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Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease.

Sellnow RC, Steece-Collier K, Altwal F, Sandoval IM, Kordower JH, Collier TJ, Sortwell CE, West AR, Manfredsson FP.

J Neurosci. 2020 Mar 27. pii: JN-RM-2936-19. doi: 10.1523/JNEUROSCI.2936-19.2020. [Epub ahead of print]


Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils.

Patterson JR, Duffy MF, Kemp CJ, Howe JW, Collier TJ, Stoll AC, Miller KM, Patel P, Levine N, Moore DJ, Luk KC, Fleming SM, Kanaan NM, Paumier KL, El-Agnaf OMA, Sortwell CE.

Neurobiol Dis. 2019 Oct;130:104525. doi: 10.1016/j.nbd.2019.104525. Epub 2019 Jul 2.


Cell therapy for Parkinson's disease: Why it doesn't work every time.

Collier TJ, Sortwell CE, Mercado NM, Steece-Collier K.

Mov Disord. 2019 Aug;34(8):1120-1127. doi: 10.1002/mds.27742. Epub 2019 Jun 24.


Locus Coeruleus Degeneration Induces Forebrain Vascular Pathology in a Transgenic Rat Model of Alzheimer's Disease.

Kelly SC, McKay EC, Beck JS, Collier TJ, Dorrance AM, Counts SE.

J Alzheimers Dis. 2019;70(2):371-388. doi: 10.3233/JAD-190090.


Statistical Appraisal of 6 Recent Clinical Trials in Cardiology: JACC State-of-the-Art Review.

Pocock SJ, Collier TJ.

J Am Coll Cardiol. 2019 Jun 4;73(21):2740-2755. doi: 10.1016/j.jacc.2019.03.484. Epub 2019 May 3. Review. Erratum in: J Am Coll Cardiol. 2019 Jul 30;74(4):595-597.


Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia.

Steece-Collier K, Stancati JA, Collier NJ, Sandoval IM, Mercado NM, Sortwell CE, Collier TJ, Manfredsson FP.

Mov Disord. 2019 May;34(5):697-707. doi: 10.1002/mds.27695. Epub 2019 Apr 19.


Design and Assembly of CRISPR/Cas9 Lentiviral and rAAV Vectors for Targeted Genome Editing.

Sandoval IM, Collier TJ, Manfredsson FP.

Methods Mol Biol. 2019;1937:29-45. doi: 10.1007/978-1-4939-9065-8_2.


Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson's Disease.

Duffy MF, Collier TJ, Patterson JR, Kemp CJ, Fischer DL, Stoll AC, Sortwell CE.

Front Neurosci. 2018 Sep 4;12:621. doi: 10.3389/fnins.2018.00621. eCollection 2018.


Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

Duffy MF, Collier TJ, Patterson JR, Kemp CJ, Luk KC, Tansey MG, Paumier KL, Kanaan NM, Fischer DL, Polinski NK, Barth OL, Howe JW, Vaikath NN, Majbour NK, El-Agnaf OMA, Sortwell CE.

J Neuroinflammation. 2018 May 29;15(1):169. doi: 10.1186/s12974-018-1202-9.


Critical Appraisal of the 2018 ACC Scientific Sessions Late-Breaking Trials From a Statistician's Perspective.

Pocock SJ, Collier TJ.

J Am Coll Cardiol. 2018 Jun 26;71(25):2957-2969. doi: 10.1016/j.jacc.2018.04.015. Epub 2018 May 9. Review.


Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

Duffy MF, Collier TJ, Patterson JR, Kemp CJ, Luk KC, Tansey MG, Paumier KL, Kanaan NM, Fischer DL, Polinski NK, Barth OL, Howe JW, Vaikath NN, Majbour NK, El-Agnaf OMA, Sortwell CE.

J Neuroinflammation. 2018 May 1;15(1):129. doi: 10.1186/s12974-018-1171-z. Erratum in: J Neuroinflammation. 2018 May 29;15(1):169.


Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression.

Fischer DL, Manfredsson FP, Kemp CJ, Cole-Strauss A, Lipton JW, Duffy MF, Polinski NK, Steece-Collier K, Collier TJ, Gombash SE, Buhlinger DJ, Sortwell CE.

Sci Rep. 2017 Nov 27;7(1):16356. doi: 10.1038/s41598-017-16690-x.


Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.

Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, Lansbury P, Lapidus L, Paumier KL.

Neurobiol Dis. 2017 Oct;106:191-204. doi: 10.1016/j.nbd.2017.07.007. Epub 2017 Jul 12.


Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration.

Fischer DL, Kemp CJ, Cole-Strauss A, Polinski NK, Paumier KL, Lipton JW, Steece-Collier K, Collier TJ, Buhlinger DJ, Sortwell CE.

J Neurosci. 2017 Jul 12;37(28):6786-6796. doi: 10.1523/JNEUROSCI.2060-16.2017. Epub 2017 Jun 12.


Aging and Parkinson's disease: Different sides of the same coin?

Collier TJ, Kanaan NM, Kordower JH.

Mov Disord. 2017 Jul;32(7):983-990. doi: 10.1002/mds.27037. Epub 2017 May 18. Review.


Effect of eplerenone in patients with heart failure and reduced ejection fraction: potential effect modification by abdominal obesity. Insight from the EMPHASIS-HF trial.

Olivier A, Pitt B, Girerd N, Lamiral Z, Machu JL, McMurray JJV, Swedberg K, van Veldhuisen DJ, Collier TJ, Pocock SJ, Rossignol P, Zannad F, Pizard A.

Eur J Heart Fail. 2017 Sep;19(9):1186-1197. doi: 10.1002/ejhf.792. Epub 2017 Mar 16.


Repairing the Aged Parkinsonian Striatum: Lessons from the Lab and Clinic.

Mercado NM, Collier TJ, Freeman T, Steece-Collier K.

J Clin Cell Immunol. 2016 Dec;7(6). pii: 476. doi: 10.4172/2155-9899.1000476. Epub 2016 Dec 6.


BDNF in the Aged Brain: Translational Implications for Parkinson's Disease.

Mercado NM, Collier TJ, Sortwell CE, Steece-Collier K.

Austin Neurol Neurosci. 2017;2(2). pii: 1021. Epub 2017 Sep 19.



Ansari BM, Hogan MP, Collier TJ, Baddeley RA, Scarci M, Coonar AS, Bottrill FE, Martinez GC, Klein AA.

Ann Thorac Surg. 2016 Oct;102(4):1411-2. doi: 10.1016/j.athoracsur.2016.03.111. No abstract available.


Editorial: Unraveling Neuroprotective and Neurodegenerative Signals in Neurodegeneration.

Vega IE, Collier TJ.

Front Neurosci. 2016 Jul 13;10:328. doi: 10.3389/fnins.2016.00328. eCollection 2016. No abstract available.


Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures.

Kneynsberg A, Collier TJ, Manfredsson FP, Kanaan NM.

J Neurosci Methods. 2016 Jun 15;266:32-41. doi: 10.1016/j.jneumeth.2016.03.004. Epub 2016 Mar 28.


The incidence and importance of anaemia in patients undergoing cardiac surgery in the UK - the first Association of Cardiothoracic Anaesthetists national audit.

Klein AA, Collier TJ, Brar MS, Evans C, Hallward G, Fletcher SN, Richards T; Association of Cardiothoracic Anaesthetists (ACTA).

Anaesthesia. 2016 Jun;71(6):627-35. doi: 10.1111/anae.13423. Epub 2016 Mar 18.


Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates.

Collier TJ, Redmond DE Jr, Steece-Collier K, Lipton JW, Manfredsson FP.

Front Neurosci. 2016 Jan 29;10:12. doi: 10.3389/fnins.2016.00012. eCollection 2016.


Aspirin does not reduce the clinical benefits of the mineralocorticoid receptor antagonist eplerenone in patients with systolic heart failure and mild symptoms: an analysis of the EMPHASIS-HF study.

Chin KL, Collier TJ, Pitt B, McMurray JJ, Swedberg K, van Veldhuisen DJ, Pocock SJ, Vincent J, Turgonyi E, Zannad F, Krum H; EMPHASIS-HF Study Investigators.

Eur J Heart Fail. 2016 Sep;18(9):1175-81. doi: 10.1002/ejhf.485. Epub 2016 Feb 2.


Statistical Controversies in Reporting of Clinical Trials: Part 2 of a 4-Part Series on Statistics for Clinical Trials.

Pocock SJ, McMurray JJV, Collier TJ.

J Am Coll Cardiol. 2015 Dec 15;66(23):2648-2662. doi: 10.1016/j.jacc.2015.10.023. Review.


Making Sense of Statistics in Clinical Trial Reports: Part 1 of a 4-Part Series on Statistics for Clinical Trials.

Pocock SJ, McMurray JJ, Collier TJ.

J Am Coll Cardiol. 2015 Dec 8;66(22):2536-49. doi: 10.1016/j.jacc.2015.10.014. Review.


Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease.

Divito CB, Steece-Collier K, Case DT, Williams SP, Stancati JA, Zhi L, Rubio ME, Sortwell CE, Collier TJ, Sulzer D, Edwards RH, Zhang H, Seal RP.

J Neurosci. 2015 Nov 11;35(45):14983-99. doi: 10.1523/JNEUROSCI.2124-15.2015.


Acute kidney injury in stable COPD and at exacerbation.

Barakat MF, McDonald HI, Collier TJ, Smeeth L, Nitsch D, Quint JK.

Int J Chron Obstruct Pulmon Dis. 2015 Sep 28;10:2067-77. doi: 10.2147/COPD.S88759. eCollection 2015.


A Randomized Controlled Trial of High-Flow Nasal Oxygen (Optiflow) as Part of an Enhanced Recovery Program After Lung Resection Surgery.

Ansari BM, Hogan MP, Collier TJ, Baddeley RA, Scarci M, Coonar AS, Bottrill FE, Martinez GC, Klein AA.

Ann Thorac Surg. 2016 Feb;101(2):459-64. doi: 10.1016/j.athoracsur.2015.07.025. Epub 2015 Sep 26.


Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration.

Madhavan L, Daley BF, Davidson BL, Boudreau RL, Lipton JW, Cole-Strauss A, Steece-Collier K, Collier TJ.

PLoS One. 2015 Sep 4;10(9):e0137136. doi: 10.1371/journal.pone.0137136. eCollection 2015.


Influence of malaria transmission intensity and the 581G mutation on the efficacy of intermittent preventive treatment in pregnancy: systematic review and meta-analysis.

Chico RM, Cano J, Ariti C, Collier TJ, Chandramohan D, Roper C, Greenwood B.

Trop Med Int Health. 2015 Dec;20(12):1621-33. doi: 10.1111/tmi.12595. Epub 2015 Sep 30. Review.


High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine.

Fischer DL, Collier TJ, Cole-Strauss A, Wohlgenant SL, Lipton JW, Steece-Collier K, Manfredsson FP, Kemp CJ, Sortwell CE.

PLoS One. 2015 Jul 29;10(7):e0133957. doi: 10.1371/journal.pone.0133957. eCollection 2015.


Clinical outcomes according to QRS duration and morphology in the Eplerenone in Mild Patients: Hospitalization and SurvIval Study in Heart Failure (EMPHASIS-HF).

Cannon JA, Collier TJ, Shen L, Swedberg K, Krum H, Van Veldhuisen DJ, Vincent J, Pocock SJ, Pitt B, Zannad F, McMurray JJ.

Eur J Heart Fail. 2015 Jul;17(7):707-16. doi: 10.1002/ejhf.303.


Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration.

Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, Lee VM, Sortwell CE.

Neurobiol Dis. 2015 Oct;82:185-199. doi: 10.1016/j.nbd.2015.06.003. Epub 2015 Jun 17.


The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes.

Kanaan NM, Collier TJ, Cole-Strauss A, Grabinski T, Mattingly ZR, Winn ME, Steece-Collier K, Sortwell CE, Manfredsson FP, Lipton JW.

PLoS One. 2015 May 20;10(5):e0127768. doi: 10.1371/journal.pone.0127768. eCollection 2015.


A potential compensatory role for endogenous striatal tyrosine hydroxylase-positive neurons in a nonhuman primate model of Parkinson's disease.

Bubak AN, Redmond DE Jr, Elsworth JD, Roth RH, Collier TJ, Bjugstad KB, Blanchard BC, Sladek JR Jr.

Cell Transplant. 2015;24(4):673-80. doi: 10.3727/096368915X687741. Epub 2015 Mar 24.


Agonists of the tissue-protective erythropoietin receptor in the treatment of Parkinson's disease.

Punnonen J, Miller JL, Collier TJ, Spencer JR.

Curr Top Med Chem. 2015;15(10):955-69. Review.


Interrogating the aged striatum: robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration.

Collier TJ, O'Malley J, Rademacher DJ, Stancati JA, Sisson KA, Sortwell CE, Paumier KL, Gebremedhin KG, Steece-Collier K.

Neurobiol Dis. 2015 May;77:191-203. doi: 10.1016/j.nbd.2015.03.005. Epub 2015 Mar 11.


Haemoconcentration of residual cardiopulmonary bypass blood using Hemosep ®: a randomised controlled trial.

Hogan M, Needham A, Ortmann E, Bottrill F, Collier TJ, Besser MW, Klein AA.

Anaesthesia. 2015 May;70(5):563-70. doi: 10.1111/anae.13019. Epub 2015 Feb 18.


Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system.

Paumier KL, Sortwell CE, Madhavan L, Terpstra B, Daley BF, Collier TJ.

Exp Neurol. 2015 Apr;266:11-21. doi: 10.1016/j.expneurol.2015.02.005. Epub 2015 Feb 12.


Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism.

Paumier KL, Sortwell CE, Madhavan L, Terpstra B, Celano SL, Green JJ, Imus NM, Marckini N, Daley B, Steece-Collier K, Collier TJ.

Neuropsychopharmacology. 2015 Mar;40(4):874-83. doi: 10.1038/npp.2014.262. Epub 2014 Sep 30.


Tools & Techniques - statistics: non-inferiority trials.

Collier TJ.

EuroIntervention. 2014 Aug;10(4):526-7. doi: 10.4244/EIJV10I4A90. No abstract available.


Neuroprotective potential of pleiotrophin overexpression in the striatonigral pathway compared with overexpression in both the striatonigral and nigrostriatal pathways.

Gombash SE, Manfredsson FP, Mandel RJ, Collier TJ, Fischer DL, Kemp CJ, Kuhn NM, Wohlgenant SL, Fleming SM, Sortwell CE.

Gene Ther. 2014 Jul;21(7):682-93. doi: 10.1038/gt.2014.42. Epub 2014 May 8.


Rebuilding the nigrostriatal dopamine pathway: 30 years and counting.

Collier TJ.

Exp Neurol. 2014 Jun;256:21-4. doi: 10.1016/j.expneurol.2014.03.011. Epub 2014 Mar 27. No abstract available.


The impact of eplerenone at different levels of risk in patients with systolic heart failure and mild symptoms: insight from a novel risk score for prognosis derived from the EMPHASIS-HF trial.

Collier TJ, Pocock SJ, McMurray JJ, Zannad F, Krum H, van Veldhuisen DJ, Swedberg K, Shi H, Vincent J, Pitt B.

Eur Heart J. 2013 Sep;34(36):2823-9. doi: 10.1093/eurheartj/eht247. Epub 2013 Jul 17.


Advances in thin tissue Golgi-Cox impregnation: fast, reliable methods for multi-assay analyses in rodent and non-human primate brain.

Levine ND, Rademacher DJ, Collier TJ, O'Malley JA, Kells AP, San Sebastian W, Bankiewicz KS, Steece-Collier K.

J Neurosci Methods. 2013 Mar 15;213(2):214-27. doi: 10.1016/j.jneumeth.2012.12.001. Epub 2013 Jan 8.


Creation of a human head phantom for testing of electroencephalography equipment and techniques.

Collier TJ, Kynor DB, Bieszczad J, Audette WE, Kobylarz EJ, Diamond SG.

IEEE Trans Biomed Eng. 2012 Sep;59(9):2628-34. doi: 10.1109/TBME.2012.2207434.


Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease.

Paumier KL, Siderowf AD, Auinger P, Oakes D, Madhavan L, Espay AJ, Revilla FJ, Collier TJ; Parkinson Study Group Genetics Epidemiology Working Group.

Mov Disord. 2012 Jun;27(7):880-7. doi: 10.1002/mds.24978. Epub 2012 May 3.


Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian rat.

Madhavan L, Daley BF, Sortwell CE, Collier TJ.

Eur J Neurosci. 2012 Mar;35(6):883-95. doi: 10.1111/j.1460-9568.2012.08019.x. Epub 2012 Mar 14.


Subthalamic nucleus stimulation increases brain derived neurotrophic factor in the nigrostriatal system and primary motor cortex.

Spieles-Engemann AL, Steece-Collier K, Behbehani MM, Collier TJ, Wohlgenant SL, Kemp CJ, Cole-Strauss A, Levine ND, Gombash SE, Thompson VB, Lipton JW, Sortwell CE.

J Parkinsons Dis. 2011;1(1):123-36.

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