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Items: 1 to 50 of 369

1.

British Red Squirrels Remain the Only Known Wild Rodent Host for Leprosy Bacilli.

Schilling AK, Avanzi C, Ulrich RG, Busso P, Pisanu B, Ferrari N, Romeo C, Mazzamuto MV, McLuckie J, Shuttleworth CM, Del-Pozo J, Lurz PWW, Escalante-Fuentes WG, Ocampo-Candiani J, Vera-Cabrera L, Stevenson K, Chapuis JL, Meredith AL, Cole ST.

Front Vet Sci. 2019 Feb 1;6:8. doi: 10.3389/fvets.2019.00008. eCollection 2019.

2.

EspL is essential for virulence and stabilizes EspE, EspF and EspH levels in Mycobacterium tuberculosis.

Sala C, Odermatt NT, Soler-Arnedo P, Gülen MF, von Schultz S, Benjak A, Cole ST.

PLoS Pathog. 2018 Dec 20;14(12):e1007491. doi: 10.1371/journal.ppat.1007491. eCollection 2018 Dec.

3.

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis.

Foo CS, Lupien A, Kienle M, Vocat A, Benjak A, Sommer R, Lamprecht DA, Steyn AJC, Pethe K, Piton J, Altmann KH, Cole ST.

MBio. 2018 Oct 9;9(5). pii: e01276-18. doi: 10.1128/mBio.01276-18.

4.

Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria.

Sommer R, Neres J, Piton J, Dhar N, van der Sar A, Mukherjee R, Laroche T, Dyson PJ, McKinney JD, Bitter W, Makarov V, Cole ST.

ACS Chem Biol. 2018 Nov 16;13(11):3184-3192. doi: 10.1021/acschembio.8b00790. Epub 2018 Oct 25.

PMID:
30289689
5.

Highly Reduced Genome of the New Species Mycobacterium uberis, the Causative Agent of Nodular Thelitis and Tuberculoid Scrotitis in Livestock and a Close Relative of the Leprosy Bacilli.

Benjak A, Avanzi C, Benito Y, Breysse F, Chartier C, Boschiroli ML, Fourichon C, Michelet L, Pin D, Flandrois JP, Bruyere P, Dumitrescu O, Cole ST, Lina G.

mSphere. 2018 Oct 3;3(5). pii: e00405-18. doi: 10.1128/mSphere.00405-18.

6.

Essential Nucleoid Associated Protein mIHF (Rv1388) Controls Virulence and Housekeeping Genes in Mycobacterium tuberculosis.

Odermatt NT, Sala C, Benjak A, Cole ST.

Sci Rep. 2018 Sep 21;8(1):14214. doi: 10.1038/s41598-018-32340-2.

7.

Evaluation of Auramine O staining and conventional PCR for leprosy diagnosis: A comparative cross-sectional study from Ethiopia.

Girma S, Avanzi C, Bobosha K, Desta K, Idriss MH, Busso P, Tsegaye Y, Nigusse S, Hailu T, Cole ST, Aseffa A.

PLoS Negl Trop Dis. 2018 Sep 4;12(9):e0006706. doi: 10.1371/journal.pntd.0006706. eCollection 2018 Sep.

8.

Optimized Background Regimen for Treatment of Active Tuberculosis with the Next-Generation Benzothiazinone Macozinone (PBTZ169).

Lupien A, Vocat A, Foo CS, Blattes E, Gillon JY, Makarov V, Cole ST.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e00840-18. doi: 10.1128/AAC.00840-18. Print 2018 Nov.

PMID:
30126954
9.

Structure-Based Drug Design and Characterization of Sulfonyl-Piperazine Benzothiazinone Inhibitors of DprE1 from Mycobacterium tuberculosis.

Piton J, Vocat A, Lupien A, Foo CS, Riabova O, Makarov V, Cole ST.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00681-18. doi: 10.1128/AAC.00681-18. Print 2018 Oct.

10.

Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos.

da Silva MB, Portela JM, Li W, Jackson M, Gonzalez-Juarrero M, Hidalgo AS, Belisle JT, Bouth RC, Gobbo AR, Barreto JG, Minervino AHH, Cole ST, Avanzi C, Busso P, Frade MAC, Geluk A, Salgado CG, Spencer JS.

PLoS Negl Trop Dis. 2018 Jun 28;12(6):e0006532. doi: 10.1371/journal.pntd.0006532. eCollection 2018 Jun.

11.

Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe.

Schuenemann VJ, Avanzi C, Krause-Kyora B, Seitz A, Herbig A, Inskip S, Bonazzi M, Reiter E, Urban C, Dangvard Pedersen D, Taylor GM, Singh P, Stewart GR, Velemínský P, Likovsky J, Marcsik A, Molnár E, Pálfi G, Mariotti V, Riga A, Belcastro MG, Boldsen JL, Nebel A, Mays S, Donoghue HD, Zakrzewski S, Benjak A, Nieselt K, Cole ST, Krause J.

PLoS Pathog. 2018 May 10;14(5):e1006997. doi: 10.1371/journal.ppat.1006997. eCollection 2018 May.

12.

Total Synthesis of Ripostatin B and Structure-Activity Relationship Studies on Ripostatin Analogs.

Glaus F, Dedić D, Tare P, Nagaraja V, Rodrigues L, Aínsa JA, Kunze J, Schneider G, Hartkoorn RC, Cole ST, Altmann KH.

J Org Chem. 2018 Jul 6;83(13):7150-7172. doi: 10.1021/acs.joc.8b00193. Epub 2018 Mar 29.

PMID:
29542926
13.

Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009-15.

Cambau E, Saunderson P, Matsuoka M, Cole ST, Kai M, Suffys P, Rosa PS, Williams D, Gupta UD, Lavania M, Cardona-Castro N, Miyamoto Y, Hagge D, Srikantam A, Hongseng W, Indropo A, Vissa V, Johnson RC, Cauchoix B, Pannikar VK, Cooreman EAWD, Pemmaraju VRR, Gillini L; WHO surveillance network of antimicrobial resistance in leprosy.

Clin Microbiol Infect. 2018 Dec;24(12):1305-1310. doi: 10.1016/j.cmi.2018.02.022. Epub 2018 Mar 1.

14.

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK.

Chiarelli LR, Mori G, Orena BS, Esposito M, Lane T, de Jesus Lopes Ribeiro AL, Degiacomi G, Zemanová J, Szádocka S, Huszár S, Palčeková Z, Manfredi M, Gosetti F, Lelièvre J, Ballell L, Kazakova E, Makarov V, Marengo E, Mikusova K, Cole ST, Riccardi G, Ekins S, Pasca MR.

Sci Rep. 2018 Feb 16;8(1):3187. doi: 10.1038/s41598-018-21614-4.

15.

Mechanical properties of silicone based composites as a temperature insensitive ballistic backing material for quantifying back face deformation.

Edwards TD, Bain ED, Cole ST, Freeney RM, Halls VA, Ivancik J, Lenhart JL, Napadensky E, Yu JH, Zheng JQ, Mrozek RA.

Forensic Sci Int. 2018 Apr;285:1-12. doi: 10.1016/j.forsciint.2018.01.014. Epub 2018 Jan 31.

PMID:
29426024
16.

Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae.

Benjak A, Avanzi C, Singh P, Loiseau C, Girma S, Busso P, Fontes ANB, Miyamoto Y, Namisato M, Bobosha K, Salgado CG, da Silva MB, Bouth RC, Frade MAC, Filho FB, Barreto JG, Nery JAC, Bührer-Sékula S, Lupien A, Al-Samie AR, Al-Qubati Y, Alkubati AS, Bretzel G, Vera-Cabrera L, Sakho F, Johnson CR, Kodio M, Fomba A, Sow SO, Gado M, Konaté O, Stefani MMA, Penna GO, Suffys PN, Sarno EN, Moraes MO, Rosa PS, Baptista IMFD, Spencer JS, Aseffa A, Matsuoka M, Kai M, Cole ST.

Nat Commun. 2018 Jan 24;9(1):352. doi: 10.1038/s41467-017-02576-z.

17.

Promoter mutagenesis for fine-tuning expression of essential genes in Mycobacterium tuberculosis.

Boldrin F, Degiacomi G, Serafini A, Kolly GS, Ventura M, Sala C, Provvedi R, Palù G, Cole ST, Manganelli R.

Microb Biotechnol. 2018 Jan;11(1):238-247. doi: 10.1111/1751-7915.12875. Epub 2017 Oct 27.

18.

Insights from the Genome Sequence of Mycobacterium lepraemurium: Massive Gene Decay and Reductive Evolution.

Benjak A, Honap TP, Avanzi C, Becerril-Villanueva E, Estrada-García I, Rojas-Espinosa O, Stone AC, Cole ST.

MBio. 2017 Oct 17;8(5). pii: e01283-17. doi: 10.1128/mBio.01283-17.

19.

NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans.

Gengenbacher M, Duque-Correa MA, Kaiser P, Schuerer S, Lazar D, Zedler U, Reece ST, Nayyar A, Cole ST, Makarov V, Barry Iii CE, Dartois V, Kaufmann SHE.

Sci Rep. 2017 Aug 18;7(1):8853. doi: 10.1038/s41598-017-09177-2.

20.

Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases.

Stefani MMA, Avanzi C, Bührer-Sékula S, Benjak A, Loiseau C, Singh P, Pontes MAA, Gonçalves HS, Hungria EM, Busso P, Piton J, Silveira MIS, Cruz R, Schetinni A, Costa MB, Virmond MCL, Diorio SM, Dias-Baptista IMF, Rosa PS, Matsuoka M, Penna MLF, Cole ST, Penna GO.

PLoS Negl Trop Dis. 2017 Jun 15;11(6):e0005598. doi: 10.1371/journal.pntd.0005598. eCollection 2017 Jun.

21.

In vitro Controlled Release from Solid Pharmaceutical Formulations of two new Adamantane Aminoethers with Antitubercular Activity (I).

Vlachou M, Siamidi A, Diamantidi E, Iliopoulou A, Papanastasiou I, Ioannidou V, Kourbeli V, Foscolos AS, Vocat A, Cole ST, Karalis V, Kellici T, Mavromoustakos T.

Drug Res (Stuttg). 2017 Aug;67(8):447-450. doi: 10.1055/s-0042-121491. Epub 2017 May 30.

PMID:
28561241
22.

Rv3852 (H-NS) of Mycobacterium tuberculosis Is Not Involved in Nucleoid Compaction and Virulence Regulation.

Odermatt NT, Sala C, Benjak A, Kolly GS, Vocat A, Lupien A, Cole ST.

J Bacteriol. 2017 Jul 25;199(16). pii: e00129-17. doi: 10.1128/JB.00129-17. Print 2017 Aug 15.

23.

Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis.

Song L, Jenner M, Masschelein J, Jones C, Bull MJ, Harris SR, Hartkoorn RC, Vocat A, Romero-Canelon I, Coupland P, Webster G, Dunn M, Weiser R, Paisey C, Cole ST, Parkhill J, Mahenthiralingam E, Challis GL.

J Am Chem Soc. 2017 Jun 14;139(23):7974-7981. doi: 10.1021/jacs.7b03382. Epub 2017 Jun 5.

24.

New 1-hydroxy-2-thiopyridine derivatives active against both replicating and dormant Mycobacterium tuberculosis.

Salina EG, Ryabova O, Vocat A, Nikonenko B, Cole ST, Makarov V.

J Infect Chemother. 2017 Nov;23(11):794-797. doi: 10.1016/j.jiac.2017.04.012. Epub 2017 May 18.

PMID:
28527650
25.

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase.

Ahmed W, Sala C, Hegde SR, Jha RK, Cole ST, Nagaraja V.

PLoS Genet. 2017 May 2;13(5):e1006754. doi: 10.1371/journal.pgen.1006754. eCollection 2017 May.

26.

Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression.

Degiacomi G, Benjak A, Madacki J, Boldrin F, Provvedi R, Palù G, Kordulakova J, Cole ST, Manganelli R.

Sci Rep. 2017 Feb 27;7:43495. doi: 10.1038/srep43495.

27.

Synthesis of Adamantane Aminoethers with Antitubercular Potential.

Foscolos AS, Papanastasiou I, Tsotinis A, Kolocouris N, Foscolos GB, Vocat A, Cole ST.

Med Chem. 2017;13(7):670-681. doi: 10.2174/1573406413666170125112709.

PMID:
28124614
28.

EspC forms a filamentous structure in the cell envelope of Mycobacterium tuberculosis and impacts ESX-1 secretion.

Lou Y, Rybniker J, Sala C, Cole ST.

Mol Microbiol. 2017 Jan;103(1):26-38. doi: 10.1111/mmi.13575. Epub 2016 Nov 25.

29.

Red squirrels in the British Isles are infected with leprosy bacilli.

Avanzi C, Del-Pozo J, Benjak A, Stevenson K, Simpson VR, Busso P, McLuckie J, Loiseau C, Lawton C, Schoening J, Shaw DJ, Piton J, Vera-Cabrera L, Velarde-Felix JS, McDermott F, Gordon SV, Cole ST, Meredith AL.

Science. 2016 Nov 11;354(6313):744-747.

PMID:
27846605
30.

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.

Singh V, Dhar N, Pató J, Kolly GS, Korduláková J, Forbak M, Evans JC, Székely R, Rybniker J, Palčeková Z, Zemanová J, Santi I, Signorino-Gelo F, Rodrigues L, Vocat A, Covarrubias AS, Rengifo MG, Johnsson K, Mowbray S, Buechler J, Delorme V, Brodin P, Knott GW, Aínsa JA, Warner DF, Kéri G, Mikušová K, McKinney JD, Cole ST, Mizrahi V, Hartkoorn RC.

Mol Microbiol. 2017 Jan;103(1):13-25. doi: 10.1111/mmi.13535. Epub 2016 Oct 29.

31.

Tuberculosis drug discovery needs public-private consortia.

Cole ST.

Drug Discov Today. 2017 Mar;22(3):477-478. doi: 10.1016/j.drudis.2016.09.026. Epub 2016 Oct 4. No abstract available.

PMID:
27717851
32.

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.

Singh V, Donini S, Pacitto A, Sala C, Hartkoorn RC, Dhar N, Keri G, Ascher DB, Mondésert G, Vocat A, Lupien A, Sommer R, Vermet H, Lagrange S, Buechler J, Warner DF, McKinney JD, Pato J, Cole ST, Blundell TL, Rizzi M, Mizrahi V.

ACS Infect Dis. 2017 Jan 13;3(1):5-17. doi: 10.1021/acsinfecdis.6b00102. Epub 2016 Sep 8.

33.

Inhibiting Mycobacterium tuberculosis within and without.

Cole ST.

Philos Trans R Soc Lond B Biol Sci. 2016 Nov 5;371(1707). pii: 20150506. doi: 10.1098/rstb.2015.0506. Review.

34.

Structural studies of Mycobacterium tuberculosis DprE1 interacting with its inhibitors.

Piton J, Foo CS, Cole ST.

Drug Discov Today. 2017 Mar;22(3):526-533. doi: 10.1016/j.drudis.2016.09.014. Epub 2016 Sep 22. Review.

PMID:
27666194
35.

Transmission of Drug-Resistant Leprosy in Guinea-Conakry Detected Using Molecular Epidemiological Approaches.

Avanzi C, Busso P, Benjak A, Loiseau C, Fomba A, Doumbia G, Camara I, Lamou A, Sock G, Drame T, Kodio M, Sakho F, Sow SO, Cole ST, Johnson RC.

Clin Infect Dis. 2016 Dec 1;63(11):1482-1484. Epub 2016 Aug 23.

PMID:
27558568
36.

Micrococcin P1 - A bactericidal thiopeptide active against Mycobacterium tuberculosis.

Degiacomi G, Personne Y, Mondésert G, Ge X, Mandava CS, Hartkoorn RC, Boldrin F, Goel P, Peisker K, Benjak A, Barrio MB, Ventura M, Brown AC, Leblanc V, Bauer A, Sanyal S, Cole ST, Lagrange S, Parish T, Manganelli R.

Tuberculosis (Edinb). 2016 Sep;100:95-101. doi: 10.1016/j.tube.2016.07.011. Epub 2016 Jul 27.

PMID:
27553416
37.

Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis.

Foo CS, Lechartier B, Kolly GS, Boy-Röttger S, Neres J, Rybniker J, Lupien A, Sala C, Piton J, Cole ST.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6451-6459. doi: 10.1128/AAC.01523-16. Print 2016 Nov.

38.

Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.

Karabanovich G, Zemanová J, Smutný T, Székely R, Šarkan M, Centárová I, Vocat A, Pávková I, Čonka P, Němeček J, Stolaříková J, Vejsová M, Vávrová K, Klimešová V, Hrabálek A, Pávek P, Cole ST, Mikušová K, Roh J.

J Med Chem. 2016 Mar 24;59(6):2362-80. doi: 10.1021/acs.jmedchem.5b00608. Epub 2016 Mar 15.

PMID:
26948407
39.

Genomic and transcriptomic analysis of the streptomycin-dependent Mycobacterium tuberculosis strain 18b.

Benjak A, Uplekar S, Zhang M, Piton J, Cole ST, Sala C.

BMC Genomics. 2016 Mar 5;17:190. doi: 10.1186/s12864-016-2528-2.

40.

Mechanistic insight into mycobacterial MmpL protein function.

Székely R, Cole ST.

Mol Microbiol. 2016 Mar;99(5):831-4. doi: 10.1111/mmi.13306. Epub 2016 Jan 19.

41.

Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure-activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-D-ribose 2'-oxidase.

Landge S, Mullick AB, Nagalapur K, Neres J, Subbulakshmi V, Murugan K, Ghosh A, Sadler C, Fellows MD, Humnabadkar V, Mahadevaswamy J, Vachaspati P, Sharma S, Kaur P, Mallya M, Rudrapatna S, Awasthy D, Sambandamurthy VK, Pojer F, Cole ST, Balganesh TS, Ugarkar BG, Balasubramanian V, Bandodkar BS, Panda M, Ramachandran V.

Bioorg Med Chem. 2015 Dec 15;23(24):7694-710. doi: 10.1016/j.bmc.2015.11.017. Epub 2015 Nov 18.

PMID:
26643218
42.

Zoonotic Leprosy in the Southeastern United States.

Sharma R, Singh P, Loughry WJ, Lockhart JM, Inman WB, Duthie MS, Pena MT, Marcos LA, Scollard DM, Cole ST, Truman RW.

Emerg Infect Dis. 2015 Dec;21(12):2127-34. doi: 10.3201/eid2112.150501.

43.

In Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis.

González-Martínez NA, Lozano-Garza HG, Castro-Garza J, De Osio-Cortez A, Vargas-Villarreal J, Cavazos-Rocha N, Ocampo-Candiani J, Makarov V, Cole ST, Vera-Cabrera L.

PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004022. doi: 10.1371/journal.pntd.0004022. eCollection 2015.

44.

GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis.

Kolly GS, Mukherjee R, Kilacsková E, Abriata LA, Raccaud M, Blaško J, Sala C, Dal Peraro M, Mikušová K, Cole ST.

J Bacteriol. 2015 Dec;197(23):3686-97. doi: 10.1128/JB.00628-15. Epub 2015 Sep 14.

45.

Lansoprazole is an antituberculous prodrug targeting cytochrome bc1.

Rybniker J, Vocat A, Sala C, Busso P, Pojer F, Benjak A, Cole ST.

Nat Commun. 2015 Jul 9;6:7659. doi: 10.1038/ncomms8659.

46.

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.

Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR.

Chem Biol. 2015 Jul 23;22(7):917-27. doi: 10.1016/j.chembiol.2015.05.016. Epub 2015 Jun 18.

47.

Whole cell screen based identification of spiropiperidines with potent antitubercular properties.

Tantry SJ, Degiacomi G, Sharma S, Jena LK, Narayan A, Guptha S, Shanbhag G, Menasinakai S, Mallya M, Awasthy D, Balakrishnan G, Kaur P, Bhattacharjee D, Narayan C, Reddy J, Naveen Kumar CN, Shandil R, Boldrin F, Ventura M, Manganelli R, Hartkoorn RC, Cole ST, Panda M, Markad SD, Ramachandran V, Ghorpade SR, Dinesh N.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3234-45. doi: 10.1016/j.bmcl.2015.05.087. Epub 2015 Jun 3.

PMID:
26087937
48.

Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis.

Korotkova N, Piton J, Wagner JM, Boy-Röttger S, Japaridze A, Evans TJ, Cole ST, Pojer F, Korotkov KV.

J Struct Biol. 2015 Aug;191(2):236-44. doi: 10.1016/j.jsb.2015.06.003. Epub 2015 Jun 4.

49.

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.

Wassermann R, Gulen MF, Sala C, Perin SG, Lou Y, Rybniker J, Schmid-Burgk JL, Schmidt T, Hornung V, Cole ST, Ablasser A.

Cell Host Microbe. 2015 Jun 10;17(6):799-810. doi: 10.1016/j.chom.2015.05.003. Epub 2015 Jun 2.

50.

Mode of Action of Clofazimine and Combination Therapy with Benzothiazinones against Mycobacterium tuberculosis.

Lechartier B, Cole ST.

Antimicrob Agents Chemother. 2015 Aug;59(8):4457-63. doi: 10.1128/AAC.00395-15. Epub 2015 May 18.

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