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Items: 1 to 50 of 69

1.

GDF15 mediates the effects of metformin on body weight and energy balance.

Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross J, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S.

Nature. 2019 Dec 25. doi: 10.1038/s41586-019-1911-y. [Epub ahead of print]

PMID:
31875646
2.

Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment.

Wray JR, Davies A, Sefton C, Allen TJ, Adamson A, Chapman P, Lam BYH, Yeo GSH, Coll AP, Harno E, White A.

Mol Metab. 2019 Aug;26:5-17. doi: 10.1016/j.molmet.2019.05.008. Epub 2019 May 18.

3.

Fully closed-loop insulin delivery improves glucose control of inpatients with type 2 diabetes receiving hemodialysis.

Bally L, Gubler P, Thabit H, Hartnell S, Ruan Y, Wilinska ME, Evans ML, Semmo M, Vogt B, Coll AP, Stettler C, Hovorka R.

Kidney Int. 2019 Sep;96(3):593-596. doi: 10.1016/j.kint.2019.03.006. Epub 2019 Mar 20.

4.

Outcome of trans-metatarsal amputations in patients with diabetes mellitus.

Humphrey JA, Kanthasamy S, Coughlin P, Coll AP, Robinson AAH.

Foot (Edinb). 2019 Sep;40:22-26. doi: 10.1016/j.foot.2019.04.003. Epub 2019 Apr 8.

PMID:
31054475
5.

Closed-loop insulin delivery in end-of-life care: a case report.

Boughton CK, Bally L, Hartnell S, Wilinska M, Coll AP, Evans M, Stettler C, Hovorka R.

Diabet Med. 2019 Dec;36(12):1711-1714. doi: 10.1111/dme.13974. Epub 2019 May 3.

6.

Fully closed-loop insulin delivery in inpatients receiving nutritional support: a two-centre, open-label, randomised controlled trial.

Boughton CK, Bally L, Martignoni F, Hartnell S, Herzig D, Vogt A, Wertli MM, Wilinska ME, Evans ML, Coll AP, Stettler C, Hovorka R.

Lancet Diabetes Endocrinol. 2019 May;7(5):368-377. doi: 10.1016/S2213-8587(19)30061-0. Epub 2019 Mar 29.

7.

Metabolic Abnormalities of Chronic High-Dose Glucocorticoids Are Not Mediated by Hypothalamic AgRP in Male Mice.

Sefton C, Davies A, Allen TJ, Wray JR, Shoop R, Adamson A, Humphreys N, Coll AP, White A, Harno E.

Endocrinology. 2019 May 1;160(5):964-978. doi: 10.1210/en.2019-00018.

8.

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.

Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S.

Cell Metab. 2019 Mar 5;29(3):707-718.e8. doi: 10.1016/j.cmet.2018.12.016. Epub 2019 Jan 10.

9.

POMC: The Physiological Power of Hormone Processing.

Harno E, Gali Ramamoorthy T, Coll AP, White A.

Physiol Rev. 2018 Oct 1;98(4):2381-2430. doi: 10.1152/physrev.00024.2017. Review.

10.

Monogenic Obesity; Using Drugs to Bypass the Problem.

Coll AP.

Cell Metab. 2018 Jul 3;28(1):1-2. doi: 10.1016/j.cmet.2018.06.015.

11.

Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care.

Bally L, Thabit H, Hartnell S, Andereggen E, Ruan Y, Wilinska ME, Evans ML, Wertli MM, Coll AP, Stettler C, Hovorka R.

N Engl J Med. 2018 Aug 9;379(6):547-556. doi: 10.1056/NEJMoa1805233. Epub 2018 Jun 25.

12.

Neuroarthropathy in diabetes: pathogenesis of Charcot arthropathy.

Johnson-Lynn SE, McCaskie AW, Coll AP, Robinson AHN.

Bone Joint Res. 2018 Jun 5;7(5):373-378. doi: 10.1302/2046-3758.75.BJR-2017-0334.R1. eCollection 2018 May.

13.

Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.

Polex-Wolf J, Lam BY, Larder R, Tadross J, Rimmington D, Bosch F, Cenzano VJ, Ayuso E, Ma MK, Rainbow K, Coll AP, O'Rahilly S, Yeo GS.

J Clin Invest. 2018 Mar 1;128(3):960-969. doi: 10.1172/JCI97007. Epub 2018 Jan 29.

14.

Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance.

Mountjoy KG, Caron A, Hubbard K, Shome A, Grey AC, Sun B, Bould S, Middleditch M, Pontré B, McGregor A, Harris PWR, Kowalczyk R, Brimble MA, Botha R, Tan KML, Piper SJ, Buchanan C, Lee S, Coll AP, Elmquist JK.

Mol Metab. 2018 Mar;9:207-216. doi: 10.1016/j.molmet.2017.11.008. Epub 2017 Nov 24.

15.

Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty.

Howard SR, Guasti L, Poliandri A, David A, Cabrera CP, Barnes MR, Wehkalampi K, O'Rahilly S, Aiken CE, Coll AP, Ma M, Rimmington D, Yeo GSH, Dunkel L.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):649-659. doi: 10.1210/jc.2017-02147.

16.

GDF15 and energy balance: homing in on a mechanism.

Cimino I, Coll AP, Yeo GSH.

Nat Med. 2017 Oct 6;23(10):1119-1120. doi: 10.1038/nm.4414. No abstract available.

PMID:
28985212
17.

Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.

Larder R, Sim MFM, Gulati P, Antrobus R, Tung YCL, Rimmington D, Ayuso E, Polex-Wolf J, Lam BYH, Dias C, Logan DW, Virtue S, Bosch F, Yeo GSH, Saudek V, O'Rahilly S, Coll AP.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9421-9426. doi: 10.1073/pnas.1707310114. Epub 2017 Aug 15.

18.

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M.

Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014.

19.

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing.

Lam BYH, Cimino I, Polex-Wolf J, Nicole Kohnke S, Rimmington D, Iyemere V, Heeley N, Cossetti C, Schulte R, Saraiva LR, Logan DW, Blouet C, O'Rahilly S, Coll AP, Yeo GSH.

Mol Metab. 2017 Mar 1;6(5):383-392. doi: 10.1016/j.molmet.2017.02.007. eCollection 2017 May.

20.

Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial.

Thabit H, Hartnell S, Allen JM, Lake A, Wilinska ME, Ruan Y, Evans ML, Coll AP, Hovorka R.

Lancet Diabetes Endocrinol. 2017 Feb;5(2):117-124. doi: 10.1016/S2213-8587(16)30280-7. Epub 2016 Nov 9.

21.

Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity.

Flint TR, Janowitz T, Connell CM, Roberts EW, Denton AE, Coll AP, Jodrell DI, Fearon DT.

Cell Metab. 2016 Nov 8;24(5):672-684. doi: 10.1016/j.cmet.2016.10.010.

22.

Elevated Hypothalamic Glucocorticoid Levels Are Associated With Obesity and Hyperphagia in Male Mice.

Sefton C, Harno E, Davies A, Small H, Allen TJ, Wray JR, Lawrence CB, Coll AP, White A.

Endocrinology. 2016 Nov;157(11):4257-4265. Epub 2016 Sep 20.

23.

Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol.

Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn EH, Gorrigan RJ, Tate PH, Guasti L; Sanger Mouse Genetics Project, O'Rahilly S, Clark AJ, Logan DW, Coll AP, Chan LF.

J Endocrinol. 2016 Jul;230(1):13-26. doi: 10.1530/JOE-16-0057. Epub 2016 Apr 22.

24.

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.

Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Lu TT, Casas E, Teperino R, Surani MA, Zvetkova I, Rimmington D, Tung YC, Lam B, Larder R, Yeo GS, O'Rahilly S, Vavouri T, Whitelaw E, Penninger JM, Jenuwein T, Cheung CL, Ferguson-Smith AC, Coll AP, Körner A, Pospisilik JA.

Cell. 2016 Jan 28;164(3):353-64. doi: 10.1016/j.cell.2015.12.025.

25.

FTO Obesity Variant and Adipocyte Browning in Humans.

O'Rahilly S, Coll AP, Yeo GS.

N Engl J Med. 2016 Jan 14;374(2):191. doi: 10.1056/NEJMc1513316. No abstract available.

PMID:
26760098
26.

FTO is necessary for the induction of leptin resistance by high-fat feeding.

Tung YC, Gulati P, Liu CH, Rimmington D, Dennis R, Ma M, Saudek V, O'Rahilly S, Coll AP, Yeo GS.

Mol Metab. 2015 Feb 7;4(4):287-98. doi: 10.1016/j.molmet.2015.01.011. eCollection 2015 Apr.

27.

Obesity and FTO: Changing Focus at a Complex Locus.

Tung YCL, Yeo GSH, O'Rahilly S, Coll AP.

Cell Metab. 2014 Nov 4;20(5):710-718. doi: 10.1016/j.cmet.2014.09.010. Epub 2014 Oct 23. Review.

28.

Genetic aspects of human obesity.

Larder R, Lim CT, Coll AP.

Handb Clin Neurol. 2014;124:93-106. doi: 10.1016/B978-0-444-59602-4.00006-X. Review.

PMID:
25248581
29.

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.

Grosse J, Heffron H, Burling K, Akhter Hossain M, Habib AM, Rogers GJ, Richards P, Larder R, Rimmington D, Adriaenssens AA, Parton L, Powell J, Binda M, Colledge WH, Doran J, Toyoda Y, Wade JD, Aparicio S, Carlton MB, Coll AP, Reimann F, O'Rahilly S, Gribble FM.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11133-8. doi: 10.1073/pnas.1411413111. Epub 2014 Jul 15.

30.

The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis.

Coll AP, Yeo GS.

Curr Opin Pharmacol. 2013 Dec;13(6):970-6. doi: 10.1016/j.coph.2013.09.010. Epub 2013 Sep 24. Review.

31.

Outcome of limited forefoot amputation with primary closure in patients with diabetes.

Shaikh N, Vaughan P, Varty K, Coll AP, Robinson AH.

Bone Joint J. 2013 Aug;95-B(8):1083-7. doi: 10.1302/0301-620X.95B8.31280.

PMID:
23908424
32.

"Are melanocortin receptors constitutively active in vivo?".

Coll AP.

Eur J Pharmacol. 2013 Nov 5;719(1-3):202-207. doi: 10.1016/j.ejphar.2013.04.051. Epub 2013 Jul 17. Review.

33.

Clinical examination enables diagnosis of silent syndromes in diabetes.

Coll AP.

BMJ. 2013 Jun 25;346:f3983. doi: 10.1136/bmj.f3983. No abstract available.

PMID:
23801683
34.

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

Roberts EW, Deonarine A, Jones JO, Denton AE, Feig C, Lyons SK, Espeli M, Kraman M, McKenna B, Wells RJ, Zhao Q, Caballero OL, Larder R, Coll AP, O'Rahilly S, Brindle KM, Teichmann SA, Tuveson DA, Fearon DT.

J Exp Med. 2013 Jun 3;210(6):1137-51. doi: 10.1084/jem.20122344. Epub 2013 May 27.

35.

Role for the obesity-related FTO gene in the cellular sensing of amino acids.

Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2557-62. doi: 10.1073/pnas.1222796110. Epub 2013 Jan 28.

36.

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

McMurray F, Church CD, Larder R, Nicholson G, Wells S, Teboul L, Tung YC, Rimmington D, Bosch F, Jimenez V, Yeo GS, O'Rahilly S, Ashcroft FM, Coll AP, Cox RD.

PLoS Genet. 2013;9(1):e1003166. doi: 10.1371/journal.pgen.1003166. Epub 2013 Jan 3.

37.

Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency.

Corander MP, Rimmington D, Challis BG, O'Rahilly S, Coll AP.

Endocrinology. 2011 May;152(5):1819-28. doi: 10.1210/en.2010-1450. Epub 2011 Mar 1.

38.

Melanocortins and body weight regulation: glucocorticoids, Agouti-related protein and beyond.

Corander MP, Coll AP.

Eur J Pharmacol. 2011 Jun 11;660(1):111-8. doi: 10.1016/j.ejphar.2010.10.103. Epub 2011 Jan 1. Review.

PMID:
21199644
39.

Where to go with FTO?

Larder R, Cheung MK, Tung YC, Yeo GS, Coll AP.

Trends Endocrinol Metab. 2011 Feb;22(2):53-9. doi: 10.1016/j.tem.2010.11.001. Epub 2010 Dec 4. Review.

PMID:
21131211
40.

The treatment of diabetic foot infections.

Powlson AS, Coll AP.

J Antimicrob Chemother. 2010 Nov;65 Suppl 3:iii3-9. doi: 10.1093/jac/dkq299. Review.

PMID:
20876626
41.

Treating obesity? It's in the bag!

Coll AP.

Cell Metab. 2010 Feb 3;11(2):95-6. doi: 10.1016/j.cmet.2010.01.006.

42.

Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll AP, Yeo GS.

PLoS One. 2010 Jan 19;5(1):e8771. doi: 10.1371/journal.pone.0008771.

43.

The effects of neurokinin B upon gonadotrophin release in male rodents.

Corander MP, Challis BG, Thompson EL, Jovanovic Z, Loraine Tung YC, Rimmington D, Huhtaniemi IT, Murphy KG, Topaloglu AK, Yeo GS, O'Rahilly S, Dhillo WS, Semple RK, Coll AP.

J Neuroendocrinol. 2010 Mar;22(3):181-7. doi: 10.1111/j.1365-2826.2009.01951.x. Epub 2009 Dec 23.

PMID:
20041982
44.

Science of self-preservation: how melanocortin action in the brain modulates body weight, blood pressure, and ischemic damage.

Corander MP, Fenech M, Coll AP.

Circulation. 2009 Dec 1;120(22):2260-8. doi: 10.1161/CIRCULATIONAHA.109.854612. Review. No abstract available.

45.

Ottawa rules, OK? Rules are different in diabetes.

Coll AP.

BMJ. 2009 Sep 1;339:b3507. doi: 10.1136/bmj.b3507. No abstract available.

PMID:
19723719
46.

SnapShot: the hormonal control of food intake.

Coll AP, Yeo GS, Farooqi IS, O'Rahilly S.

Cell. 2008 Oct 31;135(3):572.e1-2. doi: 10.1016/j.cell.2008.10.014. No abstract available.

47.

Pro-opiomelanocortin (POMC)-derived peptides and the regulation of energy homeostasis.

Coll AP, Loraine Tung YC.

Mol Cell Endocrinol. 2009 Mar 5;300(1-2):147-51. doi: 10.1016/j.mce.2008.09.007. Epub 2008 Sep 17. Review.

PMID:
18840502
48.

Top Tips in 2 minutes: diabetic feet.

Coll AP.

Br J Gen Pract. 2008 Aug;58(553):590-1. doi: 10.3399/bjgp08X319882. No abstract available.

49.

Leptin regulates peripheral lipid metabolism primarily through central effects on food intake.

Prieur X, Tung YC, Griffin JL, Farooqi IS, O'Rahilly S, Coll AP.

Endocrinology. 2008 Nov;149(11):5432-9. doi: 10.1210/en.2008-0498. Epub 2008 Jul 17.

50.

Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT/enhancer-binding protein-beta.

Sai S, Esteves CL, Kelly V, Michailidou Z, Anderson K, Coll AP, Nakagawa Y, Ohzeki T, Seckl JR, Chapman KE.

Mol Endocrinol. 2008 Sep;22(9):2049-60. doi: 10.1210/me.2007-0489. Epub 2008 Jul 10.

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