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Items: 1 to 50 of 855

1.

Review article: bacteriophages in gastroenterology-from biology to clinical applications.

Sabino J, Hirten RP, Colombel JF.

Aliment Pharmacol Ther. 2019 Nov 7. doi: 10.1111/apt.15557. [Epub ahead of print] Review.

PMID:
31696976
2.

Efficacy and safety of tofacitinib dose de-escalation and dose escalation for patients with ulcerative colitis: results from OCTAVE Open.

Sands BE, Armuzzi A, Marshall JK, Lindsay JO, Sandborn WJ, Danese S, Panés J, Bressler B, Colombel JF, Lawendy N, Maller E, Zhang H, Chan G, Salese L, Tsilkos K, Marren A, Su C.

Aliment Pharmacol Ther. 2019 Oct 29. doi: 10.1111/apt.15555. [Epub ahead of print]

PMID:
31660640
3.

Correlation of Stool Frequency and Abdominal Pain Measures With Simple Endoscopic Score for Crohn's Disease.

Lewis JD, Rutgeerts P, Feagan BG, D'haens G, Danese S, Colombel JF, Reinisch W, Rubin DT, Selinger C, Bewtra M, Barcomb L, Lacerda AP, Wallace K, Butler JW, Wu M, Zhou Q, Liao X, Sandborn WJ.

Inflamm Bowel Dis. 2019 Oct 23. pii: izz241. doi: 10.1093/ibd/izz241. [Epub ahead of print]

PMID:
31644790
4.

Anastomotic Ulcers After Ileocolic Resection for Crohn's Disease Are Common and Predict Recurrence.

Hirten RP, Ungaro RC, Castaneda D, Lopatin S, Sands BE, Colombel JF, Cohen BL.

Inflamm Bowel Dis. 2019 Oct 19. pii: izz224. doi: 10.1093/ibd/izz224. [Epub ahead of print]

PMID:
31639193
5.

Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases.

Verhelst X, Dias AM, Colombel JF, Vermeire S, Van Vlierberghe H, Callewaert N, Pinho SS.

Gastroenterology. 2019 Oct 15. pii: S0016-5085(19)41451-0. doi: 10.1053/j.gastro.2019.08.060. [Epub ahead of print] Review.

6.

Endoscopic activity in asymptomatic patients with an ileal pouch is associated with an increased risk of pouchitis.

Kayal M, Plietz M, Radcliffe M, Rizvi A, Yzet C, Tixier E, Hirten RP, Cohen B, Sylla P, Khaitov S, Greenstein A, Colombel JF, Dubinsky MC, Ungaro RC.

Aliment Pharmacol Ther. 2019 Dec;50(11-12):1189-1194. doi: 10.1111/apt.15505. Epub 2019 Oct 3.

PMID:
31579976
7.

Vedolizumab versus Adalimumab for Moderate-to-Severe Ulcerative Colitis.

Sands BE, Peyrin-Biroulet L, Loftus EV Jr, Danese S, Colombel JF, Törüner M, Jonaitis L, Abhyankar B, Chen J, Rogers R, Lirio RA, Bornstein JD, Schreiber S; VARSITY Study Group.

N Engl J Med. 2019 Sep 26;381(13):1215-1226. doi: 10.1056/NEJMoa1905725.

PMID:
31553834
8.

Emergent colectomy rates decreased while elective ileal pouch rates were stable over time: a nationwide inpatient sample study.

Kayal M, Saha A, Poojary P, Paramsothy S, Hirten R, Cohen L, Gallinger Z, Mehandru S, Cho J, Greenstein A, Nadkarni G, Dubinsky MC, Colombel JF, Cohen B, Ungaro R.

Int J Colorectal Dis. 2019 Oct;34(10):1771-1779. doi: 10.1007/s00384-019-03375-2. Epub 2019 Sep 11.

PMID:
31512019
9.

Association Between Indefinite Dysplasia and Advanced Neoplasia in Patients With Inflammatory Bowel Diseases Undergoing Surveillance.

Mahmoud R, Shah SC, Torres J, Castaneda D, Glass J, Elman J, Kumar A, Axelrad J, Harpaz N, Ullman T, Colombel JF, Oldenburg B, Itzkowitz SH.

Clin Gastroenterol Hepatol. 2019 Aug 22. pii: S1542-3565(19)30907-3. doi: 10.1016/j.cgh.2019.08.032. [Epub ahead of print]

PMID:
31446183
10.

Neonatal Life Events and the Risk of Inflammatory Bowel Disease.

Sabino J, Torres J, Colombel JF, Peter I.

Gastroenterology. 2019 Nov;157(5):1440-1441. doi: 10.1053/j.gastro.2019.04.055. Epub 2019 Aug 20. No abstract available.

PMID:
31442434
11.

Stopping Mesalamine Therapy in Patients With Crohn's Disease Starting Biologic Therapy Does Not Increase Risk of Adverse Outcomes.

Ungaro RC, Limketkai BN, Jensen CB, Yzet C, Allin KH, Agrawal M, Ullman T, Burisch J, Jess T, Colombel JF.

Clin Gastroenterol Hepatol. 2019 Aug 13. pii: S1542-3565(19)30887-0. doi: 10.1016/j.cgh.2019.08.012. [Epub ahead of print]

PMID:
31419574
12.

Outcomes and Strategies to Support a Treat-to-target Approach in Inflammatory Bowel Disease: A Systematic Review.

Colombel JF, D'haens G, Lee WJ, Petersson J, Panaccione R.

J Crohns Colitis. 2019 Aug 12. pii: jjz131. doi: 10.1093/ecco-jcc/jjz131. [Epub ahead of print]

PMID:
31403666
13.

Viewpoint: Inflammatory bowel diseases among immigrants from low- to high-incidence countries: opportunities and considerations.

Agrawal M, Burisch J, Colombel JF, Shah SC.

J Crohns Colitis. 2019 Jul 30. pii: jjz139. doi: 10.1093/ecco-jcc/jjz139. [Epub ahead of print]

PMID:
31359034
14.

Comparison of the EMA and FDA Guidelines on Ulcerative Colitis Drug Development.

Reinisch W, Gottlieb K, Colombel JF, Danese S, Panaccione R, Panes J, Peyrin-Biroulet L, Rubin D, Sands BE, Schreiber S, Vermeire S, Mulberg A, Sandborn B.

Clin Gastroenterol Hepatol. 2019 Aug;17(9):1673-1679.e1. doi: 10.1016/j.cgh.2018.10.032. Epub 2018 Oct 26. Review.

PMID:
31352970
15.

Changing epidemiology of immune-mediated inflammatory diseases in immigrants: A systematic review of population-based studies.

Agrawal M, Shah S, Patel A, Pinotti R, Colombel JF, Burisch J.

J Autoimmun. 2019 Dec;105:102303. doi: 10.1016/j.jaut.2019.07.002. Epub 2019 Jul 25.

PMID:
31351784
16.

Hormone Therapy for Cancer Is a Risk Factor for Relapse of Inflammatory Bowel Diseases.

Axelrad JE, Bazarbashi A, Zhou J, Castañeda D, Gujral A, Sperling D, Glass J, Agrawal M, Hong S, Lawlor G, Hudesman D, Chang S, Shah S, Yajnik V, Ananthakrishnan A, Khalili H, Colombel JF, Itzkowitz S; New York Crohn’s and Colitis Organization.

Clin Gastroenterol Hepatol. 2019 Jul 11. pii: S1542-3565(19)30735-9. doi: 10.1016/j.cgh.2019.06.042. [Epub ahead of print]

PMID:
31302306
17.

Tight control for Crohn's disease with adalimumab-based treatment is cost-effective: an economic assessment of the CALM trial.

Panaccione R, Colombel JF, Travis SPL, Bossuyt P, Baert F, Vaňásek T, Danalıoğlu A, Novacek G, Armuzzi A, Reinisch W, Johnson S, Buessing M, Neimark E, Petersson J, Lee WJ, D'Haens GR.

Gut. 2019 Jul 8. pii: gutjnl-2019-318256. doi: 10.1136/gutjnl-2019-318256. [Epub ahead of print]

18.

Endoscopic, Radiologic, and Histologic Healing With Vedolizumab in Patients With Active Crohn's Disease.

Danese S, Sandborn WJ, Colombel JF, Vermeire S, Glover SC, Rimola J, Siegelman J, Jones S, Bornstein JD, Feagan BG.

Gastroenterology. 2019 Oct;157(4):1007-1018.e7. doi: 10.1053/j.gastro.2019.06.038. Epub 2019 Jul 4.

19.

Treating Inflammatory Bowel Disease With Diet: A Taste Test.

Sabino J, Lewis JD, Colombel JF.

Gastroenterology. 2019 Aug;157(2):295-297. doi: 10.1053/j.gastro.2019.06.027. Epub 2019 Jun 27. No abstract available.

PMID:
31254503
20.

Systematic review with meta-analysis: association between Helicobacter pylori CagA seropositivity and odds of inflammatory bowel disease.

Tepler A, Narula N, Peek RM Jr, Patel A, Edelson C, Colombel JF, Shah SC.

Aliment Pharmacol Ther. 2019 Jul;50(2):121-131. doi: 10.1111/apt.15306. Epub 2019 Jun 5. Review.

PMID:
31165513
21.

IM-UNITI: 3 Year Efficacy, Safety, and Immunogenicity of Ustekinumab Treatment of Crohn's Disease.

Hanauer SB, Sandborn WJ, Feagan BG, Gasink C, Jacobstein D, Zou B, Johanns J, Adedokun OJ, Sands BE, Rutgeerts P, de Villiers WJS, Colombel JF, Ghosh S.

J Crohns Colitis. 2019 Jun 3. pii: jjz110. doi: 10.1093/ecco-jcc/jjz110. [Epub ahead of print]

PMID:
31158271
22.

Challenges in IBD Research: Preclinical Human IBD Mechanisms.

Pizarro TT, Stappenbeck TS, Rieder F, Rosen MJ, Colombel JF, Donowitz M, Towne J, Mazmanian SK, Faith JJ, Hodin RA, Garrett WS, Fichera A, Poritz LS, Cortes CJ, Shtraizent N, Honig G, Snapper SB, Hurtado-Lorenzo A, Salzman NH, Chang EB.

Inflamm Bowel Dis. 2019 May 16;25(Supplement_2):S5-S12. doi: 10.1093/ibd/izz075.

PMID:
31095706
23.

Treat-to-Target in Inflammatory Bowel Diseases, What Is the Target and How Do We Treat?

Agrawal M, Colombel JF.

Gastrointest Endosc Clin N Am. 2019 Jul;29(3):421-436. doi: 10.1016/j.giec.2019.02.004. Epub 2019 Apr 6. Review.

PMID:
31078245
24.

The Safety, Tolerability, and Pharmacokinetics Profile of BT-11, an Oral, Gut-Restricted Lanthionine Synthetase C-Like 2 Agonist Investigational New Drug for Inflammatory Bowel Disease: A Randomized, Double-Blind, Placebo-Controlled Phase I Clinical Trial.

Leber A, Hontecillas R, Zoccoli-Rodriguez V, Colombel JF, Chauhan J, Ehrich M, Farinola N, Bassaganya-Riera J.

Inflamm Bowel Dis. 2019 May 11. pii: izz094. doi: 10.1093/ibd/izz094. [Epub ahead of print]

PMID:
31077582
25.

Changes in Vedolizumab Utilization Across US Academic Centers and Community Practice Are Associated With Improved Effectiveness and Disease Outcomes.

Koliani-Pace JL, Singh S, Luo M, Hirten R, Aniwan S, Kochhar G, Chang S, Lukin D, Gao Y, Bohm M, Swaminath A, Gupta N, Shmidt E, Meserve J, Winters A, Chablaney S, Faleck DM, Yang J, Huang Z, Boland BS, Shashi P, Weiss A, Hudesman D, Varma S, Fischer M, Sultan K, Shen B, Kane S, Loftus EV, Sands BE, Colombel JF, Sandborn WJ, Lasch K, Siegel CA, Dulai PS.

Inflamm Bowel Dis. 2019 Oct 18;25(11):1854-1861. doi: 10.1093/ibd/izz071.

26.

Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice.

Torres J, Hu J, Seki A, Eisele C, Nair N, Huang R, Tarassishin L, Jharap B, Cote-Daigneault J, Mao Q, Mogno I, Britton GJ, Uzzan M, Chen CL, Kornbluth A, George J, Legnani P, Maser E, Loudon H, Stone J, Dubinsky M, Faith JJ, Clemente JC, Mehandru S, Colombel JF, Peter I.

Gut. 2020 Jan;69(1):42-51. doi: 10.1136/gutjnl-2018-317855. Epub 2019 Apr 29.

PMID:
31036757
27.

Cohort profile of the PRoteomic Evaluation and Discovery in an IBD Cohort of Tri-service Subjects (PREDICTS) study: Rationale, organization, design, and baseline characteristics.

Porter CK, Riddle MS, Gutierrez RL, Princen F, Strauss R, Telesco SE, Torres J, Choung RS, Laird RM, Leon F, Colombel JF, Murray JA; PREDICTS study team.

Contemp Clin Trials Commun. 2019 Mar 26;14:100345. doi: 10.1016/j.conctc.2019.100345. eCollection 2019 Jun.

28.

The Role of Early Biologic Therapy in Inflammatory Bowel Disease.

Berg DR, Colombel JF, Ungaro R.

Inflamm Bowel Dis. 2019 Nov 14;25(12):1896-1905. doi: 10.1093/ibd/izz059.

PMID:
30934053
29.

Epidemiology and implications of concurrent diagnosis of eosinophilic oesophagitis and IBD based on a prospective population-based analysis.

Limketkai BN, Shah SC, Hirano I, Bellaguarda E, Colombel JF.

Gut. 2019 Dec;68(12):2152-2160. doi: 10.1136/gutjnl-2018-318074. Epub 2019 Mar 28.

PMID:
30923072
30.

Home vs Hospital Infusion of Biologic Agents for Patients With Inflammatory Bowel Diseases.

Fenster M, Ungaro RC, Hirten R, Gallinger Z, Cohen L, Atreja A, Mehandru S, Colombel JF, Cohen BL.

Clin Gastroenterol Hepatol. 2019 Mar 22. pii: S1542-3565(19)30294-0. doi: 10.1016/j.cgh.2019.03.030. [Epub ahead of print]

PMID:
30910602
31.

A Treat-to-Target Update in Ulcerative Colitis: A Systematic Review.

Ungaro R, Colombel JF, Lissoos T, Peyrin-Biroulet L.

Am J Gastroenterol. 2019 Jun;114(6):874-883. doi: 10.14309/ajg.0000000000000183.

32.

Microbial Engraftment and Efficacy of Fecal Microbiota Transplant for Clostridium Difficile in Patients With and Without Inflammatory Bowel Disease.

Hirten RP, Grinspan A, Fu SC, Luo Y, Suarez-Farinas M, Rowland J, Contijoch EJ, Mogno I, Yang N, Luong T, Labrias PR, Peter I, Cho JH, Sands BE, Colombel JF, Faith JJ, Clemente JC.

Inflamm Bowel Dis. 2019 May 4;25(6):969-979. doi: 10.1093/ibd/izy398.

PMID:
30852592
33.

Novel Targets For Therapeutic Intervention in Inflammatory Bowel Disease. What is the Best Way to Assess the Safety Profile of a Drug?

Yzet C, Tse SS, Kayal M, Hirten R, Colombel JF.

Curr Pharm Des. 2019;25(1):57-63. doi: 10.2174/1381612825666190308102021.

PMID:
30848194
34.

Early Dose Optimisation of Golimumab in Nonresponders to Induction Treatment for Ulcerative Colitis Is Effective and Supported by Pharmacokinetic Data.

Philip G, Cornillie F, Adedokun JO, Melsheimer R, Rutgeerts P, Colombel JF, Marano C.

J Crohns Colitis. 2019 Sep 27;13(10):1257-1264. doi: 10.1093/ecco-jcc/jjz052.

PMID:
30847474
35.

Five-year Safety Data From OPUS, a European Observational Safety Registry for Adults With Ulcerative Colitis Treated With Originator Infliximab [Remicade®] or Conventional Therapy.

Panés J, Lindsay JO, Teich N, Lindgren S, Colombel JF, Cornillie F, Flynn HA, Huyck S, Stryszak P, Yao R, Philip G, Reinisch W.

J Crohns Colitis. 2019 Sep 19;13(9):1148-1157. doi: 10.1093/ecco-jcc/jjz048.

PMID:
30809631
36.

Efficacy of biological drugs in short-duration versus long-duration inflammatory bowel disease: a protocol for a systematic review and an individual-patient level meta-analysis of randomised controlled trials.

Ben-Horin S, Zhao Y, Guo J, Mao R, Novack L, Sergienko R, Zhang J, Kobayashi T, Hibi T, Chowers Y, Colombel JF, Peyrin-Biroulet L, Kaplan G, Chen MH.

BMJ Open. 2019 Jan 25;9(1):e024222. doi: 10.1136/bmjopen-2018-024222.

37.

Reply.

Hirten RP, Ghosh S, Colombel JF.

Clin Gastroenterol Hepatol. 2019 Mar;17(4):796-797. doi: 10.1016/j.cgh.2018.08.056. No abstract available.

PMID:
30782323
38.

Sex-based differences in the incidence of inflammatory bowel diseases-pooled analysis of population-based studies from the Asia-Pacific region.

Shah SC, Khalili H, Chen CY, Ahn HS, Ng SC, Burisch J, Colombel JF.

Aliment Pharmacol Ther. 2019 Apr;49(7):904-911. doi: 10.1111/apt.15178. Epub 2019 Feb 17.

PMID:
30773656
39.

Trends in hospitalisation rates for inflammatory bowel disease in western versus newly industrialised countries: a population-based study of countries in the Organisation for Economic Co-operation and Development.

King JA, Underwood FE, Panaccione N, Quan J, Windsor JW, Kotze PG, Ng SC, Ghosh S, Lakatos PL, Jess T, Panaccione R, Seow CH, Ben-Horin S, Burisch J, Colombel JF, Loftus EV Jr, Gearry R, Halfvarson J, Kaplan GG.

Lancet Gastroenterol Hepatol. 2019 Apr;4(4):287-295. doi: 10.1016/S2468-1253(19)30013-5. Epub 2019 Feb 12.

PMID:
30765267
40.

Efficacy and Safety of Adalimumab by Disease Duration: Analysis of Pooled Data From Crohn's Disease Studies.

Panaccione R, Löfberg R, Rutgeerts P, Sandborn WJ, Schreiber S, Berg S, Maa JF, Petersson J, Robinson AM, Colombel JF.

J Crohns Colitis. 2019 May 27;13(6):725-734. doi: 10.1093/ecco-jcc/jjy223.

41.

Rapid Changes in Laboratory Parameters and Early Response to Adalimumab: A Pooled Analysis From Patients With Ulcerative Colitis in Two Clinical Trials.

Hanauer S, Sandborn WJ, Colombel JF, Vermeire S, Petersson J, Kligys K, Zhou Q, Lazar A, Reinisch W.

J Crohns Colitis. 2019 Sep 19;13(9):1227-1233. doi: 10.1093/ecco-jcc/jjz031.

42.

Microscopic heterogeneity in ulcerative colitis: implications for microscopic measurement of disease activity.

Harpaz N, Ballentine S, Colombel JF, E Sands B, Ko HM.

Gut. 2019 Feb 5. pii: gutjnl-2018-318137. doi: 10.1136/gutjnl-2018-318137. [Epub ahead of print] No abstract available.

PMID:
30723105
43.

Reply.

Colombel JF, Shin A, Gibson PR.

Clin Gastroenterol Hepatol. 2019 Feb;17(3):573-574. doi: 10.1016/j.cgh.2018.08.073. No abstract available.

PMID:
30678842
44.

Incidence rates of inflammatory bowel disease in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis treated with secukinumab: a retrospective analysis of pooled data from 21 clinical trials.

Schreiber S, Colombel JF, Feagan BG, Reich K, Deodhar AA, McInnes IB, Porter B, Das Gupta A, Pricop L, Fox T.

Ann Rheum Dis. 2019 Apr;78(4):473-479. doi: 10.1136/annrheumdis-2018-214273. Epub 2019 Jan 23.

45.

Gut microbiota density influences host physiology and is shaped by host and microbial factors.

Contijoch EJ, Britton GJ, Yang C, Mogno I, Li Z, Ng R, Llewellyn SR, Hira S, Johnson C, Rabinowitz KM, Barkan R, Dotan I, Hirten RP, Fu SC, Luo Y, Yang N, Luong T, Labrias PR, Lira S, Peter I, Grinspan A, Clemente JC, Kosoy R, Kim-Schulze S, Qin X, Castillo A, Hurley A, Atreja A, Rogers J, Fasihuddin F, Saliaj M, Nolan A, Reyes-Mercedes P, Rodriguez C, Aly S, Santa-Cruz K, Peters L, Suárez-Fariñas M, Huang R, Hao K, Zhu J, Zhang B, Losic B, Irizar H, Song WM, Di Narzo A, Wang W, Cohen BL, DiMaio C, Greenwald D, Itzkowitz S, Lucas A, Marion J, Maser E, Ungaro R, Naymagon S, Novak J, Shah B, Ullman T, Rubin P, George J, Legnani P, Telesco SE, Friedman JR, Brodmerkel C, Plevy S, Cho JH, Colombel JF, Schadt EE, Argmann C, Dubinsky M, Kasarskis A, Sands B, Faith JJ.

Elife. 2019 Jan 22;8. pii: e40553. doi: 10.7554/eLife.40553.

46.

Disability in inflammatory bowel disease patients is associated with race, ethnicity and socio-economic factors.

Agrawal M, Cohen-Mekelburg S, Kayal M, Axelrad J, Galati J, Tricomi B, Kamal K, Faye AS, Abrudescu P, Scherl E, Lawlor G, Sultan K, Lukin D, Colombel JF, Ungaro RC.

Aliment Pharmacol Ther. 2019 Mar;49(5):564-571. doi: 10.1111/apt.15107. Epub 2019 Jan 20.

PMID:
30663075
47.

Association Between Helicobacter pylori Exposure and Decreased Odds of Eosinophilic Esophagitis-A Systematic Review and Meta-analysis.

Shah SC, Tepler A, Peek RM Jr, Colombel JF, Hirano I, Narula N.

Clin Gastroenterol Hepatol. 2019 Oct;17(11):2185-2198.e3. doi: 10.1016/j.cgh.2019.01.013. Epub 2019 Jan 16. Review.

PMID:
30659992
48.

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice.

Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ.

Immunity. 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015.

49.

Shorter Disease Duration Is Associated With Higher Rates of Response to Vedolizumab in Patients With Crohn's Disease But Not Ulcerative Colitis.

Faleck DM, Winters A, Chablaney S, Shashi P, Meserve J, Weiss A, Aniwan S, Koliani-Pace JL, Kochhar G, Boland BS, Singh S, Hirten R, Shmidt E, Kesar V, Lasch K, Luo M, Bohm M, Varma S, Fischer M, Hudesman D, Chang S, Lukin D, Sultan K, Swaminath A, Gupta N, Siegel CA, Shen B, Sandborn WJ, Kane S, Loftus EV Jr, Sands BE, Colombel JF, Dulai PS, Ungaro R.

Clin Gastroenterol Hepatol. 2019 Nov;17(12):2497-2505.e1. doi: 10.1016/j.cgh.2018.12.040. Epub 2019 Jan 6.

50.

No Association Between Pseudopolyps and Colorectal Neoplasia in Patients With Inflammatory Bowel Diseases.

Mahmoud R, Shah SC, Ten Hove JR, Torres J, Mooiweer E, Castaneda D, Glass J, Elman J, Kumar A, Axelrad J, Ullman T, Colombel JF, Oldenburg B, Itzkowitz SH; Dutch Initiative on Crohn and Colitis.

Gastroenterology. 2019 Apr;156(5):1333-1344.e3. doi: 10.1053/j.gastro.2018.11.067. Epub 2018 Dec 7.

PMID:
30529584

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