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Flt3L-Mediated Expansion of Plasmacytoid Dendritic Cells Suppresses HIV Infection in Humanized Mice.

Pham TNQ, Meziane O, Miah MA, Volodina O, Colas C, Béland K, Li Y, Dallaire F, Keler T, Guimond JV, Lesage S, Cheong C, Haddad É, Cohen ÉA.

Cell Rep. 2019 Nov 26;29(9):2770-2782.e5. doi: 10.1016/j.celrep.2019.10.094.


Imaging phenotypes of breast cancer heterogeneity in pre-operative breast Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) scans predict 10-year recurrence.

Chitalia R, Rowland J, McDonald ES, Pantalone L, Cohen EA, Gastounioti A, Feldman M, Schnall M, Conant E, Kontos D.

Clin Cancer Res. 2019 Nov 15. pii: clincanres.4067.2018. doi: 10.1158/1078-0432.CCR-18-4067. [Epub ahead of print]


USP18 is a significant driver of memory CD4 T-cell reduced viability caused by type I IFN signaling during primary HIV-1 infection.

Dagenais-Lussier X, Loucif H, Cadorel H, Blumberger J, Isnard S, Bego MG, Cohen ÉA, Routy JP, van Grevenynghe J; Montreal Primary Infection Study Group.

PLoS Pathog. 2019 Oct 28;15(10):e1008060. doi: 10.1371/journal.ppat.1008060. eCollection 2019 Oct.


Transcatheter Mitral Valve Edge-to-Edge Repair with the New MitraClip XTR System for Acute Mitral Regurgitation Caused by Papillary Muscle Rupture.

Komatsu I, Cohen EA, Cohen GN, Czarnecki A.

Can J Cardiol. 2019 Nov;35(11):1604.e5-1604.e7. doi: 10.1016/j.cjca.2019.06.024. Epub 2019 Jun 28.


HIV-1 persistence in the central nervous system: viral and host determinants during antiretroviral therapy.

Balcom EF, Roda WC, Cohen EA, Li MY, Power C.

Curr Opin Virol. 2019 Oct;38:54-62. doi: 10.1016/j.coviro.2019.06.004. Epub 2019 Aug 4. Review.


Fusing multimodal microscopy data for improved cell boundary estimation and fluorophore localization of Pseudomonas aeruginosa.

Ward S, Cohen EAK, Adams N.

Conf Rec Asilomar Conf Signals Syst Comput. 2018 Oct;2018. pii: ACSSC.2018.8645478. doi: 10.1109/ACSSC.2018.8645478.


Activation of the ILT7 receptor and plasmacytoid dendritic cell responses are governed by structurally-distinct BST2 determinants.

Bego MG, Miguet N, Laliberté A, Aschman N, Gerard F, Merakos AA, Weissenhorn W, Cohen ÉA.

J Biol Chem. 2019 Jul 5;294(27):10503-10518. doi: 10.1074/jbc.RA119.008481. Epub 2019 May 22.


Incorporation of Ebola glycoprotein into HIV particles facilitates dendritic cell and macrophage targeting and enhances HIV-specific immune responses.

Ao Z, Wang L, Mendoza EJ, Cheng K, Zhu W, Cohen EA, Fowke K, Qiu X, Kobinger G, Yao X.

PLoS One. 2019 May 17;14(5):e0216949. doi: 10.1371/journal.pone.0216949. eCollection 2019.


Breast Cancer Conspicuity on Simultaneously Acquired Digital Mammographic Images versus Digital Breast Tomosynthesis Images.

Korhonen KE, Conant EF, Cohen EA, Synnestvedt M, McDonald ES, Weinstein SP.

Radiology. 2019 Jul;292(1):69-76. doi: 10.1148/radiol.2019182027. Epub 2019 May 14.


HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.

Cattin A, Wiche Salinas TR, Gosselin A, Planas D, Shacklett B, Cohen EA, Ghali MP, Routy JP, Ancuta P.

AIDS. 2019 Jul 1;33(8):1293-1306. doi: 10.1097/QAD.0000000000002195.


Resolution limit of image analysis algorithms.

Cohen EAK, Abraham AV, Ramakrishnan S, Ober RJ.

Nat Commun. 2019 Feb 15;10(1):793. doi: 10.1038/s41467-019-08689-x.


HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin.

Sachan V, Lodge R, Mihara K, Hamelin J, Power C, Gelman BB, Hollenberg MD, Cohen ÉA, Seidah NG.

Cell Death Differ. 2019 Oct;26(10):1942-1954. doi: 10.1038/s41418-018-0264-7. Epub 2019 Jan 25.


Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.

Breton Y, Desrosiers V, Ouellet M, Deshiere A, Torresilla C, Cohen ÉA, Tremblay MJ.

J Virol. 2019 Mar 21;93(7). pii: e01871-18. doi: 10.1128/JVI.01871-18. Print 2019 Apr 1.


Variation in Revascularization Practice and Outcomes in Asymptomatic Stable Ischemic Heart Disease.

Czarnecki A, Qiu F, Elbaz-Greener G, Cohen EA, Ko DT, Roifman I, Wijeysundera HC.

JACC Cardiovasc Interv. 2019 Feb 11;12(3):232-241. doi: 10.1016/j.jcin.2018.10.049. Epub 2019 Jan 16.


The radial artery is protective in women and men following coronary artery bypass grafting-a substudy of the radial artery patency study.

Tam DY, Deb S, Nguyen B, Ko DT, Karkhanis R, Moussa F, Fremes J, Cohen EA, Radhakrishnan S, Fremes SE.

Ann Cardiothorac Surg. 2018 Jul;7(4):492-499. doi: 10.21037/acs.2018.05.19.


HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis.

Hossain D, Ferreira Barbosa JA, Cohen ÉA, Tsang WY.

J Biol Chem. 2018 Jun 15;293(24):9448-9460. doi: 10.1074/jbc.RA117.001444. Epub 2018 May 3.


Marital status and outcomes after myocardial infarction: Observations from the Canadian Observational Antiplatelet Study (COAPT).

Ghosh-Swaby OR, Tan M, Bagai A, Yan AT, Goodman SG, Mehta SR, Fisher HN, Cohen EA, Huynh T, Cantor WJ, Le May MR, Déry JP, Welsh RC, Udell JA.

Clin Cardiol. 2018 Mar;41(3):285-292. doi: 10.1002/clc.22901. Epub 2018 Mar 25.


Regulation of CD4 Receptor and HIV-1 Entry by MicroRNAs-221 and -222 during Differentiation of THP-1 Cells.

Lodge R, Gilmore JC, Ferreira Barbosa JA, Lombard-Vadnais F, Cohen ÉA.

Viruses. 2017 Dec 30;10(1). pii: E13. doi: 10.3390/v10010013.


The evaluation of risk-benefit ratio for gut tissue sampling in HIV cure research.

Mehraj V, Ghali P, Ramendra R, Costiniuk C, Lebouché B, Ponte R, Reinhard R, Sousa J, Chomont N, Cohen EA, Ancuta P, Routy JP.

J Virus Erad. 2017 Oct 1;3(4):212-217.


Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.

Asahchop EL, Meziane O, Mamik MK, Chan WF, Branton WG, Resch L, Gill MJ, Haddad E, Guimond JV, Wainberg MA, Baker GB, Cohen EA, Power C.

Retrovirology. 2017 Oct 16;14(1):47. doi: 10.1186/s12977-017-0370-5.


Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.

Lodge R, Ferreira Barbosa JA, Lombard-Vadnais F, Gilmore JC, Deshiere A, Gosselin A, Wiche Salinas TR, Bego MG, Power C, Routy JP, Ancuta P, Tremblay MJ, Cohen ÉA.

Cell Rep. 2017 Oct 3;21(1):141-153. doi: 10.1016/j.celrep.2017.09.030.


3D Bayesian cluster analysis of super-resolution data reveals LAT recruitment to the T cell synapse.

Griffié J, Shlomovich L, Williamson DJ, Shannon M, Aaron J, Khuon S, L Burn G, Boelen L, Peters R, Cope AP, Cohen EAK, Rubin-Delanchy P, Owen DM.

Sci Rep. 2017 Jun 22;7(1):4077. doi: 10.1038/s41598-017-04450-w.


Conserved residues within the HIV-1 Vpu transmembrane-proximal hinge region modulate BST2 binding and antagonism.

Lukhele S, Cohen ÉA.

Retrovirology. 2017 Mar 14;14(1):18. doi: 10.1186/s12977-017-0345-6.


HIV-1 Vpu Downmodulates ICAM-1 Expression, Resulting in Decreased Killing of Infected CD4+ T Cells by NK Cells.

Sugden SM, Pham TNQ, Cohen ÉA.

J Virol. 2017 Mar 29;91(8). pii: e02442-16. doi: 10.1128/JVI.02442-16. Print 2017 Apr 15.


Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells.

Yun TJ, Lee JS, Machmach K, Shim D, Choi J, Wi YJ, Jang HS, Jung IH, Kim K, Yoon WK, Miah MA, Li B, Chang J, Bego MG, Pham TN, Loschko J, Fritz JH, Krug AB, Lee SP, Keler T, Guimond JV, Haddad E, Cohen EA, Sirois MG, El-Hamamsy I, Colonna M, Oh GT, Choi JH, Cheong C.

Cell Metab. 2016 Dec 13;24(6):886. doi: 10.1016/j.cmet.2016.11.008. No abstract available.


Enhancing Virion Tethering by BST2 Sensitizes Productively and Latently HIV-infected T cells to ADCC Mediated by Broadly Neutralizing Antibodies.

Pham TN, Lukhele S, Dallaire F, Perron G, Cohen ÉA.

Sci Rep. 2016 Nov 17;6:37225. doi: 10.1038/srep37225.


HIV persists in CCR6+CD4+ T cells from colon and blood during antiretroviral therapy.

Gosselin A, Wiche Salinas TR, Planas D, Wacleche VS, Zhang Y, Fromentin R, Chomont N, Cohen ÉA, Shacklett B, Mehraj V, Ghali MP, Routy JP, Ancuta P.

AIDS. 2017 Jan 2;31(1):35-48.


Differential Control of BST2 Restriction and Plasmacytoid Dendritic Cell Antiviral Response by Antagonists Encoded by HIV-1 Group M and O Strains.

Bego MG, Cong L, Mack K, Kirchhoff F, Cohen ÉA.

J Virol. 2016 Oct 28;90(22):10236-10246. doi: 10.1128/JVI.01131-16. Print 2016 Nov 15.


Insulin Treatment Prevents Neuroinflammation and Neuronal Injury with Restored Neurobehavioral Function in Models of HIV/AIDS Neurodegeneration.

Mamik MK, Asahchop EL, Chan WF, Zhu Y, Branton WG, McKenzie BA, Cohen EA, Power C.

J Neurosci. 2016 Oct 12;36(41):10683-10695.


HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation.

Mamik MK, Hui E, Branton WG, McKenzie BA, Chisholm J, Cohen EA, Power C.

J Neuroimmune Pharmacol. 2017 Jun;12(2):233-248. doi: 10.1007/s11481-016-9708-3. Epub 2016 Oct 10.


Drivers of healthcare costs associated with the episode of care for surgical aortic valve replacement versus transcatheter aortic valve implantation.

Wijeysundera HC, Li L, Braga V, Pazhaniappan N, Pardhan AM, Lian D, Leeksma A, Peterson B, Cohen EA, Forsey A, Kingsbury KJ.

Open Heart. 2016 Aug 16;3(2):e000468. doi: 10.1136/openhrt-2016-000468. eCollection 2016.


International AIDS Society global scientific strategy: towards an HIV cure 2016.

Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F; International AIDS Society Towards a Cure Working Group, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J.

Nat Med. 2016 Aug;22(8):839-50. doi: 10.1038/nm.4108. Epub 2016 Jul 11.


Individualizing Duration of Dual Antiplatelet Therapy After Acute Coronary Syndrome or Percutaneous Coronary Intervention.

Bagai A, Bhatt DL, Eikelboom JW, Mancini GB, Cohen EA, Vijayaraghavan R, Cheema AN, Udell JA, Niznick J, Tanguay JF, Verma S, Mehta SR.

Circulation. 2016 May 24;133(21):2094-8. doi: 10.1161/CIRCULATIONAHA.115.021158. Review. No abstract available.


Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells.

Yun TJ, Lee JS, Machmach K, Shim D, Choi J, Wi YJ, Jang HS, Jung IH, Kim K, Yoon WK, Miah MA, Li B, Chang J, Bego MG, Pham TN, Loschko J, Fritz JH, Krug AB, Lee SP, Keler T, Guimond JV, Haddad E, Cohen EA, Sirois MG, El-Hamamsy I, Colonna M, Oh GT, Choi JH, Cheong C.

Cell Metab. 2016 May 10;23(5):852-66. doi: 10.1016/j.cmet.2016.04.010. Erratum in: Cell Metab. 2016 Dec 13;24(6):886.


Comparison of Radial Artery and Saphenous Vein Graft Stenosis More Than 5 Years After Coronary Artery Bypass Grafting.

Yamasaki M, Deb S, Tsubota H, Moussa F, Kiss A, Cohen EA, Radhakrishnan S, Dubbin J, Ko D, Schwartz L, Fremes SE; Radial Artery Patency Study Investigators.

Ann Thorac Surg. 2016 Sep;102(3):712-719. doi: 10.1016/j.athoracsur.2016.02.107. Epub 2016 May 4.


De Novo Belatacept in a Human Immunodeficiency Virus-Positive Kidney Transplant Recipient.

Cohen EA, Mulligan D, Kulkarni S, Tichy EM.

Am J Transplant. 2016 Sep;16(9):2753-7. doi: 10.1111/ajt.13852. Epub 2016 Jun 7.


Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence.

Sugden SM, Bego MG, Pham TN, Cohen ÉA.

Viruses. 2016 Mar 3;8(3):67. doi: 10.3390/v8030067. Review.


Listeria monocytogenes bacteremia in a pancreas transplant recipient.

Cohen EA, Topal JE, Tichy EM.

Prog Transplant. 2015 Dec;25(4):321-3. doi: 10.7182/pit2015915.


Cramér-Rao Lower Bound for Point Based Image Registration With Heteroscedastic Error Model for Application in Single Molecule Microscopy.

Cohen EA, Kim D, Ober RJ.

IEEE Trans Med Imaging. 2015 Dec;34(12):2632-44. doi: 10.1109/TMI.2015.2451513.


Medical Therapy and Coronary Revascularization for Patients With Stable Coronary Artery Disease and Unclassified Appropriateness Score.

Shuvy M, Guo H, Wijeysundera HC, Feindel CM, Cohen EA, Austin PC, Kingsbury K, Natarajan MK, Tu JV, Ko DT.

Am J Cardiol. 2015 Dec 15;116(12):1815-21. doi: 10.1016/j.amjcard.2015.09.020. Epub 2015 Oct 3.


Attacking the Supply Lines: HIV-1 Restricts Alanine Uptake to Prevent T Cell Activation.

Sugden S, Cohen ÉA.

Cell Host Microbe. 2015 Nov 11;18(5):514-7. doi: 10.1016/j.chom.2015.10.017.


Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder.

Kim W, Zekas E, Lodge R, Susan-Resiga D, Marcinkiewicz E, Essalmani R, Mihara K, Ramachandran R, Asahchop E, Gelman B, Cohen ÉA, Power C, Hollenberg MD, Seidah NG.

Mol Cell Biol. 2015 Nov;35(21):3684-700. doi: 10.1128/MCB.00764-15. Epub 2015 Aug 17.


Vpu Exploits the Cross-Talk between BST2 and the ILT7 Receptor to Suppress Anti-HIV-1 Responses by Plasmacytoid Dendritic Cells.

Bego MG, Côté É, Aschman N, Mercier J, Weissenhorn W, Cohen ÉA.

PLoS Pathog. 2015 Jul 14;11(7):e1005024. doi: 10.1371/journal.ppat.1005024. eCollection 2015 Jul.


Reperfusion Times for Radial Versus Femoral Access in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Observations From the Cardiac Care Network Provincial Primary PCI Registry.

Cantor WJ, Ko DT, Natarajan MK, Džavík V, Wijeysundera HC, Wang JT, Kingsbury KJ, Velianou JL, Cohen EA, Le May MR, Tu JV.

Circ Cardiovasc Interv. 2015 May;8(5). pii: e002097. doi: 10.1161/CIRCINTERVENTIONS.114.002097.


MitraClip for papillary muscle rupture in patient with cardiogenic shock.

Wolff R, Cohen G, Peterson C, Wong S, Hockman E, Lo J, Strauss BH, Cohen EA.

Can J Cardiol. 2014 Nov;30(11):1461.e13-4. doi: 10.1016/j.cjca.2014.07.015. Epub 2014 Jul 22.


Pharmacodynamic and clinical implications of switching between P2Y12 receptor antagonists: considerations for practice.

Bagai A, Chua D, Cohen EA, Saw J, Verma S, Vijayaraghavan R, Welsh R, Fitchett D.

Crit Pathw Cardiol. 2014 Dec;13(4):156-8. doi: 10.1097/HPC.0000000000000030. Review.


The long-term impact of diabetes on graft patency after coronary artery bypass grafting surgery: a substudy of the multicenter Radial Artery Patency Study.

Deb S, Singh SK, Moussa F, Tsubota H, Une D, Kiss A, Tomlinson G, Afshar M, Sless R, Cohen EA, Radhakrishnan S, Dubbin J, Schwartz L, Fremes SE; Radial Artery Patency Study Investigators.

J Thorac Cardiovasc Surg. 2014 Oct;148(4):1246-53; discussion 1253. doi: 10.1016/j.jtcvs.2014.06.057. Epub 2014 Jul 17.


miRNA-1236 inhibits HIV-1 infection of monocytes by repressing translation of cellular factor VprBP.

Ma L, Shen CJ, Cohen ÉA, Xiong SD, Wang JH.

PLoS One. 2014 Jun 16;9(6):e99535. doi: 10.1371/journal.pone.0099535. eCollection 2014.


Analysis of Point Based Image Registration Errors With Applications in Single Molecule Microscopy.

Cohen EA, Ober RJ.

IEEE Trans Signal Process. 2013 Dec 15;61(24):6291-6306.

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