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Items: 1 to 50 of 287

1.

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis.

Milani M, Beckett AJ, Al-Zebeeby A, Luo X, Prior IA, Cohen GM, Varadarajan S.

Cell Death Discov. 2019 Jul 17;5:117. doi: 10.1038/s41420-019-0199-x. eCollection 2019.

2.

Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis.

Yedida G, Milani M, Cohen GM, Varadarajan S.

Cell Death Dis. 2019 Jul 8;10(7):521. doi: 10.1038/s41419-019-1759-y.

3.

Hemophagocytic Lymphohistiocytosis Due to Primary HHV-8 Infection in a Liver Transplant Recipient.

Cohen GM, Langer AL, Sima H, Chang C, Troy K, Taimur S.

Transplant Direct. 2018 Nov 27;4(12):e411. doi: 10.1097/TXD.0000000000000850. eCollection 2018 Dec.

4.

Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies.

Al-Zebeeby A, Vogler M, Milani M, Richards C, Alotibi A, Greaves G, Dyer MJS, Cohen GM, Varadarajan S.

Haematologica. 2019 May;104(5):1016-1025. doi: 10.3324/haematol.2018.204701. Epub 2018 Nov 22.

5.

BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL.

Greaves G, Milani M, Butterworth M, Carter RJ, Byrne DP, Eyers PA, Luo X, Cohen GM, Varadarajan S.

Cell Death Differ. 2019 Jun;26(6):1037-1047. doi: 10.1038/s41418-018-0183-7. Epub 2018 Sep 5.

PMID:
30185825
6.

Corrigendum to "Community-Acquired Cavitary Pseudomonas Pneumonia Linked to Use of a Home Humidifier".

Woods EC, Cohen GM, Bressman E, Lin D, Zeitouni NE, Beckford C, Hamula C, van Bakel H, Sullivan M, Altman DR, Caplivski D.

Case Rep Infect Dis. 2018 Jun 5;2018:6548482. doi: 10.1155/2018/6548482. eCollection 2018.

7.

Selective BH3-mimetics targeting BCL-2, BCL-XL or MCL-1 induce severe mitochondrial perturbations.

Henz K, Al-Zebeeby A, Basoglu M, Fulda S, Cohen GM, Varadarajan S, Vogler M.

Biol Chem. 2019 Jan 28;400(2):181-185. doi: 10.1515/hsz-2018-0233.

PMID:
29924730
8.

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.

Casara P, Davidson J, Claperon A, Le Toumelin-Braizat G, Vogler M, Bruno A, Chanrion M, Lysiak-Auvity G, Le Diguarher T, Starck JB, Chen I, Whitehead N, Graham C, Matassova N, Dokurno P, Pedder C, Wang Y, Qiu S, Girard AM, Schneider E, Gravé F, Studeny A, Guasconi G, Rocchetti F, Maïga S, Henlin JM, Colland F, Kraus-Berthier L, Le Gouill S, Dyer MJS, Hubbard R, Wood M, Amiot M, Cohen GM, Hickman JA, Morris E, Murray J, Geneste O.

Oncotarget. 2018 Apr 13;9(28):20075-20088. doi: 10.18632/oncotarget.24744. eCollection 2018 Apr 13.

9.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

10.

DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis.

Milani M, Byrne DP, Greaves G, Butterworth M, Cohen GM, Eyers PA, Varadarajan S.

Cell Death Dis. 2017 Jan 12;8(1):e2552. doi: 10.1038/cddis.2016.485.

11.

Association of Picky Eating and Food Neophobia with Weight: A Systematic Review.

Brown CL, Vander Schaaf EB, Cohen GM, Irby MB, Skelton JA.

Child Obes. 2016 Aug;12(4):247-62. doi: 10.1089/chi.2015.0189. Epub 2016 May 2. Review.

12.

An Unsuspected Tooth: Spontaneous Tooth Aspiration Leading to Cardiac Arrest.

Cohen GM, Jacobson LS, Richards JB.

Am J Med Sci. 2016 Apr;351(4):426. doi: 10.1016/j.amjms.2016.02.006. Epub 2016 Feb 8. No abstract available.

PMID:
27079351
13.

High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia.

Lucas CM, Milani M, Butterworth M, Carmell N, Scott LJ, Clark RE, Cohen GM, Varadarajan S.

Leukemia. 2016 Jun;30(6):1273-81. doi: 10.1038/leu.2016.42. Epub 2016 Feb 29.

14.

BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells.

Butterworth M, Pettitt A, Varadarajan S, Cohen GM.

Br J Cancer. 2016 Mar 15;114(6):638-41. doi: 10.1038/bjc.2016.49. Epub 2016 Mar 8.

15.

More than Meets the Eye. A 23-Year-Old Woman with Rapidly Progressive Respiratory Failure, Mucositis, and Rash.

Parris RS, Cohen GM, Leahey PA, Gold HS, McSparron JI.

Ann Am Thorac Soc. 2015 Dec;12(12):1876-80. doi: 10.1513/AnnalsATS.201507-412CC. No abstract available.

PMID:
26653193
16.

Addressing Childhood Obesity: Opportunities for Prevention.

Brown CL, Halvorson EE, Cohen GM, Lazorick S, Skelton JA.

Pediatr Clin North Am. 2015 Oct;62(5):1241-61. doi: 10.1016/j.pcl.2015.05.013. Epub 2015 Jul 16. Review.

17.

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner.

Varadarajan S, Poornima P, Milani M, Gowda K, Amin S, Wang HG, Cohen GM.

Oncotarget. 2015 May 20;6(14):12668-81.

18.

The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration.

Varadarajan S, Breda C, Smalley JL, Butterworth M, Farrow SN, Giorgini F, Cohen GM.

Cell Death Differ. 2015 Aug;22(8):1388-96. doi: 10.1038/cdd.2015.1. Epub 2015 Feb 6.

19.

Generation of reactive oxygen species from silicon nanowires.

Leonard SS, Cohen GM, Kenyon AJ, Schwegler-Berry D, Fix NR, Bangsaruntip S, Roberts JR.

Environ Health Insights. 2014 Nov 9;8(Suppl 1):21-9. doi: 10.4137/EHI.S15261. eCollection 2014.

20.

Diagnostic delays and clinical decision making with centralized Xpert MTB/RIF testing in Durban, South Africa.

Cohen GM, Drain PK, Noubary F, Cloete C, Bassett IV.

J Acquir Immune Defic Syndr. 2014 Nov 1;67(3):e88-93. doi: 10.1097/QAI.0000000000000309.

21.

BIM-mediated membrane insertion of the BAK pore domain is an essential requirement for apoptosis.

Weber K, Harper N, Schwabe J, Cohen GM.

Cell Rep. 2013 Oct 31;5(2):409-20. doi: 10.1016/j.celrep.2013.09.010. Epub 2013 Oct 10.

22.

Evaluation and critical assessment of putative MCL-1 inhibitors.

Varadarajan S, Vogler M, Butterworth M, Dinsdale D, Walensky LD, Cohen GM.

Cell Death Differ. 2013 Nov;20(11):1475-84. doi: 10.1038/cdd.2013.79. Epub 2013 Jul 5.

23.

ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets.

Vogler M, Dinsdale D, Dyer MJ, Cohen GM.

Br J Haematol. 2013 Oct;163(1):139-42. doi: 10.1111/bjh.12457. Epub 2013 Jul 4. No abstract available.

PMID:
23826785
24.

Role of Education in HIV Clinical Outcomes in a Tuberculosis Endemic Setting.

Cohen GM, Werner L, Gengiah S, Naidoo K.

J Int Assoc Provid AIDS Care. 2014 Sep-Oct;13(5):402-8. doi: 10.1177/2325957413488185. Epub 2013 May 24.

25.

Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.

Varadarajan S, Butterworth M, Wei J, Pellecchia M, Dinsdale D, Cohen GM.

Neoplasia. 2013 May;15(5):568-78.

26.

Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.

Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM.

PLoS One. 2013;8(2):e56603. doi: 10.1371/journal.pone.0056603. Epub 2013 Feb 15.

27.

Telemedicine and Pediatric Obesity Treatment: Review of the literature and lessons learned.

Cohen GM, Irby MB, Boles K, Jordan C, Skelton JA.

Clin Obes. 2012;2(3-4):103-111. Epub 2012 Sep 24.

28.

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.

Varadarajan S, Bampton ET, Smalley JL, Tanaka K, Caves RE, Butterworth M, Wei J, Pellecchia M, Mitcheson J, Gant TW, Dinsdale D, Cohen GM.

Cell Death Differ. 2012 Dec;19(12):1896-907. doi: 10.1038/cdd.2012.108. Epub 2012 Sep 7.

29.

How PEPFAR's public-private partnerships achieved ambitious goals, from improving labs to strengthening supply chains.

Sturchio JL, Cohen GM.

Health Aff (Millwood). 2012 Jul;31(7):1450-8. doi: 10.1377/hlthaff.2012.0585.

PMID:
22778334
30.

Colic.

Cohen GM, Albertini LW.

Pediatr Rev. 2012 Jul;33(7):332-3; discussion 333. doi: 10.1542/pir.33-7-332. No abstract available.

PMID:
22753793
31.

Contraception and pregnancy in microbicide trials.

Sibeko S, Cohen GM, Moodley J.

Best Pract Res Clin Obstet Gynaecol. 2012 Aug;26(4):473-86. doi: 10.1016/j.bpobgyn.2012.01.005. Epub 2012 Mar 3.

32.

NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1.

Craxton A, Butterworth M, Harper N, Fairall L, Schwabe J, Ciechanover A, Cohen GM.

Cell Death Differ. 2012 Sep;19(9):1424-34. doi: 10.1038/cdd.2012.16. Epub 2012 Feb 24.

33.

Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats.

Roberts JR, Mercer RR, Chapman RS, Cohen GM, Bangsaruntip S, Schwegler-Berry D, Scabilloni JF, Castranova V, Antonini JM, Leonard SS.

J Nanomater. 2012;2012:398302.

34.

Multiple double cross-section transmission electron microscope sample preparation of specific sub-10 nm diameter Si nanowire devices.

Gignac LM, Mittal S, Bangsaruntip S, Cohen GM, Sleight JW.

Microsc Microanal. 2011 Dec;17(6):889-95. doi: 10.1017/S1431927611011974. Epub 2011 Nov 10.

PMID:
22071222
35.

BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.

Vogler M, Hamali HA, Sun XM, Bampton ET, Dinsdale D, Snowden RT, Dyer MJ, Goodall AH, Cohen GM.

Blood. 2011 Jun 30;117(26):7145-54. doi: 10.1182/blood-2011-03-344812. Epub 2011 May 11.

36.

The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein.

Vogler M, Dickens D, Dyer MJ, Owen A, Pirmohamed M, Cohen GM.

Biochem Biophys Res Commun. 2011 May 6;408(2):344-9. doi: 10.1016/j.bbrc.2011.04.043. Epub 2011 Apr 13.

PMID:
21514278
37.

The in vitro cleavage of the hAtg proteins by cell death proteases.

Norman JM, Cohen GM, Bampton ET.

Autophagy. 2010 Nov;6(8):1042-56.

PMID:
21121091
38.

Multidisciplinary treatment of pediatric obesity: nutrition evaluation and management.

Ross MM, Kolbash S, Cohen GM, Skelton JA.

Nutr Clin Pract. 2010 Aug;25(4):327-34. doi: 10.1177/0884533610373771. Review.

39.

Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood.

Vogler M, Furdas SD, Jung M, Kuwana T, Dyer MJ, Cohen GM.

Clin Cancer Res. 2010 Aug 15;16(16):4217-25. doi: 10.1158/1078-0432.CCR-10-0777. Epub 2010 Jul 2.

40.

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.

Baou M, Kohlhaas SL, Butterworth M, Vogler M, Dinsdale D, Walewska R, Majid A, Eldering E, Dyer MJ, Cohen GM.

Haematologica. 2010 Sep;95(9):1510-8. doi: 10.3324/haematol.2010.022368. Epub 2010 Apr 7.

41.

The negative consequences of other students' drinking: inventory development and assessment of differences by student characteristics and risk behaviors.

Rhodes SD, McCoy TP, Omli MR, Cohen GM, Wagoner KG, Durant RH, Vissman AT, Wolfson M.

Int J Adolesc Med Health. 2009 Oct-Dec;21(4):519-29.

42.

Enhanced Fas-associated death domain recruitment by histone deacetylase inhibitors is critical for the sensitization of chronic lymphocytic leukemia cells to TRAIL-induced apoptosis.

Inoue S, Harper N, Walewska R, Dyer MJ, Cohen GM.

Mol Cancer Ther. 2009 Nov;8(11):3088-97. doi: 10.1158/1535-7163.MCT-09-0451. Epub 2009 Nov 3.

43.

Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.

Hughes MA, Harper N, Butterworth M, Cain K, Cohen GM, MacFarlane M.

Mol Cell. 2009 Aug 14;35(3):265-79. doi: 10.1016/j.molcel.2009.06.012.

44.

Phenylarsine oxide interferes with the death inducing signaling complex and inhibits tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced apoptosis.

Sun XM, Canda-Sánchez A, Manjeri GR, Cohen GM, Pinkoski MJ.

Exp Cell Res. 2009 Aug 15;315(14):2453-62. doi: 10.1016/j.yexcr.2009.05.014. Epub 2009 May 22.

PMID:
19465019
45.

Different forms of cell death induced by putative BCL2 inhibitors.

Vogler M, Weber K, Dinsdale D, Schmitz I, Schulze-Osthoff K, Dyer MJ, Cohen GM.

Cell Death Differ. 2009 Jul;16(7):1030-9. doi: 10.1038/cdd.2009.48. Epub 2009 Apr 24.

46.

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G.

Cell Death Differ. 2009 Aug;16(8):1093-107. doi: 10.1038/cdd.2009.44. Epub 2009 Apr 17. Review.

47.

Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway.

Inoue S, Browne G, Melino G, Cohen GM.

Cell Death Differ. 2009 Jul;16(7):1053-61. doi: 10.1038/cdd.2009.29. Epub 2009 Mar 27.

48.

The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing.

Choi YE, Butterworth M, Malladi S, Duckett CS, Cohen GM, Bratton SB.

J Biol Chem. 2009 May 8;284(19):12772-82. doi: 10.1074/jbc.M807550200. Epub 2009 Mar 3.

49.

Caspase cleavage of Itch in chronic lymphocytic leukemia cells.

Rossi M, Inoue S, Walewska R, Knight RA, Dyer MJ, Cohen GM, Melino G.

Biochem Biophys Res Commun. 2009 Feb 13;379(3):659-64. doi: 10.1016/j.bbrc.2008.11.154. Epub 2008 Dec 13.

PMID:
19073138
50.

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia.

Vogler M, Butterworth M, Majid A, Walewska RJ, Sun XM, Dyer MJ, Cohen GM.

Blood. 2009 Apr 30;113(18):4403-13. doi: 10.1182/blood-2008-08-173310. Epub 2008 Nov 13.

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