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Items: 39


Survival during influenza-associated bacterial superinfection improves following viral- and bacterial-specific monoclonal antibody treatment.

Robinson KM, Ramanan K, Tobin JM, Nickolich KL, Pilewski MJ, Kallewaard NL, Sellman BR, Cohen TS, Alcorn JF.

JCI Insight. 2019 Jul 25;4(14). pii: 125554. doi: 10.1172/jci.insight.125554. eCollection 2019 Jul 25.


Use of precision cut lung slices as a translational model for the study of lung biology.

Liu G, Betts C, Cunoosamy DM, Åberg PM, Hornberg JJ, Sivars KB, Cohen TS.

Respir Res. 2019 Jul 19;20(1):162. doi: 10.1186/s12931-019-1131-x. Review.


Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice.

Ortines RV, Wang Y, Liu H, Dikeman DA, Pinsker BL, Miller RJ, Kim SE, Ackerman NE, Rizkallah JF, Marcello LT, Cohen TS, Tkaczyk C, Sellman BR, Miller LS.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00346-19. doi: 10.1128/AAC.00346-19. Print 2019 Aug.


Pulmonary nodule detection in CT scans with equivariant CNNs.

Winkels M, Cohen TS.

Med Image Anal. 2019 Jul;55:15-26. doi: 10.1016/ Epub 2019 Mar 28.


Staphylococcus aureus drives expansion of low-density neutrophils in diabetic mice.

Cohen TS, Takahashi V, Bonnell J, Tovchigrechko A, Chaerkady R, Yu W, Jones-Nelson O, Lee Y, Raja R, Hess S, Stover CK, Worthington JJ, Travis MA, Sellman BR.

J Clin Invest. 2019 Apr 15;129(5):2133-2144. doi: 10.1172/JCI126938. eCollection 2019 Apr 15.


Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils.

Zhou Y, An LL, Chaerkady R, Mittereder N, Clarke L, Cohen TS, Chen B, Hess S, Sims GP, Mustelin T.

Sci Rep. 2018 Oct 15;8(1):15228. doi: 10.1038/s41598-018-33385-z.


Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets.

Thompson JM, Miller RJ, Ashbaugh AG, Dillen CA, Pickett JE, Wang Y, Ortines RV, Sterling RS, Francis KP, Bernthal NM, Cohen TS, Tkaczyk C, Yu L, Stover CK, DiGiandomenico A, Sellman BR, Thorek DL, Miller LS.

JCI Insight. 2018 Sep 6;3(17). pii: 121737. doi: 10.1172/jci.insight.121737. eCollection 2018 Sep 6.


The Neutrophilic Response to Pseudomonas Damages the Airway Barrier, Promoting Infection by Klebsiella pneumoniae.

Jones-Nelson O, Hilliard JJ, DiGiandomenico A, Warrener P, Alfaro A, Cheng L, Stover CK, Cohen TS, Sellman BR.

Am J Respir Cell Mol Biol. 2018 Dec;59(6):745-756. doi: 10.1165/rcmb.2018-0107OC.


α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis.

Surewaard BGJ, Thanabalasuriar A, Zeng Z, Tkaczyk C, Cohen TS, Bardoel BW, Jorch SK, Deppermann C, Bubeck Wardenburg J, Davis RP, Jenne CN, Stover KC, Sellman BR, Kubes P.

Cell Host Microbe. 2018 Aug 8;24(2):271-284.e3. doi: 10.1016/j.chom.2018.06.017. Epub 2018 Jul 19.


S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking.

Cohen TS, Boland ML, Boland BB, Takahashi V, Tovchigrechko A, Lee Y, Wilde AD, Mazaitis MJ, Jones-Nelson O, Tkaczyk C, Raja R, Stover CK, Sellman BR.

Cell Rep. 2018 Feb 27;22(9):2431-2441. doi: 10.1016/j.celrep.2018.02.027.


Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus aureus-Infected Wounds in Nondiabetic and Diabetic Mice.

Ortines RV, Liu H, Cheng LI, Cohen TS, Lawlor H, Gami A, Wang Y, Dillen CA, Archer NK, Miller RJ, Ashbaugh AG, Pinsker BL, Marchitto MC, Tkaczyk C, Stover CK, Sellman BR, Miller LS.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02288-17. doi: 10.1128/AAC.02288-17. Print 2018 Mar.


Interpretation of microbiota-based diagnostics by explaining individual classifier decisions.

Eck A, Zintgraf LM, de Groot EFJ, de Meij TGJ, Cohen TS, Savelkoul PHM, Welling M, Budding AE.

BMC Bioinformatics. 2017 Oct 4;18(1):441. doi: 10.1186/s12859-017-1843-1.


Mouse model of hematogenous implant-related Staphylococcus aureus biofilm infection reveals therapeutic targets.

Wang Y, Cheng LI, Helfer DR, Ashbaugh AG, Miller RJ, Tzomides AJ, Thompson JM, Ortines RV, Tsai AS, Liu H, Dillen CA, Archer NK, Cohen TS, Tkaczyk C, Stover CK, Sellman BR, Miller LS.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5094-E5102. doi: 10.1073/pnas.1703427114. Epub 2017 Jun 12.


Anti-LPS antibodies protect against Klebsiella pneumoniae by empowering neutrophil-mediated clearance without neutralizing TLR4.

Cohen TS, Pelletier M, Cheng L, Pennini ME, Bonnell J, Cvitkovic R, Chang CS, Xiao X, Cameroni E, Corti D, Semenova E, Warrener P, Sellman BR, Suzich J, Wang Q, Stover CK.

JCI Insight. 2017 May 4;2(9). pii: 92774. doi: 10.1172/jci.insight.92774. eCollection 2017 May 4.


Role of MicroRNA in the Lung's Innate Immune Response.

Cohen TS.

J Innate Immun. 2017;9(3):243-249. doi: 10.1159/000452669. Epub 2016 Dec 3. Review.


S. aureus blocks efferocytosis of neutrophils by macrophages through the activity of its virulence factor alpha toxin.

Cohen TS, Jones-Nelson O, Hotz M, Cheng L, Miller LS, Suzich J, Stover CK, Sellman BR.

Sci Rep. 2016 Oct 14;6:35466. doi: 10.1038/srep35466.


Microbial pathogenesis and type III interferons.

Cohen TS, Parker D.

Cytokine Growth Factor Rev. 2016 Jun;29:45-51. doi: 10.1016/j.cytogfr.2016.02.005. Epub 2016 Mar 4. Review.


Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections.

Cohen TS, Hilliard JJ, Jones-Nelson O, Keller AE, O'Day T, Tkaczyk C, DiGiandomenico A, Hamilton M, Pelletier M, Wang Q, Diep BA, Le VT, Cheng L, Suzich J, Stover CK, Sellman BR.

Sci Transl Med. 2016 Mar 9;8(329):329ra31. doi: 10.1126/scitranslmed.aad9922.


Lambda Interferon Restructures the Nasal Microbiome and Increases Susceptibility to Staphylococcus aureus Superinfection.

Planet PJ, Parker D, Cohen TS, Smith H, Leon JD, Ryan C, Hammer TJ, Fierer N, Chen EI, Prince AS.

MBio. 2016 Feb 9;7(1):e01939-15. doi: 10.1128/mBio.01939-15.


MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model.

Hua L, Cohen TS, Shi Y, Datta V, Hilliard JJ, Tkaczyk C, Suzich J, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2015 Aug;59(8):4526-32. doi: 10.1128/AAC.00510-15. Epub 2015 May 18.


Toxin-induced necroptosis is a major mechanism of Staphylococcus aureus lung damage.

Kitur K, Parker D, Nieto P, Ahn DS, Cohen TS, Chung S, Wachtel S, Bueno S, Prince A.

PLoS Pathog. 2015 Apr 16;11(4):e1004820. doi: 10.1371/journal.ppat.1004820. eCollection 2015 Apr.


Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.

Westphalen K, Gusarova GA, Islam MN, Subramanian M, Cohen TS, Prince AS, Bhattacharya J.

Nature. 2014 Feb 27;506(7489):503-6. doi: 10.1038/nature12902. Epub 2014 Jan 19.


Bacterial pathogens activate a common inflammatory pathway through IFNλ regulation of PDCD4.

Cohen TS, Prince AS.

PLoS Pathog. 2013;9(10):e1003682. doi: 10.1371/journal.ppat.1003682. Epub 2013 Oct 3.


Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia.

Cohen TS, Prince AS.

J Clin Invest. 2013 Apr;123(4):1630-7. doi: 10.1172/JCI66142. Epub 2013 Mar 8.


Predictors of squamous cell carcinoma in high-risk patients in the VATTC trial.

Xiong MY, Rizzo AE, Cohen TS, Dyer RK, Korgavkar K, Bingham SF, Weinstock MA; Veterans Affairs Topical Tretinoin Chemoprevention(VATTC) Trial Group.

J Invest Dermatol. 2013 Jun;133(6):1521-32. doi: 10.1038/jid.2013.35. Epub 2013 Feb 24.


Redundant phenazine operons in Pseudomonas aeruginosa exhibit environment-dependent expression and differential roles in pathogenicity.

Recinos DA, Sekedat MD, Hernandez A, Cohen TS, Sakhtah H, Prince AS, Price-Whelan A, Dietrich LE.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19420-5. doi: 10.1073/pnas.1213901109. Epub 2012 Nov 5.


Predictors of basal cell carcinoma in high-risk patients in the VATTC (VA Topical Tretinoin Chemoprevention) trial.

Dyer RK, Weinstock MA, Cohen TS, Rizzo AE, Bingham SF; VATTC Trial Group.

J Invest Dermatol. 2012 Nov;132(11):2544-51. doi: 10.1038/jid.2012.227. Epub 2012 Jul 19.


Sepsis enhances epithelial permeability with stretch in an actin dependent manner.

Cohen TS, DiPaolo BC, Lawrence GG, Margulies SS.

PLoS One. 2012;7(6):e38748. doi: 10.1371/journal.pone.0038748. Epub 2012 Jun 19.


Cystic fibrosis: a mucosal immunodeficiency syndrome.

Cohen TS, Prince A.

Nat Med. 2012 Apr 5;18(4):509-19. doi: 10.1038/nm.2715. Review.


Staphylococcus aureus protein A mediates invasion across airway epithelial cells through activation of RhoA GTPase signaling and proteolytic activity.

Soong G, Martin FJ, Chun J, Cohen TS, Ahn DS, Prince A.

J Biol Chem. 2011 Oct 14;286(41):35891-8. doi: 10.1074/jbc.M111.295386. Epub 2011 Aug 30.


Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells.

Parker D, Cohen TS, Alhede M, Harfenist BS, Martin FJ, Prince A.

Am J Respir Cell Mol Biol. 2012 Jan;46(1):6-13. doi: 10.1165/rcmb.2011-0080OC.


Therapeutic potential of plasma gelsolin administration in a rat model of sepsis.

Cohen TS, Bucki R, Byfield FJ, Ciccarelli NJ, Rosenberg B, DiNubile MJ, Janmey PA, Margulies SS.

Cytokine. 2011 Jun;54(3):235-8. doi: 10.1016/j.cyto.2011.02.006. Epub 2011 Mar 21.


Cultured alveolar epithelial cells from septic rats mimic in vivo septic lung.

Cohen TS, Gray Lawrence G, Margulies SS.

PLoS One. 2010 Jun 25;5(6):e11322. doi: 10.1371/journal.pone.0011322.


MAPK activation modulates permeability of isolated rat alveolar epithelial cell monolayers following cyclic stretch.

Cohen TS, Gray Lawrence G, Khasgiwala A, Margulies SS.

PLoS One. 2010 Apr 28;5(4):e10385. doi: 10.1371/journal.pone.0010385.


Frequency and peak stretch magnitude affect alveolar epithelial permeability.

Cohen TS, Cavanaugh KJ, Margulies SS.

Eur Respir J. 2008 Oct;32(4):854-61. doi: 10.1183/09031936.00141007. Epub 2008 Jul 9.


Inelastic behavior in repeated shearing of bovine white matter.

Cohen TS, Smith AW, Massouros PG, Bayly PV, Shen AQ, Genin GM.

J Biomech Eng. 2008 Aug;130(4):044504. doi: 10.1115/1.2939290.


Immunoglobulin deficiency in Stickler syndrome.

Mikhak Z, Kelly P, Cohen TS, Cox JE, Kimonis VE.

Am J Med Genet A. 2006 Dec 15;140(24):2824-7. No abstract available.


Stretch increases alveolar epithelial permeability to uncharged micromolecules.

Cavanaugh KJ, Cohen TS, Margulies SS.

Am J Physiol Cell Physiol. 2006 Apr;290(4):C1179-88. Epub 2005 Nov 9.


Deformation of the human brain induced by mild acceleration.

Bayly PV, Cohen TS, Leister EP, Ajo D, Leuthardt EC, Genin GM.

J Neurotrauma. 2005 Aug;22(8):845-56.

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