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Items: 1 to 50 of 140

1.

Downregulation of CYP2D16 by ACTH in the guinea pig adrenal cortex: time course, reversibility, and mechanism of action.

Colby HD, Longhurst PA, Burczynski JM, Hayes JR, Yuan BB, Voigt JV.

Pharmacology. 2003 Mar;67(3):121-7.

PMID:
12571407
2.

Bufuralol metabolism by guinea pig adrenal and hepatic microsomes.

Colby HD, Nowak DM, Longhurst PA, Zhang X, Hayes JR, Voigt JM.

Pharmacology. 2001 May;62(4):229-33.

PMID:
11360000
3.

Changes in mitochondrial and microsomal lipid peroxidation and fatty acid profiles in adrenal glands, testes, and livers from alpha-tocopherol-deficient rats.

Burczynski JM, Southard SJ, Hayes JR, Longhurst PA, Colby HD.

Free Radic Biol Med. 2001 May 1;30(9):1029-35.

PMID:
11316583
4.

Suppression of lipid peroxidation in adrenal microsomes following ACTH administration to guinea pigs.

Burczynski JM, Hayes JR, Voigt JM, Longhurst PA, Colby HD.

J Endocrinol. 2001 Feb;168(2):333-8.

PMID:
11182771
5.

Maturational changes in CYP2D16 expression and xenobiotic metabolism in adrenal glands from male and female guinea pigs.

Yuan BB, Tchao R, Voigt JM, Colby HD.

Drug Metab Dispos. 2001 Feb;29(2):194-9.

PMID:
11159811
6.

Bimodal expression of CYP2D16 in the guinea pig adrenal cortex.

Colby HD, Huang Y, Jiang Q, Voigt JM.

Pharmacology. 2000 Aug;61(2):78-82.

PMID:
10940780
7.

Species differences in adrenal lipid peroxidation: role of alpha-tocopherol.

Burczynski JM, Hayes JR, Longhurst PA, Colby HD.

Free Radic Biol Med. 1999 Apr;26(7-8):987-91.

PMID:
10232843
8.

Effects of adrenocorticotropic hormone and dexamethasone on adrenal and hepatic alpha-tocopherol concentrations.

Feingold IB, Longhurst PA, Colby HD.

Free Radic Biol Med. 1999 Mar;26(5-6):633-8.

PMID:
10218651
9.

Effects of ACTH administration on zonation of the guinea pig adrenal cortex.

Yuan BB, Tchao R, Funae Y, Voigt JM, Colby HD.

Mol Cell Endocrinol. 1998 Nov 25;146(1-2):129-36.

PMID:
10022770
10.

Strain differences in adrenal microsomal steroid metabolism in guinea pigs.

Huang Y, Jiang Q, Debolt KM, Voigt JM, Colby HD.

J Steroid Biochem Mol Biol. 1998 Mar;64(5-6):305-11.

PMID:
9618032
11.
12.

Localization of CYP2D16 in the guinea pig adrenal cortex by immunohistochemistry and in situ hybridization.

Yuan BB, Tchao R, Voigt JM, Colby HD.

Mol Cell Endocrinol. 1997 Nov 15;134(2):139-46.

PMID:
9426157
13.

Strain differences in adrenal CYP2D16 expression in guinea pigs. Relationship to xenobiotic metabolism.

Huang Y, Jiang Q, Voigt JM, Debolt KM, Colby HD.

Biochem Pharmacol. 1996 Dec 24;52(12):1925-9.

PMID:
8951353
14.

Differential effects of adrenocorticotropin in vivo on cytochromes P4502D16 and P450c17 in the guinea pig adrenal cortex.

Jiang Q, Huang Y, Voigt JM, DeBolt KM, Kominami S, Takemori S, Funae Y, Colby HD.

Endocrinology. 1996 Nov;137(11):4811-6.

PMID:
8895351
15.

Expression and zonal distribution of CYP2D16 in the guinea pig adrenal cortex: relationship to xenobiotic metabolism.

Jiang Q, Huang Y, Voigt JM, DeBolt BK, Kominami S, Takemori S, Funae Y, Colby HD.

Mol Pharmacol. 1996 Mar;49(3):458-64.

PMID:
8643085
16.

Stimulation of microsomal spironolactone metabolism by reduced glutathione.

Colby HD, LaCagnin LB, Los LE.

Pharmacology. 1996 Jan;52(1):30-4.

PMID:
8966200
17.

Inhibition of adrenal steroid metabolism by administration of 1-aminobenzotriazole to guinea pigs.

Xu D, Voigt JM, Mico BA, Colby HD.

J Steroid Biochem Mol Biol. 1995 Sep;54(5-6):281-5.

PMID:
7577711
18.

Molecular cloning and sequencing of a guinea pig cytochrome P4502D (CYP2D16): high level expression in adrenal microsomes.

Jiang Q, Voigt JM, Colby HD.

Biochem Biophys Res Commun. 1995 Apr 26;209(3):1149-56.

PMID:
7733969
19.

Inactivation of adrenal cytochromes P450 by 1-aminobenzotriazole. Divergence of in vivo and in vitro actions.

Colby HD, Abbott B, Cachovic M, Debolt KM, Mico BA.

Biochem Pharmacol. 1995 Apr 18;49(8):1057-62.

PMID:
7748185
20.

Zonal differences in adrenocortical lipid peroxidation: role of alpha-tocopherol.

Colby HD, Larson IW, Kowalski C, Levitt M.

Free Radic Biol Med. 1995 Feb;18(2):373-6.

PMID:
7744322
21.

Hepatic metabolism of spironolactone. Production of 3-hydroxy-thiomethyl metabolites.

Los LE, Pitzenberger SM, Ramjit HG, Coddington AB, Colby HD.

Drug Metab Dispos. 1994 Nov-Dec;22(6):903-8.

PMID:
7895608
22.

Adrenal activation of carbon tetrachloride: role of microsomal P450 isozymes.

Colby HD, Purcell H, Kominami S, Takemori S, Kossor DC.

Toxicology. 1994 Nov-Dec;94(1-3):31-40.

PMID:
7801328
23.

Inhibition of adrenal cytochromes P450 by 1-aminobenzotriazole in vitro. Selectivity for xenobiotic metabolism.

Xu D, Voigt JM, Mico BA, Kominami S, Takemori S, Colby HD.

Biochem Pharmacol. 1994 Oct 7;48(7):1421-6.

PMID:
7945442
24.

In vitro assessment of adrenocortical toxicity.

Colby HD.

J Pharmacol Toxicol Methods. 1994 Sep;32(1):1-6. Review. No abstract available.

PMID:
7833501
25.
26.

Identification of spironolactone metabolites in plasma and target organs of guinea pigs.

Los LE, Coddington AB, Ramjit HG, Colby HD.

Drug Metab Dispos. 1993 Nov-Dec;21(6):1086-90.

PMID:
7905388
27.

Maturational changes in steroidogenesis in the inner and outer zones of the guinea pig adrenal cortex.

Colby HD, Levitt M, Bergstrom JM, Purcell H.

J Steroid Biochem Mol Biol. 1993 Jun;45(6):501-7.

PMID:
8518205
28.

Regulation of adrenal and hepatic alpha-tocopherol content by androgens and estrogens.

Feingold IB, Longhurst PA, Colby HD.

Biochim Biophys Acta. 1993 Mar 10;1176(1-2):192-6.

PMID:
8452874
29.

Zonal differences in the thermal lability of adrenal microsomal monooxygenases.

Colby HD, Levitt M, Larson IW.

Drug Metab Dispos. 1993 Jan-Feb;21(1):200-2. No abstract available.

PMID:
8095221
30.

Destruction of testicular cytochrome P-450 by 7 alpha-thiospironolactone is catalyzed by the 17 alpha-hydroxylase.

Kossor DC, Kominami S, Takemori S, Colby HD.

J Steroid Biochem Mol Biol. 1992 May;42(3-4):421-4.

PMID:
1606053
31.
32.

Sex differences in adrenal and hepatic alpha-tocopherol concentrations in rats.

Feingold IB, Colby HD.

Pharmacology. 1992;44(2):113-6.

PMID:
1570361
33.
34.

Mechanism of action of spironolactone on cortisol production by guinea pig adrenocortical cells.

Rourke KA, Bergstrom JM, Larson IW, Colby HD.

Mol Cell Endocrinol. 1991 Oct;81(1-3):127-34.

PMID:
1797582
35.

Role of the steroid 17 alpha-hydroxylase in spironolactone-mediated destruction of adrenal cytochrome P-450.

Kossor DC, Kominami S, Takemori S, Colby HD.

Mol Pharmacol. 1991 Aug;40(2):321-5.

PMID:
1875914
36.

Mechanisms responsible for the thermal sensitivity of adrenal microsomal monooxygenases.

Colby HD, Johnson PB, Pope MR.

Drug Metab Dispos. 1991 May-Jun;19(3):679-82.

PMID:
1680636
37.

Relationship between covalent binding to microsomal protein and the destruction of adrenal cytochrome P-450 by spironolactone.

Colby HD, O'Donnell JP, Flowers NL, Kossor DC, Johnson PB, Levitt M.

Toxicology. 1991 Apr 8;67(2):143-54.

PMID:
2031249
38.

Spironolactone inhibition of cortisol production by guinea pig adrenocortical cells.

Rourke KA, Colby HD.

Horm Metab Res. 1990 Nov;22(11):573-5.

PMID:
2177032
39.
40.

Regional differences in adrenal activation of spironolactone: relationship to steroid 17 alpha-hydroxylase activity.

Sherry JH, Johnson PB, Levitt M, Bergstrom J, Colby HD.

Drug Metab Dispos. 1989 Nov-Dec;17(6):709-10. No abstract available.

PMID:
2575513
41.

Inhibition of adrenocortical, mitochondrial and microsomal monooxygenases by SU-10'603, a steroid 17 alpha-hydroxylase inhibitor.

LaCagnin LB, Levitt M, Bergstrom JM, Colby HD.

J Steroid Biochem. 1989 Oct;33(4A):599-604.

PMID:
2811371
42.

alpha-Tocopherol depletion eliminates the regional differences in adrenal mitochondrial lipid peroxidation.

Staats DA, Lohr DP, Colby HD.

Mol Cell Endocrinol. 1989 Apr;62(2):189-95.

PMID:
2744227
43.
44.

Spironolactone metabolism in target tissues. Characteristics of deacetylation in kidney, liver, adrenal cortex, and testes.

Flowers NL, O'Donnell JP, Colby HD.

Drug Metab Dispos. 1989 Mar-Apr;17(2):186-9.

PMID:
2565209
45.

Relationship between mitochondrial lipid peroxidation and alpha-tocopherol levels in the guinea-pig adrenal cortex.

Staats DA, Lohr D, Colby HD.

Biochim Biophys Acta. 1988 Aug 12;961(3):279-84.

PMID:
3401495
46.
47.

Changes in adrenocortical monooxygenase activities in alloxan-diabetic rabbits.

Colby HD, Lacagnin LB, Longhurst PA.

J Steroid Biochem. 1988 Jun;29(6):731-3.

PMID:
3386237
48.

Inhibition of hepatic microsomal drug metabolism by the steroid hydroxylase inhibitor SU-10'603.

LaCagnin LB, Patricoski P, Colby HD.

Biochem Pharmacol. 1988 Apr 15;37(8):1625-8.

PMID:
3358792
49.

Adrenal mitochondrial metabolism of spironolactone. Absence of metabolic activation.

Flowers NL, Sherry JH, O'Donnell JP, Colby HD.

Biochem Pharmacol. 1988 Apr 15;37(8):1591-5.

PMID:
3358788
50.

Species differences in adrenal spironolactone metabolism: relationship to cytochrome P-450 destruction.

Sherry JH, Johnson PB, Colby HD.

Biochem Pharmacol. 1988 Jan 15;37(2):355-7. No abstract available.

PMID:
3342091

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