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Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma.

Wang Q, Zhu J, Wang YW, Dai Y, Wang YL, Wang C, Liu J, Baker A, Colburn NH, Yang HS.

Oncogene. 2017 Nov 9;36(45):6225-6234. doi: 10.1038/onc.2017.228. Epub 2017 Jul 10.


Diallyl Disulfide (DADS), a Constituent of Garlic, Inactivates NF-κB and Prevents Colitis-Induced Colorectal Cancer by Inhibiting GSK-3β.

Saud SM, Li W, Gray Z, Matter MS, Colburn NH, Young MR, Kim YS.

Cancer Prev Res (Phila). 2016 Jul;9(7):607-15. doi: 10.1158/1940-6207.CAPR-16-0044. Epub 2016 May 2.


Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4.

Schmid T, Blees JS, Bajer MM, Wild J, Pescatori L, Cuzzucoli Crucitti G, Scipione L, Costi R, Henrich CJ, Brüne B, Colburn NH, Di Santo R.

PLoS One. 2016 Mar 16;11(3):e0151643. doi: 10.1371/journal.pone.0151643. eCollection 2016.


Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro.

Li W, Saud SM, Young MR, Colburn NH, Hua B.

Mol Cell Biochem. 2015 Aug;406(1-2):63-73. doi: 10.1007/s11010-015-2424-0. Epub 2015 Apr 26.


Impact of dietary components on NK and Treg cell function for cancer prevention.

Kim YS, Sayers TJ, Colburn NH, Milner JA, Young HA.

Mol Carcinog. 2015 Sep;54(9):669-78. doi: 10.1002/mc.22301. Epub 2015 Apr 1. Review.


Identification and monitoring of metabolite markers of dry bean consumption in parallel human and mouse studies.

Perera T, Young MR, Zhang Z, Murphy G, Colburn NH, Lanza E, Hartman TJ, Cross AJ, Bobe G.

Mol Nutr Food Res. 2015 Apr;59(4):795-806. doi: 10.1002/mnfr.201400847. Epub 2015 Feb 23.


Nucleocytoplasmic shuttling of valosin-containing protein (VCP/p97) regulated by its N domain and C-terminal region.

Song C, Wang Q, Song C, Lockett SJ, Colburn NH, Li CC, Wang JM, Rogers TJ.

Biochim Biophys Acta. 2015 Jan;1853(1):222-32. doi: 10.1016/j.bbamcr.2014.10.019. Epub 2014 Oct 30.


The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells.

Sagher E, Hernandez L, Heywood C, Pauly GT, Young MR, Schneider J, Colburn NH, Annunziata CM.

Cancer Cell Int. 2014 Aug 12;14:75. doi: 10.1186/s12935-014-0075-y. eCollection 2014.


Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression.

Saud SM, Li W, Morris NL, Matter MS, Colburn NH, Kim YS, Young MR.

Carcinogenesis. 2014 Dec;35(12):2778-86. doi: 10.1093/carcin/bgu209. Epub 2014 Oct 3.


Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4.

Grkovic T, Blees JS, Bayer MM, Colburn NH, Thomas CL, Henrich CJ, Peach ML, McMahon JB, Schmid T, Gustafson KR.

Mar Drugs. 2014 Aug 21;12(8):4593-601. doi: 10.3390/md12084593.


Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice.

Li W, Hua B, Saud SM, Lin H, Hou W, Matter MS, Jia L, Colburn NH, Young MR.

Mol Carcinog. 2015 Oct;54(10):1096-109. doi: 10.1002/mc.22179. Epub 2014 May 17.


Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor.

Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.

Biochem Pharmacol. 2014 Apr 1;88(3):313-21. doi: 10.1016/j.bcp.2014.01.034. Epub 2014 Feb 7.


Tumor promoter-induced sulfiredoxin is required for mouse skin tumorigenesis.

Wu L, Jiang H, Chawsheen HA, Mishra M, Young MR, Gerard M, Toledano MB, Colburn NH, Wei Q.

Carcinogenesis. 2014 May;35(5):1177-84. doi: 10.1093/carcin/bgu035. Epub 2014 Feb 6.


Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65.

Hwang SK, Baker AR, Young MR, Colburn NH.

Carcinogenesis. 2014 Jul;35(7):1469-80. doi: 10.1093/carcin/bgu008. Epub 2014 Jan 11.


Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.

Saud SM, Young MR, Jones-Hall YL, Ileva L, Evbuomwan MO, Wise J, Colburn NH, Kim YS, Bobe G.

Cancer Res. 2013 Sep 1;73(17):5473-84. doi: 10.1158/0008-5472.CAN-13-0525. Epub 2013 Jul 1.


Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis.

Wei Q, Jiang H, Baker A, Dodge LK, Gerard M, Young MR, Toledano MB, Colburn NH.

Carcinogenesis. 2013 Jun;34(6):1403-10. doi: 10.1093/carcin/bgt059. Epub 2013 Feb 7.


An integrated understanding of the physiological response to elevated extracellular phosphate.

Camalier CE, Yi M, Yu LR, Hood BL, Conrads KA, Lee YJ, Lin Y, Garneys LM, Bouloux GF, Young MR, Veenstra TD, Stephens RM, Colburn NH, Conrads TP, Beck GR Jr.

J Cell Physiol. 2013 Jul;228(7):1536-50. doi: 10.1002/jcp.24312.


Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1.

Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.

PLoS One. 2012;7(10):e46567. doi: 10.1371/journal.pone.0046567. Epub 2012 Oct 2.


Targeting of Noncanonical Wnt5a Signaling by AP-1 Blocker Dominant-Negative Jun When It Inhibits Skin Carcinogenesis.

Kang MI, Baker AR, Dextras CR, Cabarcas SM, Young MR, Colburn NH.

Genes Cancer. 2012 Jan;3(1):37-50. doi: 10.1177/1947601912448820.


Plasma cytokines as potential response indicators to dietary freeze-dried black raspberries in colorectal cancer patients.

Mentor-Marcel RA, Bobe G, Sardo C, Wang LS, Kuo CT, Stoner G, Colburn NH.

Nutr Cancer. 2012 Aug;64(6):820-5. doi: 10.1080/01635581.2012.697597. Epub 2012 Jul 24.


Programmed cell death 4 (PDCD4): a novel player in ethanol-mediated suppression of protein translation in primary cortical neurons and developing cerebral cortex.

Narasimhan M, Rathinam M, Riar A, Patel D, Mummidi S, Yang HS, Colburn NH, Henderson GI, Mahimainathan L.

Alcohol Clin Exp Res. 2013 Jan;37(1):96-109. doi: 10.1111/j.1530-0277.2012.01850.x. Epub 2012 Jul 3.


Cancer stem cells: potential target for bioactive food components.

Kim YS, Farrar W, Colburn NH, Milner JA.

J Nutr Biochem. 2012 Jul;23(7):691-8. doi: 10.1016/j.jnutbio.2012.03.002. Review.


Fluorescence endoscopic detection of murine colitis-associated colon cancer by topically applied enzymatically rapid-activatable probe.

Mitsunaga M, Kosaka N, Choyke PL, Young MR, Dextras CR, Saud SM, Colburn NH, Sakabe M, Nagano T, Asanuma D, Urano Y, Kobayashi H.

Gut. 2013 Aug;62(8):1179-86. doi: 10.1136/gutjnl-2011-301795. Epub 2012 Jun 14.


Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers.

Dong S, Cahill KJ, Kang MI, Colburn NH, Henrich CJ, Wilson JA, Beutler JA, Johnson RP, Porco JA.

J Org Chem. 2011 Nov 4;76(21):8944-54. doi: 10.1021/jo201658y. Epub 2011 Oct 7.


Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600.

Zhao LX, Huang SX, Tang SK, Jiang CL, Duan Y, Beutler JA, Henrich CJ, McMahon JB, Schmid T, Blees JS, Colburn NH, Rajski SR, Shen B.

J Nat Prod. 2011 Sep 23;74(9):1990-5. doi: 10.1021/np200603g. Epub 2011 Aug 26.


Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula.

Popplewell WL, Ratnayake R, Wilson JA, Beutler JA, Colburn NH, Henrich CJ, McMahon JB, McKee TC.

J Nat Prod. 2011 Aug 26;74(8):1686-91. doi: 10.1021/np2005083. Epub 2011 Aug 1.


Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation.

Schmid T, Bajer MM, Blees JS, Eifler LK, Milke L, Rübsamen D, Schulz K, Weigert A, Baker AR, Colburn NH, Brüne B.

Carcinogenesis. 2011 Oct;32(10):1427-33. doi: 10.1093/carcin/bgr131. Epub 2011 Jul 18.


Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii.

Diyabalanage T, Ratnayake R, Wilson JA, Henrich CJ, Beutler JA, Colburn NH, McMahon JB, Gustafson KR.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4397-9. doi: 10.1016/j.bmcl.2011.06.044. Epub 2011 Jun 17.


Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo.

Gaur AB, Holbeck SL, Colburn NH, Israel MA.

Neuro Oncol. 2011 Jun;13(6):580-90. doi: 10.1093/neuonc/nor033.


Cryptocaryols A-H, α-pyrone-containing 1,3-polyols from Cryptocarya sp. implicated in stabilizing the tumor suppressor Pdcd4.

Grkovic T, Blees JS, Colburn NH, Schmid T, Thomas CL, Henrich CJ, McMahon JB, Gustafson KR.

J Nat Prod. 2011 May 27;74(5):1015-20. doi: 10.1021/np100918z. Epub 2011 May 3.


Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling.

Wei Q, Jiang H, Xiao Z, Baker A, Young MR, Veenstra TD, Colburn NH.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7004-9. doi: 10.1073/pnas.1013012108. Epub 2011 Apr 12.


Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.

Devkota KP, Ratnayake R, Colburn NH, Wilson JA, Henrich CJ, McMahon JB, Beutler JA.

J Nat Prod. 2011 Mar 25;74(3):374-7. doi: 10.1021/np100736y. Epub 2011 Feb 9.


A high-legume low-glycemic index diet reduces fasting plasma leptin in middle-aged insulin-resistant and -sensitive men.

Zhang Z, Lanza E, Ross AC, Albert PS, Colburn NH, Rovine MJ, Bagshaw D, Ulbrecht JS, Hartman TJ.

Eur J Clin Nutr. 2011 Mar;65(3):415-8. doi: 10.1038/ejcn.2010.273. Epub 2011 Jan 5.


Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols?

Bobe G, Murphy G, Albert PS, Sansbury LB, Young MR, Lanza E, Schatzkin A, Colburn NH, Cross AJ.

Eur J Cancer Prev. 2011 Mar;20(2):86-95. doi: 10.1097/CEJ.0b013e3283429e45.


Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention Trial.

Bobe G, Murphy G, Albert PS, Sansbury LB, Lanza E, Schatzkin A, Colburn NH, Cross AJ.

Br J Cancer. 2010 Oct 26;103(9):1453-61. doi: 10.1038/sj.bjc.6605915. Epub 2010 Oct 5.


A high legume low glycemic index diet improves serum lipid profiles in men.

Zhang Z, Lanza E, Kris-Etherton PM, Colburn NH, Bagshaw D, Rovine MJ, Ulbrecht JS, Bobe G, Chapkin RS, Hartman TJ.

Lipids. 2010 Sep;45(9):765-75. doi: 10.1007/s11745-010-3463-7. Epub 2010 Aug 24.


A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice.

Tichelaar JW, Yan Y, Tan Q, Wang Y, Estensen RD, Young MR, Colburn NH, Yin H, Goodin C, Anderson MW, You M.

Cancer Prev Res (Phila). 2010 Sep;3(9):1148-56. doi: 10.1158/1940-6207.CAPR-10-0023. Epub 2010 Aug 17.


Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment.

Yasuda M, Schmid T, Rübsamen D, Colburn NH, Irie K, Murakami A.

Mol Carcinog. 2010 Sep;49(9):837-48. doi: 10.1002/mc.20660.


Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion.

Santhanam AN, Baker AR, Hegamyer G, Kirschmann DA, Colburn NH.

Oncogene. 2010 Jul 8;29(27):3921-32. doi: 10.1038/onc.2010.158. Epub 2010 May 24.


Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trial.

Bobe G, Albert PS, Sansbury LB, Lanza E, Schatzkin A, Colburn NH, Cross AJ.

Cancer Prev Res (Phila). 2010 Jun;3(6):764-75. doi: 10.1158/1940-6207.CAPR-09-0161. Epub 2010 May 18.


Have tumor suppressor PDCD4 and its counteragent oncogenic miR-21 gone rogue?

Young MR, Santhanam AN, Yoshikawa N, Colburn NH.

Mol Interv. 2010 Apr;10(2):76-9. doi: 10.1124/mi.10.2.5. Review. No abstract available.


STAT2 contributes to promotion of colorectal and skin carcinogenesis.

Gamero AM, Young MR, Mentor-Marcel R, Bobe G, Scarzello AJ, Wise J, Colburn NH.

Cancer Prev Res (Phila). 2010 Apr;3(4):495-504. doi: 10.1158/1940-6207.CAPR-09-0105. Epub 2010 Mar 16.


Elevated phosphate activates N-ras and promotes cell transformation and skin tumorigenesis.

Camalier CE, Young MR, Bobe G, Perella CM, Colburn NH, Beck GR Jr.

Cancer Prev Res (Phila). 2010 Mar;3(3):359-70. doi: 10.1158/1940-6207.CAPR-09-0068. Epub 2010 Feb 9.


Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4.

Blees JS, Schmid T, Thomas CL, Baker AR, Benson L, Evans JR, Goncharova EI, Colburn NH, McMahon JB, Henrich CJ.

J Biomol Screen. 2010 Jan;15(1):21-9. doi: 10.1177/1087057109351028. Epub 2009 Nov 9.


Consumption of a legume-enriched, low-glycemic index diet is associated with biomarkers of insulin resistance and inflammation among men at risk for colorectal cancer.

Hartman TJ, Albert PS, Zhang Z, Bagshaw D, Kris-Etherton PM, Ulbrecht J, Miller CK, Bobe G, Colburn NH, Lanza E.

J Nutr. 2010 Jan;140(1):60-7. doi: 10.3945/jn.109.114249. Epub 2009 Nov 4.


JNK/AP-1 pathway is involved in tumor necrosis factor-alpha induced expression of vascular endothelial growth factor in MCF7 cells.

Yin Y, Wang S, Sun Y, Matt Y, Colburn NH, Shu Y, Han X.

Biomed Pharmacother. 2009 Jul;63(6):429-35. doi: 10.1016/j.biopha.2009.04.045. Epub 2009 Jun 9.


Noninvasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas.

Zhao C, Ivanov I, Dougherty ER, Hartman TJ, Lanza E, Bobe G, Colburn NH, Lupton JR, Davidson LA, Chapkin RS.

Cancer Prev Res (Phila). 2009 Jun;2(6):590-7. doi: 10.1158/1940-6207.CAPR-08-0233. Epub 2009 May 26.


Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction.

Yasuda M, Nishizawa T, Ohigashi H, Tanaka T, Hou DX, Colburn NH, Murakami A.

Carcinogenesis. 2009 Jul;30(7):1209-16. doi: 10.1093/carcin/bgp106. Epub 2009 May 4.


Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference.

Santhanam AN, Bindewald E, Rajasekhar VK, Larsson O, Sonenberg N, Colburn NH, Shapiro BA.

PLoS One. 2009;4(3):e4868. doi: 10.1371/journal.pone.0004868. Epub 2009 Mar 17. Erratum in: PLoS One. 2009;4(4). doi: 10.1371/annotation/6a44204e-5d20-45bf-bbce-358dc9e2de27.


Bioactive food components, inflammatory targets, and cancer prevention.

Kim YS, Young MR, Bobe G, Colburn NH, Milner JA.

Cancer Prev Res (Phila). 2009 Mar;2(3):200-8. doi: 10.1158/1940-6207.CAPR-08-0141. Epub 2009 Mar 3. Review.

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