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Items: 21

1.

The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes.

Ramos-Rodríguez M, Raurell-Vila H, Colli ML, Alvelos MI, Subirana-Granés M, Juan-Mateu J, Norris R, Turatsinze JV, Nakayasu ES, Webb-Robertson BM, Inshaw JRJ, Marchetti P, Piemonti L, Esteller M, Todd JA, Metz TO, Eizirik DL, Pasquali L.

Nat Genet. 2019 Nov;51(11):1588-1595. doi: 10.1038/s41588-019-0524-6. Epub 2019 Nov 1.

PMID:
31676868
2.

Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells.

Colli ML, Paula FM, Marselli L, Marchetti P, Roivainen M, Eizirik DL, Op de Beeck A.

J Innate Immun. 2019;11(4):375-390. doi: 10.1159/000496034. Epub 2019 Feb 20.

3.

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.

Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM, Op de Beeck A, Castela A, Marselli L, Krogvold L, Dahl-Jorgensen K, Marchetti P, Morgan NG, Richardson SJ, Eizirik DL.

EBioMedicine. 2018 Oct;36:367-375. doi: 10.1016/j.ebiom.2018.09.040. Epub 2018 Sep 27.

4.

When one becomes many-Alternative splicing in β-cell function and failure.

Alvelos MI, Juan-Mateu J, Colli ML, Turatsinze JV, Eizirik DL.

Diabetes Obes Metab. 2018 Sep;20 Suppl 2:77-87. doi: 10.1111/dom.13388. Review. Erratum in: Diabetes Obes Metab. 2018 Dec;20(12):2926.

5.

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors.

Gonzalez-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalanne AI, Sebastiani G, Carré A, Pinto S, Culina S, Corcos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann R, Eizirik DL, Verdier Y, Vinh J, Mallone R.

Cell Metab. 2018 Dec 4;28(6):946-960.e6. doi: 10.1016/j.cmet.2018.07.007. Epub 2018 Aug 2.

6.

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells.

Coomans de Brachène A, Dos Santos RS, Marroqui L, Colli ML, Marselli L, Mirmira RG, Marchetti P, Eizirik DL.

Diabetologia. 2018 Mar;61(3):636-640. doi: 10.1007/s00125-017-4536-4. Epub 2018 Jan 5.

7.

Production and characterization of a Brazilian candidate antigen for Hepatitis E Virus genotype 3 diagnosis.

de Almeida Ramos D, Miani M, Pandolfi R, Tondo L, Colli ML, Rosado Spilki F, Rovaris Gardinali N, Alves Pinto M, Kreutz LC, Frandoloso R.

FEMS Microbiol Lett. 2016 Mar;363(5):fnw021. doi: 10.1093/femsle/fnw021. Epub 2016 Jan 31.

PMID:
26832642
8.

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance.

Miani M, Barthson J, Colli ML, Brozzi F, Cnop M, Eizirik DL.

Cell Death Dis. 2013 Jul 4;4:e701. doi: 10.1038/cddis.2013.236.

9.

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.

Nogueira TC, Paula FM, Villate O, Colli ML, Moura RF, Cunha DA, Marselli L, Marchetti P, Cnop M, Julier C, Eizirik DL.

PLoS Genet. 2013 May;9(5):e1003532. doi: 10.1371/journal.pgen.1003532. Epub 2013 May 30.

10.

Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells.

Ortis F, Miani M, Colli ML, Cunha DA, Gurzov EN, Allagnat F, Chariot A, Eizirik DL.

FEBS Lett. 2012 Apr 5;586(7):984-9. doi: 10.1016/j.febslet.2012.02.021. Epub 2012 Feb 22.

11.

Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway.

Miani M, Colli ML, Ladrière L, Cnop M, Eizirik DL.

Endocrinology. 2012 Jul;153(7):3017-28. doi: 10.1210/en.2011-2090. Epub 2012 Apr 23.

PMID:
22529213
12.

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.

Eizirik DL, Sammeth M, Bouckenooghe T, Bottu G, Sisino G, Igoillo-Esteve M, Ortis F, Santin I, Colli ML, Barthson J, Bouwens L, Hughes L, Gregory L, Lunter G, Marselli L, Marchetti P, McCarthy MI, Cnop M.

PLoS Genet. 2012;8(3):e1002552. doi: 10.1371/journal.pgen.1002552. Epub 2012 Mar 8.

13.

PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.

Santin I, Moore F, Colli ML, Gurzov EN, Marselli L, Marchetti P, Eizirik DL.

Diabetes. 2011 Dec;60(12):3279-88. doi: 10.2337/db11-0758. Epub 2011 Oct 7.

14.

Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.

Colli ML, Nogueira TC, Allagnat F, Cunha DA, Gurzov EN, Cardozo AK, Roivainen M, Op de Beeck A, Eizirik DL.

PLoS Pathog. 2011 Sep;7(9):e1002267. doi: 10.1371/journal.ppat.1002267. Epub 2011 Sep 22.

15.

STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation.

Moore F, Naamane N, Colli ML, Bouckenooghe T, Ortis F, Gurzov EN, Igoillo-Esteve M, Mathieu C, Bontempi G, Thykjaer T, Ørntoft TF, Eizirik DL.

J Biol Chem. 2011 Jan 14;286(2):929-41. doi: 10.1074/jbc.M110.162131. Epub 2010 Oct 27.

16.

Mutation H63D in the HFE gene confers risk for the development of type 2 diabetes mellitus but not for chronic complications.

Colli ML, Gross JL, Canani LH.

J Diabetes Complications. 2011 Jan-Feb;25(1):25-30. doi: 10.1016/j.jdiacomp.2009.12.002. Epub 2010 Jan 25.

PMID:
20097100
17.

Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells.

Ortis F, Naamane N, Flamez D, Ladrière L, Moore F, Cunha DA, Colli ML, Thykjaer T, Thorsen K, Orntoft TF, Eizirik DL.

Diabetes. 2010 Feb;59(2):358-74. doi: 10.2337/db09-1159. Epub 2009 Nov 23.

18.

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA.

Colli ML, Moore F, Gurzov EN, Ortis F, Eizirik DL.

Hum Mol Genet. 2010 Jan 1;19(1):135-46. doi: 10.1093/hmg/ddp474.

19.

The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.

Eizirik DL, Colli ML, Ortis F.

Nat Rev Endocrinol. 2009 Apr;5(4):219-26. doi: 10.1038/nrendo.2009.21. Review.

PMID:
19352320
20.

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.

Moore F, Colli ML, Cnop M, Esteve MI, Cardozo AK, Cunha DA, Bugliani M, Marchetti P, Eizirik DL.

Diabetes. 2009 Jun;58(6):1283-91. doi: 10.2337/db08-1510. Epub 2009 Mar 31.

21.

[Pituitary abscess simulating apoplexy].

Colli ML, Migowski W Jr, Czepielewski MA, Ferreira N, Gross JL.

Arq Bras Endocrinol Metabol. 2006 Dec;50(6):1122-6. Portuguese.

PMID:
17221121

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