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Items: 37


Nephron progenitor commitment is a stochastic process influenced by cell migration.

Lawlor KT, Zappia L, Lefevre J, Park JS, Hamilton NA, Oshlack A, Little MH, Combes AN.

Elife. 2019 Jan 24;8. pii: e41156. doi: 10.7554/eLife.41156.


Single-cell analysis reveals congruence between kidney organoids and human fetal kidney.

Combes AN, Zappia L, Er PX, Oshlack A, Little MH.

Genome Med. 2019 Jan 23;11(1):3. doi: 10.1186/s13073-019-0615-0.


Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis.

Yermalovich AV, Osborne JK, Sousa P, Han A, Kinney MA, Chen MJ, Robinton DA, Montie H, Pearson DS, Wilson SB, Combes AN, Little MH, Daley GQ.

Nat Commun. 2019 Jan 11;10(1):168. doi: 10.1038/s41467-018-08127-4.


Evaluation of variability in human kidney organoids.

Phipson B, Er PX, Combes AN, Forbes TA, Howden SE, Zappia L, Yen HJ, Lawlor KT, Hale LJ, Sun J, Wolvetang E, Takasato M, Oshlack A, Little MH.

Nat Methods. 2019 Jan;16(1):79-87. doi: 10.1038/s41592-018-0253-2. Epub 2018 Dec 20.


Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment.

O'Brien LL, Combes AN, Short KM, Lindstr├Âm NO, Whitney PH, Cullen-McEwen LA, Ju A, Abdelhalim A, Michos O, Bertram JF, Smyth IM, Little MH, McMahon AP.

Elife. 2018 Dec 5;7. pii: e40392. doi: 10.7554/eLife.40392.


Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration.

Short KM, Combes AN, Lisnyak V, Lefevre JG, Jones LK, Little MH, Hamilton NA, Smyth IM.

Elife. 2018 Jul 31;7. pii: e38992. doi: 10.7554/eLife.38992.


Hamartin regulates cessation of mouse nephrogenesis independently of Mtor.

Volovelsky O, Nguyen T, Jarmas AE, Combes AN, Wilson SB, Little MH, Witte DP, Brunskill EW, Kopan R.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5998-6003. doi: 10.1073/pnas.1712955115. Epub 2018 May 21.


Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis.

Lambert B, MacLean AL, Fletcher AG, Combes AN, Little MH, Byrne HM.

J Math Biol. 2018 Jun;76(7):1673-1697. doi: 10.1007/s00285-018-1208-z. Epub 2018 Feb 1.


Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number.

Combes AN, Wilson S, Phipson B, Binnie BB, Ju A, Lawlor KT, Cebrian C, Walton SL, Smyth IM, Moritz KM, Kopan R, Oshlack A, Little MH.

Kidney Int. 2018 Mar;93(3):589-598. doi: 10.1016/j.kint.2017.09.015. Epub 2017 Dec 6.


Self-organisation after embryonic kidney dissociation is driven via selective adhesion of ureteric epithelial cells.

Lefevre JG, Chiu HS, Combes AN, Vanslambrouck JM, Ju A, Hamilton NA, Little MH.

Development. 2017 Mar 15;144(6):1087-1096. doi: 10.1242/dev.140228. Epub 2017 Feb 7.


Analysed cap mesenchyme track data from live imaging of mouse kidney development.

Lefevre JG, Combes AN, Little MH, Hamilton NA.

Data Brief. 2016 Sep 1;9:149-54. doi: 10.1016/j.dib.2016.08.053. eCollection 2016 Dec.


Understanding kidney morphogenesis to guide renal tissue regeneration.

Little MH, Combes AN, Takasato M.

Nat Rev Nephrol. 2016 Oct;12(10):624-35. doi: 10.1038/nrneph.2016.126. Epub 2016 Aug 30. Review.


Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip.

Combes AN, Lefevre JG, Wilson S, Hamilton NA, Little MH.

Dev Biol. 2016 Oct 15;418(2):297-306. doi: 10.1016/j.ydbio.2016.06.028. Epub 2016 Jun 23.


ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation.

Wainwright EN, Wilhelm D, Combes AN, Little MH, Koopman P.

Dev Biol. 2015 Aug 15;404(2):88-102. doi: 10.1016/j.ydbio.2015.05.023. Epub 2015 Jun 23.


A spatially-averaged mathematical model of kidney branching morphogenesis.

Zubkov VS, Combes AN, Short KM, Lefevre J, Hamilton NA, Smyth IM, Little MH, Byrne HM.

J Theor Biol. 2015 Aug 21;379:24-37. doi: 10.1016/j.jtbi.2015.04.015. Epub 2015 Apr 24.


Cell-cell interactions driving kidney morphogenesis.

Combes AN, Davies JA, Little MH.

Curr Top Dev Biol. 2015;112:467-508. doi: 10.1016/bs.ctdb.2014.12.002. Epub 2015 Feb 12. Review.


Towards a quantitative model of kidney morphogenesis.

Combes AN.

Nephrology (Carlton). 2015 May;20(5):312-4. doi: 10.1111/nep.12407. Review.


Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of ╬▒-globin transgene variegation.

Sorolla A, Tallack MR, Oey H, Harten SK, Daxinger LC, Magor GW, Combes AN, Ilsley M, Whitelaw E, Perkins AC.

Genomics. 2015 Feb;105(2):116-22. doi: 10.1016/j.ygeno.2014.09.013. Epub 2014 Oct 31.


An integrated pipeline for the multidimensional analysis of branching morphogenesis.

Combes AN, Short KM, Lefevre J, Hamilton NA, Little MH, Smyth IM.

Nat Protoc. 2014 Dec;9(12):2859-79. doi: 10.1038/nprot.2014.193. Epub 2014 Nov 20.


Global quantification of tissue dynamics in the developing mouse kidney.

Short KM, Combes AN, Lefevre J, Ju AL, Georgas KM, Lamberton T, Cairncross O, Rumballe BA, McMahon AP, Hamilton NA, Smyth IM, Little MH.

Dev Cell. 2014 Apr 28;29(2):188-202. doi: 10.1016/j.devcel.2014.02.017.


Luminal mitosis drives epithelial cell dispersal within the branching ureteric bud.

Packard A, Georgas K, Michos O, Riccio P, Cebrian C, Combes AN, Ju A, Ferrer-Vaquer A, Hadjantonakis AK, Zong H, Little MH, Costantini F.

Dev Cell. 2013 Nov 11;27(3):319-30. doi: 10.1016/j.devcel.2013.09.001. Epub 2013 Oct 31.


Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures.

Cerruti B, Puliafito A, Shewan AM, Yu W, Combes AN, Little MH, Chianale F, Primo L, Serini G, Mostov KE, Celani A, Gamba A.

J Cell Biol. 2013 Oct 28;203(2):359-72. doi: 10.1083/jcb.201305044. Epub 2013 Oct 21.


Modelling cell turnover in a complex tissue during development.

Lefevre J, Marshall DJ, Combes AN, Ju AL, Little MH, Hamilton NA.

J Theor Biol. 2013 Dec 7;338:66-79. doi: 10.1016/j.jtbi.2013.08.033. Epub 2013 Sep 7.


MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis.

Rakoczy J, Fernandez-Valverde SL, Glazov EA, Wainwright EN, Sato T, Takada S, Combes AN, Korbie DJ, Miller D, Grimmond SM, Little MH, Asahara H, Mattick JS, Taft RJ, Wilhelm D.

Biol Reprod. 2013 Jun 6;88(6):143. doi: 10.1095/biolreprod.113.107607. Print 2013 Jun.


Epigenetics and developmental programming of adult onset diseases.

O'Sullivan L, Combes AN, Moritz KM.

Pediatr Nephrol. 2012 Dec;27(12):2175-82. Review.


Nephron formation adopts a novel spatial topology at cessation of nephrogenesis.

Rumballe BA, Georgas KM, Combes AN, Ju AL, Gilbert T, Little MH.

Dev Biol. 2011 Dec 1;360(1):110-22. doi: 10.1016/j.ydbio.2011.09.011. Epub 2011 Sep 21.


Expression and functional analysis of Dkk1 during early gonadal development.

Combes AN, Bowles J, Feng CW, Chiu HS, Khoo PL, Jackson A, Little MH, Tam PP, Koopman P.

Sex Dev. 2011;5(3):124-30. doi: 10.1159/000327709. Epub 2011 May 24.


Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome.

Bagheri-Fam S, Argentaro A, Svingen T, Combes AN, Sinclair AH, Koopman P, Harley VR.

Hum Mol Genet. 2011 Jun 1;20(11):2213-24. doi: 10.1093/hmg/ddr109. Epub 2011 Mar 22. Erratum in: Hum Mol Genet. 2011 Sep 1;20(17):3535.


Epigenetic reprogramming: enforcer or enabler of developmental fate?

Combes AN, Whitelaw E.

Dev Growth Differ. 2010 Aug;52(6):483-91. doi: 10.1111/j.1440-169X.2010.01185.x. Review.


Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation.

Combes AN, Spiller CM, Harley VR, Sinclair AH, Dunwoodie SL, Wilhelm D, Koopman P.

Int J Dev Biol. 2010;54(4):683-9. doi: 10.1387/ijdb.092920ac.


Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.

Georgas K, Rumballe B, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, Taylor D, Grimmond SM, Potter SS, McMahon AP, Little MH.

Dev Biol. 2009 Aug 15;332(2):273-86. doi: 10.1016/j.ydbio.2009.05.578. Epub 2009 Jun 6.


Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.

Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P.

Dev Dyn. 2009 May;238(5):1033-41. doi: 10.1002/dvdy.21925.


Ex vivo magnetofection: a novel strategy for the study of gene function in mouse organogenesis.

Svingen T, Wilhelm D, Combes AN, Hosking B, Harley VR, Sinclair AH, Koopman P.

Dev Dyn. 2009 Apr;238(4):956-64. doi: 10.1002/dvdy.21919.


Endothelial cell migration directs testis cord formation.

Combes AN, Wilhelm D, Davidson T, Dejana E, Harley V, Sinclair A, Koopman P.

Dev Biol. 2009 Feb 1;326(1):112-20. doi: 10.1016/j.ydbio.2008.10.040. Epub 2008 Nov 7.


SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development.

Wilhelm D, Hiramatsu R, Mizusaki H, Widjaja L, Combes AN, Kanai Y, Koopman P.

J Biol Chem. 2007 Apr 6;282(14):10553-60. Epub 2007 Feb 2.


Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination.

Wilhelm D, Martinson F, Bradford S, Wilson MJ, Combes AN, Beverdam A, Bowles J, Mizusaki H, Koopman P.

Dev Biol. 2005 Nov 1;287(1):111-24. Epub 2005 Sep 26.


Pisrt1, a gene implicated in XX sex reversal, is expressed in gonads of both sexes during mouse development.

Loffler KA, Combes AN, Wilhelm D, Beverdam A, Bowles J, Koopman P.

Mol Genet Metab. 2005 Sep-Oct;86(1-2):286-92.


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