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Items: 1 to 50 of 218

1.

Oral vitamin B12 supplement is delivered to the distal gut, altering the corrinoid profile and selectively depleting Bacteroides in C57BL/6 mice.

Kelly CJ, Alexeev EE, Farb L, Vickery TW, Zheng L, Eric L C, Kitzenberg DA, Battista KD, Kominsky DJ, Robertson CE, Frank DN, Stabler SP, Colgan SP.

Gut Microbes. 2019 May 7:1-9. doi: 10.1080/19490976.2019.1597667. [Epub ahead of print]

PMID:
31062653
2.

Control and dysregulation of redox signalling in the gastrointestinal tract.

Campbell EL, Colgan SP.

Nat Rev Gastroenterol Hepatol. 2019 Feb;16(2):106-120. doi: 10.1038/s41575-018-0079-5. Review.

PMID:
30443019
3.

Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells.

Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens BM, Winters AC, Lin X, Ashton JM, Purev E, Xing L, Pollyea DA, Lozupone CA, Serkova NJ, Colgan SP, Jordan CT.

Cancer Cell. 2018 Oct 8;34(4):659-673.e6. doi: 10.1016/j.ccell.2018.08.016. Epub 2018 Sep 27.

PMID:
30270124
4.

Neutrophils as sources of dinucleotide polyphosphates and metabolism by epithelial ENPP1 to influence barrier function via adenosine signaling.

Curtis VF, Cartwright IM, Lee JS, Wang RX, Kao DJ, Lanis JM, Burney KM, Welch N, Hall CHT, Goldberg MS, Campbell EL, Colgan SP.

Mol Biol Cell. 2018 Nov 1;29(22):2687-2699. doi: 10.1091/mbc.E18-06-0377. Epub 2018 Sep 6.

5.

A Central Role for Heme Oxygenase-1 in the Control of Intestinal Epithelial Chemokine Expression.

Onyiah JC, Schaefer REM, Colgan SP.

J Innate Immun. 2018;10(3):228-238. doi: 10.1159/000488914. Epub 2018 May 23.

6.

Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function.

Lee JS, Wang RX, Alexeev EE, Lanis JM, Battista KD, Glover LE, Colgan SP.

J Biol Chem. 2018 Apr 20;293(16):6039-6051. doi: 10.1074/jbc.RA117.000269. Epub 2018 Feb 27.

7.

Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor.

Alexeev EE, Lanis JM, Kao DJ, Campbell EL, Kelly CJ, Battista KD, Gerich ME, Jenkins BR, Walk ST, Kominsky DJ, Colgan SP.

Am J Pathol. 2018 May;188(5):1183-1194. doi: 10.1016/j.ajpath.2018.01.011. Epub 2018 Feb 16.

8.

Regulation of immunity and inflammation by hypoxia in immunological niches.

Taylor CT, Colgan SP.

Nat Rev Immunol. 2017 Dec;17(12):774-785. doi: 10.1038/nri.2017.103. Epub 2017 Oct 3. Review.

9.

Epithelial Barrier Regulation by Hypoxia-Inducible Factor.

Glover LE, Colgan SP.

Ann Am Thorac Soc. 2017 Sep;14(Supplement_3):S233-S236. doi: 10.1513/AnnalsATS.201608-610MG. Review.

10.

Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2.

Zheng L, Kelly CJ, Battista KD, Schaefer R, Lanis JM, Alexeev EE, Wang RX, Onyiah JC, Kominsky DJ, Colgan SP.

J Immunol. 2017 Oct 15;199(8):2976-2984. doi: 10.4049/jimmunol.1700105. Epub 2017 Sep 11.

11.

Neutrophils as Components of Mucosal Homeostasis.

Hall CHT, Campbell EL, Colgan SP.

Cell Mol Gastroenterol Hepatol. 2017 Jul 19;4(3):329-337. doi: 10.1016/j.jcmgh.2017.07.001. eCollection 2017 Nov. Review.

12.

TGF-β1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis.

Nguyen N, Fernando SD, Biette KA, Hammer JA, Capocelli KE, Kitzenberg DA, Glover LE, Colgan SP, Furuta GT, Masterson JC.

Mucosal Immunol. 2018 Mar;11(2):415-426. doi: 10.1038/mi.2017.72. Epub 2017 Aug 23.

13.

Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity.

Kuhn KA, Schulz HM, Regner EH, Severs EL, Hendrickson JD, Mehta G, Whitney AK, Ir D, Ohri N, Robertson CE, Frank DN, Campbell EL, Colgan SP.

Mucosal Immunol. 2018 Mar;11(2):357-368. doi: 10.1038/mi.2017.55. Epub 2017 Aug 16.

14.

Novel therapeutic concepts for inflammatory bowel disease-from bench to bedside.

Neudecker V, Colgan SP, Eltzschig HK.

J Mol Med (Berl). 2017 Sep;95(9):899-903. doi: 10.1007/s00109-017-1574-9. No abstract available.

15.

Intestinal Epithelial Ecto-5'-Nucleotidase (CD73) Regulates Intestinal Colonization and Infection by Nontyphoidal Salmonella.

Kao DJ, Saeedi BJ, Kitzenberg D, Burney KM, Dobrinskikh E, Battista KD, Vázquez-Torres A, Colgan SP, Kominsky DJ.

Infect Immun. 2017 Sep 20;85(10). pii: e01022-16. doi: 10.1128/IAI.01022-16. Print 2017 Oct.

16.

Oxygen metabolism and innate immune responses in the gut.

Colgan SP, Campbell EL.

J Appl Physiol (1985). 2017 Nov 1;123(5):1321-1327. doi: 10.1152/japplphysiol.00113.2017. Epub 2017 Jul 13. Review.

17.

Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.

McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL.

Am J Pathol. 2017 Aug;187(8):1772-1786. doi: 10.1016/j.ajpath.2017.04.012. Epub 2017 Jun 12.

18.

Tissue metabolism and the inflammatory bowel diseases.

Lanis JM, Kao DJ, Alexeev EE, Colgan SP.

J Mol Med (Berl). 2017 Sep;95(9):905-913. doi: 10.1007/s00109-017-1544-2. Epub 2017 May 20. Review.

19.

Special pro-resolving mediator (SPM) actions in regulating gastro-intestinal inflammation and gut mucosal immune responses.

Wang RX, Colgan SP.

Mol Aspects Med. 2017 Dec;58:93-101. doi: 10.1016/j.mam.2017.02.002. Epub 2017 Feb 21. Review.

20.

Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia.

Lanis JM, Alexeev EE, Curtis VF, Kitzenberg DA, Kao DJ, Battista KD, Gerich ME, Glover LE, Kominsky DJ, Colgan SP.

Mucosal Immunol. 2017 Sep;10(5):1133-1144. doi: 10.1038/mi.2016.133. Epub 2017 Jan 18.

21.

Tissue metabolism and host-microbial interactions in the intestinal mucosa.

Chun C, Zheng L, Colgan SP.

Free Radic Biol Med. 2017 Apr;105:86-92. doi: 10.1016/j.freeradbiomed.2016.09.027. Epub 2016 Sep 28. Review.

22.

Perturbation of neddylation-dependent NF-κB responses in the intestinal epithelium drives apoptosis and inhibits resolution of mucosal inflammation.

Ehrentraut SF, Curtis VF, Wang RX, Saeedi BJ, Ehrentraut H, Onyiah JC, Kelly CJ, Campbell EL, Glover LE, Kominsky DJ, Colgan SP.

Mol Biol Cell. 2016 Sep 28. pii: mbc.E16-05-0273. [Epub ahead of print]

23.

Neutrophils and the inflammatory tissue microenvironment in the mucosa.

Campbell EL, Kao DJ, Colgan SP.

Immunol Rev. 2016 Sep;273(1):112-20. doi: 10.1111/imr.12456. Review.

24.

Creatine kinase in ischemic and inflammatory disorders.

Kitzenberg D, Colgan SP, Glover LE.

Clin Transl Med. 2016 Dec;5(1):31. doi: 10.1186/s40169-016-0114-5. Epub 2016 Aug 15. Review.

25.

Oxygen metabolism and barrier regulation in the intestinal mucosa.

Glover LE, Lee JS, Colgan SP.

J Clin Invest. 2016 Oct 3;126(10):3680-3688. doi: 10.1172/JCI84429. Epub 2016 Aug 8. Review.

26.

G2A Signaling Dampens Colitic Inflammation via Production of IFN-γ.

Frasch SC, McNamee EN, Kominsky D, Jedlicka P, Jakubzick C, Zemski Berry K, Mack M, Furuta GT, Lee JJ, Henson PM, Colgan SP, Bratton DL.

J Immunol. 2016 Aug 15;197(4):1425-34. doi: 10.4049/jimmunol.1600264. Epub 2016 Jul 8.

27.

Cytokine responses and epithelial function in the intestinal mucosa.

Onyiah JC, Colgan SP.

Cell Mol Life Sci. 2016 Nov;73(22):4203-4212. Epub 2016 Jun 6. Review.

28.

Hypoxia and Mucosal Inflammation.

Colgan SP, Campbell EL, Kominsky DJ.

Annu Rev Pathol. 2016 May 23;11:77-100. doi: 10.1146/annurev-pathol-012615-044231. Review.

29.

Hypoxia-inducible factors as molecular targets for liver diseases.

Ju C, Colgan SP, Eltzschig HK.

J Mol Med (Berl). 2016 Jun;94(6):613-27. doi: 10.1007/s00109-016-1408-1. Epub 2016 Apr 20. Review.

30.

Breathless in the Gut: Implications of Luminal O2 for Microbial Pathogenicity.

Kelly CJ, Colgan SP.

Cell Host Microbe. 2016 Apr 13;19(4):427-8. doi: 10.1016/j.chom.2016.03.014.

31.

Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia.

Selfridge AC, Cavadas MA, Scholz CC, Campbell EL, Welch LC, Lecuona E, Colgan SP, Barrett KE, Sporn PH, Sznajder JI, Cummins EP, Taylor CT.

J Biol Chem. 2016 May 27;291(22):11800-8. doi: 10.1074/jbc.M116.713941. Epub 2016 Apr 4.

32.

Hypoxia: The Force that Drives Chronic Kidney Disease.

Fu Q, Colgan SP, Shelley CS.

Clin Med Res. 2016 Mar;14(1):15-39. doi: 10.3121/cmr.2015.1282. Epub 2016 Feb 4. Review.

33.

Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia.

Zheng L, Kelly CJ, Colgan SP.

Am J Physiol Cell Physiol. 2015 Sep 15;309(6):C350-60. doi: 10.1152/ajpcell.00191.2015. Epub 2015 Jul 15. Review.

34.

Targeting hypoxia in inflammatory bowel disease.

Colgan SP.

J Investig Med. 2016 Feb;64(2):364-8. doi: 10.1097/JIM.0000000000000218. Epub 2016 Jan 11. Review.

35.

Actions of adenosine on cullin neddylation: implications for inflammatory responses.

Curtis VF, Ehrentraut SF, Colgan SP.

Comput Struct Biotechnol J. 2014 Oct 15;13:273-6. doi: 10.1016/j.csbj.2014.10.002. eCollection 2015. Review.

36.

Erratum: Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis.

Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK.

Mucosal Immunol. 2015 May;8(3):699. doi: 10.1038/mi.2015.41. No abstract available.

PMID:
25943416
37.

HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity.

Saeedi BJ, Kao DJ, Kitzenberg DA, Dobrinskikh E, Schwisow KD, Masterson JC, Kendrick AA, Kelly CJ, Bayless AJ, Kominsky DJ, Campbell EL, Kuhn KA, Furuta GT, Colgan SP, Glover LE.

Mol Biol Cell. 2015 Jun 15;26(12):2252-62. doi: 10.1091/mbc.E14-07-1194. Epub 2015 Apr 22.

38.

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function.

Kelly CJ, Zheng L, Campbell EL, Saeedi B, Scholz CC, Bayless AJ, Wilson KE, Glover LE, Kominsky DJ, Magnuson A, Weir TL, Ehrentraut SF, Pickel C, Kuhn KA, Lanis JM, Nguyen V, Taylor CT, Colgan SP.

Cell Host Microbe. 2015 May 13;17(5):662-71. doi: 10.1016/j.chom.2015.03.005. Epub 2015 Apr 9.

39.

Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis.

Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK.

Mucosal Immunol. 2015 Nov;8(6):1324-38. doi: 10.1038/mi.2015.22. Epub 2015 Apr 8. Erratum in: Mucosal Immunol. 2015 May;8(3):699.

40.

Metabolic regulation of intestinal epithelial barrier during inflammation.

Colgan SP, Curtis VF, Lanis JM, Glover LE.

Tissue Barriers. 2015 Apr 3;3(1-2):e970936. doi: 10.4161/21688362.2014.970936. eCollection 2015.

41.

Neutrophils and inflammatory resolution in the mucosa.

Colgan SP.

Semin Immunol. 2015 May;27(3):177-83. doi: 10.1016/j.smim.2015.03.007. Epub 2015 Mar 26. Review.

42.

Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa.

Campbell EL, Colgan SP.

J Leukoc Biol. 2015 Oct;98(4):517-22. doi: 10.1189/jlb.3MR1114-556R. Epub 2015 Feb 24. Review.

43.

Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia.

Xiong W, Knox AJ, Xu M, Kiseljak-Vassiliades K, Colgan SP, Brodsky KS, Kleinschmidt-Demasters BK, Lillehei KO, Wierman ME.

Mol Endocrinol. 2015 Mar;29(3):460-72. doi: 10.1210/me.2014-1332. Epub 2015 Feb 4.

44.

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases.

Eltzschig HK, Bratton DL, Colgan SP.

Nat Rev Drug Discov. 2014 Nov;13(11):852-69. doi: 10.1038/nrd4422. Review.

45.

Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses.

Curtis VF, Ehrentraut SF, Campbell EL, Glover LE, Bayless A, Kelly CJ, Kominsky DJ, Colgan SP.

FASEB J. 2015 Jan;29(1):208-15. doi: 10.1096/fj.14-259663. Epub 2014 Oct 17.

46.

Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis.

Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, Furuta GT.

Gut. 2015 Aug;64(8):1236-47. doi: 10.1136/gutjnl-2014-306998. Epub 2014 Sep 10.

47.

Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation.

Campbell EL, Bruyninckx WJ, Kelly CJ, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Saeedi BJ, Golden-Mason L, Ehrentraut SF, Curtis VF, Burgess A, Garvey JF, Sorensen A, Nemenoff R, Jedlicka P, Taylor CT, Kominsky DJ, Colgan SP.

Immunity. 2014 Jan 16;40(1):66-77. doi: 10.1016/j.immuni.2013.11.020. Epub 2014 Jan 9.

48.

Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury.

Eckle T, Kewley EM, Brodsky KS, Tak E, Bonney S, Gobel M, Anderson D, Glover LE, Riegel AK, Colgan SP, Eltzschig HK.

J Immunol. 2014 Feb 1;192(3):1249-56. doi: 10.4049/jimmunol.1100593. Epub 2014 Jan 3.

49.

IFN-γ-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia.

Kominsky DJ, Campbell EL, Ehrentraut SF, Wilson KE, Kelly CJ, Glover LE, Collins CB, Bayless AJ, Saeedi B, Dobrinskikh E, Bowers BE, MacManus CF, Müller W, Colgan SP, Bruder D.

J Immunol. 2014 Feb 1;192(3):1267-76. doi: 10.4049/jimmunol.1301757. Epub 2013 Dec 23.

50.

Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis.

Glover LE, Bowers BE, Saeedi B, Ehrentraut SF, Campbell EL, Bayless AJ, Dobrinskikh E, Kendrick AA, Kelly CJ, Burgess A, Miller L, Kominsky DJ, Jedlicka P, Colgan SP.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19820-5. doi: 10.1073/pnas.1302840110. Epub 2013 Nov 18.

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