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Items: 1 to 50 of 210

1.

Secondary nucleation in amyloid formation.

Törnquist M, Michaels TCT, Sanagavarapu K, Yang X, Meisl G, Cohen SIA, Knowles TPJ, Linse S.

Chem Commun (Camb). 2018 Jul 6. doi: 10.1039/c8cc02204f. [Epub ahead of print]

PMID:
29978862
2.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM.

ACS Chem Biol. 2018 Jun 28. doi: 10.1021/acschembio.8b00466. [Epub ahead of print]

PMID:
29953201
3.

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

Cohen SIA, Cukalevski R, Michaels TCT, Šarić A, Törnquist M, Vendruscolo M, Dobson CM, Buell AK, Knowles TPJ, Linse S.

Nat Chem. 2018 May;10(5):523-531. doi: 10.1038/s41557-018-0023-x. Epub 2018 Mar 26.

PMID:
29581486
4.

Jim's Prostate Cancer.

Cohen SI.

Tex Heart Inst J. 2017 Feb 1;44(1):9. doi: 10.14503/THIJ-16-5911. eCollection 2017 Feb. No abstract available.

5.

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.

Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MB, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SI, Cascella R, Chen SW, Limbocker R, Sormanni P, Heller GT, Aprile FA, Cremades N, Cecchi C, Chiti F, Nollen EA, Knowles TP, Vendruscolo M, Bax A, Zasloff M, Dobson CM.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E1009-E1017. doi: 10.1073/pnas.1610586114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Mar 21;114(12 ):E2543. Limboker, Ryan [corrected to Limbocker, Ryan].

6.

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease.

Habchi J, Chia S, Limbocker R, Mannini B, Ahn M, Perni M, Hansson O, Arosio P, Kumita JR, Challa PK, Cohen SI, Linse S, Dobson CM, Knowles TP, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E200-E208. doi: 10.1073/pnas.1615613114. Epub 2016 Dec 23.

7.

A Dying Man's Wish Fulfilled.

Cohen SI.

Tex Heart Inst J. 2016 Aug 1;43(4):285-6. doi: 10.14503/THIJ-16-5834. eCollection 2016 Aug. No abstract available.

8.

Phase I Trial of Anti-PSMA Designer CAR-T Cells in Prostate Cancer: Possible Role for Interacting Interleukin 2-T Cell Pharmacodynamics as a Determinant of Clinical Response.

Junghans RP, Ma Q, Rathore R, Gomes EM, Bais AJ, Lo AS, Abedi M, Davies RA, Cabral HJ, Al-Homsi AS, Cohen SI.

Prostate. 2016 Oct;76(14):1257-70. doi: 10.1002/pros.23214. Epub 2016 Jun 21.

PMID:
27324746
9.

On the Life of Larry Graves: The First Child Ever to Have a Totally Implanted Pacemaker.

Cohen SI.

Tex Heart Inst J. 2016 Feb 1;43(1):7-10. doi: 10.14503/THIJ-15-5527. eCollection 2016 Feb. Review. No abstract available.

10.

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease.

Habchi J, Arosio P, Perni M, Costa AR, Yagi-Utsumi M, Joshi P, Chia S, Cohen SI, Müller MB, Linse S, Nollen EA, Dobson CM, Knowles TP, Vendruscolo M.

Sci Adv. 2016 Feb 12;2(2):e1501244. doi: 10.1126/sciadv.1501244. eCollection 2016 Feb.

11.

Hamiltonian Dynamics of Protein Filament Formation.

Michaels TC, Cohen SI, Vendruscolo M, Dobson CM, Knowles TP.

Phys Rev Lett. 2016 Jan 22;116(3):038101. doi: 10.1103/PhysRevLett.116.038101. Epub 2016 Jan 22.

PMID:
26849615
12.

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions.

Arosio P, Müller T, Rajah L, Yates EV, Aprile FA, Zhang Y, Cohen SI, White DA, Herling TW, De Genst EJ, Linse S, Vendruscolo M, Dobson CM, Knowles TP.

ACS Nano. 2016 Jan 26;10(1):333-41. doi: 10.1021/acsnano.5b04713. Epub 2015 Dec 23.

PMID:
26678709
13.

False Alarm.

Cohen SI.

Tex Heart Inst J. 2015 Dec 1;42(6):512-3. doi: 10.14503/THIJ-15-5555. eCollection 2015 Dec. No abstract available.

14.

Mild traumatic brain injury.

Katz DI, Cohen SI, Alexander MP.

Handb Clin Neurol. 2015;127:131-56. doi: 10.1016/B978-0-444-52892-6.00009-X. Review.

PMID:
25702214
15.

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.

Cohen SIA, Arosio P, Presto J, Kurudenkandy FR, Biverstal H, Dolfe L, Dunning C, Yang X, Frohm B, Vendruscolo M, Johansson J, Dobson CM, Fisahn A, Knowles TPJ, Linse S.

Nat Struct Mol Biol. 2015 Mar;22(3):207-213. doi: 10.1038/nsmb.2971. Epub 2015 Feb 16.

16.

Accountable care around the world: a framework to guide reform strategies.

McClellan M, Kent J, Beales SJ, Cohen SI, Macdonnell M, Thoumi A, Abdulmalik M, Darzi A.

Health Aff (Millwood). 2014 Sep;33(9):1507-15. doi: 10.1377/hlthaff.2014.0373.

PMID:
25201654
17.

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.

Meisl G, Yang X, Hellstrand E, Frohm B, Kirkegaard JB, Cohen SI, Dobson CM, Linse S, Knowles TP.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9384-9. doi: 10.1073/pnas.1401564111. Epub 2014 Jun 17.

18.

Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters.

Garcia GA, Cohen SI, Dobson CM, Knowles TP.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Mar;89(3):032712. Epub 2014 Mar 24.

PMID:
24730879
19.

Spatial propagation of protein polymerization.

Cohen SI, Rajah L, Yoon CH, Buell AK, White DA, Sperling RA, Vendruscolo M, Terentjev EM, Dobson CM, Weitz DA, Knowles TP.

Phys Rev Lett. 2014 Mar 7;112(9):098101. Epub 2014 Mar 4.

PMID:
24655282
20.

Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide.

Bolognesi B, Cohen SI, Aran Terol P, Esbjörner EK, Giorgetti S, Mossuto MF, Natalello A, Brorsson AC, Knowles TP, Dobson CM, Luheshi LM.

ACS Chem Biol. 2014 Feb 21;9(2):378-82. doi: 10.1021/cb400616y. Epub 2013 Nov 25.

PMID:
24199868
21.

Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism.

Cohen SI, Linse S, Luheshi LM, Hellstrand E, White DA, Rajah L, Otzen DE, Vendruscolo M, Dobson CM, Knowles TP.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9758-63. doi: 10.1073/pnas.1218402110. Epub 2013 May 23.

22.

Hydrodynamics of hemostasis in sickle-cell disease.

Cohen SI, Mahadevan L.

Phys Rev Lett. 2013 Mar 29;110(13):138104. Epub 2013 Mar 28.

PMID:
23581379
23.

Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.

Xu LQ, Wu S, Buell AK, Cohen SI, Chen LJ, Hu WH, Cusack SA, Itzhaki LS, Zhang H, Knowles TP, Dobson CM, Welland ME, Jones GW, Perrett S.

Philos Trans R Soc Lond B Biol Sci. 2013 Mar 25;368(1617):20110410. doi: 10.1098/rstb.2011.0410. Print 2013 May 5.

24.

Clinical and demographic factors associated with employment status in US military veterans returning from Iraq and Afghanistan.

Cohen SI, Suri P, Amick MM, Yan K.

Work. 2013;44(2):213-9. doi: 10.3233/WOR-2012-1417.

PMID:
22927609
25.

Role of elongation and secondary pathways in S6 amyloid fibril growth.

Lorenzen N, Cohen SI, Nielsen SB, Herling TW, Christiansen G, Dobson CM, Knowles TP, Otzen D.

Biophys J. 2012 May 2;102(9):2167-75. doi: 10.1016/j.bpj.2012.03.047.

26.

Direct observation of the interconversion of normal and toxic forms of α-synuclein.

Cremades N, Cohen SI, Deas E, Abramov AY, Chen AY, Orte A, Sandal M, Clarke RW, Dunne P, Aprile FA, Bertoncini CW, Wood NW, Knowles TP, Dobson CM, Klenerman D.

Cell. 2012 May 25;149(5):1048-59. doi: 10.1016/j.cell.2012.03.037.

27.

From macroscopic measurements to microscopic mechanisms of protein aggregation.

Cohen SI, Vendruscolo M, Dobson CM, Knowles TP.

J Mol Biol. 2012 Aug 10;421(2-3):160-71. doi: 10.1016/j.jmb.2012.02.031. Epub 2012 Mar 8. Review.

PMID:
22406275
28.

Death and near death from cardiac arrest during the Boston Marathon.

Cohen SI, Ellis ER.

Pacing Clin Electrophysiol. 2012 Feb;35(2):241-4. doi: 10.1111/j.1540-8159.2011.03248.x. Epub 2011 Oct 31.

PMID:
22040232
29.

Nucleated polymerisation in the presence of pre-formed seed filaments.

Cohen SI, Vendruscolo M, Dobson CM, Knowles TP.

Int J Mol Sci. 2011;12(9):5844-52. doi: 10.3390/ijms12095844. Epub 2011 Sep 9.

30.

Observation of spatial propagation of amyloid assembly from single nuclei.

Knowles TP, White DA, Abate AR, Agresti JJ, Cohen SI, Sperling RA, De Genst EJ, Dobson CM, Weitz DA.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14746-51. doi: 10.1073/pnas.1105555108. Epub 2011 Aug 26.

31.

Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations.

Cohen SI, Vendruscolo M, Dobson CM, Knowles TP.

J Chem Phys. 2011 Aug 14;135(6):065107. doi: 10.1063/1.3608918.

32.
33.

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments.

Cohen SI, Vendruscolo M, Welland ME, Dobson CM, Terentjev EM, Knowles TP.

J Chem Phys. 2011 Aug 14;135(6):065105. doi: 10.1063/1.3608916.

34.

Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein.

Levitan K, Chereau D, Cohen SI, Knowles TP, Dobson CM, Fink AL, Anderson JP, Goldstein JM, Millhauser GL.

J Mol Biol. 2011 Aug 12;411(2):329-33. doi: 10.1016/j.jmb.2011.05.046. Epub 2011 Jun 12.

35.

The history and evolution of traumatic brain injury rehabilitation in military service members and veterans.

Cifu DX, Cohen SI, Lew HL, Jaffee M, Sigford B.

Am J Phys Med Rehabil. 2010 Aug;89(8):688-94. doi: 10.1097/PHM.0b013e3181e722ad.

PMID:
20647782
36.

An analytical solution to the kinetics of breakable filament assembly.

Knowles TP, Waudby CA, Devlin GL, Cohen SI, Aguzzi A, Vendruscolo M, Terentjev EM, Welland ME, Dobson CM.

Science. 2009 Dec 11;326(5959):1533-7. doi: 10.1126/science.1178250.

37.

Dr. Benedict Massell.

Cohen SI.

Clin Cardiol. 2009 Aug;32(8):E68-9. doi: 10.1002/clc.20536. No abstract available.

38.

Increased arousal in a patient with anoxic brain injury after administration of zolpidem.

Cohen SI, Duong TT.

Am J Phys Med Rehabil. 2008 Mar;87(3):229-31. doi: 10.1097/PHM.0b013e318161971b. Review.

PMID:
18174850
39.
40.

Can effect of finasteride on prostate-specific antigen be used to decrease repeat prostate biopsy?

Handel LN, Agarwal S, Schiff SF, Kelty PJ, Cohen SI.

Urology. 2006 Dec;68(6):1220-3. Epub 2006 Dec 4.

PMID:
17141826
41.

Lifelong migraine aura without headache: change of pattern with upper respiratory infection.

Cohen SI, Blau JN.

J R Soc Med. 2003 Oct;96(10):504-5. No abstract available.

42.

Potential savings from splitting newer antidepressant medications.

Cohen CI, Cohen SI.

CNS Drugs. 2002;16(5):353-8.

PMID:
11994024
43.

Treatment of insomnia.

Cohen SI.

Lancet. 2002 Apr 20;359(9315):1433-4; author reply 1434. No abstract available.

PMID:
11978361
44.

The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin.

Auerbach W, Hurlbert MS, Hilditch-Maguire P, Wadghiri YZ, Wheeler VC, Cohen SI, Joyner AL, MacDonald ME, Turnbull DH.

Hum Mol Genet. 2001 Oct 15;10(22):2515-23.

PMID:
11709539
45.

The natural history and longitudinal study of the surgically corrected clubfoot.

Sobel E, Giorgini RJ, Michel R, Cohen SI.

J Foot Ankle Surg. 2000 Sep-Oct;39(5):305-20.

PMID:
11055022
46.

Potential cost savings from pill splitting of newer psychotropic medications.

Cohen CI, Cohen SI.

Psychiatr Serv. 2000 Apr;51(4):527-9.

PMID:
10737832
47.

Pelvic resection of recurrent rectal cancer: technical considerations and outcomes.

Wanebo HJ, Antoniuk P, Koness RJ, Levy A, Vezeridis M, Cohen SI, Wrobleski DE.

Dis Colon Rectum. 1999 Nov;42(11):1438-48.

PMID:
10566532
48.

A review of comorbidity: major mental illness and problematic substance use.

Cohen SI.

Aust N Z J Psychiatry. 1999 Aug;33(4):601. No abstract available.

PMID:
10483859
49.

Morbid jealousy with unusual vulnerability to small quantities of alcohol.

Cohen SI.

Aust N Z J Psychiatry. 1999 Aug;33(4):601. No abstract available.

PMID:
10483860
50.

Four strategies for negotiated care.

Cohen SI.

J R Soc Med. 1998 Aug;91(8):454. No abstract available.

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