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Cancer Prev Res (Phila). 2018 Dec;11(12):735-778. doi: 10.1158/1940-6207.CAPR-18-0421.

AACR White Paper: Shaping the Future of Cancer Prevention - A Roadmap for Advancing Science and Public Health.

Author information

1
UC San Diego Moores Cancer Center, LaJolla, California. ehawk@mdanderson.org slippman@ucsd.edu.
2
Departments of Urology, Medicine, Systems Biology, and Pathology & Cell Biology, Institute of Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY.
3
Division of Cancer Prevention & Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX.
4
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
5
Weill Cornell Medical College, New York, NY.
6
Fred Hutchinson Cancer Center and University of Washington, Seattle, Washington.
7
UW Medicine Cancer Vaccine Institute, University of Washington, Seattle, Washington.
8
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.
9
Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, Maryland.
10
Center for Infection Research in Cancer, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
11
Janssen Research and Development LLC., Raritan, New Jersey.
12
Department of Biostatistics, University of Texas, MD Anderson Cancer Center, Houston, Texas.
13
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
14
Division of Cancer Prevention, NCI, Bethesda, Maryland.
15
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
16
Sheikh Ahmed Pancreatic Cancer Research Center, University of Texas MD Anderson Cancer Center, Houston, TX.
17
Department of Family Medicine and Public Health, UC San Diego, LaJolla, California.
18
Cancer Epidemiology & Cancer Risk and Disparity, Dana-Farber Cancer Institute, Boston, MA.
19
College of Medicine, Pennsylvania State University, Hershey, PA.
20
Departments of Clinical Cancer Prevention and GI Medical Oncology, UT MD Anderson Cancer Center, Houston, TX.
21
Division of Cancer Prevention & Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX. ehawk@mdanderson.org slippman@ucsd.edu.

Abstract

The recent pace, extent, and impact of paradigm-changing cancer prevention science has been remarkable. The American Association for Cancer Research (AACR) convened a 3-day summit, aligned with five research priorities: (i) Precancer Atlas (PCA). (ii) Cancer interception. (iii) Obesity-cancer linkage, a global epidemic of chronic low-grade inflammation. (iv) Implementation science. (v) Cancer disparities. Aligned with these priorities, AACR co-led the Lancet Commission to formally endorse and accelerate the NCI Cancer Moonshot program, facilitating new global collaborative efforts in cancer control. The expanding scope of creative impact is perhaps most startling-from NCI-funded built environments to AACR Team Science Awarded studies of Asian cancer genomes informing global primary prevention policies; cell-free epigenetic marks identifying incipient neoplastic site; practice-changing genomic subclasses in myeloproliferative neoplasia (including germline variant tightly linked to JAK2 V617F haplotype); universal germline genetic testing for pancreatic cancer; and repurposing drugs targeting immune- and stem-cell signals (e.g., IL-1β, PD-1, RANK-L) to cancer interception. Microbiota-driven IL-17 can induce stemness and transformation in pancreatic precursors (identifying another repurposing opportunity). Notable progress also includes hosting an obesity special conference (connecting epidemiologic and molecular perspectives to inform cancer research and prevention strategies), co-leading concerted national implementation efforts in HPV vaccination, and charting the future elimination of cancer disparities by integrating new science tools, discoveries and perspectives into community-engaged research, including targeted counter attacks on e-cigarette ad exploitation of children, Hispanics and Blacks. Following this summit, two unprecedented funding initiatives were catalyzed to drive cancer prevention research: the NCI Cancer Moonshot (e.g., PCA and disparities); and the AACR-Stand Up To Cancer bold "Cancer Interception" initiative.

PMID:
30530635
DOI:
10.1158/1940-6207.CAPR-18-0421
[Indexed for MEDLINE]
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