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Items: 22


BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells.

Legge DN, Shephard AP, Collard TJ, Greenhough A, Chambers AC, Clarkson RW, Paraskeva C, Williams AC.

Dis Model Mech. 2019 Mar 4;12(3). pii: dmm037697. doi: 10.1242/dmm.037697.


Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis.

Greenhough A, Bagley C, Heesom KJ, Gurevich DB, Gay D, Bond M, Collard TJ, Paraskeva C, Martin P, Sansom OJ, Malik K, Williams AC.

EMBO Mol Med. 2018 Nov;10(11). pii: e8699. doi: 10.15252/emmm.201708699.


LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity.

Morgan RG, Mortensson E, Legge DN, Gupta B, Collard TJ, Greenhough A, Williams AC.

Br J Cancer. 2018 Feb 20;118(4):558-565. doi: 10.1038/bjc.2017.412. Epub 2017 Nov 16.


BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling.

Urban BC, Collard TJ, Eagle CJ, Southern SL, Greenhough A, Hamdollah-Zadeh M, Ghosh A, Poulsom R, Paraskeva C, Silver A, Williams AC.

Gut. 2016 Jul;65(7):1151-64. doi: 10.1136/gutjnl-2014-308270. Epub 2015 Jun 1.


Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells.

Morgan RG, Molnár E, Jones RF, Collard TJ, Lane JD, Greenhough A, Paraskeva C, Williams AC.

Br J Cancer. 2015 Feb 17;112(4):714-9. doi: 10.1038/bjc.2015.4. Epub 2015 Jan 22.


Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk.

Petherick KJ, Williams AC, Lane JD, Ordóñez-Morán P, Huelsken J, Collard TJ, Smartt HJ, Batson J, Malik K, Paraskeva C, Greenhough A.

EMBO J. 2013 Jul 3;32(13):1903-16. doi: 10.1038/emboj.2013.123. Epub 2013 Jun 4.


LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs.

Al-Kharusi MR, Smartt HJ, Greenhough A, Collard TJ, Emery ED, Williams AC, Paraskeva C.

Carcinogenesis. 2013 May;34(5):1150-7. doi: 10.1093/carcin/bgt020. Epub 2013 Jan 24.


BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor β (TGF-β1) in colorectal tumour cells.

Skeen VR, Collard TJ, Southern SL, Greenhough A, Hague A, Townsend PA, Paraskeva C, Williams AC.

Oncogene. 2013 Sep 19;32(38):4490-9. doi: 10.1038/onc.2012.480. Epub 2012 Oct 29.


The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells.

Collard TJ, Urban BC, Patsos HA, Hague A, Townsend PA, Paraskeva C, Williams AC.

Cell Death Dis. 2012 Oct 11;3:e408. doi: 10.1038/cddis.2012.142.


β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

Smartt HJ, Greenhough A, Ordóñez-Morán P, Al-Kharusi M, Collard TJ, Mariadason JM, Huelsken J, Williams AC, Paraskeva C.

Br J Cancer. 2012 Oct 23;107(9):1514-7. doi: 10.1038/bjc.2012.430. Epub 2012 Oct 2.


BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis.

Southern SL, Collard TJ, Urban BC, Skeen VR, Smartt HJ, Hague A, Oakley F, Townsend PA, Perkins ND, Paraskeva C, Williams AC.

Oncogene. 2012 May 31;31(22):2761-72. doi: 10.1038/onc.2011.452. Epub 2011 Oct 3.


The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.

Patsos HA, Greenhough A, Hicks DJ, Al Kharusi M, Collard TJ, Lane JD, Paraskeva C, Williams AC.

Int J Oncol. 2010 Jul;37(1):187-93.


BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity.

Clemo NK, Collard TJ, Southern SL, Edwards KD, Moorghen M, Packham G, Hague A, Paraskeva C, Williams AC.

Carcinogenesis. 2008 Apr;29(4):849-57. doi: 10.1093/carcin/bgn004. Epub 2008 Jan 19.


Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells.

H-Zadeh AM, Collard TJ, Malik K, Hicks DJ, Paraskeva C, Williams AC.

Int J Oncol. 2006 Nov;29(5):1279-86.


Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-kappaB.

Williams AC, Smartt H, H-Zadeh AM, Macfarlane M, Paraskeva C, Collard TJ.

Cell Death Differ. 2007 Jan;14(1):137-45. Epub 2006 Apr 28.


The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines.

Arhel NJ, Packham G, Townsend PA, Collard TJ, H-Zadeh AM, Sharp A, Cutress RI, Malik K, Hague A, Paraskeva C, Williams AC.

Int J Cancer. 2003 Sep 1;106(3):364-71.


Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells.

Williams AC, Collard TJ, Perks CM, Newcomb P, Moorghen M, Holly JM, Paraskeva C.

Cancer Res. 2000 Jan 1;60(1):22-7.

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