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Items: 1 to 50 of 83

1.

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope.

MacLachlan BJ, Dolton G, Papakyriakou A, Greenshields-Watson A, Mason GH, Schauenburg A, Besneux M, Szomolay B, Elliott T, Sewell AK, Gallimore A, Rizkallah P, Cole DK, Godkin A.

J Biol Chem. 2019 Dec 27;294(52):20246-20258. doi: 10.1074/jbc.RA119.009437. Epub 2019 Oct 16.

2.

VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium.

Bagaev DV, Vroomans RMA, Samir J, Stervbo U, Rius C, Dolton G, Greenshields-Watson A, Attaf M, Egorov ES, Zvyagin IV, Babel N, Cole DK, Godkin AJ, Sewell AK, Kesmir C, Chudakov DM, Luciani F, Shugay M.

Nucleic Acids Res. 2020 Jan 8;48(D1):D1057-D1062. doi: 10.1093/nar/gkz874.

3.

TCR-induced alteration of primary MHC peptide anchor residue.

Madura F, Rizkallah PJ, Legut M, Holland CJ, Fuller A, Bulek A, Schauenburg AJ, Trimby A, Hopkins JR, Wells SA, Godkin A, Miles JJ, Sami M, Li Y, Liddy N, Jakobsen BK, Loveridge EJ, Cole DK, Sewell AK.

Eur J Immunol. 2019 Jul;49(7):1052-1066. doi: 10.1002/eji.201948085. Epub 2019 May 27.

4.

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma.

Galloway SAE, Dolton G, Attaf M, Wall A, Fuller A, Rius C, Bianchi V, Theaker S, Lloyd A, Caillaud ME, Svane IM, Donia M, Cole DK, Szomolay B, Rizkallah P, Sewell AK.

Front Immunol. 2019 Mar 13;10:319. doi: 10.3389/fimmu.2019.00319. eCollection 2019.

5.

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions.

Baker AT, Greenshields-Watson A, Coughlan L, Davies JA, Uusi-Kerttula H, Cole DK, Rizkallah PJ, Parker AL.

Nat Commun. 2019 Feb 14;10(1):741. doi: 10.1038/s41467-019-08599-y.

6.

Real-time binding kinetic analyses of the interaction of the dietary stain orange II with dentin matrix.

Alraies A, Cole DK, Rees JS, Glasse C, Young N, Waddington RJ, Sloan AJ.

J Dent. 2019 Jan;80:80-88. doi: 10.1016/j.jdent.2018.06.001. Epub 2018 Jun 9.

PMID:
29894765
7.

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.

Tungatt K, Dolton G, Morgan SB, Attaf M, Fuller A, Whalley T, Hemmink JD, Porter E, Szomolay B, Montoya M, Hammond JA, Miles JJ, Cole DK, Townsend A, Bailey M, Rizkallah PJ, Charleston B, Tchilian E, Sewell AK.

PLoS Pathog. 2018 May 17;14(5):e1007017. doi: 10.1371/journal.ppat.1007017. eCollection 2018 May.

8.

In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.

Holland CJ, MacLachlan BJ, Bianchi V, Hesketh SJ, Morgan R, Vickery O, Bulek AM, Fuller A, Godkin A, Sewell AK, Rizkallah PJ, Wells S, Cole DK.

Front Immunol. 2018 Apr 11;9:674. doi: 10.3389/fimmu.2018.00674. eCollection 2018.

9.

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

Miles JJ, Tan MP, Dolton G, Edwards ES, Galloway SA, Laugel B, Clement M, Makinde J, Ladell K, Matthews KK, Watkins TS, Tungatt K, Wong Y, Lee HS, Clark RJ, Pentier JM, Attaf M, Lissina A, Ager A, Gallimore A, Rizkallah PJ, Gras S, Rossjohn J, Burrows SR, Cole DK, Price DA, Sewell AK.

J Clin Invest. 2018 Apr 2;128(4):1569-1580. doi: 10.1172/JCI91512. Epub 2018 Mar 12.

10.

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.

Cole DK, Fuller A, Dolton G, Zervoudi E, Legut M, Miles K, Blanchfield L, Madura F, Holland CJ, Bulek AM, Bridgeman JS, Miles JJ, Schauenburg AJA, Beck K, Evavold BD, Rizkallah PJ, Sewell AK.

Front Immunol. 2017 Nov 10;8:1503. doi: 10.3389/fimmu.2017.01503. eCollection 2017.

11.

Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation.

Jones N, Cronin JG, Dolton G, Panetti S, Schauenburg AJ, Galloway SAE, Sewell AK, Cole DK, Thornton CA, Francis NJ.

Front Immunol. 2017 Nov 9;8:1516. doi: 10.3389/fimmu.2017.01516. eCollection 2017.

12.

Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.

Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA.

Nat Med. 2017 Dec;23(12):1416-1423. doi: 10.1038/nm.4444. Epub 2017 Nov 13.

PMID:
29131157
13.

T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus.

Bovay A, Zoete V, Dolton G, Bulek AM, Cole DK, Rizkallah PJ, Fuller A, Beck K, Michielin O, Speiser DE, Sewell AK, Fuertes Marraco SA.

Eur J Immunol. 2018 Feb;48(2):258-272. doi: 10.1002/eji.201747082. Epub 2017 Dec 11.

14.

Thermal Stability of Heterotrimeric pMHC Proteins as Determined by Circular Dichroism Spectroscopy.

Fuller A, Wall A, Crowther MD, Lloyd A, Zhurov A, Sewell AK, Cole DK, Beck K.

Bio Protoc. 2017 Jul 5;7(13). pii: e2366. doi: 10.21769/BioProtoc.2366.

15.

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.

MacLachlan BJ, Greenshields-Watson A, Mason GH, Schauenburg AJ, Bianchi V, Rizkallah PJ, Sewell AK, Fuller A, Cole DK.

J Vis Exp. 2017 Feb 6;(120). doi: 10.3791/54991.

16.

Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.

Cole DK, van den Berg HA, Lloyd A, Crowther MD, Beck K, Ekeruche-Makinde J, Miles JJ, Bulek AM, Dolton G, Schauenburg AJ, Wall A, Fuller A, Clement M, Laugel B, Rizkallah PJ, Wooldridge L, Sewell AK.

J Biol Chem. 2017 Jan 20;292(3):802-813. doi: 10.1074/jbc.M116.741603. Epub 2016 Nov 30.

17.

Paediatric non-progression following grandmother-to-child HIV transmission.

Tsai MH, Muenchhoff M, Adland E, Carlqvist A, Roider J, Cole DK, Sewell AK, Carlson J, Ndung'u T, Goulder PJ.

Retrovirology. 2016 Sep 8;13(1):65. doi: 10.1186/s12977-016-0300-y.

18.

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Cole DK, Bulek AM, Dolton G, Schauenberg AJ, Szomolay B, Rittase W, Trimby A, Jothikumar P, Fuller A, Skowera A, Rossjohn J, Zhu C, Miles JJ, Peakman M, Wooldridge L, Rizkallah PJ, Sewell AK.

J Clin Invest. 2016 Sep 1;126(9):3626. doi: 10.1172/JCI89919. Epub 2016 Aug 15. No abstract available.

19.

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Cole DK, Bulek AM, Dolton G, Schauenberg AJ, Szomolay B, Rittase W, Trimby A, Jothikumar P, Fuller A, Skowera A, Rossjohn J, Zhu C, Miles JJ, Peakman M, Wooldridge L, Rizkallah PJ, Sewell AK.

J Clin Invest. 2016 Jun 1;126(6):2191-204. doi: 10.1172/JCI85679. Epub 2016 May 16. Erratum in: J Clin Invest. 2016 Sep 1;126(9):3626.

20.

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.

Bianchi V, Bulek A, Fuller A, Lloyd A, Attaf M, Rizkallah PJ, Dolton G, Sewell AK, Cole DK.

J Biol Chem. 2016 Apr 22;291(17):8951-9. doi: 10.1074/jbc.M115.707414. Epub 2016 Feb 25.

21.

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones.

Theaker SM, Rius C, Greenshields-Watson A, Lloyd A, Trimby A, Fuller A, Miles JJ, Cole DK, Peakman M, Sewell AK, Dolton G.

J Immunol Methods. 2016 Mar;430:43-50. doi: 10.1016/j.jim.2016.01.014. Epub 2016 Jan 28.

22.

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.

Raman MC, Rizkallah PJ, Simmons R, Donnellan Z, Dukes J, Bossi G, Le Provost GS, Todorov P, Baston E, Hickman E, Mahon T, Hassan N, Vuidepot A, Sami M, Cole DK, Jakobsen BK.

Sci Rep. 2016 Jan 13;6:18851. doi: 10.1038/srep18851.

23.

Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers.

Holland CJ, Dolton G, Scurr M, Ladell K, Schauenburg AJ, Miners K, Madura F, Sewell AK, Price DA, Cole DK, Godkin AJ.

J Immunol. 2015 Dec 15;195(12):5827-36. doi: 10.4049/jimmunol.1402787. Epub 2015 Nov 9.

24.

The impact of HLA class I and EBV latency-II antigen-specific CD8(+) T cells on the pathogenesis of EBV(+) Hodgkin lymphoma.

Jones K, Wockner L, Brennan RM, Keane C, Chattopadhyay PK, Roederer M, Price DA, Cole DK, Hassan B, Beck K, Gottlieb D, Ritchie DS, Seymour JF, Vari F, Crooks P, Burrows SR, Gandhi MK.

Clin Exp Immunol. 2016 Feb;183(2):206-20. doi: 10.1111/cei.12716. Epub 2015 Nov 13.

25.

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide.

Motozono C, Pearson JA, De Leenheer E, Rizkallah PJ, Beck K, Trimby A, Sewell AK, Wong FS, Cole DK.

J Biol Chem. 2015 Jul 31;290(31):18924-33. doi: 10.1074/jbc.M114.622522. Epub 2015 Jun 17.

26.

More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers.

Dolton G, Tungatt K, Lloyd A, Bianchi V, Theaker SM, Trimby A, Holland CJ, Donia M, Godkin AJ, Cole DK, Straten PT, Peakman M, Svane IM, Sewell AK.

Immunology. 2015 Sep;146(1):11-22. doi: 10.1111/imm.12499. Review.

27.

The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy.

Legut M, Cole DK, Sewell AK.

Cell Mol Immunol. 2015 Nov;12(6):656-68. doi: 10.1038/cmi.2015.28. Epub 2015 Apr 13. Review.

28.

The ultimate mix and match: making sense of HLA alleles and peptide repertoires.

Cole DK.

Immunol Cell Biol. 2015 Jul;93(6):515-6. doi: 10.1038/icb.2015.40. Epub 2015 Mar 31. No abstract available.

PMID:
25823993
29.

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.

Kløverpris HN, Cole DK, Fuller A, Carlson J, Beck K, Schauenburg AJ, Rizkallah PJ, Buus S, Sewell AK, Goulder P.

Retrovirology. 2015 Feb 20;12:20. doi: 10.1186/s12977-015-0149-5.

30.

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics.

Neller MA, Ladell K, McLaren JE, Matthews KK, Gostick E, Pentier JM, Dolton G, Schauenburg AJ, Koning D, Fontaine Costa AI, Watkins TS, Venturi V, Smith C, Khanna R, Miners K, Clement M, Wooldridge L, Cole DK, van Baarle D, Sewell AK, Burrows SR, Price DA, Miles JJ.

Immunol Cell Biol. 2015 Aug;93(7):625-33. doi: 10.1038/icb.2015.17. Epub 2015 Mar 24.

31.

The T cell antigen receptor: the Swiss army knife of the immune system.

Attaf M, Legut M, Cole DK, Sewell AK.

Clin Exp Immunol. 2015 Jul;181(1):1-18. doi: 10.1111/cei.12622. Epub 2015 May 14. Review.

32.

Structural basis for ineffective T-cell responses to MHC anchor residue-improved "heteroclitic" peptides.

Madura F, Rizkallah PJ, Holland CJ, Fuller A, Bulek A, Godkin AJ, Schauenburg AJ, Cole DK, Sewell AK.

Eur J Immunol. 2015 Feb;45(2):584-91. doi: 10.1002/eji.201445114. Epub 2014 Dec 28.

33.

Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs.

Tungatt K, Bianchi V, Crowther MD, Powell WE, Schauenburg AJ, Trimby A, Donia M, Miles JJ, Holland CJ, Cole DK, Godkin AJ, Peakman M, Straten PT, Svane IM, Sewell AK, Dolton G.

J Immunol. 2015 Jan 1;194(1):463-74. doi: 10.4049/jimmunol.1401785. Epub 2014 Dec 1.

34.

Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment.

Straetemans T, Berrevoets C, Coccoris M, Treffers-Westerlaken E, Wijers R, Cole DK, Dardalhon V, Sewell AK, Taylor N, Verweij J, Debets R.

Mol Ther. 2015 Feb;23(2):396-406. doi: 10.1038/mt.2014.215. Epub 2014 Nov 3.

35.

Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.

Stepanek O, Prabhakar AS, Osswald C, King CG, Bulek A, Naeher D, Beaufils-Hugot M, Abanto ML, Galati V, Hausmann B, Lang R, Cole DK, Huseby ES, Sewell AK, Chakraborty AK, Palmer E.

Cell. 2014 Oct 9;159(2):333-45. doi: 10.1016/j.cell.2014.08.042. Epub 2014 Oct 2.

36.

A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells.

Knight RR, Dolton G, Kronenberg-Versteeg D, Eichmann M, Zhao M, Huang GC, Beck K, Cole DK, Sewell AK, Skowera A, Peakman M.

Clin Exp Immunol. 2015 Jan;179(1):100-7. doi: 10.1111/cei.12436.

37.

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells.

Dolton G, Lissina A, Skowera A, Ladell K, Tungatt K, Jones E, Kronenberg-Versteeg D, Akpovwa H, Pentier JM, Holland CJ, Godkin AJ, Cole DK, Neller MA, Miles JJ, Price DA, Peakman M, Sewell AK.

Clin Exp Immunol. 2014 Jul;177(1):47-63. doi: 10.1111/cei.12339.

38.

Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01.

Motozono C, Kuse N, Sun X, Rizkallah PJ, Fuller A, Oka S, Cole DK, Sewell AK, Takiguchi M.

J Immunol. 2014 Apr 1;192(7):3428-34. doi: 10.4049/jimmunol.1302667. Epub 2014 Mar 5.

39.

The versatility of the αβ T-cell antigen receptor.

Bhati M, Cole DK, McCluskey J, Sewell AK, Rossjohn J.

Protein Sci. 2014 Mar;23(3):260-72. doi: 10.1002/pro.2412. Epub 2014 Jan 28. Review.

40.

T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.

Cole DK, Miles KM, Madura F, Holland CJ, Schauenburg AJ, Godkin AJ, Bulek AM, Fuller A, Akpovwa HJ, Pymm PG, Liddy N, Sami M, Li Y, Rizkallah PJ, Jakobsen BK, Sewell AK.

J Biol Chem. 2014 Jan 10;289(2):628-38. doi: 10.1074/jbc.M113.522110. Epub 2013 Nov 6.

41.

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation.

van den Berg HA, Ladell K, Miners K, Laugel B, Llewellyn-Lacey S, Clement M, Cole DK, Gostick E, Wooldridge L, Sewell AK, Bridgeman JS, Price DA.

Front Immunol. 2013 Sep 5;4:250. doi: 10.3389/fimmu.2013.00250. eCollection 2013.

42.

Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough.

Holland CJ, Cole DK, Godkin A.

Front Immunol. 2013 Jul 1;4:172. doi: 10.3389/fimmu.2013.00172. eCollection 2013.

43.

Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode.

Cole DK, Sami M, Scott DR, Rizkallah PJ, Borbulevych OY, Todorov PT, Moysey RK, Jakobsen BK, Boulter JM, Baker BM, Yi Li.

Front Immunol. 2013 Jun 26;4:168. doi: 10.3389/fimmu.2013.00168. eCollection 2013.

44.

T-cell receptor specificity maintained by altered thermodynamics.

Madura F, Rizkallah PJ, Miles KM, Holland CJ, Bulek AM, Fuller A, Schauenburg AJ, Miles JJ, Liddy N, Sami M, Li Y, Hossain M, Baker BM, Jakobsen BK, Sewell AK, Cole DK.

J Biol Chem. 2013 Jun 28;288(26):18766-75. doi: 10.1074/jbc.M113.464560. Epub 2013 May 22.

45.

Peptide length determines the outcome of TCR/peptide-MHCI engagement.

Ekeruche-Makinde J, Miles JJ, van den Berg HA, Skowera A, Cole DK, Dolton G, Schauenburg AJ, Tan MP, Pentier JM, Llewellyn-Lacey S, Miles KM, Bulek AM, Clement M, Williams T, Trimby A, Bailey M, Rizkallah P, Rossjohn J, Peakman M, Price DA, Burrows SR, Sewell AK, Wooldridge L.

Blood. 2013 Feb 14;121(7):1112-23. doi: 10.1182/blood-2012-06-437202. Epub 2012 Dec 18.

46.

Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers.

Holland CJ, Rizkallah PJ, Vollers S, Calvo-Calle JM, Madura F, Fuller A, Sewell AK, Stern LJ, Godkin A, Cole DK.

Sci Rep. 2012;2:629. doi: 10.1038/srep00629. Epub 2012 Sep 4.

47.

T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.

Ekeruche-Makinde J, Clement M, Cole DK, Edwards ES, Ladell K, Miles JJ, Matthews KK, Fuller A, Lloyd KA, Madura F, Dolton GM, Pentier J, Lissina A, Gostick E, Baxter TK, Baker BM, Rizkallah PJ, Price DA, Wooldridge L, Sewell AK.

J Biol Chem. 2012 Oct 26;287(44):37269-81. doi: 10.1074/jbc.M112.386409. Epub 2012 Sep 5.

48.

Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.

Knight RR, Kronenberg D, Zhao M, Huang GC, Eichmann M, Bulek A, Wooldridge L, Cole DK, Sewell AK, Peakman M, Skowera A.

Diabetes. 2013 Jan;62(1):205-13. doi: 10.2337/db12-0315. Epub 2012 Aug 30.

49.

The molecular determinants of CD8 co-receptor function.

Cole DK, Laugel B, Clement M, Price DA, Wooldridge L, Sewell AK.

Immunology. 2012 Oct;137(2):139-48. doi: 10.1111/j.1365-2567.2012.03625.x. Review.

50.

TCR/pMHC Optimized Protein crystallization Screen.

Bulek AM, Madura F, Fuller A, Holland CJ, Schauenburg AJ, Sewell AK, Rizkallah PJ, Cole DK.

J Immunol Methods. 2012 Aug 31;382(1-2):203-10. doi: 10.1016/j.jim.2012.06.007. Epub 2012 Jun 15.

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