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Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics.

Adam Y, Kim JJ, Lou S, Zhao Y, Xie ME, Brinks D, Wu H, Mostajo-Radji MA, Kheifets S, Parot V, Chettih S, Williams KJ, Gmeiner B, Farhi SL, Madisen L, Buchanan EK, Kinsella I, Zhou D, Paninski L, Harvey CD, Zeng H, Arlotta P, Campbell RE, Cohen AE.

Nature. 2019 May;569(7756):413-417. doi: 10.1038/s41586-019-1166-7. Epub 2019 May 1.


The crystal structure of dGTPase reveals the molecular basis of dGTP selectivity.

Barnes CO, Wu Y, Song J, Lin G, Baxter EL, Brewster AS, Nagarajan V, Holmes A, Soltis SM, Sauter NK, Ahn J, Cohen AE, Calero G.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9333-9339. doi: 10.1073/pnas.1814999116. Epub 2019 Apr 24.


Wide-Area All-Optical Neurophysiology in Acute Brain Slices.

Farhi SL, Parot VJ, Grama A, Yamagata M, Abdelfattah AS, Adam Y, Lou S, Kim JJ, Campbell RE, Cox DD, Cohen AE.

J Neurosci. 2019 Jun 19;39(25):4889-4908. doi: 10.1523/JNEUROSCI.0168-19.2019. Epub 2019 Apr 5.


X-ray driven reduction of Cpd I of Catalase-3 from N. crassa reveals differential sensitivity of active sites and formation of ferrous state.

Zárate-Romero A, Stojanoff V, Cohen AE, Hansberg W, Rudiño-Piñera E.

Arch Biochem Biophys. 2019 May 15;666:107-115. doi: 10.1016/ Epub 2019 Mar 30.


The Macromolecular Femtosecond Crystallography Instrument at the Linac Coherent Light Source.

Sierra RG, Batyuk A, Sun Z, Aquila A, Hunter MS, Lane TJ, Liang M, Yoon CH, Alonso-Mori R, Armenta R, Castagna JC, Hollenbeck M, Osier TO, Hayes M, Aldrich J, Curtis R, Koglin JE, Rendahl T, Rodriguez E, Carbajo S, Guillet S, Paul R, Hart P, Nakahara K, Carini G, DeMirci H, Dao EH, Hayes BM, Rao YP, Chollet M, Feng Y, Fuller FD, Kupitz C, Sato T, Seaberg MH, Song S, van Driel TB, Yavas H, Zhu D, Cohen AE, Wakatsuki S, Boutet S.

J Synchrotron Radiat. 2019 Mar 1;26(Pt 2):346-357. doi: 10.1107/S1600577519001577. Epub 2019 Feb 22.


Strategies for sample delivery for femtosecond crystallography.

Martiel I, Müller-Werkmeister HM, Cohen AE.

Acta Crystallogr D Struct Biol. 2019 Feb 1;75(Pt 2):160-177. doi: 10.1107/S2059798318017953. Epub 2019 Feb 19. Review.


Cell Membranes Resist Flow.

Shi Z, Graber ZT, Baumgart T, Stone HA, Cohen AE.

Cell. 2018 Dec 13;175(7):1769-1779.e13. doi: 10.1016/j.cell.2018.09.054. Epub 2018 Nov 1.


Geometry-Dependent Arrhythmias in Electrically Excitable Tissues.

McNamara HM, Dodson S, Huang YL, Miller EW, Sandstede B, Cohen AE.

Cell Syst. 2018 Oct 24;7(4):359-370.e6. doi: 10.1016/j.cels.2018.08.013. Epub 2018 Oct 3.


Shell Cross-Linked Micelles as Nanoreactors for Enantioselective Three-Step Tandem Catalysis.

Kuepfert M, Cohen AE, Cullen O, Weck M.

Chemistry. 2018 Dec 12;24(70):18648-18652. doi: 10.1002/chem.201804956. Epub 2018 Nov 12.


All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.

Fan LZ, Nehme R, Adam Y, Jung ES, Wu H, Eggan K, Arnold DB, Cohen AE.

Nat Methods. 2018 Oct;15(10):823-831. doi: 10.1038/s41592-018-0142-8. Epub 2018 Oct 1.


Structural basis of neurosteroid anesthetic action on GABAA receptors.

Chen Q, Wells MM, Arjunan P, Tillman TS, Cohen AE, Xu Y, Tang P.

Nat Commun. 2018 Sep 28;9(1):3972. doi: 10.1038/s41467-018-06361-4.


Sculpting light to reveal brain function.

Cohen AE, Farhi SL.

Nat Neurosci. 2018 Jun;21(6):776-778. doi: 10.1038/s41593-018-0158-5. No abstract available.


All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS.

Kiskinis E, Kralj JM, Zou P, Weinstein EN, Zhang H, Tsioras K, Wiskow O, Ortega JA, Eggan K, Cohen AE.

Stem Cell Reports. 2018 Jun 5;10(6):1991-2004. doi: 10.1016/j.stemcr.2018.04.020. Epub 2018 May 17.


Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope.

Barnes CO, Gristick HB, Freund NT, Escolano A, Lyubimov AY, Hartweger H, West AP Jr, Cohen AE, Nussenzweig MC, Bjorkman PJ.

Nat Commun. 2018 Mar 28;9(1):1251. doi: 10.1038/s41467-018-03632-y.


Ultrawidefield microscope for high-speed fluorescence imaging and targeted optogenetic stimulation.

Werley CA, Chien MP, Cohen AE.

Biomed Opt Express. 2017 Nov 29;8(12):5794-5813. doi: 10.1364/BOE.8.005794. eCollection 2017 Dec 1.


The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.

Mathews II, Allison K, Robbins T, Lyubimov AY, Uervirojnangkoorn M, Brunger AT, Khosla C, DeMirci H, McPhillips SE, Hollenbeck M, Soltis M, Cohen AE.

Biochemistry. 2017 Sep 12;56(36):4751-4756. doi: 10.1021/acs.biochem.7b00711. Epub 2017 Aug 31.


Optogenetic Approaches to Drug Discovery in Neuroscience and Beyond.

Zhang H, Cohen AE.

Trends Biotechnol. 2017 Jul;35(7):625-639. doi: 10.1016/j.tibtech.2017.04.002. Epub 2017 May 25. Review.


End-Functionalized Palladium SCS Pincer Polymers via Controlled Radical Polymerizations.

Lye DS, Cohen AE, Wong MZ, Weck M.

Macromol Rapid Commun. 2017 Jul;38(14). doi: 10.1002/marc.201700174. Epub 2017 May 22.


Voltage imaging with genetically encoded indicators.

Xu Y, Zou P, Cohen AE.

Curr Opin Chem Biol. 2017 Aug;39:1-10. doi: 10.1016/j.cbpa.2017.04.005. Epub 2017 Apr 28. Review.


Geometry-dependent functional changes in iPSC-derived cardiomyocytes probed by functional imaging and RNA sequencing.

Werley CA, Chien MP, Gaublomme J, Shekhar K, Butty V, Yi BA, Kralj JM, Bloxham W, Boyer LA, Regev A, Cohen AE.

PLoS One. 2017 Mar 23;12(3):e0172671. doi: 10.1371/journal.pone.0172671. eCollection 2017.


Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.

Ogden KK, Chen W, Swanger SA, McDaniel MJ, Fan LZ, Hu C, Tankovic A, Kusumoto H, Kosobucki GJ, Schulien AJ, Su Z, Pecha J, Bhattacharya S, Petrovski S, Cohen AE, Aizenman E, Traynelis SF, Yuan H.

PLoS Genet. 2017 Jan 17;13(1):e1006536. doi: 10.1371/journal.pgen.1006536. eCollection 2017 Jan.


Genetically Targeted All-Optical Electrophysiology with a Transgenic Cre-Dependent Optopatch Mouse.

Lou S, Adam Y, Weinstein EN, Williams E, Williams K, Parot V, Kavokine N, Liberles S, Madisen L, Zeng H, Cohen AE.

J Neurosci. 2016 Oct 26;36(43):11059-11073.


Painting with Rainbows: Patterning Light in Space, Time, and Wavelength for Multiphoton Optogenetic Sensing and Control.

Brinks D, Adam Y, Kheifets S, Cohen AE.

Acc Chem Res. 2016 Nov 15;49(11):2518-2526. Epub 2016 Oct 27. Review.


The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction.

Wu Y, Zhou X, Barnes CO, DeLucia M, Cohen AE, Gronenborn AM, Ahn J, Calero G.

Nat Struct Mol Biol. 2016 Oct;23(10):933-940. doi: 10.1038/nsmb.3284. Epub 2016 Aug 29.


Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels.

Zhang H, Reichert E, Cohen AE.

Elife. 2016 May 24;5. pii: e15202. doi: 10.7554/eLife.15202.


Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging.

Dempsey GT, Chaudhary KW, Atwater N, Nguyen C, Brown BS, McNeish JD, Cohen AE, Kralj JM.

J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:240-50. doi: 10.1016/j.vascn.2016.05.003. Epub 2016 May 13.


Transmission electron microscopy for the evaluation and optimization of crystal growth.

Stevenson HP, Lin G, Barnes CO, Sutkeviciute I, Krzysiak T, Weiss SC, Reynolds S, Wu Y, Nagarajan V, Makhov AM, Lawrence R, Lamm E, Clark L, Gardella TJ, Hogue BG, Ogata CM, Ahn J, Gronenborn AM, Conway JF, Vilardaga JP, Cohen AE, Calero G.

Acta Crystallogr D Struct Biol. 2016 May;72(Pt 5):603-15. doi: 10.1107/S2059798316001546. Epub 2016 Apr 26.


The Stanford Automated Mounter: pushing the limits of sample exchange at the SSRL macromolecular crystallography beamlines.

Russi S, Song J, McPhillips SE, Cohen AE.

J Appl Crystallogr. 2016 Feb 24;49(Pt 2):622-626. eCollection 2016 Apr 1.


Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.

Roessler CG, Agarwal R, Allaire M, Alonso-Mori R, Andi B, Bachega JFR, Bommer M, Brewster AS, Browne MC, Chatterjee R, Cho E, Cohen AE, Cowan M, Datwani S, Davidson VL, Defever J, Eaton B, Ellson R, Feng Y, Ghislain LP, Glownia JM, Han G, Hattne J, Hellmich J, Héroux A, Ibrahim M, Kern J, Kuczewski A, Lemke HT, Liu P, Majlof L, McClintock WM, Myers S, Nelsen S, Olechno J, Orville AM, Sauter NK, Soares AS, Soltis SM, Song H, Stearns RG, Tran R, Tsai Y, Uervirojnangkoorn M, Wilmot CM, Yachandra V, Yano J, Yukl ET, Zhu D, Zouni A.

Structure. 2016 Apr 5;24(4):631-640. doi: 10.1016/j.str.2016.02.007. Epub 2016 Mar 17.


Optogenetics: Turning the Microscope on Its Head.

Cohen AE.

Biophys J. 2016 Mar 8;110(5):997-1003. doi: 10.1016/j.bpj.2016.02.011. Review. No abstract available.


Assessment of microcrystal quality by transmission electron microscopy for efficient serial femtosecond crystallography.

Barnes CO, Kovaleva EG, Fu X, Stevenson HP, Brewster AS, DePonte DP, Baxter EL, Cohen AE, Calero G.

Arch Biochem Biophys. 2016 Jul 15;602:61-68. doi: 10.1016/ Epub 2016 Mar 2. Review.


A Bright and Fast Red Fluorescent Protein Voltage Indicator That Reports Neuronal Activity in Organotypic Brain Slices.

Abdelfattah AS, Farhi SL, Zhao Y, Brinks D, Zou P, Ruangkittisakul A, Platisa J, Pieribone VA, Ballanyi K, Cohen AE, Campbell RE.

J Neurosci. 2016 Feb 24;36(8):2458-72. doi: 10.1523/JNEUROSCI.3484-15.2016. Erratum in: J Neurosci. 2018 Mar 21;38(12):3147-3148.


High-density grids for efficient data collection from multiple crystals.

Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):2-11. doi: 10.1107/S2059798315020847. Epub 2016 Jan 1.


Goniometer-based femtosecond X-ray diffraction of mutant 30S ribosomal subunit crystals.

Dao EH, Sierra RG, Laksmono H, Lemke HT, Alonso-Mori R, Coey A, Larsen K, Baxter EL, Cohen AE, Soltis SM, DeMirci H.

Struct Dyn. 2015 Apr 30;2(4):041706. doi: 10.1063/1.4919407. eCollection 2015 Jul.


Crystal structure of the pristine peroxidase ferryl center and its relevance to proton-coupled electron transfer.

Chreifi G, Baxter EL, Doukov T, Cohen AE, McPhillips SE, Song J, Meharenna YT, Soltis SM, Poulos TL.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1226-31. doi: 10.1073/pnas.1521664113. Epub 2016 Jan 19. Erratum in: Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1586.


UV-Visible Absorption Spectroscopy Enhanced X-ray Crystallography at Synchrotron and X-ray Free Electron Laser Sources.

Cohen AE, Doukov T, Soltis MS.

Protein Pept Lett. 2016;23(3):283-90. Review.


Two-photon imaging of a magneto-fluorescent indicator for 3D optical magnetometry.

Lee H, Brinks D, Cohen AE.

Opt Express. 2015 Oct 19;23(21):28022-30. doi: 10.1364/OE.23.028022.


All-Optical Interrogation of Neural Circuits.

Emiliani V, Cohen AE, Deisseroth K, Häusser M.

J Neurosci. 2015 Oct 14;35(41):13917-26. doi: 10.1523/JNEUROSCI.2916-15.2015.


A Low Affinity GCaMP3 Variant (GCaMPer) for Imaging the Endoplasmic Reticulum Calcium Store.

Henderson MJ, Baldwin HA, Werley CA, Boccardo S, Whitaker LR, Yan X, Holt GT, Schreiter ER, Looger LL, Cohen AE, Kim DS, Harvey BK.

PLoS One. 2015 Oct 9;10(10):e0139273. doi: 10.1371/journal.pone.0139273. eCollection 2015.


Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.

Keedy DA, Kenner LR, Warkentin M, Woldeyes RA, Hopkins JB, Thompson MC, Brewster AS, Van Benschoten AH, Baxter EL, Uervirojnangkoorn M, McPhillips SE, Song J, Alonso-Mori R, Holton JM, Weis WI, Brunger AT, Soltis SM, Lemke H, Gonzalez A, Sauter NK, Cohen AE, van den Bedem H, Thorne RE, Fraser JS.

Elife. 2015 Sep 30;4. pii: e07574. doi: 10.7554/eLife.07574.


Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.

Chen Q, Kinde MN, Arjunan P, Wells MM, Cohen AE, Xu Y, Tang P.

Sci Rep. 2015 Sep 8;5:13833. doi: 10.1038/srep13833.


Nano-mechanical measurements of protein-DNA interactions with a silicon nitride pulley.

Shon MJ, Cohen AE.

Nucleic Acids Res. 2016 Jan 8;44(1):e7. doi: 10.1093/nar/gkv866. Epub 2015 Sep 3.


Two-Photon Lifetime Imaging of Voltage Indicating Proteins as a Probe of Absolute Membrane Voltage.

Brinks D, Klein AJ, Cohen AE.

Biophys J. 2015 Sep 1;109(5):914-21. doi: 10.1016/j.bpj.2015.07.038.


Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.

Zhou Q, Lai Y, Bacaj T, Zhao M, Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Sauter NK, Cohen AE, Soltis SM, Alonso-Mori R, Chollet M, Lemke HT, Pfuetzner RA, Choi UB, Weis WI, Diao J, Südhof TC, Brunger AT.

Nature. 2015 Sep 3;525(7567):62-7. doi: 10.1038/nature14975. Epub 2015 Aug 17.


Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.

Barnes CO, Calero M, Malik I, Graham BW, Spahr H, Lin G, Cohen AE, Brown IS, Zhang Q, Pullara F, Trakselis MA, Kaplan CD, Calero G.

Mol Cell. 2015 Jul 16;59(2):258-69. doi: 10.1016/j.molcel.2015.06.034.


Can Species Distribution Models Aid Bioassessment when Reference Sites are Lacking? Tests Based on Freshwater Fishes.

Labay BJ, Hendrickson DA, Cohen AE, Bonner TH, King RS, Kleinsasser LJ, Linam GW, Winemiller KO.

Environ Manage. 2015 Oct;56(4):835-46. doi: 10.1007/s00267-015-0567-0. Epub 2015 Jun 20.


Capture and X-ray diffraction studies of protein microcrystals in a microfluidic trap array.

Lyubimov AY, Murray TD, Koehl A, Araci IE, Uervirojnangkoorn M, Zeldin OB, Cohen AE, Soltis SM, Baxter EL, Brewster AS, Sauter NK, Brunger AT, Berger JM.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):928-40. doi: 10.1107/S1399004715002308. Epub 2015 Mar 27.


Photostick: a method for selective isolation of target cells from culture.

Chien MP, Werley CA, Farhi SL, Cohen AE.

Chem Sci. 2015 Mar;6(3):1701-1705.


Goniometer-based femtosecond crystallography with X-ray free electron lasers.

Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17122-7. doi: 10.1073/pnas.1418733111. Epub 2014 Oct 31.

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