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Items: 31


Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90.

Jin J, Tian R, Pasculescu A, Dai AY, Williton K, Taylor L, Savitski MM, Bantscheff M, Woodgett JR, Pawson T, Colwill K.

Mol Cell Biol. 2016 Jan 11;36(6):1007-18. doi: 10.1128/MCB.01045-15.


Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K.

Sci Signal. 2015 Apr 7;8(371):rs3. doi: 10.1126/scisignal.2005700.


CoreFlow: a computational platform for integration, analysis and modeling of complex biological data.

Pasculescu A, Schoof EM, Creixell P, Zheng Y, Olhovsky M, Tian R, So J, Vanderlaan RD, Pawson T, Linding R, Colwill K.

J Proteomics. 2014 Apr 4;100:167-73. doi: 10.1016/j.jprot.2014.01.023. Epub 2014 Feb 3.


Temporal regulation of EGF signalling networks by the scaffold protein Shc1.

Zheng Y, Zhang C, Croucher DR, Soliman MA, St-Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Colwill K, Dai AY, Bagshaw R, Dennis JW, Gingras AC, Daly RJ, Pawson T.

Nature. 2013 Jul 11;499(7457):166-71. doi: 10.1038/nature12308.


MERTK interactions with SH2-domain proteins in the retinal pigment epithelium.

Shelby SJ, Colwill K, Dhe-Paganon S, Pawson T, Thompson DA.

PLoS One. 2013;8(2):e53964. doi: 10.1371/journal.pone.0053964. Epub 2013 Feb 4.


Splice-mediated motif switching regulates disabled-1 phosphorylation and SH2 domain interactions.

Gao Z, Poon HY, Li L, Li X, Palmesino E, Glubrecht DD, Colwill K, Dutta I, Kania A, Pawson T, Godbout R.

Mol Cell Biol. 2012 Jul;32(14):2794-808. doi: 10.1128/MCB.00570-12. Epub 2012 May 14.


Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).

Gustafsson MO, Hussain A, Mohammad DK, Mohamed AJ, Nguyen V, Metalnikov P, Colwill K, Pawson T, Smith CI, Nore BF.

Mol Cell Biol. 2012 Jul;32(13):2440-53. doi: 10.1128/MCB.06620-11. Epub 2012 Apr 23.


OpenFreezer: a reagent information management software system.

Olhovsky M, Williton K, Dai AY, Pasculescu A, Lee JP, Goudreault M, Wells CD, Park JG, Gingras AC, Linding R, Pawson T, Colwill K.

Nat Methods. 2011 Jul 28;8(8):612-3. doi: 10.1038/nmeth.1658. No abstract available.


Mapping protein interactions by combining antibody affinity maturation and mass spectrometry.

Dyson MR, Zheng Y, Zhang C, Colwill K, Pershad K, Kay BK, Pawson T, McCafferty J.

Anal Biochem. 2011 Oct 1;417(1):25-35. doi: 10.1016/j.ab.2011.05.005. Epub 2011 May 31.


A roadmap to generate renewable protein binders to the human proteome.

Colwill K; Renewable Protein Binder Working Group, Gräslund S.

Nat Methods. 2011 May 15;8(7):551-8. doi: 10.1038/nmeth.1607.


ProHits: integrated software for mass spectrometry-based interaction proteomics.

Liu G, Zhang J, Larsen B, Stark C, Breitkreutz A, Lin ZY, Breitkreutz BJ, Ding Y, Colwill K, Pasculescu A, Pawson T, Wrana JL, Nesvizhskii AI, Raught B, Tyers M, Gingras AC.

Nat Biotechnol. 2010 Oct;28(10):1015-7. doi: 10.1038/nbt1010-1015. No abstract available.


NOS1AP associates with Scribble and regulates dendritic spine development.

Richier L, Williton K, Clattenburg L, Colwill K, O'Brien M, Tsang C, Kolar A, Zinck N, Metalnikov P, Trimble WS, Krueger SR, Pawson T, Fawcett JP.

J Neurosci. 2010 Mar 31;30(13):4796-805. doi: 10.1523/JNEUROSCI.3726-09.2010.


Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display.

Pershad K, Pavlovic JD, Gräslund S, Nilsson P, Colwill K, Karatt-Vellatt A, Schofield DJ, Dyson MR, Pawson T, Kay BK, McCafferty J.

Protein Eng Des Sel. 2010 Apr;23(4):279-88. doi: 10.1093/protein/gzq003. Epub 2010 Feb 17.


Towards proteome scale antibody selections using phage display.

Mersmann M, Meier D, Mersmann J, Helmsing S, Nilsson P, Gräslund S; Structural Genomics Consortium, Colwill K, Hust M, Dübel S.

N Biotechnol. 2010 May 31;27(2):118-28. doi: 10.1016/j.nbt.2009.10.007. Epub 2009 Oct 31.


NetworKIN: a resource for exploring cellular phosphorylation networks.

Linding R, Jensen LJ, Pasculescu A, Olhovsky M, Colwill K, Bork P, Yaffe MB, Pawson T.

Nucleic Acids Res. 2008 Jan;36(Database issue):D695-9. Epub 2007 Nov 2.


Defining the specificity space of the human SRC homology 2 domain.

Huang H, Li L, Wu C, Schibli D, Colwill K, Ma S, Li C, Roy P, Ho K, Songyang Z, Pawson T, Gao Y, Li SS.

Mol Cell Proteomics. 2008 Apr;7(4):768-84. Epub 2007 Oct 22.


Systematic discovery of in vivo phosphorylation networks.

Linding R, Jensen LJ, Ostheimer GJ, van Vugt MA, Jørgensen C, Miron IM, Diella F, Colwill K, Taylor L, Elder K, Metalnikov P, Nguyen V, Pasculescu A, Jin J, Park JG, Samson LD, Woodgett JR, Russell RB, Bork P, Yaffe MB, Pawson T.

Cell. 2007 Jun 29;129(7):1415-26. Epub 2007 Jun 14.


Large-scale mapping of human protein-protein interactions by mass spectrometry.

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D.

Mol Syst Biol. 2007;3:89. Epub 2007 Mar 13.


A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.

Wells CD, Fawcett JP, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T.

Cell. 2006 May 5;125(3):535-48.


Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites.

Colwill K, Wells CD, Elder K, Goudreault M, Hersi K, Kulkarni S, Hardy WR, Pawson T, Morin GB.

BMC Biotechnol. 2006 Mar 6;6:13.


Characterization of the yeast amphiphysins Rvs161p and Rvs167p reveals roles for the Rvs heterodimer in vivo.

Friesen H, Humphries C, Ho Y, Schub O, Colwill K, Andrews B.

Mol Biol Cell. 2006 Mar;17(3):1306-21. Epub 2006 Jan 4.


WW domains provide a platform for the assembly of multiprotein networks.

Ingham RJ, Colwill K, Howard C, Dettwiler S, Lim CS, Yu J, Hersi K, Raaijmakers J, Gish G, Mbamalu G, Taylor L, Yeung B, Vassilovski G, Amin M, Chen F, Matskova L, Winberg G, Ernberg I, Linding R, O'donnell P, Starostine A, Keller W, Metalnikov P, Stark C, Pawson T.

Mol Cell Biol. 2005 Aug;25(16):7092-106.


Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1.

Johnston JB, Wang G, Barrett JW, Nazarian SH, Colwill K, Moran M, McFadden G.

J Virol. 2005 Aug;79(16):10750-63.


Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking.

Friesen H, Colwill K, Robertson K, Schub O, Andrews B.

Genetics. 2005 Jun;170(2):555-68. Epub 2005 Mar 31. Erratum in: Genetics. 2009 Aug;182(4):1399.


Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak.

Wang G, Barrett JW, Nazarian SH, Everett H, Gao X, Bleackley C, Colwill K, Moran MF, McFadden G.

J Virol. 2004 Jul;78(13):7097-111.


Interaction of yeast Rvs167 and Pho85 cyclin-dependent kinase complexes may link the cell cycle to the actin cytoskeleton.

Lee J, Colwill K, Aneliunas V, Tennyson C, Moore L, Ho Y, Andrews B.

Curr Biol. 1998 Dec 3;8(24):1310-21.


RS cyclophilins: identification of an NK-TR1-related cyclophilin.

Nestel FP, Colwill K, Harper S, Pawson T, Anderson SK.

Gene. 1996 Nov 21;180(1-2):151-5.


SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors.

Colwill K, Feng LL, Yeakley JM, Gish GD, Cáceres JF, Pawson T, Fu XD.

J Biol Chem. 1996 Oct 4;271(40):24569-75.


The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

Colwill K, Pawson T, Andrews B, Prasad J, Manley JL, Bell JC, Duncan PI.

EMBO J. 1996 Jan 15;15(2):265-75.

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