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Items: 1 to 50 of 104


Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways.

Fuellen G, Jansen L, Cohen AA, Luyten W, Gogol M, Simm A, Saul N, Cirulli F, Berry A, Antal P, Köhling R, Wouters B, Möller S.

Aging Dis. 2019 Aug 1;10(4):883-900. doi: 10.14336/AD.2018.1030. eCollection 2019 Aug. Review.


Determinants of left atrium thrombi in scheduled cardioversion: an ENSURE-AF study analysis.

Merino JL, Lip GYH, Heidbuchel H, Cohen AA, De Caterina R, de Groot JR, Ezekowitz MD, Le Heuzey JY, Themistoclakis S, Jin J, Melino M, Winters SM, Merkely B, Goette A.

Europace. 2019 Aug 22. pii: euz213. doi: 10.1093/europace/euz213. [Epub ahead of print]


One-Step Triple-Layer Reconstruction of an Exposed Calvarium in a Radiated Tinea Capitis Patient.

Shay T, Har-Shai L, Cohen AA, Ad-El DD.

J Craniofac Surg. 2019 Jul 24. doi: 10.1097/SCS.0000000000005754. [Epub ahead of print]


Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.

Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West AP Jr, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC.

Nature. 2019 Jun;570(7762):468-473. doi: 10.1038/s41586-019-1250-z. Epub 2019 May 29.


Modelling sea lice control by lumpfish on Atlantic salmon farms: interactions with mate limitation, temperature and treatment rules.

McEwan GF, Groner ML, Cohen AAB, Imsland AKD, Revie CW.

Dis Aquat Organ. 2019 Feb 21;133(1):69-82. doi: 10.3354/dao03329.


An emergent integrated aging process conserved across primates.

Wey TW, Roberge É, Legeault V, Kemnitz JW, Ferrucci L, Cohen AA.

J Gerontol A Biol Sci Med Sci. 2019 May 2. pii: glz110. doi: 10.1093/gerona/glz110. [Epub ahead of print]


Causes and short-term consequences of variation in milk composition in wild sheep.

Renaud LA, Blanchet FG, Cohen AA, Pelletier F.

J Anim Ecol. 2019 Jun;88(6):857-869. doi: 10.1111/1365-2656.12977. Epub 2019 Apr 12.


Conservation of physiological dysregulation signatures of aging across primates.

Dansereau G, Wey TW, Legault V, Brunet MA, Kemnitz JW, Ferrucci L, Cohen AA.

Aging Cell. 2019 Apr;18(2):e12925. doi: 10.1111/acel.12925. Epub 2019 Feb 11.


Spontaneous conversion in patients with non-valvular atrial fibrillation planned for electrical cardioversion: A subanalysis of the EdoxabaN versus warfarin in subjectS UndeRgoing cardiovErsion Of Atrial Fibrillation (ENSURE-AF) trial.

Cohen AA, Heidbuchel H, Le Heuzey JY, De Caterina R, Merino JL, Jin J, Melino M, Winters SM, Goette A, Lip GYH.

Am Heart J. 2019 Mar;209:131-135. doi: 10.1016/j.ahj.2018.10.008. Epub 2018 Nov 22. No abstract available.


Improving Outcome in Immediate Alloplastic Breast Reconstruction, an Algorithm for Operative Decision Making.

Shay T, Cohen AA, Ad-El D.

Plast Reconstr Surg Glob Open. 2018 Oct 2;6(10):e1845. doi: 10.1097/GOX.0000000000001845. eCollection 2018 Oct.


Physiological predictors of reproductive performance in the European Starling (Sturnus vulgaris).

Fowler MA, Paquet M, Legault V, Cohen AA, Williams TD.

Front Zool. 2018 Nov 22;15:45. doi: 10.1186/s12983-018-0288-3. eCollection 2018.


"Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease.

Arbeev KG, Ukraintseva SV, Bagley O, Zhbannikov IY, Cohen AA, Kulminski AM, Yashin AI.

J Gerontol A Biol Sci Med Sci. 2019 Mar 14;74(4):462-468. doi: 10.1093/gerona/gly136.


Recognition of the polycistronic nature of human genes is critical to understanding the genotype-phenotype relationship.

Brunet MA, Levesque SA, Hunting DJ, Cohen AA, Roucou X.

Genome Res. 2018 May;28(5):609-624. doi: 10.1101/gr.230938.117. Epub 2018 Apr 6. Review.


Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

Fulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, Witkowski JM, Franceschi C.

Front Immunol. 2018 Jan 10;8:1960. doi: 10.3389/fimmu.2017.01960. eCollection 2017. Review.


Co-existence of multiple trade-off currencies shapes evolutionary outcomes.

Cohen AA, Isaksson C, Salguero-Gómez R.

PLoS One. 2017 Dec 7;12(12):e0189124. doi: 10.1371/journal.pone.0189124. eCollection 2017.


Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?

Belsky DW, Moffitt TE, Cohen AA, Corcoran DL, Levine ME, Prinz JA, Schaefer J, Sugden K, Williams B, Poulton R, Caspi A.

Am J Epidemiol. 2018 Jun 1;187(6):1220-1230. doi: 10.1093/aje/kwx346.


Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins.

Samandi S, Roy AV, Delcourt V, Lucier JF, Gagnon J, Beaudoin MC, Vanderperre B, Breton MA, Motard J, Jacques JF, Brunelle M, Gagnon-Arsenault I, Fournier I, Ouangraoua A, Hunting DJ, Cohen AA, Landry CR, Scott MS, Roucou X.

Elife. 2017 Oct 30;6. pii: e27860. doi: 10.7554/eLife.27860.


Mother's curse neutralizes natural selection against a human genetic disease over three centuries.

Milot E, Moreau C, Gagnon A, Cohen AA, Brais B, Labuda D.

Nat Ecol Evol. 2017 Sep;1(9):1400-1406. doi: 10.1038/s41559-017-0276-6. Epub 2017 Aug 21.


The mystery of life beyond menopause.

Cohen AA.

Nat Ecol Evol. 2017 Nov;1(11):1604-1605. doi: 10.1038/s41559-017-0356-7. No abstract available.


Men Sustain Higher Dysregulation Levels Than Women Without Becoming Frail.

Cohen AA, Legault V, Li Q, Fried LP, Ferrucci L.

J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):175-184. doi: 10.1093/gerona/glx146.


The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations.

Cohen AA, Legault V, Fuellen G, Fülöp T, Fried LP, Ferrucci L.

Exp Gerontol. 2018 Jul 1;107:11-17. doi: 10.1016/j.exger.2017.07.011. Epub 2017 Jul 16. Review.


Aging across the tree of life: The importance of a comparative perspective for the use of animal models in aging.

Cohen AA.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2680-2689. doi: 10.1016/j.bbadis.2017.05.028. Epub 2017 Jul 6. Review.


Interview with Alexander Cohen.

Cohen AA.

Future Cardiol. 2017 May;13(3):207-209. doi: 10.2217/fca-2017-0024. Epub 2017 Jun 1.


Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop.

Wang H, Cohen AA, Galimidi RP, Gristick HB, Jensen GJ, Bjorkman PJ.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7151-E7158. Epub 2016 Oct 31.


Deep biomarkers of aging are population-dependent.

Cohen AA, Morissette-Thomas V, Ferrucci L, Fried LP.

Aging (Albany NY). 2016 Sep 8;8(9):2253-2255. doi: 10.18632/aging.101034. No abstract available.


Comparative effectiveness and safety of antipsychotic drugs in schizophrenia treatment: a real-world observational study.

Vanasse A, Blais L, Courteau J, Cohen AA, Roberge P, Larouche A, Grignon S, Fleury MJ, Lesage A, Demers MF, Roy MA, Carrier JD, Delorme A.

Acta Psychiatr Scand. 2016 Nov;134(5):374-384. doi: 10.1111/acps.12621. Epub 2016 Jul 12.


Maternal levels of endocrine disruptors, polybrominated diphenyl ethers, in early pregnancy are not associated with lower birth weight in the Canadian birth cohort GESTE.

Serme-Gbedo YK, Abdelouahab N, Pasquier JC, Cohen AA, Takser L.

Environ Health. 2016 Apr 12;15:49. doi: 10.1186/s12940-016-0134-z.


Optimal Versus Realized Trajectories of Physiological Dysregulation in Aging and Their Relation to Sex-Specific Mortality Risk.

Arbeev KG, Cohen AA, Arbeeva LS, Milot E, Stallard E, Kulminski AM, Akushevich I, Ukraintseva SV, Christensen K, Yashin AI.

Front Public Health. 2016 Jan 25;4:3. doi: 10.3389/fpubh.2016.00003. eCollection 2016.


Homeostatic dysregulation proceeds in parallel in multiple physiological systems.

Li Q, Wang S, Milot E, Bergeron P, Ferrucci L, Fried LP, Cohen AA.

Aging Cell. 2015 Dec;14(6):1103-12. doi: 10.1111/acel.12402. Epub 2015 Sep 29.


A theoretical model of the evolution of actuarial senescence under environmental stress.

Watson H, Cohen AA, Isaksson C.

Exp Gerontol. 2015 Nov;71:80-8. doi: 10.1016/j.exger.2015.08.009. Epub 2015 Aug 31.


Direct Oral Anticoagulants and Their Use in Treatment and Secondary Prevention of Acute Symptomatic Venous Thromboembolism.

Granziera S, Hasan A, Cohen AA.

Clin Appl Thromb Hemost. 2016 Apr;22(3):209-21. doi: 10.1177/1076029615600791. Epub 2015 Aug 31. Review.


Frailty, Inflammation and Immunosenescence.

Fulop T, McElhaney J, Pawelec G, Cohen AA, Morais JA, Dupuis G, Baehl S, Camous X, Witkowski JM, Larbi A.

Interdiscip Top Gerontol Geriatr. 2015;41:26-40. doi: 10.1159/000381134. Epub 2015 Jul 17. Review.


Complex systems dynamics in aging: new evidence, continuing questions.

Cohen AA.

Biogerontology. 2016 Feb;17(1):205-20. doi: 10.1007/s10522-015-9584-x. Epub 2015 May 20. Review.


Physiological and comparative evidence fails to confirm an adaptive role for aging in evolution.

Cohen AA.

Curr Aging Sci. 2015 Apr 22. [Epub ahead of print]


Neighbourhood immigration, health care utilization and outcomes in patients with diabetes living in the Montreal metropolitan area (Canada): a population health perspective.

Vanasse A, Courteau J, Orzanco MG, Bergeron P, Cohen AA, Niyonsenga T.

BMC Health Serv Res. 2015 Apr 9;15:146. doi: 10.1186/s12913-015-0824-1.


Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition.

Cohen AA, Li Q, Milot E, Leroux M, Faucher S, Morissette-Thomas V, Legault V, Fried LP, Ferrucci L.

PLoS One. 2015 Apr 13;10(4):e0122541. doi: 10.1371/journal.pone.0122541. eCollection 2015.


Detection of a novel, integrative aging process suggests complex physiological integration.

Cohen AA, Milot E, Li Q, Bergeron P, Poirier R, Dusseault-Bélanger F, Fülöp T, Leroux M, Legault V, Metter EJ, Fried LP, Ferrucci L.

PLoS One. 2015 Mar 11;10(3):e0116489. doi: 10.1371/journal.pone.0116489. eCollection 2015.


Environmental Factors Associated With Social Participation of Older Adults Living in Metropolitan, Urban, and Rural Areas: The NuAge Study.

Levasseur M, Cohen AA, Dubois MF, Généreux M, Richard L, Therrien FH, Payette H.

Am J Public Health. 2015 Aug;105(8):1718-25. doi: 10.2105/AJPH.2014.302415. Epub 2015 Feb 17.


Effects of categorization method, regression type, and variable distribution on the inflation of Type-I error rate when categorizing a confounding variable.

Barnwell-Ménard JL, Li Q, Cohen AA.

Stat Med. 2015 Mar 15;34(6):936-49. doi: 10.1002/sim.6387. Epub 2014 Dec 11.


Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations.

Milot E, Morissette-Thomas V, Li Q, Fried LP, Ferrucci L, Cohen AA.

Mech Ageing Dev. 2014 Nov-Dec;141-142:56-63. doi: 10.1016/j.mad.2014.10.001. Epub 2014 Oct 20.


Stress responsive biochemical anabolic/catabolic ratio and telomere length in older adults.

Vasunilashorn S, Cohen AA.

Biodemography Soc Biol. 2014;60(2):174-84. doi: 10.1080/19485565.2014.950722.


Beta-blockers are associated with increased risk of first cardiovascular events in non-diabetic hypertensive elderly patients.

Brouwers FM, Courteau J, Cohen AA, Farand P, Cloutier L, Asghari S, Vanasse A.

Pharmacoepidemiol Drug Saf. 2014 Nov;23(11):1139-46. doi: 10.1002/pds.3675. Epub 2014 Jul 5.


Inflamm-aging does not simply reflect increases in pro-inflammatory markers.

Morrisette-Thomas V, Cohen AA, Fülöp T, Riesco É, Legault V, Li Q, Milot E, Dusseault-Bélanger F, Ferrucci L.

Mech Ageing Dev. 2014 Jul;139:49-57. doi: 10.1016/j.mad.2014.06.005. Epub 2014 Jul 8.


Cross-population validation of statistical distance as a measure of physiological dysregulation during aging.

Cohen AA, Milot E, Li Q, Legault V, Fried LP, Ferrucci L.

Exp Gerontol. 2014 Sep;57:203-10. doi: 10.1016/j.exger.2014.04.016. Epub 2014 May 5.


Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques.

Amarenco P, Davis S, Jones EF, Cohen AA, Heiss WD, Kaste M, Laouénan C, Young D, Macleod M, Donnan GA; Aortic Arch Related Cerebral Hazard Trial Investigators.

Stroke. 2014 May;45(5):1248-57. doi: 10.1161/STROKEAHA.113.004251. Epub 2014 Apr 3.


NOACs for thromboprophylaxis in medical patients.

Cohen AA, Rider T.

Best Pract Res Clin Haematol. 2013 Jun;26(2):183-90. doi: 10.1016/j.beha.2013.07.002. Epub 2013 Jul 21. Review.


Ecological immunology in a fluctuating environment: an integrative analysis of tree swallow nestling immune defense.

Pigeon G, Bélisle M, Garant D, Cohen AA, Pelletier F.

Ecol Evol. 2013 Apr;3(4):1091-103. doi: 10.1002/ece3.504. Epub 2013 Mar 9.


Does elapsed time between first diagnosis of schizophrenia and migration between health territories vary by place of residence? A survival analysis approach.

Ngamini Ngui A, Cohen AA, Courteau J, Lesage A, Fleury MJ, Grégoire JP, Moisan J, Vanasse A.

Health Place. 2013 Mar;20:66-74. doi: 10.1016/j.healthplace.2012.12.003. Epub 2013 Jan 7.


A novel statistical approach shows evidence for multi-system physiological dysregulation during aging.

Cohen AA, Milot E, Yong J, Seplaki CL, Fülöp T, Bandeen-Roche K, Fried LP.

Mech Ageing Dev. 2013 Mar;134(3-4):110-7. doi: 10.1016/j.mad.2013.01.004. Epub 2013 Jan 31.

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