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Items: 1 to 50 of 116

1.

Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.

Wang S, Watanabe T, Matsuzawa K, Katsumi A, Kakeno M, Matsui T, Ye F, Sato K, Murase K, Sugiyama I, Kimura K, Mizoguchi A, Ginsberg MH, Collard JG, Kaibuchi K.

J Cell Biol. 2012 Oct 15;199(2):331-45. doi: 10.1083/jcb.201202041.

2.

Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.

Iden S, van Riel WE, Schäfer R, Song JY, Hirose T, Ohno S, Collard JG.

Cancer Cell. 2012 Sep 11;22(3):389-403. doi: 10.1016/j.ccr.2012.08.004.

3.

The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network.

Ellenbroek SI, Iden S, Collard JG.

Small GTPases. 2012 Jan-Mar;3(1):4-14. doi: 10.4161/sgtp.19379. Epub 2012 Jan 1.

4.

Cell polarity proteins and cancer.

Ellenbroek SI, Iden S, Collard JG.

Semin Cancer Biol. 2012 Jun;22(3):208-15. doi: 10.1016/j.semcancer.2012.02.012. Epub 2012 Mar 23. Review.

PMID:
22465739
5.

Concepts of metastasis in flux: the stromal progression model.

Sleeman JP, Christofori G, Fodde R, Collard JG, Berx G, Decraene C, Rüegg C.

Semin Cancer Biol. 2012 Jun;22(3):174-86. doi: 10.1016/j.semcancer.2012.02.007. Epub 2012 Feb 21. Review.

6.

Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling.

Hajdo-Milasinovic A, van der Kammen RA, Moneva Z, Collard JG.

J Cell Sci. 2009 Jun 15;122(Pt 12):2127-36. doi: 10.1242/jcs.039958.

7.

The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration.

Gérard A, van der Kammen RA, Janssen H, Ellenbroek SI, Collard JG.

Blood. 2009 Jun 11;113(24):6138-47. doi: 10.1182/blood-2008-07-167668. Epub 2009 Jan 12.

8.

Crosstalk between small GTPases and polarity proteins in cell polarization.

Iden S, Collard JG.

Nat Rev Mol Cell Biol. 2008 Nov;9(11):846-59. doi: 10.1038/nrm2521. Review.

PMID:
18946474
9.

Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice.

Strumane K, Rygiel T, van der Valk M, Collard JG.

J Cancer Res Clin Oncol. 2009 Jan;135(1):69-80. doi: 10.1007/s00432-008-0437-8. Epub 2008 Jul 1.

PMID:
18592271
10.

The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation.

Rygiel TP, Mertens AE, Strumane K, van der Kammen R, Collard JG.

J Cell Sci. 2008 Apr 15;121(Pt 8):1183-92. doi: 10.1242/jcs.017194. Epub 2008 Mar 18.

11.

Rho GTPases: functions and association with cancer.

Ellenbroek SI, Collard JG.

Clin Exp Metastasis. 2007;24(8):657-72. Epub 2007 Nov 14. Review.

PMID:
18000759
12.

The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity.

Pegtel DM, Ellenbroek SI, Mertens AE, van der Kammen RA, de Rooij J, Collard JG.

Curr Biol. 2007 Oct 9;17(19):1623-34. Epub 2007 Sep 6.

13.

Increased Rac activity is required for the progression of T-lymphomas induced by Pten-deficiency.

Strumane K, Song JY, Baas I, Collard JG.

Leuk Res. 2008 Jan;32(1):113-20. Epub 2007 May 22.

PMID:
17521720
14.

The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization.

Gérard A, Mertens AE, van der Kammen RA, Collard JG.

J Cell Biol. 2007 Mar 12;176(6):863-75.

15.

Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells.

Hajdo-Milasinović A, Ellenbroek SI, van Es S, van der Vaart B, Collard JG.

J Cell Sci. 2007 Feb 15;120(Pt 4):555-66. Epub 2007 Jan 23.

16.

Prognostic relevance of Tiam1 protein expression in prostate carcinomas.

Engers R, Mueller M, Walter A, Collard JG, Willers R, Gabbert HE.

Br J Cancer. 2006 Oct 23;95(8):1081-6. Epub 2006 Sep 26.

17.

The Rac activator Tiam1 and Ras-induced oncogenesis.

Strumane K, Rygiel TP, Collard JG.

Methods Enzymol. 2006;407:269-81.

PMID:
16757331
18.

Tiam1 takes PARt in cell polarity.

Mertens AE, Pegtel DM, Collard JG.

Trends Cell Biol. 2006 Jun;16(6):308-16. Epub 2006 May 2. Review.

PMID:
16650994
19.

Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization.

Ten Klooster JP, Evers EE, Janssen L, Machesky LM, Michiels F, Hordijk P, Collard JG.

Biochem J. 2006 Jul 1;397(1):39-45.

20.

The Rac activator Tiam1 is required for (alpha)3(beta)1-mediated laminin-5 deposition, cell spreading, and cell migration.

Hamelers IH, Olivo C, Mertens AE, Pegtel DM, van der Kammen RA, Sonnenberg A, Collard JG.

J Cell Biol. 2005 Dec 5;171(5):871-81.

21.

The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.

Malliri A, Rygiel TP, van der Kammen RA, Song JY, Engers R, Hurlstone AF, Clevers H, Collard JG.

J Biol Chem. 2006 Jan 6;281(1):543-8. Epub 2005 Oct 25.

22.

The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex.

Mertens AE, Rygiel TP, Olivo C, van der Kammen R, Collard JG.

J Cell Biol. 2005 Sep 26;170(7):1029-37.

23.
24.

Activation of gef-h1, a guanine nucleotide exchange factor for RhoA, by DNA transfection.

Brecht M, Steenvoorden AC, Collard JG, Luf S, Erz D, Bartram CR, Janssen JW.

Int J Cancer. 2005 Feb 10;113(4):533-40.

25.

The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism.

Uhlenbrock K, Eberth A, Herbrand U, Daryab N, Stege P, Meier F, Friedl P, Collard JG, Ahmadian MR.

J Cell Sci. 2004 Sep 15;117(Pt 20):4863-71. Epub 2004 Aug 31.

26.

Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases.

Zimmerman AW, Nelissen JM, van Emst-de Vries SE, Willems PH, de Lange F, Collard JG, van Leeuwen FN, Figdor CG.

J Cell Sci. 2004 Jun 1;117(Pt 13):2841-52.

27.

Rap1 regulates E-cadherin-mediated cell-cell adhesion.

Price LS, Hajdo-Milasinovic A, Zhao J, Zwartkruis FJ, Collard JG, Bos JL.

J Biol Chem. 2004 Aug 20;279(34):35127-32. Epub 2004 May 27.

28.

The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions.

Malliri A, van Es S, Huveneers S, Collard JG.

J Biol Chem. 2004 Jul 16;279(29):30092-8. Epub 2004 May 11.

29.

Cancer: Kip moving.

Collard JG.

Nature. 2004 Apr 15;428(6984):705-8. No abstract available.

PMID:
15085115
30.

RhoA activation promotes transendothelial migration of monocytes via ROCK.

Honing H, van den Berg TK, van der Pol SM, Dijkstra CD, van der Kammen RA, Collard JG, de Vries HE.

J Leukoc Biol. 2004 Mar;75(3):523-8. Epub 2003 Nov 21.

PMID:
14634067
31.

Role of Rho-family proteins in cell adhesion and cancer.

Malliri A, Collard JG.

Curr Opin Cell Biol. 2003 Oct;15(5):583-9. Review.

PMID:
14519393
32.
33.

Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network. Adherens junctions and myosin light chain as targets of Rac1 and RhoA.

Cascone I, Giraudo E, Caccavari F, Napione L, Bertotti E, Collard JG, Serini G, Bussolino F.

J Biol Chem. 2003 Dec 12;278(50):50702-13. Epub 2003 Sep 12. Erratum in: J Biol Chem. 2004 Aug 27;279(35):37208-9.

34.

Calcium signaling regulates translocation and activation of Rac.

Price LS, Langeslag M, ten Klooster JP, Hordijk PL, Jalink K, Collard JG.

J Biol Chem. 2003 Oct 10;278(41):39413-21. Epub 2003 Jul 29.

35.

Regulation of Tiam1-Rac signalling.

Mertens AE, Roovers RC, Collard JG.

FEBS Lett. 2003 Jul 3;546(1):11-6. Review.

36.

Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1.

Cascone I, Audero E, Giraudo E, Napione L, Maniero F, Philips MR, Collard JG, Serini G, Bussolino F.

Blood. 2003 Oct 1;102(7):2482-90. Epub 2003 Jun 19.

37.

Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.

Van Leeuwen FN, Olivo C, Grivell S, Giepmans BN, Collard JG, Moolenaar WH.

J Biol Chem. 2003 Jan 3;278(1):400-6. Epub 2002 Oct 21.

38.

B plexins activate Rho through PDZ-RhoGEF.

Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG.

FEBS Lett. 2002 Oct 9;529(2-3):168-72.

39.

Activation of small GTPase Rho is required for autocrine motility factor signaling.

Tsutsumi S, Gupta SK, Hogan V, Collard JG, Raz A.

Cancer Res. 2002 Aug 1;62(15):4484-90.

40.

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.

Lambert JM, Lambert QT, Reuther GW, Malliri A, Siderovski DP, Sondek J, Collard JG, Der CJ.

Nat Cell Biol. 2002 Aug;4(8):621-5.

PMID:
12134164
41.

Determination of the activity of Rho-like GTPases in cells.

Malliri A, ten Klooster JP, Olivio C, Collard JG.

Methods Mol Biol. 2002;189:99-109. No abstract available.

PMID:
12094598
42.

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

Malliri A, van der Kammen RA, Clark K, van der Valk M, Michiels F, Collard JG.

Nature. 2002 Jun 20;417(6891):867-71.

PMID:
12075356
43.

Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells.

van Wetering S, van Buul JD, Quik S, Mul FP, Anthony EC, ten Klooster JP, Collard JG, Hordijk PL.

J Cell Sci. 2002 May 1;115(Pt 9):1837-46.

44.

Rac affects invasion of human renal cell carcinomas by up-regulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression.

Engers R, Springer E, Michiels F, Collard JG, Gabbert HE.

J Biol Chem. 2001 Nov 9;276(45):41889-97. Epub 2001 Sep 10.

45.

An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration.

Palacios F, Price L, Schweitzer J, Collard JG, D'Souza-Schorey C.

EMBO J. 2001 Sep 3;20(17):4973-86.

46.

Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion.

Price LS, Collard JG.

Semin Cancer Biol. 2001 Apr;11(2):167-73. Review.

PMID:
11322835
47.

Differential effect of simvastatin on various signal transduction intermediates in cultured human smooth muscle cells.

Nègre-Aminou P, van Erck M, van Leeuwen RE, Collard JG, Cohen LH.

Biochem Pharmacol. 2001 Apr 15;61(8):991-8.

PMID:
11286990
48.

Rho-like GTPases in tumor cell invasion.

Evers EE, van der Kammen RA, ten Klooster JP, Collard JG.

Methods Enzymol. 2000;325:403-15. No abstract available.

PMID:
11036622
49.

Expression of Rho GTPases using retroviral vectors.

Michiels F, van der Kammen RA, Janssen L, Nolan G, Collard JG.

Methods Enzymol. 2000;325:295-302. No abstract available.

PMID:
11036612
50.

Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases.

van Nieuw Amerongen GP, van Delft S, Vermeer MA, Collard JG, van Hinsbergh VW.

Circ Res. 2000 Aug 18;87(4):335-40.

PMID:
10948069

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