig E, Borlaug BA, Chung WK, Comhair SAA, Erzurum SC, Frantz RP, Gray MP, Grunig G, Hassoun PM, Hill NS, Horn EM, Hu B, Lempel JK, Maron BA, Mathai SC, Olman MA, Rischard FP, Systrom DM, Tang WHW, Waxman AB, Xiao L, Yuan JX, Leopold JA; PVDOMICS Study Group.

Circ Res. 2017 Oct 27;121(10):1136-1139. doi: 10.1161/CIRCRESAHA.117.311737. No abstract available.

8.

Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age.

Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN.

J Allergy Clin Immunol Pract. 2018 Mar - Apr;6(2):545-554.e4. doi: 10.1016/j.jaip.2017.05.032. Epub 2017 Aug 31.

9.

Pulmonary arterial hypertension treatment with carvedilol for heart failure: a randomized controlled trial.

Farha S, Saygin D, Park MM, Cheong HI, Asosingh K, Comhair SA, Stephens OR, Roach EC, Sharp J, Highland KB, DiFilippo FP, Neumann DR, Tang WHW, Erzurum SC.

JCI Insight. 2017 Aug 17;2(16). pii: 95240. doi: 10.1172/jci.insight.95240. eCollection 2017 Aug 17.

10.

Arginine metabolic endotypes related to asthma severity.

Xu W, Comhair SAA, Janocha AJ, Lara A, Mavrakis LA, Bennett CD, Kalhan SC, Erzurum SC.

PLoS One. 2017 Aug 10;12(8):e0183066. doi: 10.1371/journal.pone.0183066. eCollection 2017.

11.

Natural killer cell-mediated inflammation resolution is disabled in severe asthma.

Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators.

Sci Immunol. 2017 Mar 10;2(9). pii: eaam5446. doi: 10.1126/sciimmunol.aam5446.

12.

Antioxidant defense and oxidative damage vary widely among high-altitude residents.

Janocha AJ, Comhair SAA, Basnyat B, Neupane M, Gebremedhin A, Khan A, Ricci KS, Zhang R, Erzurum SC, Beall CM.

Am J Hum Biol. 2017 Nov;29(6). doi: 10.1002/ajhb.23039. Epub 2017 Jul 20.

13.

ALX receptor ligands define a biochemical endotype for severe asthma.

Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD; National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators.

JCI Insight. 2017 Jul 20;2(14). pii: 93534. doi: 10.1172/jci.insight.93534. eCollection 2017 Jul 20. Erratum in: JCI Insight. 2018 Mar 22;3(6):.

14.

Genomic stability of pulmonary artery endothelial colony-forming cells in culture.

Drake KM, Federici C, Duong HT, Comhair SA, Erzurum SC, Asosingh K, Aldred MA.

Pulm Circ. 2017 Apr-Jun;7(2):421-427. doi: 10.1177/2045893217700901. Epub 2017 May 12.

15.

Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma.

Wang Z, DiDonato JA, Buffa J, Comhair SA, Aronica MA, Dweik RA, Lee NA, Lee JJ, Thomassen MJ, Kavuru M, Erzurum SC, Hazen SL.

J Biol Chem. 2016 Oct 14;291(42):22118-22135. Epub 2016 Sep 1.

16.

Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations.

Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators.

Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-313. doi: 10.1164/rccm.201602-0419OC. Erratum in: Am J Respir Crit Care Med. 2018 Apr 1;197(7):971.

17.

Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension.

Liu F, Haeger CM, Dieffenbach PB, Sicard D, Chrobak I, Coronata AM, Suárez Velandia MM, Vitali S, Colas RA, Norris PC, Marinković A, Liu X, Ma J, Rose CD, Lee SJ, Comhair SA, Erzurum SC, McDonald JD, Serhan CN, Walsh SR, Tschumperlin DJ, Fredenburgh LE.

JCI Insight. 2016 Jun 2;1(8). pii: e86987.

18.

Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012.

Zein JG, Udeh BL, Teague WG, Koroukian SM, Schlitz NK, Bleecker ER, Busse WB, Calhoun WJ, Castro M, Comhair SA, Fitzpatrick AM, Israel E, Wenzel SE, Holguin F, Gaston BM, Erzurum SC; Severe Asthma Research Program.

PLoS One. 2016 Jun 13;11(6):e0157301. doi: 10.1371/journal.pone.0157301. eCollection 2016.

19.

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts.

Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV; National Heart, Lung, and Blood Institute Severe Asthma Research Program.

Lancet Respir Med. 2016 Jul;4(7):574-584. doi: 10.1016/S2213-2600(16)30048-0. Epub 2016 Jun 6. Erratum in: Lancet Respir Med. 2018 Mar;6(3):e10.

20.

Increased mitochondrial arginine metabolism supports bioenergetics in asthma.

Xu W, Ghosh S, Comhair SA, Asosingh K, Janocha AJ, Mavrakis DA, Bennett CD, Gruca LL, Graham BB, Queisser KA, Kao CC, Wedes SH, Petrich JM, Tuder RM, Kalhan SC, Erzurum SC.

J Clin Invest. 2016 Jul 1;126(7):2465-81. doi: 10.1172/JCI82925. Epub 2016 May 23.

21.

Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial Hypertension.

Barnes JW, Kucera ET, Tian L, Mellor NE, Dvorina N, Baldwin WW 3rd, Aldred MA, Farver CF, Comhair SA, Aytekin M, Dweik RA.

Am J Respir Cell Mol Biol. 2016 Oct;55(4):564-575.

22.

Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension.

Ghosh S, Gupta M, Xu W, Mavrakis DA, Janocha AJ, Comhair SA, Haque MM, Stuehr DJ, Yu J, Polgar P, Naga Prasad SV, Erzurum SC.

Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1199-205. doi: 10.1152/ajplung.00092.2016. Epub 2016 Apr 29.

23.

Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma.

Ghosh A, Koziol-White CJ, Asosingh K, Cheng G, Ruple L, Groneberg D, Friebe A, Comhair SA, Stasch JP, Panettieri RA Jr, Aronica MA, Erzurum SC, Stuehr DJ.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2355-62. doi: 10.1073/pnas.1524398113. Epub 2016 Apr 11.

24.

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness.

Hoffman SM, Chapman DG, Lahue KG, Cahoon JM, Rattu GK, Daphtary N, Aliyeva M, Fortner KA, Erzurum SC, Comhair SA, Woodruff PG, Bhakta N, Dixon AE, Irvin CG, Janssen-Heininger YM, Poynter ME, Anathy V.

J Allergy Clin Immunol. 2016 Mar;137(3):822-32.e7. doi: 10.1016/j.jaci.2015.08.018. Epub 2015 Oct 4.

25.

Asthma Is More Severe in Older Adults.

Zein JG, Dweik RA, Comhair SA, Bleecker ER, Moore WC, Peters SP, Busse WW, Jarjour NN, Calhoun WJ, Castro M, Chung KF, Fitzpatrick A, Israel E, Teague WG, Wenzel SE, Love TE, Gaston BM, Erzurum SC; Severe Asthma Research Program.

PLoS One. 2015 Jul 22;10(7):e0133490. doi: 10.1371/journal.pone.0133490. eCollection 2015.

26.

Reply: To PMID 25488689.

Cowan DC, Taylor DR, Comhair SA.

J Allergy Clin Immunol. 2015 Aug;136(2):515-6. doi: 10.1016/j.jaci.2015.04.038. Epub 2015 Jun 9. No abstract available.

PMID:
26070884
27.

Metabolomic Endotype of Asthma.

Comhair SA, McDunn J, Bennett C, Fettig J, Erzurum SC, Kalhan SC.

J Immunol. 2015 Jul 15;195(2):643-50. doi: 10.4049/jimmunol.1500736. Epub 2015 Jun 5.

28.

Coenzyme Q in asthma.

Comhair SA, Grandon D, Khan A, Zhang R, Hazen SL, Erzurum SC.

Am J Respir Crit Care Med. 2015 Jun 1;191(11):1336-8. doi: 10.1164/rccm.201412-2259LE. No abstract available.

29.

Arginine metabolic endotypes in pulmonary arterial hypertension.

Kao CC, Wedes SH, Hsu JW, Bohren KM, Comhair SA, Jahoor F, Erzurum SC.

Pulm Circ. 2015 Mar;5(1):124-34. doi: 10.1086/679720.

30.

Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension.

Federici C, Drake KM, Rigelsky CM, McNelly LN, Meade SL, Comhair SA, Erzurum SC, Aldred MA.

Am J Respir Crit Care Med. 2015 Jul 15;192(2):219-28. doi: 10.1164/rccm.201411-2128OC.

31.

Endothelial chromosome 13 deletion in congenital heart disease-associated pulmonary arterial hypertension dysregulates SMAD9 signaling.

Drake KM, Comhair SA, Erzurum SC, Tuder RM, Aldred MA.

Am J Respir Crit Care Med. 2015 Apr 1;191(7):850-4. doi: 10.1164/rccm.201411-1985LE. No abstract available.

32.

Carboxyhemoglobin and methemoglobin in asthma.

Naples R, Laskowski D, McCarthy K, Mattox E, Comhair SA, Erzurum SC.

Lung. 2015 Apr;193(2):183-7. doi: 10.1007/s00408-015-9686-x. Epub 2015 Feb 14.

33.

O-linked β-N-acetylglucosamine transferase directs cell proliferation in idiopathic pulmonary arterial hypertension.

Barnes JW, Tian L, Heresi GA, Farver CF, Asosingh K, Comhair SA, Aulak KS, Dweik RA.

Circulation. 2015 Apr 7;131(14):1260-8. doi: 10.1161/CIRCULATIONAHA.114.013878. Epub 2015 Feb 6.

34.

Biomarker-based asthma phenotypes of corticosteroid response.

Cowan DC, Taylor DR, Peterson LE, Cowan JO, Palmay R, Williamson A, Hammel J, Erzurum SC, Hazen SL, Comhair SA.

J Allergy Clin Immunol. 2015 Apr;135(4):877-83.e1. doi: 10.1016/j.jaci.2014.10.026. Epub 2014 Dec 6.

35.

Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.

Kim J, Hwangbo C, Hu X, Kang Y, Papangeli I, Mehrotra D, Park H, Ju H, McLean DL, Comhair SA, Erzurum SC, Chun HJ.

Circulation. 2015 Jan 13;131(2):190-9. doi: 10.1161/CIRCULATIONAHA.114.013339. Epub 2014 Oct 21.

36.

Coenzyme Q supplementation in pulmonary arterial hypertension.

Sharp J, Farha S, Park MM, Comhair SA, Lundgrin EL, Tang WH, Bongard RD, Merker MP, Erzurum SC.

Redox Biol. 2014 Jul 31;2:884-91. doi: 10.1016/j.redox.2014.06.010. eCollection 2014.

37.

Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation.

Penumatsa KC, Toksoz D, Warburton RR, Hilmer AJ, Liu T, Khosla C, Comhair SA, Fanburg BL.

Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L576-85. doi: 10.1152/ajplung.00162.2014. Epub 2014 Aug 15.

38.

Redox imaging of inflammation in asthma.

Ratanamaneechat S, Neumann DR, Difilippo FP, Comhair SA, Asosingh K, Ghosh S, Grandon D, Khan A, Aronica MA, Erzurum SC.

Am J Respir Crit Care Med. 2014 Mar 15;189(6):743-6. doi: 10.1164/rccm.201310-1872LE. No abstract available.

39.

A novel method for pulmonary research: assessment of bioenergetic function at the air-liquid interface.

Xu W, Janocha AJ, Leahy RA, Klatte R, Dudzinski D, Mavrakis LA, Comhair SA, Lauer ME, Cotton CU, Erzurum SC.

Redox Biol. 2014 Jan 16;2:513-9. doi: 10.1016/j.redox.2014.01.004. eCollection 2014.

40.

Modification of hyaluronan by heavy chains of inter-α-inhibitor in idiopathic pulmonary arterial hypertension.

Lauer ME, Aytekin M, Comhair SA, Loftis J, Tian L, Farver CF, Hascall VC, Dweik RA.

J Biol Chem. 2014 Mar 7;289(10):6791-8. doi: 10.1074/jbc.M113.512491. Epub 2014 Jan 8.

41.

Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year.

Lundgrin EL, Park MM, Sharp J, Tang WH, Thomas JD, Asosingh K, Comhair SA, DiFilippo FP, Neumann DR, Davis L, Graham BB, Tuder RM, Dostanic I, Erzurum SC.

Ann Am Thorac Soc. 2013 Feb;10(1):1-9. doi: 10.1513/AnnalsATS.201206-029OC.

42.

Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma.

Ghelfi E, Yu CW, Elmasri H, Terwelp M, Lee CG, Bhandari V, Comhair SA, Erzurum SC, Hotamisligil GS, Elias JA, Cataltepe S.

Am J Pathol. 2013 Apr;182(4):1425-33. doi: 10.1016/j.ajpath.2012.12.009. Epub 2013 Feb 4.

43.

High mobility group box 1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of Toll-like receptor 4.

Bauer EM, Shapiro R, Zheng H, Ahmad F, Ishizawar D, Comhair SA, Erzurum SC, Billiar TR, Bauer PM.

Mol Med. 2013 Feb 8;18:1509-18. doi: 10.2119/molmed.2012.00283.

44.

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension.

Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ.

Nat Med. 2013 Jan;19(1):74-82. doi: 10.1038/nm.3040. Epub 2012 Dec 23.

45.

An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype.

Holguin F, Comhair SA, Hazen SL, Powers RW, Khatri SS, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Chung KF, Erzurum SC, Wenzel SE.

Am J Respir Crit Care Med. 2013 Jan 15;187(2):153-9. doi: 10.1164/rccm.201207-1270OC. Epub 2012 Nov 29.

46.

Disulfide bond as a switch for copper-zinc superoxide dismutase activity in asthma.

Ghosh S, Willard B, Comhair SA, Dibello P, Xu W, Shiva S, Aulak KS, Kinter M, Erzurum SC.

Antioxid Redox Signal. 2013 Feb 1;18(4):412-23. doi: 10.1089/ars.2012.4566. Epub 2012 Sep 7.

47.

Mast cell number, phenotype, and function in human pulmonary arterial hypertension.

Farha S, Sharp J, Asosingh K, Park M, Comhair SA, Tang WH, Thomas J, Farver C, Hsieh F, Loyd JE, Erzurum SC.

Pulm Circ. 2012 Apr-Jun;2(2):220-8. doi: 10.4103/2045-8932.97609.

48.

Pulmonary artery endothelium resident endothelial colony-forming cells in pulmonary arterial hypertension.

Duong HT, Comhair SA, Aldred MA, Mavrakis L, Savasky BM, Erzurum SC, Asosingh K.

Pulm Circ. 2011 Oct-Dec;1(4):475-86. doi: 10.4103/2045-8932.93547.

49.

Serotonylated fibronectin is elevated in pulmonary hypertension.

Wei L, Warburton RR, Preston IR, Roberts KE, Comhair SA, Erzurum SC, Hill NS, Fanburg BL.

Am J Physiol Lung Cell Mol Physiol. 2012 Jun 15;302(12):L1273-9. doi: 10.1152/ajplung.00082.2012. Epub 2012 Apr 20.

50.

Human primary lung endothelial cells in culture.

Comhair SA, Xu W, Mavrakis L, Aldred MA, Asosingh K, Erzurum SC.

Am J Respir Cell Mol Biol. 2012 Jun;46(6):723-30. doi: 10.1165/rcmb.2011-0416TE. Epub 2012 Mar 15.

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