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Avraham Ben-Nun-Pioneer, fighter, friend.

Cohen IR, Wekerle H.

Eur J Immunol. 2019 Apr;49(4):521-522. doi: 10.1002/eji.201970046. No abstract available.


Can immunization with Bacillus Calmette-Guérin (BCG) protect against Alzheimer's disease?

Gofrit ON, Bercovier H, Klein BY, Cohen IR, Ben-Hur T, Greenblatt CL.

Med Hypotheses. 2019 Feb;123:95-97. doi: 10.1016/j.mehy.2019.01.007. Epub 2019 Jan 11.


The SLE-key test serological signature: new insights into the course of lupus.

Putterman C, Pisetsky DS, Petri M, Caricchio R, Wu AHB, Sanz I, Oates JC, Wallace S, Sorek R, Gerwien R, Safer P, Jakobi-Brook K, Cohen IR.

Rheumatology (Oxford). 2018 Sep 1;57(9):1632-1640. doi: 10.1093/rheumatology/key149.


Heat shock protein 60 enhances CD4+CD25+ regulatory T cell function via innate TLR2 signaling.

Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR.

J Clin Invest. 2018 Jun 1;128(6):2651. doi: 10.1172/JCI121856. Epub 2018 May 7. No abstract available.


T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences.

Madi A, Poran A, Shifrut E, Reich-Zeliger S, Greenstein E, Zaretsky I, Arnon T, Laethem FV, Singer A, Lu J, Sun PD, Cohen IR, Friedman N.

Elife. 2017 Jul 21;6. pii: e22057. doi: 10.7554/eLife.22057.


Human neonatal thymectomy induces altered B-cell responses and autoreactivity.

van den Broek T, Madi A, Delemarre EM, Schadenberg AWL, Tesselaar K, Borghans JAM, Nierkens S, Redegeld FA, Otten HG, Rossetti M, Albani S, Sorek R, Cohen IR, Jansen NJG, van Wijk F.

Eur J Immunol. 2017 Nov;47(11):1970-1981. doi: 10.1002/eji.201746971. Epub 2017 Sep 6.


Activation of the Akt-CREB signalling axis by a proline-rich heptapeptide confers resistance to stress-induced cell death and inflammation.

Herkel J, Schrader J, Erez N, Lohse AW, Cohen IR.

Immunology. 2017 Aug;151(4):474-480. doi: 10.1111/imm.12745. Epub 2017 May 16.


Updating Darwin: Information and entropy drive the evolution of life.

Cohen IR.

F1000Res. 2016 Dec 1;5:2808. doi: 10.12688/f1000research.10289.1. eCollection 2016.


SLE-key(®) rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus: Developing the ImmunArray iCHIP(®).

Putterman C, Wu A, Reiner-Benaim A, Batty DS Jr, Sanz I, Oates J, Jakobi K, Petri M, Safer P, Gerwien R, Sorek R, Blumenstein Y, Cohen IR.

J Immunol Methods. 2016 Feb;429:1-6. doi: 10.1016/j.jim.2015.12.003. Epub 2015 Dec 8.


Gut feelings of safety: tolerance to the microbiota mediated by innate immune receptors.

Swiatczak B, Cohen IR.

Microbiol Immunol. 2015 Oct;59(10):573-85. doi: 10.1111/1348-0421.12318. Review.


Guanine polynucleotides are self-antigens for human natural autoantibodies and are significantly reduced in the human genome.

Fattal I, Shental N, Ben-Dor S, Molad Y, Gabrielli A, Pokroy-Shapira E, Oren S, Livneh A, Langevitz P, Zandman-Goddard G, Sarig O, Margalit R, Gafter U, Domany E, Cohen IR.

Immunology. 2015 Nov;146(3):401-10. doi: 10.1111/imm.12514. Epub 2015 Sep 7.


Association of Sphingosine-1-phosphate (S1P)/S1P Receptor-1 Pathway with Cell Proliferation and Survival in Canine Hemangiosarcoma.

Rodriguez AM, Graef AJ, LeVine DN, Cohen IR, Modiano JF, Kim JH.

J Vet Intern Med. 2015 Jul-Aug;29(4):1088-97. doi: 10.1111/jvim.13570. Epub 2015 Jun 25. Erratum in: J Vet Intern Med. 2018 Nov;32(6):2311.


Tumor-associated and disease-associated autoantibody repertoires in healthy colostrum and maternal and newborn cord sera.

Madi A, Bransburg-Zabary S, Maayan-Metzger A, Dar G, Ben-Jacob E, Cohen IR.

J Immunol. 2015 Jun 1;194(11):5272-81. doi: 10.4049/jimmunol.1402771. Epub 2015 Apr 27.


Interpersonal struggle or interpersonal bonding? Comment on "personality from a cognitive-biological perspective", by Y. Neuman.

Cohen IR.

Phys Life Rev. 2014 Dec;11(4):687-8. doi: 10.1016/j.plrev.2014.10.002. Epub 2014 Oct 14. No abstract available.


T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity.

Madi A, Shifrut E, Reich-Zeliger S, Gal H, Best K, Ndifon W, Chain B, Cohen IR, Friedman N.

Genome Res. 2014 Oct;24(10):1603-12. doi: 10.1101/gr.170753.113. Epub 2014 Jul 14.


Activation of benign autoimmunity as both tumor and autoimmune disease immunotherapy: a comprehensive review.

Cohen IR.

J Autoimmun. 2014 Nov;54:112-7. doi: 10.1016/j.jaut.2014.05.002. Epub 2014 Jun 10. Review.


Pemphigus vulgaris is characterized by low IgG reactivities to specific self-antigens along with high IgG reactivity to desmoglein 3.

Fattal I, Rimer J, Shental N, Molad Y, Gabrielli A, Livneh A, Sarig O, Goldberg I, Gafter U, Domany E, Cohen IR.

Immunology. 2014 Nov;143(3):374-80. doi: 10.1111/imm.12316.


Treatment of recent-onset type 1 diabetic patients with DiaPep277: results of a double-blind, placebo-controlled, randomized phase 3 trial.

Raz I, Ziegler AG, Linn T, Schernthaner G, Bonnici F, Distiller LA, Giordano C, Giorgino F, de Vries L, Mauricio D, Procházka V, Wainstein J, Elias D, Avron A, Tamir M, Eren R, Peled D, Dagan S, Cohen IR, Pozzilli P; DIA-AID 1 Writing Group.

Diabetes Care. 2014;37(5):1392-400. doi: 10.2337/dc13-1391. Retraction in: Diabetes Care. 2015 Jan;38(1):178.


Do all creatures possess an acquired immune system of some sort?

Rimer J, Cohen IR, Friedman N.

Bioessays. 2014 Mar;36(3):273-81. doi: 10.1002/bies.201300124. Epub 2014 Jan 14. Review.


Evaluation of long-term treatment effect in a type 1 diabetes intervention trial: differences after stimulation with glucagon or a mixed meal.

Pozzilli P, Raz I, Peled D, Elias D, Avron A, Tamir M, Eren R, Dagan S, Cohen IR.

Diabetes Care. 2014;37(5):1384-91. doi: 10.2337/dc13-1392. Epub 2014 Jan 9. Retraction in: Diabetes Care. 2015 Jan;38(1):179.


Epstein-Barr virus antibodies mark systemic lupus erythematosus and scleroderma patients negative for anti-DNA.

Fattal I, Shental N, Molad Y, Gabrielli A, Pokroy-Shapira E, Oren S, Livneh A, Langevitz P, Pauzner R, Sarig O, Gafter U, Domany E, Cohen IR.

Immunology. 2014 Feb;141(2):276-85. doi: 10.1111/imm.12200.


DiaPep277® and immune intervention for treatment of type 1 diabetes.

Schloot NC, Cohen IR.

Clin Immunol. 2013 Dec;149(3):307-16. doi: 10.1016/j.clim.2013.09.001. Epub 2013 Sep 11. Review.


Signaling via TLR2 and TLR4 Directly Down-Regulates T Cell Effector Functions: The Regulatory Face of Danger Signals.

Zanin-Zhorov A, Cohen IR.

Front Immunol. 2013 Jul 25;4:211. doi: 10.3389/fimmu.2013.00211. eCollection 2013.


Autoantibody repertoires, natural biomarkers, and system controllers.

Cohen IR.

Trends Immunol. 2013 Dec;34(12):620-5. doi: 10.1016/ Epub 2013 Jun 13. Review.


Individual and meta-immune networks.

Bransburg-Zabary S, Kenett DY, Dar G, Madi A, Merbl Y, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E.

Phys Biol. 2013 Apr;10(2):025003. doi: 10.1088/1478-3975/10/2/025003. Epub 2013 Mar 15.


Beta-lactam antibiotics modulate T-cell functions and gene expression via covalent binding to cellular albumin.

Mor F, Cohen IR.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2981-6. doi: 10.1073/pnas.1215722110. Epub 2013 Feb 4.


T cell vaccination benefits relapsing progressive multiple sclerosis patients: a randomized, double-blind clinical trial.

Karussis D, Shor H, Yachnin J, Lanxner N, Amiel M, Baruch K, Keren-Zur Y, Haviv O, Filippi M, Petrou P, Hajag S, Vourka-Karussis U, Vaknin-Dembinsky A, Khoury S, Abramsky O, Atlan H, Cohen IR, Abulafia-Lapid R.

PLoS One. 2012;7(12):e50478. doi: 10.1371/journal.pone.0050478. Epub 2012 Dec 14.


The natural autoantibody repertoire in newborns and adults: a current overview.

Madi A, Bransburg-Zabary S, Kenett DY, Ben-Jacob E, Cohen IR.

Adv Exp Med Biol. 2012;750:198-212. doi: 10.1007/978-1-4614-3461-0_15. Review.


Mouse dendritic cells pulsed with capsular polysaccharide induce resistance to lethal pneumococcal challenge: roles of T cells and B cells.

Cohen N, Margalit R, Pevsner-Fischer M, Yona S, Jung S, Eisenbach L, Cohen IR.

PLoS One. 2012;7(6):e39193. doi: 10.1371/journal.pone.0039193. Epub 2012 Jun 18.


Antigen microarrays identify CNS-produced autoantibodies in RRMS.

Quintana FJ, Farez MF, Izquierdo G, Lucas M, Cohen IR, Weiner HL.

Neurology. 2012 Feb 21;78(8):532-9. doi: 10.1212/WNL.0b013e318247f9f3. Epub 2012 Jan 18.


Split immunity: immune inhibition of rat gliomas by subcutaneous exposure to unmodified live tumor cells.

Volovitz I, Marmor Y, Azulay M, Machlenkin A, Goldberger O, Mor F, Slavin S, Ram Z, Cohen IR, Eisenbach L.

J Immunol. 2011 Nov 15;187(10):5452-62. doi: 10.4049/jimmunol.1003946. Epub 2011 Oct 12.


Stable changes in mesenchymal stromal cells from multiple myeloma patients revealed through their responses to Toll-like receptor ligands and epidermal growth factor.

Pevsner-Fischer M, Levin S, Hammer-Topaz T, Cohen Y, Mor F, Wagemaker G, Nagler A, Cohen IR, Zipori D.

Stem Cell Rev Rep. 2012 Jun;8(2):343-54. doi: 10.1007/s12015-011-9310-2.


Systemic features of immune recognition in the gut.

Swiatczak B, Rescigno M, Cohen IR.

Microbes Infect. 2011 Nov;13(12-13):983-91. doi: 10.1016/j.micinf.2011.06.011. Epub 2011 Jul 7. Review.


Amyloid beta-HSP60 peptide conjugate vaccine treats a mouse model of Alzheimer's disease.

Nemirovsky A, Fisher Y, Baron R, Cohen IR, Monsonego A.

Vaccine. 2011 May 23;29(23):4043-50. doi: 10.1016/j.vaccine.2011.03.033. Epub 2011 Apr 5.


Analyses of antigen dependency networks unveil immune system reorganization between birth and adulthood.

Madi A, Kenett DY, Bransburg-Zabary S, Merbl Y, Quintana FJ, Boccaletti S, Tauber AI, Cohen IR, Ben-Jacob E.

Chaos. 2011 Mar;21(1):016109. doi: 10.1063/1.3543800.


Corrigendum to "Stress Proteins and Cytokines are Urinary Biomarkers for Diagnosis and Staging of Bladder Cancer" [Eur Urol 2011;59:113-9].

Margel D, Pevsner-Fischer M, Baniel J, Yossepowitch O, Cohen IR.

Eur Urol. 2011 Apr;59(4):670. doi: 10.1016/j.eururo.2010.12.016. Epub 2010 Dec 21. No abstract available.


Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.

Madi A, Kenett DY, Bransburg-Zabary S, Merbl Y, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E.

PLoS One. 2011 Mar 8;6(3):e17445. doi: 10.1371/journal.pone.0017445.


Reactive animation: from piecemeal experimentation to reactive biological systems.

Vainas O, Harel D, Cohen IR, Efroni S.

Autoimmunity. 2011 Jun;44(4):271-81. doi: 10.3109/08916934.2010.523260. Epub 2011 Jan 19. Review.


The HSP60 immune system network.

Quintana FJ, Cohen IR.

Trends Immunol. 2011 Feb;32(2):89-95. doi: 10.1016/ Epub 2010 Dec 8. Review.


Integrative analysis correlates donor transcripts to recipient autoantibodies in primary graft dysfunction after lung transplantation.

Hagedorn PH, Burton CM, Sahar E, Domany E, Cohen IR, Flyvbjerg H, Iversen M.

Immunology. 2011 Mar;132(3):394-400. doi: 10.1111/j.1365-2567.2010.03373.x. Epub 2010 Nov 11.


Stress proteins and cytokines are urinary biomarkers for diagnosis and staging of bladder cancer.

Margel D, Pevsner-Fischer M, Baniel J, Yossepowitch O, Cohen IR.

Eur Urol. 2011 Jan;59(1):113-9. doi: 10.1016/j.eururo.2010.10.008. Epub 2010 Oct 15. Erratum in: Eur Urol. 2011 Apr;59(4):670. Pesvner-Fischer, Meirav [corrected to Pevsner-Fischer, Meirav].


HIV-1 gp41 and TCRalpha trans-membrane domains share a motif exploited by the HIV virus to modulate T-cell proliferation.

Cohen T, Cohen SJ, Antonovsky N, Cohen IR, Shai Y.

PLoS Pathog. 2010 Sep 2;6(9):e1001085. doi: 10.1371/journal.ppat.1001085.


T cell vaccination induces the elimination of EAE effector T cells: analysis using GFP-transduced, encephalitogenic T cells.

Volovitz I, Marmor Y, Mor F, Flügel A, Odoardi F, Eisenbach L, Cohen IR.

J Autoimmun. 2010 Sep;35(2):135-44. doi: 10.1016/j.jaut.2010.05.003. Epub 2010 Jun 26.


Chimeric vaccine composed of viral peptide and mammalian heat-shock protein 60 peptide protects against West Nile virus challenge.

Gershoni-Yahalom O, Landes S, Kleiman-Shoval S, Ben-Nathan D, Kam M, Lachmi BE, Khinich Y, Simanov M, Samina I, Eitan A, Cohen IR, Rager-Zisman B, Porgador A.

Immunology. 2010 Aug;130(4):527-35. doi: 10.1111/j.1365-2567.2010.03251.x. Epub 2010 Mar 16.


An antibody profile of systemic lupus erythematosus detected by antigen microarray.

Fattal I, Shental N, Mevorach D, Anaya JM, Livneh A, Langevitz P, Zandman-Goddard G, Pauzner R, Lerner M, Blank M, Hincapie ME, Gafter U, Naparstek Y, Shoenfeld Y, Domany E, Cohen IR.

Immunology. 2010 Jul;130(3):337-43. doi: 10.1111/j.1365-2567.2010.03245.x. Epub 2010 Feb 26.


Chronic rejection of a lung transplant is characterized by a profile of specific autoantibodies.

Hagedorn PH, Burton CM, Carlsen J, Steinbrüchel D, Andersen CB, Sahar E, Domany E, Cohen IR, Flyvbjerg H, Iversen M.

Immunology. 2010 Jul;130(3):427-35. doi: 10.1111/j.1365-2567.2010.03246.x. Epub 2010 Feb 26.

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