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Items: 26

1.

Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.

Didiot MC, Ferguson CM, Ly S, Coles AH, Smith AO, Bicknell AA, Hall LM, Sapp E, Echeverria D, Pai AA, DiFiglia M, Moore MJ, Hayward LJ, Aronin N, Khvorova A.

Cell Rep. 2018 Sep 4;24(10):2553-2560.e5. doi: 10.1016/j.celrep.2018.07.106.

2.

Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.

Godinho BMDC, Henninger N, Bouley J, Alterman JF, Haraszti RA, Gilbert JW, Sapp E, Coles AH, Biscans A, Nikan M, Echeverria D, DiFiglia M, Aronin N, Khvorova A.

Mol Ther. 2018 Nov 7;26(11):2580-2591. doi: 10.1016/j.ymthe.2018.08.005. Epub 2018 Aug 8.

PMID:
30143435
3.

Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs.

Osborn MF, Coles AH, Golebiowski D, Echeverria D, Moazami MP, Watts JK, Sena-Esteves M, Khvorova A.

Mol Cancer Ther. 2018 Jun;17(6):1251-1258. doi: 10.1158/1535-7163.MCT-17-1144. Epub 2018 Apr 13.

PMID:
29654062
4.

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.

Hassler MR, Turanov AA, Alterman JF, Haraszti RA, Coles AH, Osborn MF, Echeverria D, Nikan M, Salomon WE, Roux L, Godinho BMDC, Davis SM, Morrissey DV, Zamore PD, Karumanchi SA, Moore MJ, Aronin N, Khvorova A.

Nucleic Acids Res. 2018 Mar 16;46(5):2185-2196. doi: 10.1093/nar/gky037.

5.

Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.

Godinho BMDC, Gilbert JW, Haraszti RA, Coles AH, Biscans A, Roux L, Nikan M, Echeverria D, Hassler M, Khvorova A.

Nucleic Acid Ther. 2017 Dec;27(6):323-334. doi: 10.1089/nat.2017.0690. Epub 2017 Oct 12.

PMID:
29022758
6.

A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons in vitro with Oligonucleotide Therapeutics.

Alterman JF, Coles AH, Hall LM, Aronin N, Khvorova A, Didiot MC.

Bio Protoc. 2017 Aug 20;7(16). pii: e2501. doi: 10.21769/BioProtoc.2501.

7.

5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.

Haraszti RA, Roux L, Coles AH, Turanov AA, Alterman JF, Echeverria D, Godinho BMDC, Aronin N, Khvorova A.

Nucleic Acids Res. 2017 Jul 27;45(13):7581-7592. doi: 10.1093/nar/gkx507.

8.

Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.

Nikan M, Osborn MF, Coles AH, Biscans A, Godinho BMDC, Haraszti RA, Sapp E, Echeverria D, DiFiglia M, Aronin N, Khvorova A.

Bioconjug Chem. 2017 Jun 21;28(6):1758-1766. doi: 10.1021/acs.bioconjchem.7b00226. Epub 2017 May 10.

9.

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing.

Didiot MC, Hall LM, Coles AH, Haraszti RA, Godinho BM, Chase K, Sapp E, Ly S, Alterman JF, Hassler MR, Echeverria D, Raj L, Morrissey DV, DiFiglia M, Aronin N, Khvorova A.

Mol Ther. 2016 Oct;24(10):1836-1847. doi: 10.1038/mt.2016.126. Epub 2016 Jun 27.

10.

Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain.

Nikan M, Osborn MF, Coles AH, Godinho BM, Hall LM, Haraszti RA, Hassler MR, Echeverria D, Aronin N, Khvorova A.

Mol Ther Nucleic Acids. 2016 Aug 9;5(8):e344. doi: 10.1038/mtna.2016.50.

11.

Magnitude of and Prognostic Factors Associated With 1-Year Mortality After Hospital Discharge for Acute Decompensated Heart Failure Based on Ejection Fraction Findings.

Coles AH, Tisminetzky M, Yarzebski J, Lessard D, Gore JM, Darling CE, Goldberg RJ.

J Am Heart Assoc. 2015 Dec 23;4(12). pii: e002303. doi: 10.1161/JAHA.115.002303.

12.

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain.

Alterman JF, Hall LM, Coles AH, Hassler MR, Didiot MC, Chase K, Abraham J, Sottosanti E, Johnson E, Sapp E, Osborn MF, Difiglia M, Aronin N, Khvorova A.

Mol Ther Nucleic Acids. 2015 Dec 1;4:e266. doi: 10.1038/mtna.2015.38.

13.

A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo.

Coles AH, Osborn MF, Alterman JF, Turanov AA, Godinho BM, Kennington L, Chase K, Aronin N, Khvorova A.

Nucleic Acid Ther. 2016 Apr;26(2):86-92. doi: 10.1089/nat.2015.0578. Epub 2015 Nov 23.

14.

Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs.

Osborn MF, Alterman JF, Nikan M, Cao H, Didiot MC, Hassler MR, Coles AH, Khvorova A.

Nucleic Acids Res. 2015 Oct 15;43(18):8664-72. doi: 10.1093/nar/gkv942. Epub 2015 Sep 22.

15.

Long-term survival for patients with acute decompensated heart failure according to ejection fraction findings.

Coles AH, Fisher K, Darling C, Yarzebski J, McManus DD, Gore JM, Lessard D, Goldberg RJ.

Am J Cardiol. 2014 Sep 15;114(6):862-8. doi: 10.1016/j.amjcard.2014.06.017. Epub 2014 Jul 2.

16.

Hdac6 regulates Tip60-p400 function in stem cells.

Chen PB, Hung JH, Hickman TL, Coles AH, Carey JF, Weng Z, Chu F, Fazzio TG.

Elife. 2013 Dec 3;2:e01557. doi: 10.7554/eLife.01557.

17.

Survival after hospital discharge for ST-segment elevation and non-ST-segment elevation acute myocardial infarction: a population-based study.

Darling CE, Fisher KA, McManus DD, Coles AH, Spencer FA, Gore JM, Goldberg RJ.

Clin Epidemiol. 2013 Jul 22;5:229-36. doi: 10.2147/CLEP.S45646. Print 2013.

18.

Recent trends in post-discharge mortality among patients with an initial acute myocardial infarction.

Coles AH, Fisher KA, Darling C, McManus D, Maitas O, Yarzebski J, Gore JM, Lessard D, Goldberg RJ.

Am J Cardiol. 2012 Oct 15;110(8):1073-7. doi: 10.1016/j.amjcard.2012.05.046. Epub 2012 Jul 3.

19.

Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity.

Coles AH, Gannon H, Cerny A, Kurt-Jones E, Jones SN.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11423-8. doi: 10.1073/pnas.0912116107. Epub 2010 Jun 7. Erratum in: Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):994.

20.

Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis.

Sluss HK, Gannon H, Coles AH, Shen Q, Eischen CM, Jones SN.

Mol Cancer Res. 2010 Feb;8(2):216-22. doi: 10.1158/1541-7786.MCR-09-0324. Epub 2010 Feb 9.

21.

p37Ing1b regulates B-cell proliferation and cooperates with p53 to suppress diffuse large B-cell lymphomagenesis.

Coles AH, Marfella CG, Imbalzano AN, Steinman HA, Garlick DS, Gerstein RM, Jones SN.

Cancer Res. 2008 Nov 1;68(21):8705-14. doi: 10.1158/0008-5472.CAN-08-0923.

22.

The ING gene family in the regulation of cell growth and tumorigenesis.

Coles AH, Jones SN.

J Cell Physiol. 2009 Jan;218(1):45-57. doi: 10.1002/jcp.21583. Review.

23.

Noncanonical Wnt signaling promotes apoptosis in thymocyte development.

Liang H, Coles AH, Zhu Z, Zayas J, Jurecic R, Kang J, Jones SN.

J Exp Med. 2007 Dec 24;204(13):3077-84. Epub 2007 Dec 10.

24.

Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.

Coles AH, Liang H, Zhu Z, Marfella CG, Kang J, Imbalzano AN, Jones SN.

Cancer Res. 2007 Mar 1;67(5):2054-61.

25.

Mutation of the SNF2 family member Chd2 affects mouse development and survival.

Marfella CG, Ohkawa Y, Coles AH, Garlick DS, Jones SN, Imbalzano AN.

J Cell Physiol. 2006 Oct;209(1):162-71. Erratum in: J Cell Physiol. 2007 Aug;212(2):562.

PMID:
16810678
26.

Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue.

Liang H, Chen Q, Coles AH, Anderson SJ, Pihan G, Bradley A, Gerstein R, Jurecic R, Jones SN.

Cancer Cell. 2003 Nov;4(5):349-60.

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