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Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.

Song Y, Dagil L, Fairall L, Robertson N, Wu M, Ragan TJ, Savva CG, Saleh A, Morone N, Kunze MBA, Jamieson AG, Cole PA, Hansen DF, Schwabe JWR.

Cell Rep. 2020 Feb 25;30(8):2699-2711.e8. doi: 10.1016/j.celrep.2020.01.091.


Early resection of ectopic bone in patients with heterotopic ossification about the hip after trauma.

Cole PA, Dugarte AJ, Talbot M, Routt MLC Jr.

Injury. 2020 Jan 23. pii: S0020-1383(20)30046-2. doi: 10.1016/j.injury.2020.01.021. [Epub ahead of print]


Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity.

Xiong Y, Wang L, Di Giorgio E, Akimova T, Beier UH, Han R, Trevisanut M, Kalin JH, Cole PA, Hancock WW.

J Clin Invest. 2020 Jan 9. pii: 131375. doi: 10.1172/JCI131375. [Epub ahead of print]


The Development of a Surgical Mission in the Peruvian Amazon: A 15-Year Expedition.

Lezak BA, Cole PA Jr, Schroder LK, Cole PA.

J Bone Joint Surg Am. 2020 Feb 19;102(4):e13. doi: 10.2106/JBJS.19.00813.


Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer.

Miller SA, Policastro RA, Savant SS, Sriramkumar S, Ding N, Lu X, Mohammad HP, Cao S, Kalin JH, Cole PA, Zentner GE, O'Hagan HM.

Mol Cancer Res. 2020 Feb;18(2):264-277. doi: 10.1158/1541-7786.MCR-19-0748. Epub 2019 Nov 8.


Editorial overview: Biological catalysis at the cross-roads of signaling and metabolism.

Cole PA, Mattevi A.

Curr Opin Struct Biol. 2019 Dec;59:iii-v. doi: 10.1016/ Epub 2019 Oct 22. No abstract available.


Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG.

Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y.

Cancer Cell. 2019 Nov 11;36(5):528-544.e10. doi: 10.1016/j.ccell.2019.09.005. Epub 2019 Oct 17.


Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.

Jiang H, Thomas SN, Chen Z, Chiang CY, Cole PA.

J Biol Chem. 2019 Nov 15;294(46):17421-17436. doi: 10.1074/jbc.RA119.009211. Epub 2019 Oct 2.


A Survey of High- and Low-Energy Acetabular Fractures in Elderly Patients.

Dyskin E, Hill BW, Torchia MT, Cole PA.

Geriatr Orthop Surg Rehabil. 2019 Aug 20;10:2151459319870426. doi: 10.1177/2151459319870426. eCollection 2019.


Evaluation of a High-risk Patient Reminder System for Colonoscopy Surveillance.

Grimes AD, Cole PA, Grimes RW.

Am J Health Behav. 2019 Jul 1;43(4):671-679. doi: 10.5993/AJHB.43.4.2.


Analysis of Site-Specific Phosphorylation of PTEN by Using Enzyme-Catalyzed Expressed Protein Ligation.

Henager SH, Henriquez S, Dempsey DR, Cole PA.

Chembiochem. 2020 Jan 15;21(1-2):64-68. doi: 10.1002/cbic.201900316. Epub 2019 Sep 30.


CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers.

Van de Velde S, Wiater E, Tran M, Hwang Y, Cole PA, Montminy M.

Mol Cell Biol. 2019 Aug 12;39(17). pii: e00200-19. doi: 10.1128/MCB.00200-19. Print 2019 Sep 1.


Patient Outcomes in Orthopaedic Trauma: How to Evaluate if Your Treatment Is Really Working?

Nauth A, Wasserstein D, Tornetta P 3rd, Cole PA, Obremskey WT, Attum B, Slobogean GP.

J Orthop Trauma. 2019 Jun;33 Suppl 6:S20-S24. doi: 10.1097/BOT.0000000000001470.


Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells.

Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Cole PA, Dent SYR, Hancock WW.

Cancers (Basel). 2019 Apr 18;11(4). pii: E554. doi: 10.3390/cancers11040554.


Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP.

Zucconi BE, Makofske JL, Meyers DJ, Hwang Y, Wu M, Kuroda MI, Cole PA.

Biochemistry. 2019 Apr 23;58(16):2133-2143. doi: 10.1021/acs.biochem.9b00160. Epub 2019 Apr 11.


MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma.

Kim E, Zucconi BE, Wu M, Nocco SE, Meyers DJ, McGee JS, Venkatesh S, Cohen DL, Gonzalez EC, Ryu B, Cole PA, Alani RM.

Cancer Res. 2019 May 15;79(10):2649-2661. doi: 10.1158/0008-5472.CAN-18-2331. Epub 2019 Mar 25.


AKTivation mechanisms.

Cole PA, Chu N, Salguero AL, Bae H.

Curr Opin Struct Biol. 2019 Dec;59:47-53. doi: 10.1016/ Epub 2019 Mar 20. Review.


Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model.

Kalin JH, Eroglu A, Liu H, Holtzclaw WD, Leigh I, Proby CM, Fahey JW, Cole PA, Dinkova-Kostova AT.

PLoS One. 2019 Mar 13;14(3):e0213095. doi: 10.1371/journal.pone.0213095. eCollection 2019.


Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II.

Miller MS, Maheshwari S, Shi W, Gao Y, Chu N, Soares AS, Cole PA, Amzel LM, Fuchs MR, Jakoncic J, Gabelli SB.

Molecules. 2019 Jan 30;24(3). pii: E496. doi: 10.3390/molecules24030496.


Injury mechanism, epidemiology, and Hospital trends of scapula fractures: A 10-year retrospective study of the National Trauma Data Bank.

Tatro JM, Schroder LK, Molitor BA, Parker ED, Cole PA.

Injury. 2019 Feb;50(2):376-381. doi: 10.1016/j.injury.2019.01.017. Epub 2019 Jan 14.


A biomechanical study comparing minimally invasive anterior pelvic ring fixation techniques to external fixation.

MacCormick LM, Chen F, Gilbertson J, Khan S, Schroder LK, Bechtold JE, Cole PA.

Injury. 2019 Feb;50(2):251-255. doi: 10.1016/j.injury.2018.07.011. Epub 2018 Jul 18.


Consortium of Orthopaedic Academic Traumatologists: A Model for Collaboration in Orthopaedic Surgery.

Miclau T, MacKechnie MC, Shearer DW; COACT group.

J Orthop Trauma. 2018 Oct;32 Suppl 7:S3-S7. doi: 10.1097/BOT.0000000000001288.


Protein Chemical Approaches to Understanding PTEN Lipid Phosphatase Regulation.

Dempsey DR, Cole PA.

Methods Enzymol. 2018;607:405-422. doi: 10.1016/bs.mie.2018.05.007. Epub 2018 Jun 30.


Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.

Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA.

Cell. 2018 Aug 9;174(4):897-907.e14. doi: 10.1016/j.cell.2018.07.003. Epub 2018 Aug 2.


Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms.

Dempsey DR, Jiang H, Kalin JH, Chen Z, Cole PA.

J Am Chem Soc. 2018 Aug 1;140(30):9374-9378. doi: 10.1021/jacs.8b05098. Epub 2018 Jul 23.


Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action.

Bhat S, Hwang Y, Gibson MD, Morgan MT, Taverna SD, Zhao Y, Wolberger C, Poirier MG, Cole PA.

J Am Chem Soc. 2018 Aug 1;140(30):9478-9485. doi: 10.1021/jacs.8b03572. Epub 2018 Jul 24.


Posterior Scapula Approaches: Extensile and Modified Judet.

Cole PA, Dugarte AJ.

J Orthop Trauma. 2018 Aug;32 Suppl 1:S10-S11. doi: 10.1097/BOT.0000000000001208.


N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions.

Weiser BP, Rodriguez G, Cole PA, Stivers JT.

Nucleic Acids Res. 2018 Aug 21;46(14):7169-7178. doi: 10.1093/nar/gky525.


Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex.

Wu M, Hayward D, Kalin JH, Song Y, Schwabe JW, Cole PA.

Elife. 2018 Jun 5;7. pii: e37231. doi: 10.7554/eLife.37231.


Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome.

Weinert BT, Narita T, Satpathy S, Srinivasan B, Hansen BK, Schölz C, Hamilton WB, Zucconi BE, Wang WW, Liu WR, Brickman JM, Kesicki EA, Lai A, Bromberg KD, Cole PA, Choudhary C.

Cell. 2018 Jun 28;174(1):231-244.e12. doi: 10.1016/j.cell.2018.04.033. Epub 2018 May 24.


Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, Faivre E, Ferguson D, Buchanan FG, Martin RL, Torrent M, Chiang GG, Karukurichi K, Langston JW, Weinert BT, Choudhary C, de Vries P, Kluge AF, Patane MA, Van Drie JH, Wang C, McElligott D, Kesicki EA, Marmorstein R, Sun C, Cole PA, Rosenberg SH, Michaelides MR, Lai A, Bromberg KD.

Nature. 2018 Jun;558(7710):E1. doi: 10.1038/s41586-018-0111-5.


Five to Ten-Year Outcomes of Operatively Treated Scapular Fractures.

Tatro JM, Gilbertson JA, Schroder LK, Cole PA.

J Bone Joint Surg Am. 2018 May 16;100(10):871-878. doi: 10.2106/JBJS.17.00673.


Factors Associated With Revision Surgery After Internal Fixation of Hip Fractures.

Sprague S, Schemitsch EH, Swiontkowski M, Della Rocca GJ, Jeray KJ, Liew S, Slobogean GP, Bzovsky S, Heels-Ansdell D, Zhou Q, Bhandari M; FAITH Investigators.

J Orthop Trauma. 2018 May;32(5):223-230. doi: 10.1097/BOT.0000000000001162.


Factors associated with health-related quality of life, hip function, and health utility after operative management of femoral neck fractures.

Sprague S, Bhandari M, Heetveld MJ, Liew S, Scott T, Bzovsky S, Heels-Ansdell D, Zhou Q, Swiontkowski M, Schemitsch EH; FAITH Investigators.

Bone Joint J. 2018 Mar 1;100-B(3):361-369. doi: 10.1302/0301-620X.100B3.BJJ-2017-0853.R1.


Displacement of diaphyseal clavicle fractures related to patient position and progressive displacement in the peri-injury period.

Onizuka N, Anderson JP, Gilbertson JA, MacCormick LM, Cole PA.

J Shoulder Elbow Surg. 2018 Apr;27(4):667-673. doi: 10.1016/j.jse.2018.01.004.


Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases.

Michaelides MR, Kluge A, Patane M, Van Drie JH, Wang C, Hansen TM, Risi RM, Mantei R, Hertel C, Karukurichi K, Nesterov A, McElligott D, de Vries P, Langston JW, Cole PA, Marmorstein R, Liu H, Lasko L, Bromberg KD, Lai A, Kesicki EA.

ACS Med Chem Lett. 2017 Dec 13;9(1):28-33. doi: 10.1021/acsmedchemlett.7b00395. eCollection 2018 Jan 11.


Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase.

Wang Z, Kim MS, Martinez-Ferrando I, Koleske AJ, Pandey A, Cole PA.

Biochemistry. 2018 Feb 27;57(8):1390-1398. doi: 10.1021/acs.biochem.7b01158. Epub 2018 Feb 6.


Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.

Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA.

Nat Commun. 2018 Jan 4;9(1):53. doi: 10.1038/s41467-017-02242-4.


Minimally invasive anterior pelvic internal fixation: An anatomic study comparing Pelvic Bridge to INFIX.

Reichel LM, MacCormick LM, Dugarte AJ, Rizkala AR, Graves SC, Cole PA.

Injury. 2018 Feb;49(2):309-314. doi: 10.1016/j.injury.2017.12.009. Epub 2017 Dec 19.


CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II.

Boija A, Mahat DB, Zare A, Holmqvist PH, Philip P, Meyers DJ, Cole PA, Lis JT, Stenberg P, Mannervik M.

Mol Cell. 2017 Nov 2;68(3):491-503.e5. doi: 10.1016/j.molcel.2017.09.031. Epub 2017 Oct 19.


Vitamin D Use and Health Outcomes After Surgery for Hip Fracture.

Sprague S, Slobogean GP, Bogoch E, Petrisor B, Garibaldi A, O'Hara N, Bhandari M; FAITH Investigators.

Orthopedics. 2017 Oct 1;40(5):e868-e875. doi: 10.3928/01477447-20170907-01.


Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells.

Esadze A, Rodriguez G, Weiser BP, Cole PA, Stivers JT.

Nucleic Acids Res. 2017 Dec 1;45(21):12413-12424. doi: 10.1093/nar/gkx848.


Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, Faivre E, Ferguson D, Buchanan FG, Martin RL, Torrent M, Chiang GG, Karukurichi K, Langston JW, Weinert BT, Choudhary C, de Vries P, Van Drie JH, McElligott D, Kesicki E, Marmorstein R, Sun C, Cole PA, Rosenberg SH, Michaelides MR, Lai A, Bromberg KD.

Nature. 2017 Oct 5;550(7674):128-132. doi: 10.1038/nature24028. Epub 2017 Sep 27. Erratum in: Nature. 2018 May 16;:.


Effect of Vascular Injury on Functional Outcome in Knees with Multi-Ligament Injury: A Matched-Cohort Analysis.

Sanders TL, Johnson NR, Levy NM, Cole PA Jr, Krych AJ, Stuart M, Levy BA.

J Bone Joint Surg Am. 2017 Sep 20;99(18):1565-1571. doi: 10.2106/JBJS.16.01540.


Disordered N-Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation.

Rodriguez G, Esadze A, Weiser BP, Schonhoft JD, Cole PA, Stivers JT.

ACS Chem Biol. 2017 Sep 15;12(9):2260-2263. doi: 10.1021/acschembio.7b00521. Epub 2017 Aug 15.


Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein Semisynthesis.

Weiser BP, Stivers JT, Cole PA.

Biophys J. 2017 Jul 25;113(2):393-401. doi: 10.1016/j.bpj.2017.06.016.


Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity.

Cao J, Peng J, An H, He Q, Boronina T, Guo S, White MF, Cole PA, He L.

Nat Commun. 2017 Jul 25;8(1):131. doi: 10.1038/s41467-017-00163-w.


The Pelvic Bridge: A Subcutaneous Approach for Anterior Pelvic Fixation.

Cole PA, Hesse DK, Dugarte AJ, Dyskin E.

JBJS Essent Surg Tech. 2017 Jul 12;7(3):e20. doi: 10.2106/JBJS.ST.15.00085. eCollection 2017 Sep 28.


Allosteric regulation of epigenetic modifying enzymes.

Zucconi BE, Cole PA.

Curr Opin Chem Biol. 2017 Aug;39:109-115. doi: 10.1016/j.cbpa.2017.05.015. Epub 2017 Jul 6. Review.


Open Reduction and Internal Fixation of a Middle-Third Clavicle Fracture with a Superior Plate.

Cole PA, Dyskin E, Dugarte AJ, Hesse D.

JBJS Essent Surg Tech. 2017 Jun 14;7(2):e16. doi: 10.2106/JBJS.ST.16.00007. eCollection 2017 Jun 28.

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