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Items: 28


Pharmacogenomic, physiological, and biochemical investigations on safety and efficacy biomarkers associated with the peroxisome proliferator-activated receptor-gamma activator rosiglitazone in rodents: a translational medicine investigation.

Wang X, Liu X, Zhan Y, Lavallie ER, Diblasio-Smith L, Collins-Racie L, Mounts WM, Rutkowski JL, Xu X, Goltsman I, Abassi Z, Winaver J, Feuerstein GZ.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):820-9. doi: 10.1124/jpet.110.167635. Epub 2010 Jun 2.


LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model.

Li N, Rivéra-Bermúdez MA, Zhang M, Tejada J, Glasson SS, Collins-Racie LA, Lavallie ER, Wang Y, Chang KC, Nagpal S, Morris EA, Flannery CR, Yang Z.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3734-9. doi: 10.1073/pnas.0911377107. Epub 2010 Feb 3.


Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo.

Chamberland A, Wang E, Jones AR, Collins-Racie LA, LaVallie ER, Huang Y, Liu L, Morris EA, Flannery CR, Yang Z.

J Biol Chem. 2009 Oct 2;284(40):27352-9. doi: 10.1074/jbc.M109.037051. Epub 2009 Aug 5.


Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration.

Lakshman KM, Bhasin S, Corcoran C, Collins-Racie LA, Tchistiakova L, Forlow SB, St Ledger K, Burczynski ME, Dorner AJ, Lavallie ER.

Mol Cell Endocrinol. 2009 Apr 10;302(1):26-32. doi: 10.1016/j.mce.2008.12.019. Epub 2009 Jan 21.


Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis.

Collins-Racie LA, Yang Z, Arai M, Li N, Majumdar MK, Nagpal S, Mounts WM, Dorner AJ, Morris E, LaVallie ER.

Osteoarthritis Cartilage. 2009 Jul;17(7):832-42. doi: 10.1016/j.joca.2008.12.011. Epub 2009 Jan 19.


Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.

Mosyak L, Georgiadis K, Shane T, Svenson K, Hebert T, McDonagh T, Mackie S, Olland S, Lin L, Zhong X, Kriz R, Reifenberg EL, Collins-Racie LA, Corcoran C, Freeman B, Zollner R, Marvell T, Vera M, Sum PE, Lavallie ER, Stahl M, Somers W.

Protein Sci. 2008 Jan;17(1):16-21. Epub 2007 Nov 27.


Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes.

LaVallie ER, Chockalingam PS, Collins-Racie LA, Freeman BA, Keohan CC, Leitges M, Dorner AJ, Morris EA, Majumdar MK, Arai M.

J Biol Chem. 2006 Aug 25;281(34):24124-37. Epub 2006 Jun 23.


Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.

Zeng W, Corcoran C, Collins-Racie LA, Lavallie ER, Morris EA, Flannery CR.

Biochim Biophys Acta. 2006 Mar;1760(3):517-24. Epub 2006 Feb 17.


A neurogenomics approach to gene expression analysis in the developing brain.

Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T.

Brain Res Mol Brain Res. 2004 Dec 20;132(2):116-27.


Identification and characterisation of the posteriorly-expressed Xenopus neurotrophin receptor homolog genes fullback and fullback-like.

Bromley E, Knapp D, Wardle FC, Sun BI, Collins-Racie L, LaVallie E, Smith JC, Sive HL.

Gene Expr Patterns. 2004 Nov;5(1):135-40.


ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage.

Collins-Racie LA, Flannery CR, Zeng W, Corcoran C, Annis-Freeman B, Agostino MJ, Arai M, DiBlasio-Smith E, Dorner AJ, Georgiadis KE, Jin M, Tan XY, Morris EA, LaVallie ER.

Matrix Biol. 2004 Jul;23(4):219-30.


Effect of adenovirus-mediated overexpression of bovine ADAMTS-4 and human ADAMTS-5 in primary bovine articular chondrocyte pellet culture system.

Arai M, Anderson D, Kurdi Y, Annis-Freeman B, Shields K, Collins-Racie LA, Corcoran C, DiBlasio-Smith E, Pittman DD, Dorner AJ, Morris E, LaVallie ER.

Osteoarthritis Cartilage. 2004 Aug;12(8):599-613.


Thioredoxin and related proteins as multifunctional fusion tags for soluble expression in E. coli.

LaVallie ER, DiBlasio-Smith EA, Collins-Racie LA, Lu Z, McCoy JM.

Methods Mol Biol. 2003;205:119-40. No abstract available.


Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites.

Flannery CR, Zeng W, Corcoran C, Collins-Racie LA, Chockalingam PS, Hebert T, Mackie SA, McDonagh T, Crawford TK, Tomkinson KN, LaVallie ER, Morris EA.

J Biol Chem. 2002 Nov 8;277(45):42775-80. Epub 2002 Aug 28.


Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development.

Horsfield J, Ramachandran A, Reuter K, LaVallie E, Collins-Racie L, Crosier K, Crosier P.

Mech Dev. 2002 Jul;115(1-2):15-26.


ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.

Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD.

J Biol Chem. 2002 May 3;277(18):16059-66. Epub 2002 Feb 19.


In situ hybridization screen in zebrafish for the selection of genes encoding secreted proteins.

Crosier PS, Bardsley A, Horsfield JA, Krassowska AK, Lavallie ER, Collins-Racie LA, Postlethwait JH, Yan YL, McCoy JM, Crosier KE.

Dev Dyn. 2001 Dec;222(4):637-44.


Cloning and expression of a novel cysteine-rich secreted protein family member expressed in thyroid and pancreatic mesoderm within the chicken embryo.

Smith DM, Collins-Racie LA, Marigo VA, Roberts DJ, Davis NM, Hartmann C, Schweitzer R, LaVallie ER, Gamer L, McCoy J, Tabin CJ.

Mech Dev. 2001 Apr;102(1-2):223-6.


Different activities of the frizzled-related proteins frzb2 and sizzled2 during Xenopus anteroposterior patterning.

Bradley L, Sun B, Collins-Racie L, LaVallie E, McCoy J, Sive H.

Dev Biol. 2000 Nov 1;227(1):118-32.


Thioredoxin as a fusion partner for production of soluble recombinant proteins in Escherichia coli.

LaVallie ER, Lu Z, Diblasio-Smith EA, Collins-Racie LA, McCoy JM.

Methods Enzymol. 2000;326:322-40. No abstract available.


A genetic selection for isolating cDNA clones that encode signal peptides.

Jacobs KA, Collins-Racie LA, Colbert M, Duckett M, Evans C, Golden-Fleet M, Kelleher K, Kriz R, La Vallie ER, Merberg D, Spaulding V, Stover J, Williamson MJ, McCoy JM.

Methods Enzymol. 1999;303:468-79. No abstract available.


derrière: a TGF-beta family member required for posterior development in Xenopus.

Sun BI, Bush SM, Collins-Racie LA, LaVallie ER, DiBlasio-Smith EA, Wolfman NM, McCoy JM, Sive HL.

Development. 1999 Apr;126(7):1467-82.


The CXC-chemokine, H174: expression in the central nervous system.

Luo Y, Kim R, Gabuzda D, Mi S, Collins-Racie LA, Lu Z, Jacobs KA, Dorf ME.

J Neurovirol. 1998 Dec;4(6):575-85.


Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells.

Tanabe S, Lu Z, Luo Y, Quackenbush EJ, Berman MA, Collins-Racie LA, Mi S, Reilly C, Lo D, Jacobs KA, Dorf ME.

J Immunol. 1997 Dec 1;159(11):5671-9.


A genetic selection for isolating cDNAs encoding secreted proteins.

Jacobs KA, Collins-Racie LA, Colbert M, Duckett M, Golden-Fleet M, Kelleher K, Kriz R, LaVallie ER, Merberg D, Spaulding V, Stover J, Williamson MJ, McCoy JM.

Gene. 1997 Oct 1;198(1-2):289-96.


Histidine patch thioredoxins. Mutant forms of thioredoxin with metal chelating affinity that provide for convenient purifications of thioredoxin fusion proteins.

Lu Z, DiBlasio-Smith EA, Grant KL, Warne NW, LaVallie ER, Collins-Racie LA, Follettie MT, Williamson MJ, McCoy JM.

J Biol Chem. 1996 Mar 1;271(9):5059-65.


Production of a recombinant bovine enterokinase catalytic subunit in the methylotrophic yeast Pichia pastoris.

Vozza LA, Wittwer L, Higgins DR, Purcell TJ, Bergseid M, Collins-Racie LA, LaVallie ER, Hoeffler JP.

Biotechnology (N Y). 1996 Jan;14(1):77-81.


Production of recombinant bovine enterokinase catalytic subunit in Escherichia coli using the novel secretory fusion partner DsbA.

Collins-Racie LA, McColgan JM, Grant KL, DiBlasio-Smith EA, McCoy JM, LaVallie ER.

Biotechnology (N Y). 1995 Sep;13(9):982-7.


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