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GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.

Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S.

Cell Metab. 2019 Jan 2. pii: S1550-4131(18)30753-8. doi: 10.1016/j.cmet.2018.12.016. [Epub ahead of print]


POMC: The Physiological Power of Hormone Processing.

Harno E, Gali Ramamoorthy T, Coll AP, White A.

Physiol Rev. 2018 Oct 1;98(4):2381-2430. doi: 10.1152/physrev.00024.2017. Review.


Monogenic Obesity; Using Drugs to Bypass the Problem.

Coll AP.

Cell Metab. 2018 Jul 3;28(1):1-2. doi: 10.1016/j.cmet.2018.06.015.


Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care.

Bally L, Thabit H, Hartnell S, Andereggen E, Ruan Y, Wilinska ME, Evans ML, Wertli MM, Coll AP, Stettler C, Hovorka R.

N Engl J Med. 2018 Aug 9;379(6):547-556. doi: 10.1056/NEJMoa1805233. Epub 2018 Jun 25.


Network Modeling Unravels Mechanisms of Crosstalk between Ethylene and Salicylate Signaling in Potato.

Ramšak Ž, Coll A, Stare T, Tzfadia O, Baebler Š, Van de Peer Y, Gruden K.

Plant Physiol. 2018 Sep;178(1):488-499. doi: 10.1104/pp.18.00450. Epub 2018 Jun 22.


Neuroarthropathy in diabetes: pathogenesis of Charcot arthropathy.

Johnson-Lynn SE, McCaskie AW, Coll AP, Robinson AHN.

Bone Joint Res. 2018 Jun 5;7(5):373-378. doi: 10.1302/2046-3758.75.BJR-2017-0334.R1. eCollection 2018 May.


Oral health knowledge, perceptions and practices among parents, guardians and teachers in South Wales, UK: A qualitative study.

Filipponi T, Richards W, Coll AM.

Br Dent J. 2018 Apr 13;224(7):517-522. doi: 10.1038/sj.bdj.2018.223. Epub 2018 Mar 23. No abstract available.


Cell Death Is Not Sufficient for the Restriction of Potato Virus Y Spread in Hypersensitive Response-Conferred Resistance in Potato.

Lukan T, Baebler Š, Pompe-Novak M, Guček K, Zagorščak M, Coll A, Gruden K.

Front Plant Sci. 2018 Feb 15;9:168. doi: 10.3389/fpls.2018.00168. eCollection 2018.


Al2O3/TiO2 inverse opals from electrosprayed self-assembled templates.

Coll A, Bermejo S, Hernández D, Castañer L.

Beilstein J Nanotechnol. 2018 Jan 19;9:216-223. doi: 10.3762/bjnano.9.23. eCollection 2018.


Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.

Polex-Wolf J, Lam BY, Larder R, Tadross J, Rimmington D, Bosch F, Cenzano VJ, Ayuso E, Ma MK, Rainbow K, Coll AP, O'Rahilly S, Yeo GS.

J Clin Invest. 2018 Mar 1;128(3):960-969. doi: 10.1172/JCI97007. Epub 2018 Jan 29.


Plant X-tender: An extension of the AssemblX system for the assembly and expression of multigene constructs in plants.

Lukan T, Machens F, Coll A, Baebler Š, Messerschmidt K, Gruden K.

PLoS One. 2018 Jan 4;13(1):e0190526. doi: 10.1371/journal.pone.0190526. eCollection 2018.


Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance.

Mountjoy KG, Caron A, Hubbard K, Shome A, Grey AC, Sun B, Bould S, Middleditch M, Pontré B, McGregor A, Harris PWR, Kowalczyk R, Brimble MA, Botha R, Tan KML, Piper SJ, Buchanan C, Lee S, Coll AP, Elmquist JK.

Mol Metab. 2018 Mar;9:207-216. doi: 10.1016/j.molmet.2017.11.008. Epub 2017 Nov 24.


Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty.

Howard SR, Guasti L, Poliandri A, David A, Cabrera CP, Barnes MR, Wehkalampi K, O'Rahilly S, Aiken CE, Coll AP, Ma M, Rimmington D, Yeo GSH, Dunkel L.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):649-659. doi: 10.1210/jc.2017-02147.


GDF15 and energy balance: homing in on a mechanism.

Cimino I, Coll AP, Yeo GSH.

Nat Med. 2017 Oct 6;23(10):1119-1120. doi: 10.1038/nm.4414. No abstract available.


Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.

Larder R, Sim MFM, Gulati P, Antrobus R, Tung YCL, Rimmington D, Ayuso E, Polex-Wolf J, Lam BYH, Dias C, Logan DW, Virtue S, Bosch F, Yeo GSH, Saudek V, O'Rahilly S, Coll AP.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9421-9426. doi: 10.1073/pnas.1707310114. Epub 2017 Aug 15.


Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M.

Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014.


Advanced oxidation of commercial herbicides mixture: experimental design and phytotoxicity evaluation.

López A, Coll A, Lescano M, Zalazar C.

Environ Sci Pollut Res Int. 2018 Aug;25(22):21393-21402. doi: 10.1007/s11356-017-9041-2. Epub 2017 May 5.


Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing.

Lam BYH, Cimino I, Polex-Wolf J, Nicole Kohnke S, Rimmington D, Iyemere V, Heeley N, Cossetti C, Schulte R, Saraiva LR, Logan DW, Blouet C, O'Rahilly S, Coll AP, Yeo GSH.

Mol Metab. 2017 Mar 1;6(5):383-392. doi: 10.1016/j.molmet.2017.02.007. eCollection 2017 May.


Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial.

Thabit H, Hartnell S, Allen JM, Lake A, Wilinska ME, Ruan Y, Evans ML, Coll AP, Hovorka R.

Lancet Diabetes Endocrinol. 2017 Feb;5(2):117-124. doi: 10.1016/S2213-8587(16)30280-7. Epub 2016 Nov 9.


Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity.

Flint TR, Janowitz T, Connell CM, Roberts EW, Denton AE, Coll AP, Jodrell DI, Fearon DT.

Cell Metab. 2016 Nov 8;24(5):672-684. doi: 10.1016/j.cmet.2016.10.010.


Elevated Hypothalamic Glucocorticoid Levels Are Associated With Obesity and Hyperphagia in Male Mice.

Sefton C, Harno E, Davies A, Small H, Allen TJ, Wray JR, Lawrence CB, Coll AP, White A.

Endocrinology. 2016 Nov;157(11):4257-4265. Epub 2016 Sep 20.


GenoCAD Plant Grammar to Design Plant Expression Vectors for Promoter Analysis.

Coll A, Wilson ML, Gruden K, Peccoud J.

Methods Mol Biol. 2016;1482:219-32. doi: 10.1007/978-1-4939-6396-6_14.


Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol.

Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn EH, Gorrigan RJ, Tate PH, Guasti L; Sanger Mouse Genetics Project, O'Rahilly S, Clark AJ, Logan DW, Coll AP, Chan LF.

J Endocrinol. 2016 Jul;230(1):13-26. doi: 10.1530/JOE-16-0057. Epub 2016 Apr 22.


A compact and integrated immunoassay with on-chip dispensing and magnetic particle handling.

Zirath H, Peham JR, Schnetz G, Coll A, Brandhoff L, Spittler A, Vellekoop MJ, Redl H.

Biomed Microdevices. 2016 Feb;18(1):16. doi: 10.1007/s10544-016-0045-3.


Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.

Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Lu TT, Casas E, Teperino R, Surani MA, Zvetkova I, Rimmington D, Tung YC, Lam B, Larder R, Yeo GS, O'Rahilly S, Vavouri T, Whitelaw E, Penninger JM, Jenuwein T, Cheung CL, Ferguson-Smith AC, Coll AP, Körner A, Pospisilik JA.

Cell. 2016 Jan 28;164(3):353-64. doi: 10.1016/j.cell.2015.12.025.


FTO Obesity Variant and Adipocyte Browning in Humans.

O'Rahilly S, Coll AP, Yeo GS.

N Engl J Med. 2016 Jan 14;374(2):191. doi: 10.1056/NEJMc1513316. No abstract available.


Providers' perspectives on preconception counseling and safer conception for HIV-infected women.

Coll AS, Potter JE, Chakhtoura N, Alcaide ML, Cook R, Jones DL.

AIDS Care. 2016;28(4):513-8. doi: 10.1080/09540121.2015.1112349. Epub 2015 Nov 18.


Perspectives on safer conception practices and preconception counseling among women living with HIV.

Jean J, Coll A, Monda M, Potter J, Jones D.

Health Care Women Int. 2016 Oct;37(10):1096-118. doi: 10.1080/07399332.2015.1107068. Epub 2015 Oct 22.


Inter-professional prescribing masterclass for medical students and non-medical prescribing students (nurses and pharmacists): a pilot study.

Paterson R, Rolfe A, Coll A, Kinnear M.

Scott Med J. 2015 Nov;60(4):202-7. doi: 10.1177/0036933015606583. Epub 2015 Sep 23.


Correction: Rule-Based Design of Plant Expression Vectors Using GenoCAD.

Coll A, Wilson ML, Gruden K, Peccoud J.

PLoS One. 2015 Aug 13;10(8):e0136004. doi: 10.1371/journal.pone.0136004. eCollection 2015. No abstract available.


Rule-Based Design of Plant Expression Vectors Using GenoCAD.

Coll A, Wilson ML, Gruden K, Peccoud J.

PLoS One. 2015 Jul 6;10(7):e0132502. doi: 10.1371/journal.pone.0132502. eCollection 2015. Erratum in: PLoS One. 2015;10(8):e0136004.


FTO is necessary for the induction of leptin resistance by high-fat feeding.

Tung YC, Gulati P, Liu CH, Rimmington D, Dennis R, Ma M, Saudek V, O'Rahilly S, Coll AP, Yeo GS.

Mol Metab. 2015 Feb 7;4(4):287-98. doi: 10.1016/j.molmet.2015.01.011. eCollection 2015 Apr.


Obesity and FTO: Changing Focus at a Complex Locus.

Tung YCL, Yeo GSH, O'Rahilly S, Coll AP.

Cell Metab. 2014 Nov 4;20(5):710-718. doi: 10.1016/j.cmet.2014.09.010. Epub 2014 Oct 23. Review.


Genetic aspects of human obesity.

Larder R, Lim CT, Coll AP.

Handb Clin Neurol. 2014;124:93-106. doi: 10.1016/B978-0-444-59602-4.00006-X. Review.


A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

Al Olama AA, Kote-Jarai Z, Berndt SI, Conti DV, Schumacher F, Han Y, Benlloch S, Hazelett DJ, Wang Z, Saunders E, Leongamornlert D, Lindstrom S, Jugurnauth-Little S, Dadaev T, Tymrakiewicz M, Stram DO, Rand K, Wan P, Stram A, Sheng X, Pooler LC, Park K, Xia L, Tyrer J, Kolonel LN, Le Marchand L, Hoover RN, Machiela MJ, Yeager M, Burdette L, Chung CC, Hutchinson A, Yu K, Goh C, Ahmed M, Govindasami K, Guy M, Tammela TL, Auvinen A, Wahlfors T, Schleutker J, Visakorpi T, Leinonen KA, Xu J, Aly M, Donovan J, Travis RC, Key TJ, Siddiq A, Canzian F, Khaw KT, Takahashi A, Kubo M, Pharoah P, Pashayan N, Weischer M, Nordestgaard BG, Nielsen SF, Klarskov P, Røder MA, Iversen P, Thibodeau SN, McDonnell SK, Schaid DJ, Stanford JL, Kolb S, Holt S, Knudsen B, Coll AH, Gapstur SM, Diver WR, Stevens VL, Maier C, Luedeke M, Herkommer K, Rinckleb AE, Strom SS, Pettaway C, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Chokkalingam AP, Cannon-Albright L, Cybulski C, Wokołorczyk D, Kluźniak W, Park J, Sellers T, Lin HY, Isaacs WB, Partin AW, Brenner H, Dieffenbach AK, Stegmaier C, Chen C, Giovannucci EL, Ma J, Stampfer M, Penney KL, Mucci L, John EM, Ingles SA, Kittles RA, Murphy AB, Pandha H, Michael A, Kierzek AM, Blot W, Signorello LB, Zheng W, Albanes D, Virtamo J, Weinstein S, Nemesure B, Carpten J, Leske C, Wu SY, Hennis A, Kibel AS, Rybicki BA, Neslund-Dudas C, Hsing AW, Chu L, Goodman PJ, Klein EA, Zheng SL, Batra J, Clements J, Spurdle A, Teixeira MR, Paulo P, Maia S, Slavov C, Kaneva R, Mitev V, Witte JS, Casey G, Gillanders EM, Seminara D, Riboli E, Hamdy FC, Coetzee GA, Li Q, Freedman ML, Hunter DJ, Muir K, Gronberg H, Neal DE, Southey M, Giles GG, Severi G; Breast and Prostate Cancer Cohort Consortium (BPC3); PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; COGS (Collaborative Oncological Gene-environment Study) Consortium; GAME-ON/ELLIPSE Consortium, Cook MB, Nakagawa H, Wiklund F, Kraft P, Chanock SJ, Henderson BE, Easton DF, Eeles RA, Haiman CA.

Nat Genet. 2014 Oct;46(10):1103-9. doi: 10.1038/ng.3094. Epub 2014 Sep 14.


Involvement of potato (Solanum tuberosum L.) MKK6 in response to potato virus Y.

Lazar A, Coll A, Dobnik D, Baebler S, Bedina-Zavec A, Zel J, Gruden K.

PLoS One. 2014 Aug 11;9(8):e104553. doi: 10.1371/journal.pone.0104553. eCollection 2014.


Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.

Grosse J, Heffron H, Burling K, Akhter Hossain M, Habib AM, Rogers GJ, Richards P, Larder R, Rimmington D, Adriaenssens AA, Parton L, Powell J, Binda M, Colledge WH, Doran J, Toyoda Y, Wade JD, Aparicio S, Carlton MB, Coll AP, Reimann F, O'Rahilly S, Gribble FM.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11133-8. doi: 10.1073/pnas.1411413111. Epub 2014 Jul 15.


The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis.

Coll AP, Yeo GS.

Curr Opin Pharmacol. 2013 Dec;13(6):970-6. doi: 10.1016/j.coph.2013.09.010. Epub 2013 Sep 24. Review.


Outcome of limited forefoot amputation with primary closure in patients with diabetes.

Shaikh N, Vaughan P, Varty K, Coll AP, Robinson AH.

Bone Joint J. 2013 Aug;95-B(8):1083-7. doi: 10.1302/0301-620X.95B8.31280.


"Are melanocortin receptors constitutively active in vivo?".

Coll AP.

Eur J Pharmacol. 2013 Nov 5;719(1-3):202-7. doi: 10.1016/j.ejphar.2013.04.051. Epub 2013 Jul 17. Review.


Clinical examination enables diagnosis of silent syndromes in diabetes.

Coll AP.

BMJ. 2013 Jun 25;346:f3983. doi: 10.1136/bmj.f3983. No abstract available.


Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

Roberts EW, Deonarine A, Jones JO, Denton AE, Feig C, Lyons SK, Espeli M, Kraman M, McKenna B, Wells RJ, Zhao Q, Caballero OL, Larder R, Coll AP, O'Rahilly S, Brindle KM, Teichmann SA, Tuveson DA, Fearon DT.

J Exp Med. 2013 Jun 3;210(6):1137-51. doi: 10.1084/jem.20122344. Epub 2013 May 27.


Role for the obesity-related FTO gene in the cellular sensing of amino acids.

Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2557-62. doi: 10.1073/pnas.1222796110. Epub 2013 Jan 28.


Colloidal crystals by electrospraying polystyrene nanofluids.

Coll A, Bermejo S, Hernández D, Castañer L.

Nanoscale Res Lett. 2013 Jan 12;8(1):26. doi: 10.1186/1556-276X-8-26.


Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

McMurray F, Church CD, Larder R, Nicholson G, Wells S, Teboul L, Tung YC, Rimmington D, Bosch F, Jimenez V, Yeo GS, O'Rahilly S, Ashcroft FM, Coll AP, Cox RD.

PLoS Genet. 2013;9(1):e1003166. doi: 10.1371/journal.pgen.1003166. Epub 2013 Jan 3.


Design of antimicrobial stewardship care bundles on the high dependency unit.

Coll A, Kinnear M, Kinnear A.

Int J Clin Pharm. 2012 Dec;34(6):845-54. doi: 10.1007/s11096-012-9680-9. Epub 2012 Aug 3.


Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency.

Corander MP, Rimmington D, Challis BG, O'Rahilly S, Coll AP.

Endocrinology. 2011 May;152(5):1819-28. doi: 10.1210/en.2010-1450. Epub 2011 Mar 1.


Melanocortins and body weight regulation: glucocorticoids, Agouti-related protein and beyond.

Corander MP, Coll AP.

Eur J Pharmacol. 2011 Jun 11;660(1):111-8. doi: 10.1016/j.ejphar.2010.10.103. Epub 2011 Jan 1. Review.


Where to go with FTO?

Larder R, Cheung MK, Tung YC, Yeo GS, Coll AP.

Trends Endocrinol Metab. 2011 Feb;22(2):53-9. doi: 10.1016/j.tem.2010.11.001. Epub 2010 Dec 4. Review.


Only half the transcriptomic differences between resistant genetically modified and conventional rice are associated with the transgene.

Montero M, Coll A, Nadal A, Messeguer J, Pla M.

Plant Biotechnol J. 2011 Aug;9(6):693-702. doi: 10.1111/j.1467-7652.2010.00572.x. Epub 2010 Oct 29.

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