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Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling.

Lin RZ, Lu Z, Anyukhovsky EP, Jiang YP, Wang HZ, Gao J, Rosen MR, Ballou LM, Cohen IS.

J Gen Physiol. 2019 Aug 5;151(8):1051-1058. doi: 10.1085/jgp.201812293. Epub 2019 Jun 19.


Gluten in Celiac Disease-More or Less?

Cohen IS, Day AS, Shaoul R.

Rambam Maimonides Med J. 2019 Jan 28;10(1). doi: 10.5041/RMMJ.10360. Review.


Non-Invasive Intra-cardiac Pressure Measurements Using Subharmonic-Aided Pressure Estimation: Proof of Concept in Humans.

Dave JK, Kulkarni SV, Pangaonkar PP, Stanczak M, McDonald ME, Cohen IS, Mehrotra P, Savage MP, Walinsky P, Ruggiero NJ 2nd, Fischman DL, Ogilby D, VanWhy C, Lombardi M, Forsberg F.

Ultrasound Med Biol. 2017 Nov;43(11):2718-2724. doi: 10.1016/j.ultrasmedbio.2017.07.009. Epub 2017 Aug 12.


Defining the factors that affect solute permeation of gap junction channels.

Valiunas V, Cohen IS, Brink PR.

Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):96-101. doi: 10.1016/j.bbamem.2017.07.002. Epub 2017 Jul 6. Review.


Acquired long QT syndrome and phosphoinositide 3-kinase.

Cohen IS, Lin RZ, Ballou LM.

Trends Cardiovasc Med. 2017 Oct;27(7):451-459. doi: 10.1016/j.tcm.2017.05.005. Epub 2017 May 17. Review.


Induced Pluripotent Stem Cell-Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function.

Chauveau S, Anyukhovsky EP, Ben-Ari M, Naor S, Jiang YP, Danilo P Jr, Rahim T, Burke S, Qiu X, Potapova IA, Doronin SV, Brink PR, Binah O, Cohen IS, Rosen MR.

Circ Arrhythm Electrophysiol. 2017 May;10(5):e004508. doi: 10.1161/CIRCEP.116.004508.


Pressure-overload-induced angiotensin-mediated early remodeling in mouse heart.

Kim JH, Jiang YP, Cohen IS, Lin RZ, Mathias RT.

PLoS One. 2017 May 2;12(5):e0176713. doi: 10.1371/journal.pone.0176713. eCollection 2017.


The renin-angiotensin system regulates transmural electrical remodeling in response to mechanical load.

Cohen IS, Mathias RT.

Prog Biophys Mol Biol. 2016 Dec;122(3):187-201. doi: 10.1016/j.pbiomolbio.2016.09.004. Epub 2016 Sep 16. Review. No abstract available.


High-resolution genomic assays provide insight into the division of labor between TLS and HDR in mammalian replication of damaged DNA.

Livneh Z, Cohen IS, Paz-Elizur T, Davidovsky D, Carmi D, Swain U, Mirlas-Neisberg N.

DNA Repair (Amst). 2016 Aug;44:59-67. doi: 10.1016/j.dnarep.2016.05.007. Epub 2016 May 16. Review.


In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.

Hirota K, Tsuda M, Mohiuddin, Tsurimoto T, Cohen IS, Livneh Z, Kobayashi K, Narita T, Nishihara K, Murai J, Iwai S, Guilbaud G, Sale JE, Takeda S.

Nucleic Acids Res. 2016 Sep 6;44(15):7242-50. doi: 10.1093/nar/gkw439. Epub 2016 May 16.


Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration.

Qiu XS, Chauveau S, Anyukhovsky EP, Rahim T, Jiang YP, Harleton E, Feinmark SJ, Lin RZ, Coronel R, Janse MJ, Opthof T, Rosen TS, Cohen IS, Rosen MR.

Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003655. doi: 10.1161/CIRCEP.115.003655.


Angiotensin II Type 1 Receptor-Mediated Electrical Remodeling in Mouse Cardiac Myocytes.

Kim J, Gao J, Cohen IS, Mathias RT.

PLoS One. 2015 Oct 2;10(10):e0138711. doi: 10.1371/journal.pone.0138711. eCollection 2015.


Development of a universal RNA beacon for exogenous gene detection.

Guo Y, Lu Z, Cohen IS, Scarlata S.

Stem Cells Transl Med. 2015 May;4(5):476-82. doi: 10.5966/sctm.2014-0166. Epub 2015 Mar 13.


Inhibition of histone deacetylase (HDAC) by 4-phenylbutyrate results in increased junctional conductance between rat corpora smooth muscle cells.

Wang HZ, Rosati B, Gordon C, Valiunas V, McKinnon D, Cohen IS, Brink PR.

Front Pharmacol. 2015 Feb 3;6:9. doi: 10.3389/fphar.2015.00009. eCollection 2015.


A comparison of two cellular delivery mechanisms for small interfering RNA.

Valiunas V, Wang HZ, Li L, Gordon C, Valiuniene L, Cohen IS, Brink PR.

Physiol Rep. 2015 Feb 3;3(2). pii: e12286. doi: 10.14814/phy2.12286. Print 2015 Feb 1.


DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes.

Cohen IS, Bar C, Paz-Elizur T, Ainbinder E, Leopold K, de Wind N, Geacintov N, Livneh Z.

Nucleic Acids Res. 2015 Feb 18;43(3):1637-45.


Control of cardiac repolarization by phosphoinositide 3-kinase signaling to ion channels.

Ballou LM, Lin RZ, Cohen IS.

Circ Res. 2015 Jan 2;116(1):127-37. doi: 10.1161/CIRCRESAHA.116.303975. Review.


Autocrine A2 in the T-system of ventricular myocytes creates transmural gradients in ion transport: a mechanism to match contraction with load?

Gao J, Sun X, Potapova IA, Cohen IS, Mathias RT, Kim JH.

Biophys J. 2014 Jun 3;106(11):2364-74. doi: 10.1016/j.bpj.2014.04.042.


Stem cell-based biological pacemakers from proof of principle to therapy: a review.

Chauveau S, Brink PR, Cohen IS.

Cytotherapy. 2014 Jul;16(7):873-80. doi: 10.1016/j.jcyt.2014.02.014. Epub 2014 May 13. Review.


Intracellular ATP binding is required to activate the slowly activating K+ channel I(Ks).

Li Y, Gao J, Lu Z, McFarland K, Shi J, Bock K, Cohen IS, Cui J.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18922-7. doi: 10.1073/pnas.1315649110. Epub 2013 Nov 4.


Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells.

Potapova IA, Cohen IS, Doronin SV.

PLoS One. 2013 Sep 12;8(9):e73929. doi: 10.1371/journal.pone.0073929. eCollection 2013.


Computational optogenetics: empirically-derived voltage- and light-sensitive channelrhodopsin-2 model.

Williams JC, Xu J, Lu Z, Klimas A, Chen X, Ambrosi CM, Cohen IS, Entcheva E.

PLoS Comput Biol. 2013;9(9):e1003220. doi: 10.1371/journal.pcbi.1003220. Epub 2013 Sep 12.


The effects of the histone deacetylase inhibitor 4-phenylbutyrate on gap junction conductance and permeability.

Kaufman J, Gordon C, Bergamaschi R, Wang HZ, Cohen IS, Valiunas V, Brink PR.

Front Pharmacol. 2013 Sep 3;4:111. doi: 10.3389/fphar.2013.00111. eCollection 2013.


Increased persistent sodium current due to decreased PI3K signaling contributes to QT prolongation in the diabetic heart.

Lu Z, Jiang YP, Wu CY, Ballou LM, Liu S, Carpenter ES, Rosen MR, Cohen IS, Lin RZ.

Diabetes. 2013 Dec;62(12):4257-65. doi: 10.2337/db13-0420. Epub 2013 Aug 23.


Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells.

Izhar L, Ziv O, Cohen IS, Geacintov NE, Livneh Z.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1462-9. doi: 10.1073/pnas.1216894110. Epub 2013 Mar 25.


HCN2/SkM1 gene transfer into canine left bundle branch induces stable, autonomically responsive biological pacing at physiological heart rates.

Boink GJ, Duan L, Nearing BD, Shlapakova IN, Sosunov EA, Anyukhovsky EP, Bobkov E, Kryukova Y, Ozgen N, Danilo P Jr, Cohen IS, Verrier RL, Robinson RB, Rosen MR.

J Am Coll Cardiol. 2013 Mar 19;61(11):1192-201. doi: 10.1016/j.jacc.2012.12.031. Epub 2013 Feb 6.


MATLAB implementation of a dynamic clamp with bandwidth of >125 kHz capable of generating I Na at 37 °C.

Clausen C, Valiunas V, Brink PR, Cohen IS.

Pflugers Arch. 2013 Apr;465(4):497-507. doi: 10.1007/s00424-012-1186-8. Epub 2012 Dec 9.


Complex mitral valve endocarditis involving a left atrial false tendon.

Chhabra SK, Bogar LJ, DeCaro MV, Cohen IS.

J Am Coll Cardiol. 2012 Dec 4;60(22):2330. doi: 10.1016/j.jacc.2012.03.084. No abstract available.


Microtubules and angiotensin II receptors contribute to modulation of repolarization induced by ventricular pacing.

Özgen N, Lu Z, Boink GJ, Lau DH, Shlapakova IN, Bobkov Y, Danilo P Jr, Cohen IS, Rosen MR.

Heart Rhythm. 2012 Nov;9(11):1865-72. doi: 10.1016/j.hrthm.2012.07.014. Epub 2012 Jul 20.


Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2.

Boink GJ, Nearing BD, Shlapakova IN, Duan L, Kryukova Y, Bobkov Y, Tan HL, Cohen IS, Danilo P Jr, Robinson RB, Verrier RL, Rosen MR.

Circulation. 2012 Jul 31;126(5):528-36. doi: 10.1161/CIRCULATIONAHA.111.083584. Epub 2012 Jun 29.


Effect of skeletal muscle Na(+) channel delivered via a cell platform on cardiac conduction and arrhythmia induction.

Boink GJ, Lu J, Driessen HE, Duan L, Sosunov EA, Anyukhovsky EP, Shlapakova IN, Lau DH, Rosen TS, Danilo P, Jia Z, Ozgen N, Bobkov Y, Guo Y, Brink PR, Kryukova Y, Robinson RB, Entcheva E, Cohen IS, Rosen MR.

Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):831-40. doi: 10.1161/CIRCEP.111.969907. Epub 2012 Jun 21.


Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome.

Lu Z, Wu CY, Jiang YP, Ballou LM, Clausen C, Cohen IS, Lin RZ.

Sci Transl Med. 2012 Apr 25;4(131):131ra50. doi: 10.1126/scitranslmed.3003623.


Improving cardiac conduction with a skeletal muscle sodium channel by gene and cell therapy.

Lu J, Wang HZ, Jia Z, Zuckerman J, Lu Z, Guo Y, Boink GJ, Brink PR, Robinson RB, Entcheva E, Cohen IS.

J Cardiovasc Pharmacol. 2012 Jul;60(1):88-99. doi: 10.1097/FJC.0b013e3182588b00.


SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic.

Boink GJ, Lau DH, Shlapakova IN, Sosunov EA, Anyukhovsky EP, Driessen HE, Dun W, Chen M, Danilo P Jr, Rosen TS, Őzgen N, Duffy HS, Kryukova Y, Boyden PA, Robinson RB, Brink PR, Cohen IS, Rosen MR.

Cardiovasc Res. 2012 Jun 1;94(3):450-9. doi: 10.1093/cvr/cvs107. Epub 2012 Feb 27.


Can gap junctions deliver?

Brink PR, Valiunas V, Gordon C, Rosen MR, Cohen IS.

Biochim Biophys Acta. 2012 Aug;1818(8):2076-81. doi: 10.1016/j.bbamem.2011.09.025. Epub 2011 Oct 2. Review.


PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes.

Wu CY, Jia Z, Wang W, Ballou LM, Jiang YP, Chen B, Mathias RT, Cohen IS, Song LS, Entcheva E, Lin RZ.

PLoS One. 2011;6(9):e24404. doi: 10.1371/journal.pone.0024404. Epub 2011 Sep 2.


The road to biological pacing.

Rosen MR, Robinson RB, Brink PR, Cohen IS.

Nat Rev Cardiol. 2011 Aug 16;8(11):656-66. doi: 10.1038/nrcardio.2011.120. Review.


Stimulating cardiac muscle by light: cardiac optogenetics by cell delivery.

Jia Z, Valiunas V, Lu Z, Bien H, Liu H, Wang HZ, Rosati B, Brink PR, Cohen IS, Entcheva E.

Circ Arrhythm Electrophysiol. 2011 Oct;4(5):753-60. doi: 10.1161/CIRCEP.111.964247. Epub 2011 Aug 9.


Restoration of defective L-type Ca2+ current in cardiac myocytes of type 2 diabetic db/db mice by Akt and PKC-ι.

Lu Z, Ballou LM, Jiang YP, Cohen IS, Lin RZ.

J Cardiovasc Pharmacol. 2011 Oct;58(4):439-45. doi: 10.1097/FJC.0b013e318228e68c.


Implantation of sinoatrial node cells into canine right ventricle: biological pacing appears limited by the substrate.

Zhang H, Lau DH, Shlapakova IN, Zhao X, Danilo P, Robinson RB, Cohen IS, Qu D, Xu Z, Rosen MR.

Cell Transplant. 2011;20(11-12):1907-14. doi: 10.3727/096368911X565038. Epub 2011 Mar 8.


Expression of skeletal muscle sodium channel (Nav1.4) or connexin32 prevents reperfusion arrhythmias in murine heart.

Anyukhovsky EP, Sosunov EA, Kryukova YN, Prestia K, Ozgen N, Rivaud M, Cohen IS, Robinson RB, Rosen MR.

Cardiovasc Res. 2011 Jan 1;89(1):41-50. doi: 10.1093/cvr/cvq284. Epub 2010 Sep 7.


Biological pacemakers in canines exhibit positive chronotropic response to emotional arousal.

Shlapakova IN, Nearing BD, Lau DH, Boink GJ, Danilo P Jr, Kryukova Y, Robinson RB, Cohen IS, Rosen MR, Verrier RL.

Heart Rhythm. 2010 Dec;7(12):1835-40. doi: 10.1016/j.hrthm.2010.08.004. Epub 2010 Aug 11.


Strategies for regeneration of heart muscle.

Guyette JP, Cohen IS, Gaudette GR.

Crit Rev Eukaryot Gene Expr. 2010;20(1):35-50. Review.


In vivo cellular delivery of siRNA.

Brink PR, Robinson RB, Rosen MR, Cohen IS.

IDrugs. 2010 Jun;13(6):383-7. Review.


Underestimation of left atrial size measured with transthoracic echocardiography compared with 3D MDCT.

Koka AR, Yau J, Van Why C, Cohen IS, Halpern EJ.

AJR Am J Roentgenol. 2010 May;194(5):W375-81. doi: 10.2214/AJR.09.3183.


Cardiac expression of skeletal muscle sodium channels increases longitudinal conduction velocity in the canine 1-week myocardial infarction.

Coronel R, Lau DH, Sosunov EA, Janse MJ, Danilo P Jr, Anyukhovsky EP, Wilms-Schopman FJ, Opthof T, Shlapakova IN, Ozgen N, Prestia K, Kryukova Y, Cohen IS, Robinson RB, Rosen MR.

Heart Rhythm. 2010 Aug;7(8):1104-10. doi: 10.1016/j.hrthm.2010.04.009. Epub 2010 Apr 10.


A transmural gradient in the cardiac Na/K pump generates a transmural gradient in Na/Ca exchange.

Wang W, Gao J, Entcheva E, Cohen IS, Gordon C, Mathias RT.

J Membr Biol. 2010 Feb;233(1-3):51-62. doi: 10.1007/s00232-010-9224-y. Epub 2010 Feb 4.


Coupling an HCN2-expressing cell to a myocyte creates a two-cell pacing unit.

Valiunas V, Kanaporis G, Valiuniene L, Gordon C, Wang HZ, Li L, Robinson RB, Rosen MR, Cohen IS, Brink PR.

J Physiol. 2009 Nov 1;587(Pt 21):5211-26. doi: 10.1113/jphysiol.2009.180505. Epub 2009 Sep 7.


Valvular heart disease in osteogenesis imperfecta: presentation of a case and review of the literature.

Bonita RE, Cohen IS, Berko BA.

Echocardiography. 2010 Jan;27(1):69-73. doi: 10.1111/j.1540-8175.2009.00973.x. Epub 2009 Aug 31. Review.


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