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Items: 1 to 50 of 122

1.

HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma.

Zein J, Gaston B, Bazeley P, DeBoer MD, Igo RP Jr, Bleecker ER, Meyers D, Comhair S, Marozkina NV, Cotton C, Patel M, Alyamani M, Xu W, Busse WW, Calhoun WJ, Ortega V, Hawkins GA, Castro M, Chung KF, Fahy JV, Fitzpatrick AM, Israel E, Jarjour NN, Levy B, Mauger DT, Moore WC, Noel P, Peters SP, Teague WG, Wenzel SE, Erzurum SC, Sharifi N.

Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2187-2193. doi: 10.1073/pnas.1918819117. Epub 2020 Jan 13.

2.

O-GlcNAc Transferase Regulates Angiogenesis in Idiopathic Pulmonary Arterial Hypertension.

Barnes JW, Tian L, Krick S, Helton ES, Denson RS, Comhair SAA, Dweik RA.

Int J Mol Sci. 2019 Dec 13;20(24). pii: E6299. doi: 10.3390/ijms20246299.

3.

Integrative proteomics and phosphoproteomics in pulmonary arterial hypertension.

Xu W, Comhair SAA, Chen R, Hu B, Hou Y, Zhou Y, Mavrakis LA, Janocha AJ, Li L, Zhang D, Willard BB, Asosingh K, Cheng F, Erzurum SC.

Sci Rep. 2019 Dec 9;9(1):18623. doi: 10.1038/s41598-019-55053-6.

4.

Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension.

Oliveira SDS, Chen J, Castellon M, Mao M, Raj JU, Comhair S, Erzurum S, Silva CLM, Machado RF, Bonini MG, Minshall RD.

Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1191-1202. doi: 10.1161/ATVBAHA.118.312038.

PMID:
30943774
5.

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.

Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV.

Am J Respir Crit Care Med. 2019 May 1;199(9):1076-1085. doi: 10.1164/rccm.201810-1869OC.

PMID:
30888839
6.

IL-27 targets Foxp3+ Tregs to mediate antiinflammatory functions during experimental allergic airway inflammation.

Nguyen QT, Jang E, Le HT, Kim S, Kim D, Dvorina N, Aronica MA, Baldwin WM 3rd, Asosingh K, Comhair S, Min B.

JCI Insight. 2019 Jan 24;4(2). pii: 123216. doi: 10.1172/jci.insight.123216. [Epub ahead of print]

7.

Endothelial Phenotype Evoked by Low Dose Carvedilol in Pulmonary Hypertension.

Cheong HI, Farha S, Park MM, Thomas JD, Saygin D, Comhair SAA, Sharp J, Highland KB, Tang WHW, Erzurum SC.

Front Cardiovasc Med. 2018 Dec 12;5:180. doi: 10.3389/fcvm.2018.00180. eCollection 2018.

8.

Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1.

Ma Z, Yu YR, Badea CT, Kovacs JJ, Xiong X, Comhair S, Piantadosi CA, Rajagopal S.

Circulation. 2019 Mar 26;139(13):1629-1642. doi: 10.1161/CIRCULATIONAHA.118.034961.

PMID:
30586762
9.

The utility of biomarkers in diagnosis of aspirin exacerbated respiratory disease.

Comhair SAA, Bochenek G, Baicker-McKee S, Wang Z, Stachura T, Sanak M, Hammel JP, Hazen SL, Erzurum SC, Nizankowska-Mogilnicka E.

Respir Res. 2018 Oct 30;19(1):210. doi: 10.1186/s12931-018-0909-6.

10.

Therapeutic Engagement of the Histone Deacetylase IIA-Myocyte Enhancer Factor 2 Axis Improves Experimental Pulmonary Hypertension.

Sofer A, Lee S, Papangeli I, Adachi T, Hwangbo C, Comhair S, DaSilva-Jardine P, Kim J, Schwarz JJ, Erzurum SC, Chun HJ.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1345-1348. doi: 10.1164/rccm.201805-0817LE. No abstract available.

11.

ALX receptor ligands define a biochemical endotype for severe asthma.

Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD; National Heart Lung and Blood Institute’s Severe Asthma Research Program- Investigators.

JCI Insight. 2018 Mar 22;3(6). pii: 120932. doi: 10.1172/jci.insight.120932. No abstract available.

12.

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.

Peters MC, Kerr S, Dunican EM, Woodruff PG, Fajt ML, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Wenzel SE, Fahy JV; National Heart, Lung and Blood Institute Severe Asthma Research Program 3.

J Allergy Clin Immunol. 2019 Jan;143(1):104-113.e14. doi: 10.1016/j.jaci.2017.12.1009. Epub 2018 Mar 7.

13.

Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1.

Sysol JR, Chen J, Singla S, Zhao S, Comhair S, Natarajan V, Machado RF.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L461-L472. doi: 10.1152/ajplung.00057.2017. Epub 2017 Nov 22.

14.

Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38-Mitogen-activated Protein Kinase-Dependent Apoptosis.

Allawzi AM, Vang A, Clements RT, Jhun BS, Kue NR, Mancini TJ, Landi AK, Terentyev D, O-Uchi J, Comhair SA, Erzurum SC, Choudhary G.

Am J Respir Cell Mol Biol. 2018 May;58(5):658-667. doi: 10.1165/rcmb.2016-0344OC.

15.

PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics.

Hemnes AR, Beck GJ, Newman JH, Abidov A, Aldred MA, Barnard J, Berman Rosenzweig E, Borlaug BA, Chung WK, Comhair SAA, Erzurum SC, Frantz RP, Gray MP, Grunig G, Hassoun PM, Hill NS, Horn EM, Hu B, Lempel JK, Maron BA, Mathai SC, Olman MA, Rischard FP, Systrom DM, Tang WHW, Waxman AB, Xiao L, Yuan JX, Leopold JA; PVDOMICS Study Group.

Circ Res. 2017 Oct 27;121(10):1136-1139. doi: 10.1161/CIRCRESAHA.117.311737. No abstract available.

16.

Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age.

Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN.

J Allergy Clin Immunol Pract. 2018 Mar - Apr;6(2):545-554.e4. doi: 10.1016/j.jaip.2017.05.032. Epub 2017 Aug 31.

17.

Pulmonary arterial hypertension treatment with carvedilol for heart failure: a randomized controlled trial.

Farha S, Saygin D, Park MM, Cheong HI, Asosingh K, Comhair SA, Stephens OR, Roach EC, Sharp J, Highland KB, DiFilippo FP, Neumann DR, Tang WHW, Erzurum SC.

JCI Insight. 2017 Aug 17;2(16). pii: 95240. doi: 10.1172/jci.insight.95240. eCollection 2017 Aug 17.

18.

Arginine metabolic endotypes related to asthma severity.

Xu W, Comhair SAA, Janocha AJ, Lara A, Mavrakis LA, Bennett CD, Kalhan SC, Erzurum SC.

PLoS One. 2017 Aug 10;12(8):e0183066. doi: 10.1371/journal.pone.0183066. eCollection 2017.

19.

Natural killer cell-mediated inflammation resolution is disabled in severe asthma.

Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators.

Sci Immunol. 2017 Mar 10;2(9). pii: eaam5446. doi: 10.1126/sciimmunol.aam5446.

20.

Antioxidant defense and oxidative damage vary widely among high-altitude residents.

Janocha AJ, Comhair SAA, Basnyat B, Neupane M, Gebremedhin A, Khan A, Ricci KS, Zhang R, Erzurum SC, Beall CM.

Am J Hum Biol. 2017 Nov;29(6). doi: 10.1002/ajhb.23039. Epub 2017 Jul 20.

21.

ALX receptor ligands define a biochemical endotype for severe asthma.

Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD; National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators.

JCI Insight. 2017 Jul 20;2(14). pii: 93534. doi: 10.1172/jci.insight.93534. eCollection 2017 Jul 20. Erratum in: JCI Insight. 2018 Mar 22;3(6):.

22.

Genomic stability of pulmonary artery endothelial colony-forming cells in culture.

Drake KM, Federici C, Duong HT, Comhair SA, Erzurum SC, Asosingh K, Aldred MA.

Pulm Circ. 2017 Apr-Jun;7(2):421-427. doi: 10.1177/2045893217700901. Epub 2017 May 12.

23.

Modulation of Endothelial Bone Morphogenetic Protein Receptor Type 2 Activity by Vascular Endothelial Growth Factor Receptor 3 in Pulmonary Arterial Hypertension.

Hwangbo C, Lee HW, Kang H, Ju H, Wiley DS, Papangeli I, Han J, Kim JD, Dunworth WP, Hu X, Lee S, El-Hely O, Sofer A, Pak B, Peterson L, Comhair S, Hwang EM, Park JY, Thomas JL, Bautch VL, Erzurum SC, Chun HJ, Jin SW.

Circulation. 2017 Jun 6;135(23):2288-2298. doi: 10.1161/CIRCULATIONAHA.116.025390. Epub 2017 Mar 29.

24.

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension.

Chen J, Sysol JR, Singla S, Zhao S, Yamamura A, Valdez-Jasso D, Abbasi T, Shioura KM, Sahni S, Reddy V, Sridhar A, Gao H, Torres J, Camp SM, Tang H, Ye SQ, Comhair S, Dweik R, Hassoun P, Yuan JX, Garcia JGN, Machado RF.

Circulation. 2017 Apr 18;135(16):1532-1546. doi: 10.1161/CIRCULATIONAHA.116.024557. Epub 2017 Feb 15.

25.

Co-Occurrence of Asthma and Nephrolithiasis in Children.

Kartha GK, Li I, Comhair S, Erzurum SC, Monga M.

PLoS One. 2017 Jan 12;12(1):e0168813. doi: 10.1371/journal.pone.0168813. eCollection 2017.

26.

Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma.

Wang Z, DiDonato JA, Buffa J, Comhair SA, Aronica MA, Dweik RA, Lee NA, Lee JJ, Thomassen MJ, Kavuru M, Erzurum SC, Hazen SL.

J Biol Chem. 2016 Oct 14;291(42):22118-22135. Epub 2016 Sep 1.

27.

Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations.

Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators.

Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-313. doi: 10.1164/rccm.201602-0419OC. Erratum in: Am J Respir Crit Care Med. 2018 Apr 1;197(7):971.

28.

Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension.

Liu F, Haeger CM, Dieffenbach PB, Sicard D, Chrobak I, Coronata AM, Suárez Velandia MM, Vitali S, Colas RA, Norris PC, Marinković A, Liu X, Ma J, Rose CD, Lee SJ, Comhair SA, Erzurum SC, McDonald JD, Serhan CN, Walsh SR, Tschumperlin DJ, Fredenburgh LE.

JCI Insight. 2016 Jun 2;1(8). pii: e86987.

29.

Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012.

Zein JG, Udeh BL, Teague WG, Koroukian SM, Schlitz NK, Bleecker ER, Busse WB, Calhoun WJ, Castro M, Comhair SA, Fitzpatrick AM, Israel E, Wenzel SE, Holguin F, Gaston BM, Erzurum SC; Severe Asthma Research Program.

PLoS One. 2016 Jun 13;11(6):e0157301. doi: 10.1371/journal.pone.0157301. eCollection 2016.

30.

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts.

Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV; National Heart, Lung, and Blood Institute Severe Asthma Research Program.

Lancet Respir Med. 2016 Jul;4(7):574-584. doi: 10.1016/S2213-2600(16)30048-0. Epub 2016 Jun 6. Erratum in: Lancet Respir Med. 2018 Mar;6(3):e10.

31.

Pathological Hyaluronan Matrices in Cystic Fibrosis Airways and Secretions.

Matuska B, Comhair S, Farver C, Chmiel J, Midura RJ, Bonfield T, Lauer ME.

Am J Respir Cell Mol Biol. 2016 Oct;55(4):576-585.

32.

Mitochondrial Haplogroups and Risk of Pulmonary Arterial Hypertension.

Farha S, Hu B, Comhair S, Zein J, Dweik R, Erzurum SC, Aldred MA.

PLoS One. 2016 May 25;11(5):e0156042. doi: 10.1371/journal.pone.0156042. eCollection 2016.

33.

Isolation and analysis of sugar nucleotides using solid phase extraction and fluorophore assisted carbohydrate electrophoresis.

Barnes J, Tian L, Loftis J, Hiznay J, Comhair S, Lauer M, Dweik R.

MethodsX. 2016 Mar 14;3:251-60. doi: 10.1016/j.mex.2016.03.010. eCollection 2016.

34.

Increased mitochondrial arginine metabolism supports bioenergetics in asthma.

Xu W, Ghosh S, Comhair SA, Asosingh K, Janocha AJ, Mavrakis DA, Bennett CD, Gruca LL, Graham BB, Queisser KA, Kao CC, Wedes SH, Petrich JM, Tuder RM, Kalhan SC, Erzurum SC.

J Clin Invest. 2016 Jul 1;126(7):2465-81. doi: 10.1172/JCI82925. Epub 2016 May 23.

35.

Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial Hypertension.

Barnes JW, Kucera ET, Tian L, Mellor NE, Dvorina N, Baldwin WW 3rd, Aldred MA, Farver CF, Comhair SA, Aytekin M, Dweik RA.

Am J Respir Cell Mol Biol. 2016 Oct;55(4):564-575.

36.

Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension.

Ghosh S, Gupta M, Xu W, Mavrakis DA, Janocha AJ, Comhair SA, Haque MM, Stuehr DJ, Yu J, Polgar P, Naga Prasad SV, Erzurum SC.

Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1199-205. doi: 10.1152/ajplung.00092.2016. Epub 2016 Apr 29.

37.

Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma.

Ghosh A, Koziol-White CJ, Asosingh K, Cheng G, Ruple L, Groneberg D, Friebe A, Comhair SA, Stasch JP, Panettieri RA Jr, Aronica MA, Erzurum SC, Stuehr DJ.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2355-62. doi: 10.1073/pnas.1524398113. Epub 2016 Apr 11.

38.

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness.

Hoffman SM, Chapman DG, Lahue KG, Cahoon JM, Rattu GK, Daphtary N, Aliyeva M, Fortner KA, Erzurum SC, Comhair SA, Woodruff PG, Bhakta N, Dixon AE, Irvin CG, Janssen-Heininger YM, Poynter ME, Anathy V.

J Allergy Clin Immunol. 2016 Mar;137(3):822-32.e7. doi: 10.1016/j.jaci.2015.08.018. Epub 2015 Oct 4.

39.

Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation.

Lauer ME, Majors AK, Comhair S, Ruple LM, Matuska B, Subramanian A, Farver C, Dworski R, Grandon D, Laskowski D, Dweik RA, Erzurum SC, Hascall VC, Aronica MA.

J Biol Chem. 2015 Sep 18;290(38):23124-34. doi: 10.1074/jbc.M115.663823. Epub 2015 Jul 24.

40.

Asthma Is More Severe in Older Adults.

Zein JG, Dweik RA, Comhair SA, Bleecker ER, Moore WC, Peters SP, Busse WW, Jarjour NN, Calhoun WJ, Castro M, Chung KF, Fitzpatrick A, Israel E, Teague WG, Wenzel SE, Love TE, Gaston BM, Erzurum SC; Severe Asthma Research Program.

PLoS One. 2015 Jul 22;10(7):e0133490. doi: 10.1371/journal.pone.0133490. eCollection 2015.

41.

Impaired Global Right Ventricular Longitudinal Strain Predicts Long-Term Adverse Outcomes in Patients with Pulmonary Arterial Hypertension.

Park JH, Park MM, Farha S, Sharp J, Lundgrin E, Comhair S, Tang WH, Erzurum SC, Thomas JD.

J Cardiovasc Ultrasound. 2015 Jun;23(2):91-9. doi: 10.4250/jcu.2015.23.2.91. Epub 2015 Jun 26.

42.

Reply: To PMID 25488689.

Cowan DC, Taylor DR, Comhair SA.

J Allergy Clin Immunol. 2015 Aug;136(2):515-6. doi: 10.1016/j.jaci.2015.04.038. Epub 2015 Jun 9. No abstract available.

PMID:
26070884
43.

Metabolomic Endotype of Asthma.

Comhair SA, McDunn J, Bennett C, Fettig J, Erzurum SC, Kalhan SC.

J Immunol. 2015 Jul 15;195(2):643-50. doi: 10.4049/jimmunol.1500736. Epub 2015 Jun 5.

44.

Coenzyme Q in asthma.

Comhair SA, Grandon D, Khan A, Zhang R, Hazen SL, Erzurum SC.

Am J Respir Crit Care Med. 2015 Jun 1;191(11):1336-8. doi: 10.1164/rccm.201412-2259LE. No abstract available.

45.

Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma.

Gupta MK, Asosingh K, Aronica M, Comhair S, Cao G, Erzurum S, Panettieri RA Jr, Naga Prasad SV.

PLoS One. 2015 May 29;10(5):e0125803. doi: 10.1371/journal.pone.0125803. eCollection 2015.

46.

Arginine metabolic endotypes in pulmonary arterial hypertension.

Kao CC, Wedes SH, Hsu JW, Bohren KM, Comhair SA, Jahoor F, Erzurum SC.

Pulm Circ. 2015 Mar;5(1):124-34. doi: 10.1086/679720.

47.

Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension.

Federici C, Drake KM, Rigelsky CM, McNelly LN, Meade SL, Comhair SA, Erzurum SC, Aldred MA.

Am J Respir Crit Care Med. 2015 Jul 15;192(2):219-28. doi: 10.1164/rccm.201411-2128OC.

48.

Endothelial chromosome 13 deletion in congenital heart disease-associated pulmonary arterial hypertension dysregulates SMAD9 signaling.

Drake KM, Comhair SA, Erzurum SC, Tuder RM, Aldred MA.

Am J Respir Crit Care Med. 2015 Apr 1;191(7):850-4. doi: 10.1164/rccm.201411-1985LE. No abstract available.

49.

Shot-noise limited Faraday rotation spectroscopy for detection of nitric oxide isotopes in breath, urine, and blood.

Wang Y, Nikodem M, Zhang E, Cikach F, Barnes J, Comhair S, Dweik RA, Kao C, Wysocki G.

Sci Rep. 2015 Mar 13;5:9096. doi: 10.1038/srep09096.

50.

Carboxyhemoglobin and methemoglobin in asthma.

Naples R, Laskowski D, McCarthy K, Mattox E, Comhair SA, Erzurum SC.

Lung. 2015 Apr;193(2):183-7. doi: 10.1007/s00408-015-9686-x. Epub 2015 Feb 14.

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