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Items: 1 to 50 of 74

1.

Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks.

Grimes M, Hall B, Foltz L, Levy T, Rikova K, Gaiser J, Cook W, Smirnova E, Wheeler T, Clark NR, Lachmann A, Zhang B, Hornbeck P, Ma'ayan A, Comb M.

Sci Signal. 2018 May 22;11(531). pii: eaaq1087. doi: 10.1126/scisignal.aaq1087.

PMID:
29789295
2.

Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts.

Palacios-Moreno J, Foltz L, Guo A, Stokes MP, Kuehn ED, George L, Comb M, Grimes ML.

PLoS Comput Biol. 2015 Apr 17;11(4):e1004130. doi: 10.1371/journal.pcbi.1004130. eCollection 2015 Apr.

3.

Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.

Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN.

Mol Cell. 2014 Feb 20;53(4):577-90. doi: 10.1016/j.molcel.2013.12.018. Epub 2014 Jan 23.

4.

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ.

Mol Cell Proteomics. 2014 Jan;13(1):372-87. doi: 10.1074/mcp.O113.027870. Epub 2013 Oct 15.

5.

Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs.

Dhar S, Vemulapalli V, Patananan AN, Huang GL, Di Lorenzo A, Richard S, Comb MJ, Guo A, Clarke SG, Bedford MT.

Sci Rep. 2013;3:1311. doi: 10.1038/srep01311.

6.

Quantitative profiling of DNA damage and apoptotic pathways in UV damaged cells using PTMScan Direct.

Stokes MP, Silva JC, Jia X, Lee KA, Polakiewicz RD, Comb MJ.

Int J Mol Sci. 2012 Dec 21;14(1):286-307. doi: 10.3390/ijms14010286.

7.

Phosphorylation and assembly of glutamate receptors after brain ischemia.

Zhang F, Guo A, Liu C, Comb M, Hu B.

Stroke. 2013 Jan;44(1):170-6. doi: 10.1161/STROKEAHA.112.667253. Epub 2012 Dec 4.

8.

Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer.

Ren H, Tan ZP, Zhu X, Crosby K, Haack H, Ren JM, Beausoleil S, Moritz A, Innocenti G, Rush J, Zhang Y, Zhou XM, Gu TL, Yang YF, Comb MJ.

Cancer Res. 2012 Jul 1;72(13):3312-23. doi: 10.1158/0008-5472.CAN-11-3931. Epub 2012 May 8.

9.

A proteomics approach for the identification and cloning of monoclonal antibodies from serum.

Cheung WC, Beausoleil SA, Zhang X, Sato S, Schieferl SM, Wieler JS, Beaudet JG, Ramenani RK, Popova L, Comb MJ, Rush J, Polakiewicz RD.

Nat Biotechnol. 2012 Mar 25;30(5):447-52. doi: 10.1038/nbt.2167.

PMID:
22446692
10.

PTMScan direct: identification and quantification of peptides from critical signaling proteins by immunoaffinity enrichment coupled with LC-MS/MS.

Stokes MP, Farnsworth CL, Moritz A, Silva JC, Jia X, Lee KA, Guo A, Polakiewicz RD, Comb MJ.

Mol Cell Proteomics. 2012 May;11(5):187-201. doi: 10.1074/mcp.M111.015883. Epub 2012 Feb 9.

11.

The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY.

Ezell SA, Polytarchou C, Hatziapostolou M, Guo A, Sanidas I, Bihani T, Comb MJ, Sourvinos G, Tsichlis PN.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):E613-21. doi: 10.1073/pnas.1115029109. Epub 2012 Feb 6.

12.

Systematic and quantitative assessment of the ubiquitin-modified proteome.

Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.

Mol Cell. 2011 Oct 21;44(2):325-40. doi: 10.1016/j.molcel.2011.08.025. Epub 2011 Sep 8.

13.

Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma.

Gu TL, Deng X, Huang F, Tucker M, Crosby K, Rimkunas V, Wang Y, Deng G, Zhu L, Tan Z, Hu Y, Wu C, Nardone J, MacNeill J, Ren J, Reeves C, Innocenti G, Norris B, Yuan J, Yu J, Haack H, Shen B, Peng C, Li H, Zhou X, Liu X, Rush J, Comb MJ.

PLoS One. 2011 Jan 6;6(1):e15640. doi: 10.1371/journal.pone.0015640.

14.

Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases.

Moritz A, Li Y, Guo A, Villén J, Wang Y, MacNeill J, Kornhauser J, Sprott K, Zhou J, Possemato A, Ren JM, Hornbeck P, Cantley LC, Gygi SP, Rush J, Comb MJ.

Sci Signal. 2010 Aug 24;3(136):ra64. doi: 10.1126/scisignal.2000998.

15.

Calorie restriction alters mitochondrial protein acetylation.

Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB.

Aging Cell. 2009 Sep;8(5):604-6. doi: 10.1111/j.1474-9726.2009.00503.x. Epub 2009 Jul 9.

16.

Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer.

Yu J, Kane S, Wu J, Benedettini E, Li D, Reeves C, Innocenti G, Wetzel R, Crosby K, Becker A, Ferrante M, Cheung WC, Hong X, Chirieac LR, Sholl LM, Haack H, Smith BL, Polakiewicz RD, Tan Y, Gu TL, Loda M, Zhou X, Comb MJ.

Clin Cancer Res. 2009 May 1;15(9):3023-8. doi: 10.1158/1078-0432.CCR-08-2739. Epub 2009 Apr 14.

17.

The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.

Boccalatte FE, Voena C, Riganti C, Bosia A, D'Amico L, Riera L, Cheng M, Ruggeri B, Jensen ON, Goss VL, Lee K, Nardone J, Rush J, Polakiewicz RD, Comb MJ, Chiarle R, Inghirami G.

Blood. 2009 Mar 19;113(12):2776-90. doi: 10.1182/blood-2008-06-161018. Epub 2008 Oct 9.

18.

A wide-ranging cellular response to UV damage of DNA.

Stokes MP, Comb MJ.

Cell Cycle. 2008 Jul 15;7(14):2097-9. Epub 2008 May 21. Erratum in: Cell Cycle. 2008 Sep 1;7(17):2774.

PMID:
18635954
19.

HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization.

Li Y, Zhang X, Polakiewicz RD, Yao TP, Comb MJ.

J Biol Chem. 2008 May 9;283(19):12686-90. doi: 10.1074/jbc.C700185200. Epub 2008 Mar 20.

20.

Signaling networks assembled by oncogenic EGFR and c-Met.

Guo A, Villén J, Kornhauser J, Lee KA, Stokes MP, Rikova K, Possemato A, Nardone J, Innocenti G, Wetzel R, Wang Y, MacNeill J, Mitchell J, Gygi SP, Rush J, Polakiewicz RD, Comb MJ.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):692-7. doi: 10.1073/pnas.0707270105. Epub 2008 Jan 7.

21.

Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.

Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ.

Cell. 2007 Dec 14;131(6):1190-203.

22.

Profiling of UV-induced ATM/ATR signaling pathways.

Stokes MP, Rush J, Macneill J, Ren JM, Sprott K, Nardone J, Yang V, Beausoleil SA, Gygi SP, Livingstone M, Zhang H, Polakiewicz RD, Comb MJ.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19855-60. Epub 2007 Dec 6.

23.

Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia.

Gu TL, Goss VL, Reeves C, Popova L, Nardone J, Macneill J, Walters DK, Wang Y, Rush J, Comb MJ, Druker BJ, Polakiewicz RD.

Blood. 2006 Dec 15;108(13):4202-4. Epub 2006 Aug 31.

24.

A common phosphotyrosine signature for the Bcr-Abl kinase.

Goss VL, Lee KA, Moritz A, Nardone J, Spek EJ, MacNeill J, Rush J, Comb MJ, Polakiewicz RD.

Blood. 2006 Jun 15;107(12):4888-97. Epub 2006 Feb 23.

25.

Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase.

Balan V, Leicht DT, Zhu J, Balan K, Kaplun A, Singh-Gupta V, Qin J, Ruan H, Comb MJ, Tzivion G.

Mol Biol Cell. 2006 Mar;17(3):1141-53. Epub 2006 Jan 11.

26.

A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D.

Döppler H, Storz P, Li J, Comb MJ, Toker A.

J Biol Chem. 2005 Apr 15;280(15):15013-9. Epub 2005 Feb 22.

27.

High throughput proteome screening for biomarker detection.

Pan S, Zhang H, Rush J, Eng J, Zhang N, Patterson D, Comb MJ, Aebersold R.

Mol Cell Proteomics. 2005 Feb;4(2):182-90. Epub 2005 Jan 5.

28.

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ.

Nat Biotechnol. 2005 Jan;23(1):94-101. Epub 2004 Dec 12.

PMID:
15592455
29.

Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding.

Shen YH, Godlewski J, Bronisz A, Zhu J, Comb MJ, Avruch J, Tzivion G.

Mol Biol Cell. 2003 Nov;14(11):4721-33. Epub 2003 Aug 7.

30.

A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.

Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J.

J Biol Chem. 2003 Sep 12;278(37):34897-909. Epub 2003 Jul 2.

31.

Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs.

Zhang H, Zha X, Tan Y, Hornbeck PV, Mastrangelo AJ, Alessi DR, Polakiewicz RD, Comb MJ.

J Biol Chem. 2002 Oct 18;277(42):39379-87. Epub 2002 Jul 31.

32.

STK25 is a candidate gene for pseudopseudohypoparathyroidism.

Davids MS, Crawford E, Weremowicz S, Morton CC, Copeland NG, Gilbert DJ, Jenkins NA, Phelan MC, Comb MJ, Melnick MB.

Genomics. 2001 Sep;77(1-2):2-4.

PMID:
11543625
33.
34.

BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival.

Tan Y, Demeter MR, Ruan H, Comb MJ.

J Biol Chem. 2000 Aug 18;275(33):25865-9.

35.

FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions.

Peterson RT, Beal PA, Comb MJ, Schreiber SL.

J Biol Chem. 2000 Mar 10;275(10):7416-23.

36.

p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway.

Tan Y, Ruan H, Demeter MR, Comb MJ.

J Biol Chem. 1999 Dec 3;274(49):34859-67.

37.

Survival- and death-promoting events after transient cerebral ischemia: phosphorylation of Akt, release of cytochrome C and Activation of caspase-like proteases.

Ouyang YB, Tan Y, Comb M, Liu CL, Martone ME, Siesjö BK, Hu BR.

J Cereb Blood Flow Metab. 1999 Oct;19(10):1126-35.

PMID:
10532637
38.

mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control.

Polakiewicz RD, Schieferl SM, Gingras AC, Sonenberg N, Comb MJ.

J Biol Chem. 1998 Sep 4;273(36):23534-41.

39.

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.

Weng QP, Kozlowski M, Belham C, Zhang A, Comb MJ, Avruch J.

J Biol Chem. 1998 Jun 26;273(26):16621-9.

40.

A mitogen-activated protein kinase pathway is required for mu-opioid receptor desensitization.

Polakiewicz RD, Schieferl SM, Dorner LF, Kansra V, Comb MJ.

J Biol Chem. 1998 May 15;273(20):12402-6.

41.

Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a.

Low KG, Dorner LF, Fernando DB, Grossman J, Jeang KT, Comb MJ.

J Virol. 1997 Mar;71(3):1956-62.

42.

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.

Tan Y, Rouse J, Zhang A, Cariati S, Cohen P, Comb MJ.

EMBO J. 1996 Sep 2;15(17):4629-42.

44.

Fibroblast growth factor and cyclic AMP (cAMP) synergistically activate gene expression at a cAMP response element.

Tan Y, Low KG, Boccia C, Grossman J, Comb MJ.

Mol Cell Biol. 1994 Nov;14(11):7546-56.

45.
47.

Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression.

Chu HM, Tan Y, Kobierski LA, Balsam LB, Comb MJ.

Mol Endocrinol. 1994 Jan;8(1):59-68.

PMID:
8152431
48.

Stress-induced regulation of a human proenkephalin-beta-galactosidase fusion gene in the hypothalamus of transgenic mice.

Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, Comb M, Hyman SE.

Mol Endocrinol. 1994 Jan;8(1):116-25.

PMID:
8152426
49.

Everything activates c-fos--how can it matter?

Hyman SE, Kosofsky BE, Nguyen TV, Cohen BM, Comb MJ.

NIDA Res Monogr. 1993;125:25-38. Review.

PMID:
8341366
50.

Expression and regulation of a proenkephalin beta-galactosidase fusion gene in the reproductive system of transgenic mice.

Borsook D, Rosen H, Collard M, Dressler H, Herrup K, Comb MJ, Hyman SE.

Mol Endocrinol. 1992 Sep;6(9):1502-12.

PMID:
1435791

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