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Items: 1 to 50 of 135

1.

A Dried Blood Spot Analysis for Solithromycin in Adolescents, Children, and Infants: A Short Communication.

Beechinor RJ, Cohen-Wolkowiez M, Jasion T, Hornik CP, Lang JE, Hernandez R, Gonzalez D.

Ther Drug Monit. 2019 Jul 15. doi: 10.1097/FTD.0000000000000670. [Epub ahead of print]

PMID:
31318840
2.

Population Pharmacokinetics of Milrinone in Infants, Children, and Adolescents.

Hornik CP, Yogev R, Mourani PM, Watt KM, Sullivan JE, Atz AM, Speicher D, Al-Uzri A, Adu-Darko M, Payne EH, Gelber CE, Lin S, Harper B, Melloni C, Cohen-Wolkowiez M, Gonzalez D; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee.

J Clin Pharmacol. 2019 Jul 17. doi: 10.1002/jcph.1499. [Epub ahead of print]

PMID:
31317556
3.

Physiologically-Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants.

Gerhart JG, Watt KM, Edginton A, Wade KC, Salerno SN, Benjamin DK Jr, Smith PB, Hornik CP, Cohen-Wolkowiez M, Duara S, Ross A, Shattuck K, Stewart DL, Neu N, Gonzalez D; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee.

CPT Pharmacometrics Syst Pharmacol. 2019 Jul;8(7):500-510. doi: 10.1002/psp4.12414. Epub 2019 May 22.

4.

Pitfalls of using numerical predictive checks for population physiologically-based pharmacokinetic model evaluation.

Maharaj AR, Wu H, Hornik CP, Cohen-Wolkowiez M.

J Pharmacokinet Pharmacodyn. 2019 Jun;46(3):263-272. doi: 10.1007/s10928-019-09636-5. Epub 2019 Apr 23.

PMID:
31016557
5.

Cefazolin pharmacokinetics in premature infants.

Balevic SJ, Smith PB, Testoni D, Wu H, Brouwer KLR, Zimmerman KO, Rivera-Chaparro ND, Benjamin DK Jr, Cohen-Wolkowiez M.

J Perinatol. 2019 Apr 3. doi: 10.1038/s41372-019-0368-z. [Epub ahead of print]

PMID:
30944398
6.

Rifampin Pharmacokinetics and Safety in Preterm and Term Infants.

Smith PB, Cotten CM, Hudak ML, Sullivan JE, Poindexter BB, Cohen-Wolkowiez M, Boakye-Agyeman F, Lewandowski A, Anand R, Benjamin DK Jr, Laughon MM; Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00284-19. doi: 10.1128/AAC.00284-19. Print 2019 Jun.

PMID:
30910891
7.

Physiologically Based Pharmacokinetic Modeling for Trimethoprim and Sulfamethoxazole in Children.

Thompson EJ, Wu H, Maharaj A, Edginton AN, Balevic SJ, Cobbaert M, Cunningham AP, Hornik CP, Cohen-Wolkowiez M.

Clin Pharmacokinet. 2019 Jul;58(7):887-898. doi: 10.1007/s40262-018-00733-1.

PMID:
30840200
8.

Pharmacokinetics of ticarcillin-clavulanate in premature infants.

Watt KM, Hornik CP, Balevic SJ, Mundakel G, Cotten CM, Harper B, Benjamin DK Jr, Anand R, Laughon M, Smith PB, Cohen-Wolkowiez M; Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee.

Br J Clin Pharmacol. 2019 May;85(5):1021-1027. doi: 10.1111/bcp.13882. Epub 2019 Mar 6.

PMID:
30710387
9.

Development of Therapeutics for Children-A Tricky Balancing Act.

Cohen-Wolkowiez M, Benjamin DK Jr.

JAMA Pediatr. 2019 Jan 1;173(1):18-19. doi: 10.1001/jamapediatrics.2018.4026. No abstract available.

PMID:
30452501
10.

Hydroxychloroquine Levels throughout Pregnancies Complicated by Rheumatic Disease: Implications for Maternal and Neonatal Outcomes.

Balevic SJ, Cohen-Wolkowiez M, Eudy AM, Green TP, Schanberg LE, Clowse MEB.

J Rheumatol. 2019 Jan;46(1):57-63. doi: 10.3899/jrheum.180158. Epub 2018 Oct 1.

PMID:
30275257
11.

Population Pharmacokinetics and Exploratory Exposure-Response Relationships of Diazepam in Children Treated for Status Epilepticus.

Ku LC, Hornik CP, Beechinor RJ, Chamberlain JM, Guptill JT, Harper B, Capparelli EV, Martz K, Anand R, Cohen-Wolkowiez M, Gonzalez D; Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee.

CPT Pharmacometrics Syst Pharmacol. 2018 Nov;7(11):718-727. doi: 10.1002/psp4.12349. Epub 2018 Sep 28.

12.

Pharmacokinetics of Hydroxychloroquine in Pregnancies with Rheumatic Diseases.

Balevic SJ, Green TP, Clowse MEB, Eudy AM, Schanberg LE, Cohen-Wolkowiez M.

Clin Pharmacokinet. 2019 Apr;58(4):525-533. doi: 10.1007/s40262-018-0712-z.

PMID:
30255310
13.

Innovative Study Designs Optimizing Clinical Pharmacology Research in Infants and Children.

Balevic SJ, Cohen-Wolkowiez M.

J Clin Pharmacol. 2018 Oct;58 Suppl 10:S58-S72. doi: 10.1002/jcph.1053.

PMID:
30248192
14.

Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass.

Zimmerman KO, Wu H, Laughon M, Greenberg RG, Walczak R, Schulman SR, Smith PB, Hornik CP, Cohen-Wolkowiez M, Watt KM.

Anesth Analg. 2018 Aug 22. doi: 10.1213/ANE.0000000000003700. [Epub ahead of print]

PMID:
30138171
15.

A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents.

Shakhnovich V, Brian Smith P, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL, Cohen-Wolkowiez M; Best Pharmaceuticals for Children Act–Pediatric Trials Network.

Paediatr Drugs. 2018 Oct;20(5):483-495. doi: 10.1007/s40272-018-0305-1.

PMID:
30097906
16.

Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO.

Watt KM, Cohen-Wolkowiez M, Barrett JS, Sevestre M, Zhao P, Brouwer KLR, Edginton AN.

CPT Pharmacometrics Syst Pharmacol. 2018 Oct;7(10):629-637. doi: 10.1002/psp4.12338. Epub 2018 Aug 13.

17.

External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.

Ge S, Beechinor RJ, Hornik CP, Standing JF, Zimmerman K, Cohen-Wolkowiez M, Laughon MM, Clark R, Gonzalez D.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00669-18. doi: 10.1128/AAC.00669-18. Print 2018 Sep.

18.

Population Pharmacokinetics and Safety of Solithromycin following Intravenous and Oral Administration in Infants, Children, and Adolescents.

Gonzalez D, James LP, Al-Uzri A, Bosheva M, Adler-Shohet FC, Mendley SR, Bradley JS, Espinosa C, Tsonkova E, Moffett K, Marquez L, Simonsen KA, Stoilov S, Boakye-Agyeman F, Jasion T, Hornik CP, Hernandez R, Benjamin DK Jr, Cohen-Wolkowiez M.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00692-18. doi: 10.1128/AAC.00692-18. Print 2018 Aug.

19.

Reply.

Shakhnovich V, Smith PB, Wu H, Cohen-Wolkowiez M, Kearns GL.

J Pediatr. 2018 Jul;198:327-328. doi: 10.1016/j.jpeds.2018.03.001. Epub 2018 Apr 18. No abstract available.

PMID:
29680472
20.

Population Pharmacokinetics of Intramuscular and Intravenous Ketamine in Children.

Hornik CP, Gonzalez D, van den Anker J, Atz AM, Yogev R, Poindexter BB, Ng KC, Delmore P, Harper BL, Melloni C, Lewandowski A, Gelber C, Cohen-Wolkowiez M, Lee JH; Pediatric Trial Network Steering Committee.

J Clin Pharmacol. 2018 Apr 20. doi: 10.1002/jcph.1116. [Epub ahead of print]

PMID:
29677389
21.

Safety, Effectiveness and Exposure-response of Micafungin in Infants: Application of an Established Pharmacokinetics Model to Electronic Health Records.

Rivera-Chaparro ND, Ericson J, Wu H, Smith PB, Clark RH, Benjamin DK Jr, Cohen-Wolkowiez M, Greenberg RG.

Pediatr Infect Dis J. 2019 Feb;38(2):e26-e28. doi: 10.1097/INF.0000000000002045.

PMID:
29601453
22.

A pharmacokinetic model for amiodarone in infants developed from an opportunistic sampling trial and published literature data.

Dallefeld SH, Atz AM, Yogev R, Sullivan JE, Al-Uzri A, Mendley SR, Laughon M, Hornik CP, Melloni C, Harper B, Lewandowski A, Mitchell J, Wu H, Green TP, Cohen-Wolkowiez M.

J Pharmacokinet Pharmacodyn. 2018 Jun;45(3):419-430. doi: 10.1007/s10928-018-9576-y. Epub 2018 Feb 12.

23.

Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis.

Autmizguine J, Tan S, Cohen-Wolkowiez M, Cotten CM, Wiederhold N, Goldberg RN, Adams-Chapman I, Stoll BJ, Smith PB, Benjamin DK Jr; NICHD Neonatal Research Network.

Pediatr Infect Dis J. 2018 Sep;37(9):923-929. doi: 10.1097/INF.0000000000001913.

PMID:
29369937
24.

Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates.

Le J, Poindexter B, Sullivan JE, Laughon M, Delmore P, Blackford M, Yogev R, James LP, Melloni C, Harper B, Mitchell J, Benjamin DK Jr, Boakye-Agyeman F, Cohen-Wolkowiez M.

Ther Drug Monit. 2018 Feb;40(1):103-108. doi: 10.1097/FTD.0000000000000466.

25.

Population Pharmacokinetics of Trimethoprim-Sulfamethoxazole in Infants and Children.

Autmizguine J, Melloni C, Hornik CP, Dallefeld S, Harper B, Yogev R, Sullivan JE, Atz AM, Al-Uzri A, Mendley S, Poindexter B, Mitchell J, Lewandowski A, Delmore P, Cohen-Wolkowiez M, Gonzalez D; the Pediatric Trials Network Steering Committee.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01813-17. doi: 10.1128/AAC.01813-17. Print 2018 Jan.

26.

Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid.

Salerno SN, Edginton A, Cohen-Wolkowiez M, Hornik CP, Watt KM, Jamieson BD, Gonzalez D.

CPT Pharmacometrics Syst Pharmacol. 2017 Dec;6(12):814-822. doi: 10.1002/psp4.12252. Epub 2017 Oct 25.

27.

Antifungal Extraction by the Extracorporeal Membrane Oxygenation Circuit.

Watt KM, Cohen-Wolkowiez M, Williams DC, Bonadonna DK, Cheifetz IM, Thakker D, Benjamin DK Jr, Brouwer KLR.

J Extra Corpor Technol. 2017 Sep;49(3):150-159.

28.

External Evaluation of Two Fluconazole Infant Population Pharmacokinetic Models.

Hwang MF, Beechinor RJ, Wade KC, Benjamin DK Jr, Smith PB, Hornik CP, Capparelli EV, Duara S, Kennedy KA, Cohen-Wolkowiez M, Gonzalez D.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01352-17. doi: 10.1128/AAC.01352-17. Print 2017 Dec.

29.

Association between oral sildenafil dosing, predicted exposure, and systemic hypotension in hospitalised infants.

Hornik CP, Onufrak NJ, Smith PB, Cohen-Wolkowiez M, Laughon MM, Clark RH, Gonzalez D.

Cardiol Young. 2018 Jan;28(1):85-92. doi: 10.1017/S1047951117001639. Epub 2017 Aug 8.

30.

Improving Pediatric Protein Binding Estimates: An Evaluation of α1-Acid Glycoprotein Maturation in Healthy and Infected Subjects.

Maharaj AR, Gonzalez D, Cohen-Wolkowiez M, Hornik CP, Edginton AN.

Clin Pharmacokinet. 2018 May;57(5):577-589. doi: 10.1007/s40262-017-0576-7.

31.

Dosing antibiotics in neonates: review of the pharmacokinetic data.

Rivera-Chaparro ND, Cohen-Wolkowiez M, Greenberg RG.

Future Microbiol. 2017 Sep;12:1001-1016. doi: 10.2217/fmb-2017-0058. Epub 2017 Jul 31.

32.

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys.

Nelson CS, Cruz DV, Tran D, Bialas KM, Stamper L, Wu H, Gilbert M, Blair R, Alvarez X, Itell H, Chen M, Deshpande A, Chiuppesi F, Wussow F, Diamond DJ, Vandergrift N, Walter MR, Barry PA, Cohen-Wolkowiez M, Koelle K, Kaur A, Permar SR.

JCI Insight. 2017 Jul 6;2(13). pii: 94002. doi: 10.1172/jci.insight.94002. eCollection 2017 Jul 6.

33.

Population Pharmacokinetics/Pharmacodynamics of 3,4-Diaminopyridine Free Base in Patients With Lambert-Eaton Myasthenia.

Thakkar N, Guptill JT, Aleš K, Jacobus D, Jacobus L, Peloquin C, Cohen-Wolkowiez M, Gonzalez D; DAPPER Study Group.

CPT Pharmacometrics Syst Pharmacol. 2017 Sep;6(9):625-634. doi: 10.1002/psp4.12218. Epub 2017 Jul 24.

34.

Clinical Trial Design in Juvenile Idiopathic Arthritis.

Balevic SJ, Becker ML, Cohen-Wolkowiez M, Schanberg LE.

Paediatr Drugs. 2017 Oct;19(5):379-389. doi: 10.1007/s40272-017-0244-2.

35.

Population Pharmacokinetics of Dexmedetomidine in Infants.

Greenberg RG, Wu H, Laughon M, Capparelli E, Rowe S, Zimmerman KO, Smith PB, Cohen-Wolkowiez M.

J Clin Pharmacol. 2017 Sep;57(9):1174-1182. doi: 10.1002/jcph.904. Epub 2017 Apr 25.

36.

Use of Population Pharmacokinetics and Electronic Health Records to Assess Piperacillin-Tazobactam Safety in Infants.

Salerno S, Hornik CP, Cohen-Wolkowiez M, Smith PB, Ku LC, Kelly MS, Clark R, Gonzalez D; Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee.

Pediatr Infect Dis J. 2017 Sep;36(9):855-859. doi: 10.1097/INF.0000000000001610.

37.

Development of a Pediatric Physiologically-Based Pharmacokinetic Model of Clindamycin Using Opportunistic Pharmacokinetic Data.

Hornik CP, Wu H, Edginton AN, Watt K, Cohen-Wolkowiez M, Gonzalez D.

Clin Pharmacokinet. 2017 Nov;56(11):1343-1353. doi: 10.1007/s40262-017-0525-5.

38.

Pharmacokinetics of Clindamycin in Obese and Nonobese Children.

Smith MJ, Gonzalez D, Goldman JL, Yogev R, Sullivan JE, Reed MD, Anand R, Martz K, Berezny K, Benjamin DK Jr, Smith PB, Cohen-Wolkowiez M, Watt K; Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02014-16. doi: 10.1128/AAC.02014-16. Print 2017 Apr.

39.

A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation.

Ericson JE, Zimmerman KO, Gonzalez D, Melloni C, Guptill JT, Hill KD, Wu H, Cohen-Wolkowiez M.

Ther Drug Monit. 2017 Feb;39(1):13-20. doi: 10.1097/FTD.0000000000000364. Review.

40.

Dalbavancin Pharmacokinetics and Safety in Children 3 Months to 11 Years of Age.

Gonzalez D, Bradley JS, Blumer J, Yogev R, Watt KM, James LP, Palazzi DL, Bhatt-Mehta V, Sullivan JE, Zhang L, Murphy J, Ussery XT, Puttagunta S, Dunne MW, Cohen-Wolkowiez M.

Pediatr Infect Dis J. 2017 Jul;36(7):645-653. doi: 10.1097/INF.0000000000001538.

41.

Population Pharmacokinetics and Exploratory Pharmacodynamics of Lorazepam in Pediatric Status Epilepticus.

Gonzalez D, Chamberlain JM, Guptill JT, Cohen-Wolkowiez M, Harper B, Zhao J, Capparelli EV; Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee.

Clin Pharmacokinet. 2017 Aug;56(8):941-951. doi: 10.1007/s40262-016-0486-0.

42.

Electronic Health Records and Pharmacokinetic Modeling to Assess the Relationship between Ampicillin Exposure and Seizure Risk in Neonates.

Hornik CP, Benjamin DK Jr, Smith PB, Pencina MJ, Tremoulet AH, Capparelli EV, Ericson JE, Clark RH, Cohen-Wolkowiez M; Best Pharmaceuticals for Children Act—Pediatric Trials Network.

J Pediatr. 2016 Nov;178:125-129.e1. doi: 10.1016/j.jpeds.2016.07.011. Epub 2016 Aug 10.

43.

Use of Therapeutic Drug Monitoring, Electronic Health Record Data, and Pharmacokinetic Modeling to Determine the Therapeutic Index of Phenytoin and Lamotrigine.

Ku LC, Wu H, Greenberg RG, Hill KD, Gonzalez D, Hornik CP, Berezny A, Guptill JT, Jiang W, Zheng N, Cohen-Wolkowiez M, Melloni C.

Ther Drug Monit. 2016 Dec;38(6):728-737.

44.

Pharmacokinetics and Safety of Micafungin in Infants Supported With Extracorporeal Membrane Oxygenation.

Autmizguine J, Hornik CP, Benjamin DK Jr, Brouwer KL, Hupp SR, Cohen-Wolkowiez M, Watt KM.

Pediatr Infect Dis J. 2016 Nov;35(11):1204-1210.

45.

Therapeutic Index Estimation of Antiepileptic Drugs: A Systematic Literature Review Approach.

Greenberg RG, Melloni C, Wu H, Gonzalez D, Ku L, Hill KD, Hornik CP, Cohen-Wolkowiez M, Guptill JT.

Clin Neuropharmacol. 2016 Sep-Oct;39(5):232-40. doi: 10.1097/WNF.0000000000000172. Review.

46.

Advances in Pediatric Pharmacology, Therapeutics, and Toxicology.

Wang LA, Cohen-Wolkowiez M, Gonzalez D.

Adv Pediatr. 2016 Aug;63(1):227-54. doi: 10.1016/j.yapd.2016.04.015. Review. No abstract available.

47.

Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.

Wang LA, Gonzalez D, Leeder JS, Tyndale RF, Pearce RE, Benjamin DK Jr, Kearns GL, Cohen-Wolkowiez M; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee.

J Clin Pharmacol. 2017 Feb;57(2):230-234. doi: 10.1002/jcph.797. Epub 2016 Aug 23. No abstract available.

48.

Exposure Matching of Pediatric Anti-infective Drugs: Review of Drugs Submitted to the Food and Drug Administration for Pediatric Approval.

Zimmerman K, Putera M, Hornik CP, Brian Smith P, Benjamin DK Jr, Mulugeta Y, Burckart GJ, Cohen-Wolkowiez M, Gonzalez D.

Clin Ther. 2016 Sep;38(9):1995-2005. doi: 10.1016/j.clinthera.2016.06.003. Epub 2016 Jun 28. Review.

49.

Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients.

Zimmerman KO, Wu H, Greenberg R, Guptill JT, Hill K, Patel UD, Ku L, Gonzalez D, Hornik C, Jiang W, Zheng N, Melloni C, Cohen-Wolkowiez M.

Ther Drug Monit. 2016 Oct;38(5):600-6. doi: 10.1097/FTD.0000000000000313.

50.

An opportunistic study evaluating pharmacokinetics of sildenafil for the treatment of pulmonary hypertension in infants.

Thakkar N, Gonzalez D, Cohen-Wolkowiez M, Massaro MM, Bernhardt J, Zane NR, Laughon MM.

J Perinatol. 2016 Sep;36(9):744-7. doi: 10.1038/jp.2016.79. Epub 2016 May 12.

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