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Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.

Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA.

Cell. 2018 Aug 9;174(4):897-907.e14. doi: 10.1016/j.cell.2018.07.003. Epub 2018 Aug 2.


Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms.

Dempsey DR, Jiang H, Kalin JH, Chen Z, Cole PA.

J Am Chem Soc. 2018 Aug 1;140(30):9374-9378. doi: 10.1021/jacs.8b05098. Epub 2018 Jul 23.


Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action.

Bhat S, Hwang Y, Gibson MD, Morgan MT, Taverna SD, Zhao Y, Wolberger C, Poirier MG, Cole PA.

J Am Chem Soc. 2018 Aug 1;140(30):9478-9485. doi: 10.1021/jacs.8b03572. Epub 2018 Jul 24.


Posterior Scapula Approaches: Extensile and Modified Judet.

Cole PA, Dugarte AJ.

J Orthop Trauma. 2018 Aug;32 Suppl 1:S10-S11. doi: 10.1097/BOT.0000000000001208.


N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions.

Weiser BP, Rodriguez G, Cole PA, Stivers JT.

Nucleic Acids Res. 2018 Jun 18. doi: 10.1093/nar/gky525. [Epub ahead of print]


Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex.

Wu M, Hayward D, Kalin JH, Song Y, Schwabe JW, Cole PA.

Elife. 2018 Jun 5;7. pii: e37231. doi: 10.7554/eLife.37231.


Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome.

Weinert BT, Narita T, Satpathy S, Srinivasan B, Hansen BK, Schölz C, Hamilton WB, Zucconi BE, Wang WW, Liu WR, Brickman JM, Kesicki EA, Lai A, Bromberg KD, Cole PA, Choudhary C.

Cell. 2018 Jun 28;174(1):231-244.e12. doi: 10.1016/j.cell.2018.04.033. Epub 2018 May 24.


Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, Faivre E, Ferguson D, Buchanan FG, Martin RL, Torrent M, Chiang GG, Karukurichi K, Langston JW, Weinert BT, Choudhary C, de Vries P, Kluge AF, Patane MA, Van Drie JH, Wang C, McElligott D, Kesicki EA, Marmorstein R, Sun C, Cole PA, Rosenberg SH, Michaelides MR, Lai A, Bromberg KD.

Nature. 2018 Jun;558(7710):E1. doi: 10.1038/s41586-018-0111-5.


Five to Ten-Year Outcomes of Operatively Treated Scapular Fractures.

Tatro JM, Gilbertson JA, Schroder LK, Cole PA.

J Bone Joint Surg Am. 2018 May 16;100(10):871-878. doi: 10.2106/JBJS.17.00673.


Factors Associated With Revision Surgery After Internal Fixation of Hip Fractures.

Sprague S, Schemitsch EH, Swiontkowski M, Della Rocca GJ, Jeray KJ, Liew S, Slobogean GP, Bzovsky S, Heels-Ansdell D, Zhou Q, Bhandari M; FAITH Investigators.

J Orthop Trauma. 2018 May;32(5):223-230. doi: 10.1097/BOT.0000000000001162.


Factors associated with health-related quality of life, hip function, and health utility after operative management of femoral neck fractures.

Sprague S, Bhandari M, Heetveld MJ, Liew S, Scott T, Bzovsky S, Heels-Ansdell D, Zhou Q, Swiontkowski M, Schemitsch EH; FAITH Investigators.

Bone Joint J. 2018 Mar 1;100-B(3):361-369. doi: 10.1302/0301-620X.100B3.BJJ-2017-0853.R1.


Displacement of diaphyseal clavicle fractures related to patient position and progressive displacement in the peri-injury period.

Onizuka N, Anderson JP, Gilbertson JA, MacCormick LM, Cole PA.

J Shoulder Elbow Surg. 2018 Apr;27(4):667-673. doi: 10.1016/j.jse.2018.01.004.


Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases.

Michaelides MR, Kluge A, Patane M, Van Drie JH, Wang C, Hansen TM, Risi RM, Mantei R, Hertel C, Karukurichi K, Nesterov A, McElligott D, de Vries P, Langston JW, Cole PA, Marmorstein R, Liu H, Lasko L, Bromberg KD, Lai A, Kesicki EA.

ACS Med Chem Lett. 2017 Dec 13;9(1):28-33. doi: 10.1021/acsmedchemlett.7b00395. eCollection 2018 Jan 11.


Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase.

Wang Z, Kim MS, Martinez-Ferrando I, Koleske AJ, Pandey A, Cole PA.

Biochemistry. 2018 Feb 27;57(8):1390-1398. doi: 10.1021/acs.biochem.7b01158. Epub 2018 Feb 6.


Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.

Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA.

Nat Commun. 2018 Jan 4;9(1):53. doi: 10.1038/s41467-017-02242-4.


Minimally invasive anterior pelvic internal fixation: An anatomic study comparing Pelvic Bridge to INFIX.

Reichel LM, MacCormick LM, Dugarte AJ, Rizkala AR, Graves SC, Cole PA.

Injury. 2018 Feb;49(2):309-314. doi: 10.1016/j.injury.2017.12.009. Epub 2017 Dec 19.


CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II.

Boija A, Mahat DB, Zare A, Holmqvist PH, Philip P, Meyers DJ, Cole PA, Lis JT, Stenberg P, Mannervik M.

Mol Cell. 2017 Nov 2;68(3):491-503.e5. doi: 10.1016/j.molcel.2017.09.031. Epub 2017 Oct 19.


Vitamin D Use and Health Outcomes After Surgery for Hip Fracture.

Sprague S, Slobogean GP, Bogoch E, Petrisor B, Garibaldi A, O'Hara N, Bhandari M; FAITH Investigators.

Orthopedics. 2017 Oct 1;40(5):e868-e875. doi: 10.3928/01477447-20170907-01.


Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells.

Esadze A, Rodriguez G, Weiser BP, Cole PA, Stivers JT.

Nucleic Acids Res. 2017 Dec 1;45(21):12413-12424. doi: 10.1093/nar/gkx848.


Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, Faivre E, Ferguson D, Buchanan FG, Martin RL, Torrent M, Chiang GG, Karukurichi K, Langston JW, Weinert BT, Choudhary C, de Vries P, Van Drie JH, McElligott D, Kesicki E, Marmorstein R, Sun C, Cole PA, Rosenberg SH, Michaelides MR, Lai A, Bromberg KD.

Nature. 2017 Oct 5;550(7674):128-132. doi: 10.1038/nature24028. Epub 2017 Sep 27. Erratum in: Nature. 2018 May 16;:.


Effect of Vascular Injury on Functional Outcome in Knees with Multi-Ligament Injury: A Matched-Cohort Analysis.

Sanders TL, Johnson NR, Levy NM, Cole PA Jr, Krych AJ, Stuart M, Levy BA.

J Bone Joint Surg Am. 2017 Sep 20;99(18):1565-1571. doi: 10.2106/JBJS.16.01540.


Disordered N-Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation.

Rodriguez G, Esadze A, Weiser BP, Schonhoft JD, Cole PA, Stivers JT.

ACS Chem Biol. 2017 Sep 15;12(9):2260-2263. doi: 10.1021/acschembio.7b00521. Epub 2017 Aug 15.


Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein Semisynthesis.

Weiser BP, Stivers JT, Cole PA.

Biophys J. 2017 Jul 25;113(2):393-401. doi: 10.1016/j.bpj.2017.06.016.


Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity.

Cao J, Peng J, An H, He Q, Boronina T, Guo S, White MF, Cole PA, He L.

Nat Commun. 2017 Jul 25;8(1):131. doi: 10.1038/s41467-017-00163-w.


Allosteric regulation of epigenetic modifying enzymes.

Zucconi BE, Cole PA.

Curr Opin Chem Biol. 2017 Aug;39:109-115. doi: 10.1016/j.cbpa.2017.05.015. Epub 2017 Jul 6. Review.


Comparison of 2 versus 3 dimensional fracture mapping strategies for 3 dimensional computerized tomography reconstructions of scapula neck and body fractures.

Dugarte AJ, Tkany L, Schroder LK, Petersik A, Cole PA.

J Orthop Res. 2018 Jan;36(1):265-271. doi: 10.1002/jor.23603. Epub 2017 Jun 2.


A Tunable Brake for HECT Ubiquitin Ligases.

Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA.

Mol Cell. 2017 May 4;66(3):345-357.e6. doi: 10.1016/j.molcel.2017.03.020.


Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution.

Mo GC, Ross B, Hertel F, Manna P, Yang X, Greenwald E, Booth C, Plummer AM, Tenner B, Chen Z, Wang Y, Kennedy EJ, Cole PA, Fleming KG, Palmer A, Jimenez R, Xiao J, Dedecker P, Zhang J.

Nat Methods. 2017 Apr;14(4):427-434. doi: 10.1038/nmeth.4221. Epub 2017 Mar 13.


Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial.

Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) Investigators.

Lancet. 2017 Apr 15;389(10078):1519-1527. doi: 10.1016/S0140-6736(17)30066-1. Epub 2017 Mar 3.


Functional Outcomes of Operative Management of Scapula Fractures in a Geriatric Cohort.

Cole PA Jr, Gilbertson JA, Cole PA Sr.

J Orthop Trauma. 2017 Jan;31(1):e1-e8. doi: 10.1097/BOT.0000000000000710.


Interaction with the DNA Repair Protein Thymine DNA Glycosylase Regulates Histone Acetylation by p300.

Henry RA, Mancuso P, Kuo YM, Tricarico R, Tini M, Cole PA, Bellacosa A, Andrews AJ.

Biochemistry. 2016 Dec 13;55(49):6766-6775. Epub 2016 Dec 1.


Enzyme-catalyzed expressed protein ligation.

Henager SH, Chu N, Chen Z, Bolduc D, Dempsey DR, Hwang Y, Wells J, Cole PA.

Nat Methods. 2016 Nov;13(11):925-927. doi: 10.1038/nmeth.4004. Epub 2016 Sep 26.


An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor.

Hsiao PY, Kalin JH, Sun IH, Amin MN, Lo YC, Chiang MJ, Giddens J, Sysa-Shah P, Gabrielson K, Wang LX, Powell JD, Cole PA.

Chembiochem. 2016 Oct 17;17(20):1951-1960. doi: 10.1002/cbic.201600337. Epub 2016 Aug 26.


Functional Outcomes After Operative Management of Extra-Articular Glenoid Neck and Scapular Body Fractures.

Schroder LK, Gauger EM, Gilbertson JA, Cole PA.

J Bone Joint Surg Am. 2016 Oct 5;98(19):1623-1630.


Erratum to: CBP binding outside of promoters and enhancers in Drosophila melanogaster.

Philip P, Boija A, Vaid R, Churcher AM, Meyers DJ, Cole PA, Mannervik M, Stenberg P.

Epigenetics Chromatin. 2016 Sep 12;9(1):38. doi: 10.1186/s13072-016-0088-y. eCollection 2016.


Nanosilver inhibits nitrification and reduces ammonia-oxidising bacterial but not archaeal amoA gene abundance in estuarine sediments.

Beddow J, Stolpe B, Cole PA, Lead JR, Sapp M, Lyons BP, Colbeck I, Whitby C.

Environ Microbiol. 2017 Feb;19(2):500-510. doi: 10.1111/1462-2920.13441. Epub 2016 Jul 29.


LSD1 Histone Demethylase Assays and Inhibition.

Hayward D, Cole PA.

Methods Enzymol. 2016;573:261-78. doi: 10.1016/bs.mie.2016.01.020. Epub 2016 Feb 23. Review.


Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112.

Zucconi BE, Luef B, Xu W, Henry RA, Nodelman IM, Bowman GD, Andrews AJ, Cole PA.

Biochemistry. 2016 Jul 12;55(27):3727-34. doi: 10.1021/acs.biochem.6b00480. Epub 2016 Jul 1.


Does Participation in a Randomized Clinical Trial Change Outcomes? An Evaluation of Patients Not Enrolled in the SPRINT Trial.

Lin CA, Bhandari M, Guyatt G, Walter SD, Schemitsch EH, Swiontkowski M, Sanders D, Tornetta P 3rd; SPRINT Investigators.

J Orthop Trauma. 2016 Mar;30(3):156-61.


Correction to Protein Lysine Acetylation by p300/CBP.

Dancy BM, Cole PA.

Chem Rev. 2016 Jul 27;116(14):8314. doi: 10.1021/acs.chemrev.6b00351. Epub 2016 Jun 15. No abstract available.


Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases.

Chen Z, Thomas SN, Bolduc DM, Jiang X, Zhang X, Wolberger C, Cole PA.

Biochemistry. 2016 Jul 5;55(26):3658-66. doi: 10.1021/acs.biochem.6b00448. Epub 2016 Jun 22.


Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation.

Chen Z, Dempsey DR, Thomas SN, Hayward D, Bolduc DM, Cole PA.

J Biol Chem. 2016 Jul 1;291(27):14160-9. doi: 10.1074/jbc.M116.728980. Epub 2016 May 11.


Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin.

Robert C, Nagaria PK, Pawar N, Adewuyi A, Gojo I, Meyers DJ, Cole PA, Rassool FV.

Leuk Res. 2016 Jun;45:14-23. doi: 10.1016/j.leukres.2016.03.007. Epub 2016 Mar 30.


A Patient Follow-up Program for Short-Term Surgical Mission Trips to a Developing Country.

Torchia MT, Schroder LK, Hill BW, Cole PA.

J Bone Joint Surg Am. 2016 Feb 3;98(3):226-32. doi: 10.2106/JBJS.O.00087.


YcgC represents a new protein deacetylase family in prokaryotes.

Tu S, Guo SJ, Chen CS, Liu CX, Jiang HW, Ge F, Deng JY, Zhou YM, Czajkowsky DM, Li Y, Qi BR, Ahn YH, Cole PA, Zhu H, Tao SC.

Elife. 2015 Dec 30;4. pii: e05322. doi: 10.7554/eLife.05322.


CBP binding outside of promoters and enhancers in Drosophila melanogaster.

Philip P, Boija A, Vaid R, Churcher AM, Meyers DJ, Cole PA, Mannervik M, Stenberg P.

Epigenetics Chromatin. 2015 Nov 24;8:48. doi: 10.1186/s13072-015-0042-4. eCollection 2015. Erratum in: Epigenetics Chromatin. 2016;9(1):38.


Character, Incidence, and Predictors of Knee Pain and Activity After Infrapatellar Intramedullary Nailing of an Isolated Tibia Fracture.

Obremskey W, Agel J, Archer K, To P, Tornetta P 3rd; SPRINT Investigators.

J Orthop Trauma. 2016 Mar;30(3):135-41. doi: 10.1097/BOT.0000000000000475.


Minimally-invasive fixation for anterior pelvic ring disruptions.

Cole PA, Dyskin EA, Gilbertson JA.

Injury. 2015 Sep;46 Suppl 3:S27-34. doi: 10.1016/S0020-1383(15)30008-5. Review.


Hypoxia mediated pulmonary edema: potential influence of oxidative stress, sympathetic activation and cerebral blood flow.

Khademi S, Frye MA, Jeckel KM, Schroeder T, Monnet E, Irwin DC, Cole PA, Bell C, Miller BF, Hamilton KL.

BMC Physiol. 2015 Oct 9;15:4. doi: 10.1186/s12899-015-0018-4.


Open Reduction and Internal Fixation of Scapula Fractures in a Geriatric Series.

Cole PA Jr, Jacobson AR, Cole PA Sr.

Geriatr Orthop Surg Rehabil. 2015 Sep;6(3):180-5. doi: 10.1177/2151458515584049.

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