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The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential.

Friesen WJ, Johnson B, Sierra J, Zhuo J, Vazirani P, Xue X, Tomizawa Y, Baiazitov R, Morrill C, Ren H, Babu S, Moon YC, Branstrom A, Mollin A, Hedrick J, Sheedy J, Elfring G, Weetall M, Colacino JM, Welch EM, Peltz SW.

PLoS One. 2018 Oct 25;13(10):e0206158. doi: 10.1371/journal.pone.0206158. eCollection 2018.


Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties.

Cao L, Weetall M, Trotta C, Cintron K, Ma J, Kim MJ, Furia B, Romfo C, Graci JD, Li W, Du J, Sheedy J, Hedrick J, Risher N, Yeh S, Qi H, Arasu T, Hwang S, Lennox W, Kong R, Petruska J, Moon YC, Babiak J, Davis TW, Jacobson A, Almstead NG, Branstrom A, Colacino JM, Peltz SW.

Mol Cancer Ther. 2019 Jan;18(1):3-16. doi: 10.1158/1535-7163.MCT-18-0863. Epub 2018 Oct 23.


Identification of benzazole compounds that induce HIV-1 transcription.

Graci JD, Michaels D, Chen G, Schiralli Lester GM, Nodder S, Weetall M, Karp GM, Gu Z, Colacino JM, Henderson AJ.

PLoS One. 2017 Jun 28;12(6):e0179100. doi: 10.1371/journal.pone.0179100. eCollection 2017.


The nucleoside analog clitocine is a potent and efficacious readthrough agent.

Friesen WJ, Trotta CR, Tomizawa Y, Zhuo J, Johnson B, Sierra J, Roy B, Weetall M, Hedrick J, Sheedy J, Takasugi J, Moon YC, Babu S, Baiazitov R, Leszyk JD, Davis TW, Colacino JM, Peltz SW, Welch EM.

RNA. 2017 Apr;23(4):567-577. doi: 10.1261/rna.060236.116. Epub 2017 Jan 17.


Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform.

Cao L, Weetall M, Bombard J, Qi H, Arasu T, Lennox W, Hedrick J, Sheedy J, Risher N, Brooks PC, Trifillis P, Trotta C, Moon YC, Babiak J, Almstead NG, Colacino JM, Davis TW, Peltz SW.

PLoS One. 2016 Dec 16;11(12):e0168366. doi: 10.1371/journal.pone.0168366. eCollection 2016.


PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally.

Graci JD, Jung SP, Pichardo J, Lahser F, Tong X, Gu Z, Colacino JM.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7060-7066. Print 2016 Dec.


Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.

Naryshkin NA, Weetall M, Dakka A, Narasimhan J, Zhao X, Feng Z, Ling KK, Karp GM, Qi H, Woll MG, Chen G, Zhang N, Gabbeta V, Vazirani P, Bhattacharyya A, Furia B, Risher N, Sheedy J, Kong R, Ma J, Turpoff A, Lee CS, Zhang X, Moon YC, Trifillis P, Welch EM, Colacino JM, Babiak J, Almstead NG, Peltz SW, Eng LA, Chen KS, Mull JL, Lynes MS, Rubin LL, Fontoura P, Santarelli L, Haehnke D, McCarthy KD, Schmucki R, Ebeling M, Sivaramakrishnan M, Ko CP, Paushkin SV, Ratni H, Gerlach I, Ghosh A, Metzger F.

Science. 2014 Aug 8;345(6197):688-93. doi: 10.1126/science.1250127.


Structure-activity relationship (SAR) optimization of 6-(indol-2-yl)pyridine-3-sulfonamides: identification of potent, selective, and orally bioavailable small molecules targeting hepatitis C (HCV) NS4B.

Zhang N, Zhang X, Zhu J, Turpoff A, Chen G, Morrill C, Huang S, Lennox W, Kakarla R, Liu R, Li C, Ren H, Almstead N, Venkatraman S, Njoroge FG, Gu Z, Clausen V, Graci J, Jung SP, Zheng Y, Colacino JM, Lahser F, Sheedy J, Mollin A, Weetall M, Nomeir A, Karp GM.

J Med Chem. 2014 Mar 13;57(5):2121-35. doi: 10.1021/jm401621g. Epub 2013 Dec 4.


Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B protein.

Gu Z, Graci JD, Lahser FC, Breslin JJ, Jung SP, Crona JH, McMonagle P, Xia E, Liu S, Karp G, Zhu J, Huang S, Nomeir A, Weetall M, Almstead NG, Peltz SW, Tong X, Ralston R, Colacino JM.

Antimicrob Agents Chemother. 2013 Jul;57(7):3250-61. doi: 10.1128/AAC.00527-13. Epub 2013 Apr 29.


Professor De Clercq and 25 years of international collaboration on antiviral research.

Colacino JM.

Antivir Chem Chemother. 2013 May 16;23(2):57-8. doi: 10.3851/IMP2395.


High-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor.

Micheva-Viteva S, Kobayashi Y, Edelstein LC, Pacchia AL, Lee HL, Graci JD, Breslin J, Phelan BD, Miller LK, Colacino JM, Gu Z, Ron Y, Peltz SW, Dougherty JP.

J Biol Chem. 2011 Jun 17;286(24):21083-91. doi: 10.1074/jbc.M110.195537. Epub 2011 Apr 15.


The absorption efficiency and respiration rate of the Florida lancelet, Branchiostoma floridae.

Nash TR, Ruppert EE, Colacino JM.

Comp Biochem Physiol A Mol Integr Physiol. 2009 Dec;154(4):570-4. doi: 10.1016/j.cbpa.2009.09.007. Epub 2009 Sep 13.


HIV type-1 latency: targeted induction of proviral reservoirs.

Graci JD, Colacino JM, Peltz SW, Dougherty JP, Gu Z.

Antivir Chem Chemother. 2009;19(5):177-87. Review.


PTC124 targets genetic disorders caused by nonsense mutations.

Welch EM, Barton ER, Zhuo J, Tomizawa Y, Friesen WJ, Trifillis P, Paushkin S, Patel M, Trotta CR, Hwang S, Wilde RG, Karp G, Takasugi J, Chen G, Jones S, Ren H, Moon YC, Corson D, Turpoff AA, Campbell JA, Conn MM, Khan A, Almstead NG, Hedrick J, Mollin A, Risher N, Weetall M, Yeh S, Branstrom AA, Colacino JM, Babiak J, Ju WD, Hirawat S, Northcutt VJ, Miller LL, Spatrick P, He F, Kawana M, Feng H, Jacobson A, Peltz SW, Sweeney HL.

Nature. 2007 May 3;447(7140):87-91. Epub 2007 Apr 22.


Oligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase.

Wang QM, Hockman MA, Staschke K, Johnson RB, Case KA, Lu J, Parsons S, Zhang F, Rathnachalam R, Kirkegaard K, Colacino JM.

J Virol. 2002 Apr;76(8):3865-72.


Enhanced antiviral effect in cell culture of type 1 interferon and ribozymes targeting HCV RNA.

Macejak DG, Jensen KL, Pavco PA, Phipps KM, Heinz BA, Colacino JM, Blatt LM.

J Viral Hepat. 2001 Nov;8(6):400-5.


Drug discovery and development of antiviral agents for the treatment of chronic hepatitis B virus infection.

Staschke KA, Colacino JM.

Prog Drug Res. 2001;Spec No:111-83. Review.


Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

Johnson AA, Ray AS, Hanes J, Suo Z, Colacino JM, Anderson KS, Johnson KA.

J Biol Chem. 2001 Nov 2;276(44):40847-57. Epub 2001 Aug 28.


Approaches and strategies for the treatment of influenza virus infections.

Colacino JM, Staschke KA, Laver WG.

Antivir Chem Chemother. 1999 Jul;10(4):155-85. Review.


Inhibition of influenza virus hemagglutinin-mediated membrane fusion by a compound related to podocarpic acid.

Staschke KA, Hatch SD, Tang JC, Hornback WJ, Munroe JE, Colacino JM, Muesing MA.

Virology. 1998 Sep 1;248(2):264-74.


Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection.

Tennant BC, Baldwin BH, Graham LA, Ascenzi MA, Hornbuckle WE, Rowland PH, Tochkov IA, Yeager AE, Erb HN, Colacino JM, Lopez C, Engelhardt JA, Bowsher RR, Richardson FC, Lewis W, Cote PJ, Korba BE, Gerin JL.

Hepatology. 1998 Jul;28(1):179-91.


The mini-hemoglobins in neural and body wall tissue of the nemertean worm, Cerebratulus lacteus.

Vandergon TL, Riggs CK, Gorr TA, Colacino JM, Riggs AF.

J Biol Chem. 1998 Jul 3;273(27):16998-7011.


Synthesis and antiviral activity of prodrugs of the nucleoside 1-[2',3'-dideoxy-3'-C-(hydroxymethyl)-beta-D-erythropentofuranosyl] cytosine.

Mauldin SC, Paget CJ Jr, Jones CD, Colacino JM, Baxter AJ, Staschke KA, Johansson NG, Vrang L.

Bioorg Med Chem. 1998 May;6(5):577-85.


A single sequence change destabilizes the influenza virus neuraminidase tetramer.

Colacino JM, Chirgadze NY, Garman E, Murti KG, Loncharich RJ, Baxter AJ, Staschke KA, Laver WG.

Virology. 1997 Sep 15;236(1):66-75.


Selection of influenza A and B viruses for resistance to 4-guanidino-Neu5Ac2en in cell culture.

Colacino JM, Laver WG, Air GM.

J Infect Dis. 1997 Aug;176 Suppl 1:S66-8.


Fialuridine is phosphorylated and inhibits DNA synthesis in isolated rat hepatic mitochondria.

Horn DM, Neeb LA, Colacino JM, Richardson FC.

Antiviral Res. 1997 Mar;34(1):71-4.


Differential effects of the incorporation of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) on the binding of the transcription factors, AP-1 and TFIID, to their cognate target DNA sequences.

Staschke KA, Richardson KK, Mabry TE, Baxter AJ, Scheuring JC, Huffman DM, Smith WC, Richardson FC, Colacino JM.

Nucleic Acids Res. 1996 Nov 1;24(21):4111-6.


Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.

Lewis W, Levine ES, Griniuviene B, Tankersley KO, Colacino JM, Sommadossi JP, Watanabe KA, Perrino FW.

Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3592-7.


Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2en.

Staschke KA, Colacino JM, Baxter AJ, Air GM, Bansal A, Hornback WJ, Munroe JE, Laver WG.

Virology. 1995 Dec 20;214(2):642-6.


The PETT series, a new class of potent nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase.

Ahgren C, Backro K, Bell FW, Cantrell AS, Clemens M, Colacino JM, Deeter JB, Engelhardt JA, Hogberg M, Jaskunas SR, et al.

Antimicrob Agents Chemother. 1995 Jun;39(6):1329-35.


Effect of fialuridine on replication of mitochondrial DNA in CEM cells and in human hepatoblastoma cells in culture.

Colacino JM, Malcolm SK, Jaskunas SR.

Antimicrob Agents Chemother. 1994 Sep;38(9):1997-2002.


Inhibition of duck hepatitis B virus replication by hypericin.

Moraleda G, Wu TT, Jilbert AR, Aldrich CE, Condreay LD, Larsen SH, Tang JC, Colacino JM, Mason WS.

Antiviral Res. 1993 Mar;20(3):235-47.


Alteration of hemoglobin function by diadenosine 5',5'''-P1,P4-tetraphosphate and other alarmones.

Bonaventura C, Cashon R, Colacino JM, Hilderman RH.

J Biol Chem. 1992 Mar 5;267(7):4652-7.


Red Blood Cell Oxygen Binding in Capitellid Polychaetes.

Mangum CP, Colacino JM, Grassle JP.

Biol Bull. 1992 Feb;182(1):129-134. doi: 10.2307/1542187.


Evaluation of the anti-influenza virus activities of 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and its sodium salt.

Colacino JM, DeLong DC, Nelson JR, Spitzer WA, Tang J, Victor F, Wu CY.

Antimicrob Agents Chemother. 1990 Nov;34(11):2156-63.


Cytopathogenicity, drug susceptibility, and thymidine kinase activity of a retinovirulent herpes simplex virus type 2.

Langford MP, Colacino JM, Kaiwar R, Mahjoub SB, Ganley JP.

J Med Virol. 1990 Aug;31(4):301-5.


Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses.

Tang J, Colacino JM, Larsen SH, Spitzer W.

Antiviral Res. 1990 Jun;13(6):313-25.


Physical structure and molecular cloning of equine cytomegalovirus DNA.

Colacino JM, Flowers CC, Menna J, O'Callaghan DJ, Staczek J.

Virology. 1989 Dec;173(2):566-80.


Peritoneal oxygenation of normoxic and hypoxic dogs.

Schmidt JA, Bilge FH, Colacino JM, von Recum AF.

ASAIO Trans. 1989 Jan-Mar;35(1):35-9.


A model for oxygen storage by hemoglobin.

Colacino JM, Brannan JR, Fields MA.

J Theor Biol. 1987 Jun 21;126(4):437-47.


Extended Oxygen Delivery from the Nerve Hemoglobin of Tellina alternata (Bivalvia).

Kraus DW, Colacino JM.

Science. 1986 Apr 4;232(4746):90-2.


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